BacMap

Definition	Cupriavidus metallidurans CH34 chromosome, complete genome.
Accession	NC_007973
Length	3,928,089

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The map label for this gene is dmpC [H]

Identifier: 94310264

GI number: 94310264

Start: 1435620

End: 1437131

Strand: Reverse

Name: dmpC [H]

Synonym: Rmet_1322

Alternate gene names: 94310264

Gene position: 1437131-1435620 (Counterclockwise)

Preceding gene: 94310265

Following gene: 94310263

Centisome position: 36.59

GC content: 63.49

Gene sequence:

>1512_bases
ATGCTGATTACCGATCCCCAAGCGACCGCGAGCACTGGAAACCAGTCCGGCGCTCGTGCTAAAGAAATCCACAACTTCAT
CAACGGCGAATATGTGCCGGGTCAGCGTTGGTTCGAGAAGCGCTCGCCGTTGAACAACGCGGTCATTGCCAAGGTGGCCG
AAGCCGGCCGTGCCGAAGTCGACGCGGCGGTGGCTGCGGCGCAGGCCGCGCTCAAGGGAGCGTGGGGGCGCATGAGCTTG
GCCCAGCGCGTGGAAGTGCTGTACGCGGTGGCCGACGGCATCAACCGTCGTTTTGACGACTTCCTGGCCGCTGAGGTAGA
GGACACGGGCAAGCCTATGAGCCTGGCGCGGCATGTGGACATTCCGCGTGGGGCGGCCAATTTCAAGATCTTCGCCGACG
TGGTGAAGAACGTGCCCACTGAGTTTTTTGAAATGCCTACACCGGATGGTGTCGGGGCGATCAACTACGCCATGCGTCGA
CCGGTCGGGGTGGTCGGGGTGATCTGTCCATGGAACCTGCCACTGCTGCTGATGACCTGGAAAGTCGGCCCAGCGCTGGC
CTGTGGCAACACCGTTGTGGTCAAGCCCTCCGAAGAGACGCCGCAGACCGCTGCATTGCTGGGCGAGGTGATGAACGCGG
CGGGCGTGCCGCGAGGGGTCTACAACGTCGTGCACGGCTTCGGCCCCAACTCCACCGGCGAATTCCTCACCACCCACCGC
GGCATCAACGCCATCACCTTCACCGGTGAAACCCGCACGGGTGCGGCCATCATGAAGGCCGCGGCTGACGGTGCGCGCCC
CGTGAGTCTGGAGATGGGCGGCAAGAACGCTGCCATCGTGTTTGCCGACTGCGACTTCGACGCCGCCATTGAAGGCACGC
TGCGCTCGTGCTTCGCCAACTGTGGCCAGGTCTGCCTGGGTACCGAGCGGGTATATGTCGAGCGCCCCATCTTTGATCGT
TTTGTCTCCGCGCTCAAAAAAGGCGCTGAAGGCATGCAGCTCGGCCGCCCGGAAGATCCGGCCACCGGCATGGGCCCGTT
GATTTCGCAAGAGCATCGTGACAAGGTGCTGTCGTATTACAAGAAGGCGGTTGAAGCGGGCGCGACGGTGGTGGCGGGCG
GCGGTGTACCCGATATGCCGGACGCGCTCAAAGGCGGCGCGTGGGTACAGCCCACCATCTGGACGGGCTTGGGCGACGAC
TCGGTAATTGCCCGCGAGGAGATCTTCGGCCCTTGCGTGCTGGTCATGCCATTCGACAGCGAAGAAGAGGTGATCCGCCG
TGCCAACGATAACGACTACGGCCTGGCCACGGCGATCTGGACCACCAATCTGTCGCGTGCGCACCGCGTGGCGGGGGCCA
TCGAGGTCGGCATTGCGTGGGTGAACTCCTGGTTCCTGCGCGATTTGCGCACGCCGTTCGGCGGGGCCAAGCAGTCGGGT
ATCGGGCGCGAGGGCGGAGTCCACTCGCTGGAGTTCTACACGGAACTCAAAAACGTTTGCATCAAACTGTGA

