BacMap

Definition	Cupriavidus metallidurans CH34 chromosome, complete genome.
Accession	NC_007973
Length	3,928,089

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The map label for this gene is phaB [H]

Identifier: 94310300

GI number: 94310300

Start: 1467642

End: 1468382

Strand: Direct

Name: phaB [H]

Synonym: Rmet_1358

Alternate gene names: 94310300

Gene position: 1467642-1468382 (Clockwise)

Preceding gene: 94310299

Following gene: 94310301

Centisome position: 37.36

GC content: 61.81

Gene sequence:

>741_bases
ATGACTCAGCGCATTGCATATGTGACCGGCGGCATGGGCGGCATCGGGACCGCGATTTGCCAGCGACTGGCGCGGGATGG
TTACAAGGTGGTGGCGGGCTGCGGCCCGAATTCGCCACGTCGTGAGAAGTGGCTCGAACAGCAACGCGCGCTCGGGTTTG
AATTCGTGGCGTCCGAAGGCAACGTCGCCGACTGGGACTCCACCAAGGCAGCCTTCGATAAGGTCAAGTCCGAAGTGGGC
GAGGTCGATGTGCTGATCAACAACGCCGGCATCACGCGAGACGTAGTGTTCCGCAAGATGACCCGCGCGGACTGGGATGC
GGTGATCGACACGAATCTGACGTCGCTGTTCAACGTGACCAAGCAGGTCATCGACGGCATGGCTGACCGCGGCTGGGGTC
GAATCGTCAATATTTCGTCGGTGAACGGCCAGAAGGGTCAGTTCGGTCAGACCAACTACTCGACCGCCAAGGCAGGCCTG
CACGGCTTCACGATGGCGCTGGCGCAGGAAGTGGCCACCAAGGGCGTGACCGTGAACACGGTGTCGCCGGGCTACATCGC
CACGGACATGGTCAAATCGATTCGCCAGGATGTGCTCGACAAGATCGTCGGCACGATTCCGGTCAAGCGTCTGGGCACGC
CCGAAGAAATCGCCTCGATCTGCGCTTGGCTGTCGTCGGACGAGTCGGGTTTCTCCACCGGTGCCGACTTCTCGCTGAAT
GGCGGCCTGCACATGGGCTGA

Upstream 100 bases:

>100_bases
GAGGGGTGTGCCGGCCGTGTACGTCCAGGACGGATGCGGCCGGCGTGAATAAGAAAGACCAAAGCTTCGACACGATCGGG
CGAGCCAACTAGGAGTGGAT

Downstream 100 bases:

>100_bases
CCGGCGCGCGCGCCGGATGTCGCCGTTGATGCGGCGCATCCAGCGCAGTGCACAAGCATGACCCGGCCGGGCTCCGGCTG
GCGTTTCTGGCGGGCGATGC

Product: acetyacetyl-CoA reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTQRIAYVTGGMGGIGTAICQRLARDGYKVVAGCGPNSPRREKWLEQQRALGFEFVASEGNVADWDSTKAAFDKVKSEVG
EVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGL
HGFTMALAQEVATKGVTVNTVSPGYIATDMVKSIRQDVLDKIVGTIPVKRLGTPEEIASICAWLSSDESGFSTGADFSLN
GGLHMG

Sequences:

>Translated_246_residues
MTQRIAYVTGGMGGIGTAICQRLARDGYKVVAGCGPNSPRREKWLEQQRALGFEFVASEGNVADWDSTKAAFDKVKSEVG
EVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGL
HGFTMALAQEVATKGVTVNTVSPGYIATDMVKSIRQDVLDKIVGTIPVKRLGTPEEIASICAWLSSDESGFSTGADFSLN
GGLHMG
>Mature_245_residues
TQRIAYVTGGMGGIGTAICQRLARDGYKVVAGCGPNSPRREKWLEQQRALGFEFVASEGNVADWDSTKAAFDKVKSEVGE
VDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLH
GFTMALAQEVATKGVTVNTVSPGYIATDMVKSIRQDVLDKIVGTIPVKRLGTPEEIASICAWLSSDESGFSTGADFSLNG
GLHMG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=36.7588932806324, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=34.5528455284553, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=31.8897637795276, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI4504505, Length=246, Percent_Identity=32.1138211382114, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=30.8, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=29.296875, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=29.3877551020408, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI83715985, Length=254, Percent_Identity=30.3149606299213, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI66933014, Length=227, Percent_Identity=29.5154185022026, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=28.4584980237154, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=28.2258064516129, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=28.5140562248996, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI7705855, Length=209, Percent_Identity=31.1004784688995, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI109715829, Length=239, Percent_Identity=25.5230125523013, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI31542939, Length=206, Percent_Identity=30.5825242718447, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=30.3482587064677, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7657478, Length=208, Percent_Identity=29.8076923076923, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI59889578, Length=216, Percent_Identity=28.2407407407407, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI7706318, Length=213, Percent_Identity=26.2910798122066, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI150247226, Length=192, Percent_Identity=30.2083333333333, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI22507405, Length=194, Percent_Identity=28.8659793814433, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4503817, Length=225, Percent_Identity=25.3333333333333, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4557649, Length=204, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=30.4812834224599, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI226371731, Length=223, Percent_Identity=26.9058295964126, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI40548397, Length=198, Percent_Identity=26.7676767676768, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI214010158, Length=198, Percent_Identity=26.7676767676768, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI214010156, Length=198, Percent_Identity=26.7676767676768, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI22758144, Length=198, Percent_Identity=26.7676767676768, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI19743808, Length=194, Percent_Identity=29.3814432989691, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI20149619, Length=202, Percent_Identity=28.7128712871287, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=42.5619834710744, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=37.4501992031873, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790717, Length=238, Percent_Identity=29.8319327731092, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1789208, Length=246, Percent_Identity=30.0813008130081, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=31.5573770491803, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=27.4590163934426, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=31.5789473684211, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787905, Length=240, Percent_Identity=28.75, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1787820, Length=224, Percent_Identity=28.125, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=26.8, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=27.6679841897233, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786701, Length=206, Percent_Identity=28.6407766990291, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=24.9027237354086, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=40.4858299595142, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=36.5853658536585, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=32.2709163346614, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17568967, Length=248, Percent_Identity=34.2741935483871, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=30.4, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=29.9212598425197, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=30.46875, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=29.9595141700405, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=27.2357723577236, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=29.7297297297297, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI193203115, Length=192, Percent_Identity=32.2916666666667, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=32.2916666666667, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=29.0836653386454, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=28.740157480315, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=27.9850746268657, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17561272, Length=196, Percent_Identity=29.5918367346939, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=29.1666666666667, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=242, Percent_Identity=27.6859504132231, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=29.1512915129151, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=28.735632183908, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=250, Percent_Identity=27.6, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=27.1698113207547, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=243, Percent_Identity=29.2181069958848, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=26.8939393939394, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=27.5471698113208, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=269, Percent_Identity=26.7657992565056, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=257, Percent_Identity=28.4046692607004, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=243, Percent_Identity=28.8065843621399, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=239, Percent_Identity=27.6150627615063, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=193, Percent_Identity=25.9067357512953, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=253, Percent_Identity=32.8063241106719, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=25.0980392156863, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=200, Percent_Identity=28.5, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=36.3265306122449, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=32.8063241106719, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=29.9595141700405, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=30.5555555555556, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357041, Length=248, Percent_Identity=32.258064516129, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24643142, Length=242, Percent_Identity=29.3388429752066, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=29.9610894941634, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=32.03125, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI18859837, Length=232, Percent_Identity=32.7586206896552, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24644337, Length=169, Percent_Identity=32.5443786982249, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21358495, Length=198, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641232, Length=217, Percent_Identity=29.9539170506912, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24584748, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161076933, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640442, Length=196, Percent_Identity=31.1224489795918, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007236, Length=203, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648693, Length=204, Percent_Identity=29.9019607843137, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355889, Length=204, Percent_Identity=29.9019607843137, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281364494, Length=197, Percent_Identity=27.4111675126904, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355631, Length=174, Percent_Identity=28.1609195402299, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24649181, Length=189, Percent_Identity=31.2169312169312, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571387, Length=202, Percent_Identity=29.7029702970297, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28574402, Length=194, Percent_Identity=27.319587628866, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24581726, Length=145, Percent_Identity=26.8965517241379, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24584744, Length=194, Percent_Identity=27.319587628866, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011283
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.36 [H]

Molecular weight: Translated: 26360; Mature: 26229

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRIAYVTGGMGGIGTAICQRLARDGYKVVAGCGPNSPRREKWLEQQRALGFEFVASEG
CCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCC
NVADWDSTKAAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVT
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
KQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNT
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEC
VSPGYIATDMVKSIRQDVLDKIVGTIPVKRLGTPEEIASICAWLSSDESGFSTGADFSLN
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEC
GGLHMG
CCCCCC
>Mature Secondary Structure 
TQRIAYVTGGMGGIGTAICQRLARDGYKVVAGCGPNSPRREKWLEQQRALGFEFVASEG
CCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCC
NVADWDSTKAAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVT
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
KQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNT
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEC
VSPGYIATDMVKSIRQDVLDKIVGTIPVKRLGTPEEIASICAWLSSDESGFSTGADFSLN
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEC
GGLHMG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2670935 [H]