Upstream 100 bases:

>100_bases
CGGATTGAGCCTGCTAGGTCTAACTCAAACCTGAATCTTTCCGGAAAGTCGACTGCCGCCGCGACCACATTTGCCTAACA
AGGAAGTTTACTGAAACATC

Downstream 100 bases:

>100_bases
TCATGGACAAAACTCAAATCACCCAGCTTGGCGACGCCCTGTATCAGGCACTGACCACGCGAACCGTGCTCGATCCGCTG
ACCGAGCGCCACCCCGATAT

Product: 2-hydroxymuconic semialdehyde dehydrogenase

Products: 5-carboxymethyl-2-hydroxymuconate; NADH; H+

Alternate protein names: HMSD [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MLITDPQATASTGNQSGARAKEIHNFINGEYVPGQRWFEKRSPLNNAVIAKVAEAGRAEVDAAVAAAQAALKGAWGRMSL
AQRVEVLYAVADGINRRFDDFLAAEVEDTGKPMSLARHVDIPRGAANFKIFADVVKNVPTEFFEMPTPDGVGAINYAMRR
PVGVVGVICPWNLPLLLMTWKVGPALACGNTVVVKPSEETPQTAALLGEVMNAAGVPRGVYNVVHGFGPNSTGEFLTTHR
GINAITFTGETRTGAAIMKAAADGARPVSLEMGGKNAAIVFADCDFDAAIEGTLRSCFANCGQVCLGTERVYVERPIFDR
FVSALKKGAEGMQLGRPEDPATGMGPLISQEHRDKVLSYYKKAVEAGATVVAGGGVPDMPDALKGGAWVQPTIWTGLGDD
SVIAREEIFGPCVLVMPFDSEEEVIRRANDNDYGLATAIWTTNLSRAHRVAGAIEVGIAWVNSWFLRDLRTPFGGAKQSG
IGREGGVHSLEFYTELKNVCIKL

Sequences:

>Translated_503_residues
MLITDPQATASTGNQSGARAKEIHNFINGEYVPGQRWFEKRSPLNNAVIAKVAEAGRAEVDAAVAAAQAALKGAWGRMSL
AQRVEVLYAVADGINRRFDDFLAAEVEDTGKPMSLARHVDIPRGAANFKIFADVVKNVPTEFFEMPTPDGVGAINYAMRR
PVGVVGVICPWNLPLLLMTWKVGPALACGNTVVVKPSEETPQTAALLGEVMNAAGVPRGVYNVVHGFGPNSTGEFLTTHR
GINAITFTGETRTGAAIMKAAADGARPVSLEMGGKNAAIVFADCDFDAAIEGTLRSCFANCGQVCLGTERVYVERPIFDR
FVSALKKGAEGMQLGRPEDPATGMGPLISQEHRDKVLSYYKKAVEAGATVVAGGGVPDMPDALKGGAWVQPTIWTGLGDD
SVIAREEIFGPCVLVMPFDSEEEVIRRANDNDYGLATAIWTTNLSRAHRVAGAIEVGIAWVNSWFLRDLRTPFGGAKQSG
IGREGGVHSLEFYTELKNVCIKL
>Mature_503_residues
MLITDPQATASTGNQSGARAKEIHNFINGEYVPGQRWFEKRSPLNNAVIAKVAEAGRAEVDAAVAAAQAALKGAWGRMSL
AQRVEVLYAVADGINRRFDDFLAAEVEDTGKPMSLARHVDIPRGAANFKIFADVVKNVPTEFFEMPTPDGVGAINYAMRR
PVGVVGVICPWNLPLLLMTWKVGPALACGNTVVVKPSEETPQTAALLGEVMNAAGVPRGVYNVVHGFGPNSTGEFLTTHR
GINAITFTGETRTGAAIMKAAADGARPVSLEMGGKNAAIVFADCDFDAAIEGTLRSCFANCGQVCLGTERVYVERPIFDR
FVSALKKGAEGMQLGRPEDPATGMGPLISQEHRDKVLSYYKKAVEAGATVVAGGGVPDMPDALKGGAWVQPTIWTGLGDD
SVIAREEIFGPCVLVMPFDSEEEVIRRANDNDYGLATAIWTTNLSRAHRVAGAIEVGIAWVNSWFLRDLRTPFGGAKQSG
IGREGGVHSLEFYTELKNVCIKL

Specific function: 2-hydroxymuconic acid semialdehyde can be converted to 2-hydroxypent-2,4-dienoate either directly by the action of 2- hydroxymuconic semialdehyde hydrolase (HMSH) or by the action of three sequential enzymes, the first of which is HMSD [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI12007648, Length=482, Percent_Identity=43.1535269709544, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI25952152, Length=482, Percent_Identity=39.8340248962656, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI115387104, Length=463, Percent_Identity=39.3088552915767, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI153266822, Length=483, Percent_Identity=39.7515527950311, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI25777724, Length=483, Percent_Identity=36.6459627329193, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI25777732, Length=483, Percent_Identity=37.0600414078675, Blast_Score=312, Evalue=6e-85,
Organism=Homo sapiens, GI21361176, Length=493, Percent_Identity=37.525354969574, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI25777730, Length=483, Percent_Identity=37.0600414078675, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI301500698, Length=482, Percent_Identity=35.6846473029046, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI25777728, Length=427, Percent_Identity=36.768149882904, Blast_Score=293, Evalue=4e-79,
Organism=Homo sapiens, GI238814322, Length=483, Percent_Identity=34.1614906832298, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI21614513, Length=483, Percent_Identity=35.4037267080745, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI25777726, Length=483, Percent_Identity=32.9192546583851, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI4507229, Length=479, Percent_Identity=35.9081419624217, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI25777721, Length=492, Percent_Identity=35.1626016260163, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI11095441, Length=480, Percent_Identity=28.5416666666667, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI310128093, Length=462, Percent_Identity=28.7878787878788, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI188035924, Length=470, Percent_Identity=28.5106382978723, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI310128103, Length=462, Percent_Identity=28.7878787878788, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI310128091, Length=340, Percent_Identity=31.7647058823529, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI73466520, Length=427, Percent_Identity=26.2295081967213, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4557303, Length=427, Percent_Identity=26.2295081967213, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI206597441, Length=450, Percent_Identity=27.7777777777778, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI206597439, Length=450, Percent_Identity=27.7777777777778, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI22907049, Length=450, Percent_Identity=27.7777777777778, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI310128089, Length=327, Percent_Identity=30.8868501529052, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI310128097, Length=255, Percent_Identity=34.9019607843137, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI71773324, Length=349, Percent_Identity=29.7994269340974, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4502043, Length=349, Percent_Identity=29.7994269340974, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI238814371, Length=349, Percent_Identity=29.7994269340974, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI73695881, Length=348, Percent_Identity=28.1609195402299, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI73695879, Length=348, Percent_Identity=28.1609195402299, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI223972651, Length=475, Percent_Identity=26.7368421052632, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI310128095, Length=315, Percent_Identity=30.1587301587302, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI238859541, Length=483, Percent_Identity=26.9151138716356, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI25777736, Length=483, Percent_Identity=26.9151138716356, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI25777734, Length=483, Percent_Identity=26.9151138716356, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI223972653, Length=335, Percent_Identity=26.865671641791, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310128087, Length=282, Percent_Identity=23.758865248227, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1787558, Length=498, Percent_Identity=40.5622489959839, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1786504, Length=489, Percent_Identity=41.3087934560327, Blast_Score=341, Evalue=8e-95,
Organism=Escherichia coli, GI87081896, Length=484, Percent_Identity=36.7768595041322, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI87082295, Length=485, Percent_Identity=35.4639175257732, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1787715, Length=485, Percent_Identity=36.2886597938144, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI1789015, Length=480, Percent_Identity=35.4166666666667, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1787684, Length=481, Percent_Identity=33.2640332640333, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87081926, Length=448, Percent_Identity=27.6785714285714, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1788042, Length=477, Percent_Identity=29.559748427673, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI1787250, Length=466, Percent_Identity=27.8969957081545, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787653, Length=464, Percent_Identity=23.7068965517241, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17551164, Length=485, Percent_Identity=40, Blast_Score=338, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI25144435, Length=492, Percent_Identity=38.6178861788618, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17562198, Length=483, Percent_Identity=39.5445134575569, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI25143876, Length=480, Percent_Identity=37.2916666666667, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI25143874, Length=480, Percent_Identity=37.2916666666667, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71995606, Length=483, Percent_Identity=38.3022774327122, Blast_Score=311, Evalue=7e-85,
Organism=Caenorhabditis elegans, GI32564736, Length=436, Percent_Identity=38.0733944954128, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI133930964, Length=484, Percent_Identity=35.7438016528926, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI71995613, Length=421, Percent_Identity=38.7173396674584, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17534119, Length=463, Percent_Identity=33.2613390928726, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71986308, Length=493, Percent_Identity=30.6288032454361, Blast_Score=195, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI115534176, Length=483, Percent_Identity=28.7784679089027, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25146391, Length=344, Percent_Identity=30.2325581395349, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25146394, Length=344, Percent_Identity=30.2325581395349, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI32566756, Length=344, Percent_Identity=30.2325581395349, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17564084, Length=346, Percent_Identity=29.4797687861272, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17534447, Length=464, Percent_Identity=26.7241379310345, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32564151, Length=419, Percent_Identity=26.2529832935561, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI115532534, Length=345, Percent_Identity=27.8260869565217, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71990744, Length=298, Percent_Identity=26.510067114094, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324950, Length=489, Percent_Identity=37.0143149284254, Blast_Score=309, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6320917, Length=488, Percent_Identity=36.8852459016393, Blast_Score=308, Evalue=9e-85,
Organism=Saccharomyces cerevisiae, GI6323821, Length=487, Percent_Identity=34.4969199178645, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6323822, Length=491, Percent_Identity=34.826883910387, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6325196, Length=491, Percent_Identity=32.3828920570265, Blast_Score=263, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6319478, Length=480, Percent_Identity=31.875, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6321828, Length=517, Percent_Identity=26.4990328820116, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321826, Length=507, Percent_Identity=26.0355029585799, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323757, Length=326, Percent_Identity=27.6073619631902, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI20129399, Length=491, Percent_Identity=38.9002036659878, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24585660, Length=514, Percent_Identity=34.4357976653696, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24650465, Length=491, Percent_Identity=37.0672097759674, Blast_Score=303, Evalue=3e-82,
Organism=Drosophila melanogaster, GI281362580, Length=465, Percent_Identity=34.4086021505376, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI62472918, Length=465, Percent_Identity=34.4086021505376, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI62472926, Length=465, Percent_Identity=34.4086021505376, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI62472936, Length=465, Percent_Identity=34.4086021505376, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI21356737, Length=465, Percent_Identity=34.4086021505376, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24638876, Length=480, Percent_Identity=27.0833333333333, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24638878, Length=480, Percent_Identity=27.0833333333333, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24666674, Length=466, Percent_Identity=26.8240343347639, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI281360299, Length=341, Percent_Identity=29.0322580645161, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360297, Length=341, Percent_Identity=29.0322580645161, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360295, Length=341, Percent_Identity=29.0322580645161, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24586250, Length=341, Percent_Identity=29.0322580645161, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360301, Length=341, Percent_Identity=29.0322580645161, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360303, Length=341, Percent_Identity=28.1524926686217, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45552499, Length=341, Percent_Identity=28.1524926686217, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24668425, Length=472, Percent_Identity=23.728813559322, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24668417, Length=472, Percent_Identity=23.728813559322, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24668413, Length=472, Percent_Identity=23.728813559322, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360293, Length=157, Percent_Identity=35.6687898089172, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571806, Length=507, Percent_Identity=22.879684418146, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28571798, Length=507, Percent_Identity=22.879684418146, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28571796, Length=507, Percent_Identity=22.879684418146, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28571794, Length=507, Percent_Identity=22.879684418146, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28571802, Length=507, Percent_Identity=22.879684418146, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28571800, Length=507, Percent_Identity=22.879684418146, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR017628 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: 1.2.1.60

Molecular weight: Translated: 53737; Mature: 53737

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLITDPQATASTGNQSGARAKEIHNFINGEYVPGQRWFEKRSPLNNAVIAKVAEAGRAEV
CEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCHHH
DAAVAAAQAALKGAWGRMSLAQRVEVLYAVADGINRRFDDFLAAEVEDTGKPMSLARHVD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
IPRGAANFKIFADVVKNVPTEFFEMPTPDGVGAINYAMRRPVGVVGVICPWNLPLLLMTW
CCCCCCCHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCEEEEEE
KVGPALACGNTVVVKPSEETPQTAALLGEVMNAAGVPRGVYNVVHGFGPNSTGEFLTTHR
CCCCCEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHCC
GINAITFTGETRTGAAIMKAAADGARPVSLEMGGKNAAIVFADCDFDAAIEGTLRSCFAN
CCEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHH
CGQVCLGTERVYVERPIFDRFVSALKKGAEGMQLGRPEDPATGMGPLISQEHRDKVLSYY
CCHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHH
KKAVEAGATVVAGGGVPDMPDALKGGAWVQPTIWTGLGDDSVIAREEIFGPCVLVMPFDS
HHHHHCCCEEEECCCCCCCCHHHCCCCEECCEEEECCCCCCCEEHHHHCCCEEEEEECCC
EEEVIRRANDNDYGLATAIWTTNLSRAHRVAGAIEVGIAWVNSWFLRDLRTPFGGAKQSG
HHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
IGREGGVHSLEFYTELKNVCIKL
CCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLITDPQATASTGNQSGARAKEIHNFINGEYVPGQRWFEKRSPLNNAVIAKVAEAGRAEV
CEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCHHH
DAAVAAAQAALKGAWGRMSLAQRVEVLYAVADGINRRFDDFLAAEVEDTGKPMSLARHVD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
IPRGAANFKIFADVVKNVPTEFFEMPTPDGVGAINYAMRRPVGVVGVICPWNLPLLLMTW
CCCCCCCHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCEEEEEE
KVGPALACGNTVVVKPSEETPQTAALLGEVMNAAGVPRGVYNVVHGFGPNSTGEFLTTHR
CCCCCEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHCC
GINAITFTGETRTGAAIMKAAADGARPVSLEMGGKNAAIVFADCDFDAAIEGTLRSCFAN
CCEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHH
CGQVCLGTERVYVERPIFDRFVSALKKGAEGMQLGRPEDPATGMGPLISQEHRDKVLSYY
CCHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHH
KKAVEAGATVVAGGGVPDMPDALKGGAWVQPTIWTGLGDDSVIAREEIFGPCVLVMPFDS
HHHHHCCCEEEECCCCCCCCHHHCCCCEECCEEEECCCCCCCEEHHHHCCCEEEEEECCC
EEEVIRRANDNDYGLATAIWTTNLSRAHRVAGAIEVGIAWVNSWFLRDLRTPFGGAKQSG
HHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
IGREGGVHSLEFYTELKNVCIKL
CCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-carboxymethyl-2-hydroxymuconate semialdehyde; H2O; NAD+

Specific reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2194577 [H]