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The map label for this gene is prlC [H]

Identifier: 94310136

GI number: 94310136

Start: 1304603

End: 1306705

Strand: Reverse

Name: prlC [H]

Synonym: Rmet_1191

Alternate gene names: 94310136

Gene position: 1306705-1304603 (Counterclockwise)

Preceding gene: 94310137

Following gene: 94310135

Centisome position: 33.27

GC content: 65.95

Gene sequence:

>2103_bases
ATGACTGATACTACCGACCGCGCCAGCAACCCTCTGCTTGATTTCTCCGACCTGCCGCGCTTCGCGGAGATCCGGCCCGA
GCACATTGGCCCGGCGCTGGACGTGCTGCTCGCCCAGGCGCAGGCAGCCGTCGCCCGCGCCGAGGACCCGGCCACCCCCG
CCACCTGGGCCAGCGCCGTTGAGGCACTGGAGGTCGCCACGGAGCCGCTCGGCCGCGCCTGGGGCGTGGTCGGGCATCTC
AGCGCCGTAGCCGACACCCCCGAGTTGCGCAAGGCACACGCCGACAACCTGCCCCGCATGACCGAATTCTGGTCATCGCT
GGGCCAGAGTCTGGCCCTGTACGAGAAGTACAAGGCCGTCGCCGCCGGCCCCGAGTTCGCAGGCCTTTCGCCAGCGCGCA
AGCAACTGCTCGAGAACGAGCTGCGCGGATTCCGCCTGGGCGGCGCCGAACTGGCCGAGGACAAGAAGCCGCGCTTTGCC
GAGATCCAGGAACAGCAGGCGCAACTGTCGAAGGCGTTCTCCGACCACGTGCTCGATGCCACCAATGGCTACGCCCTATA
TATCGAGGACGAGGCACGCCTGTCCGGTATTCCGGCCGACGCAAAGGAAGCCGCGGCGCTGGCCGCCCAGAAGGATGGCA
AGGCAGGCTGGAAGTTCACGCTGCACTTTCCGTCGTACTTCCCGGTGCTGCAGTATGCGGACGACCGCGCGCTGCGCCAG
ACCATGTACGAGGCCAGCGTCACGCGCGCCTCGGAACTGGGCCCGCAGCACGGCAATGGTCAGGCCGACTGGGACAACAC
GGCCAATATGCGCGAGCAACTGACGCTACGCCGTGAAGAGGCGCATATGCTGGGCTACGCCAACTATGGCGAAGTCTCGC
TGGTGCCGAAAATGGCCGAGTCGCCAGCCGAAGTGCTCAAGTTCCTCGACGAACTGGCCGTCAAGGCCCGCCCGTTCGCT
GAACACGACTGGACCGAACTGCGCGAGTTCGCCGCGGCCGAACTCGGCCTGAACGACGTCGCGCCGTGGGATGTCGCCTA
CGCGTCCGAAAAGCTGCGCCAGAAGCGCTATTCGTTCTCCGACGACGAGGTCAAGCAGTACTTCCAGGAACCGAAGGTGC
TCGAAGGGCTGTTCGGCGTCGCCGAGAAGCTGTTCTCGGTCCGCATCCAGCCGGACACGACGCAGACCTGGCACAAGGAC
GTGCGCTTCTTCCGCGTGGTGTCGCCCCAGGGCGCACTGCTCGCCCAGTTCTACATTGACCTGTACGCGCGCGAAGGCAA
GCGCGGCGGCGCCTGGATGGACGATGCGCGTGGCCGCAAGGAACGCGGCAACGGCACCGTGCAAACGCCGGTGGCCTACC
TGACCTGCAATTTCACCGCGCCGGTCGGCGACAAGCCCGCCCTGTTCACGCATGATGAAGTGATCACGATGTTCCACGAG
TTCGGCCACGGGCTGCACCATATGCTGACGCAGGTGGGCGACCTCGGCGTGTCCGGCATCAACGGCGTGGAATGGGATGC
CGTGGAGCTGCCGTCACAGTTCATGGAGAACTTCTGCTGGGAATACGAGGTGCTGTCGACGATGACGGCCCACGTGGAAA
CCGGCGCGCCGCTGCCGCGCGCGCTGTTCGATCGCATGCTGGCCGCGAAGAACTTCCAGAACGGCATGATGACGCTGCGC
CAGATCGTGTTCTCGTCGTTCGACATGCACCTGCATACCGACTACGACCCGCAGGGCGCGGTATCGGTGCTCGAGCTGTC
GCGCCAGATCAACGACGCGAAGCATGTGGTGCCCCAGTCGCCGCTGTCGCGCTGGCCGAACACGTTCAGCCACATCTTCG
CGGGTGGCTATGCCGCCGGTTACTACAGCTACAAGTGGGCCGAAGTGTTGTCCGCCGATGTTTACGCAGCATTCGAGGAA
GCCGCGCAGCTCTCCGGCAGCGTGCTCGACAGCGCCACCGGCGAGCGTTATCGCCGCGAGATCCTGTCGGTGGGCGGTAG
CCGCCCGGCGATGGAATCGTTCGTGGCGTTCCGCGGCCGCGCGCCGCAGATCGACGCACTGCTGCGGCACGGTGGCATGA
CGGAAGCAGCAGTCGCTGCCTGA

Upstream 100 bases:

>100_bases
CAATTGCGCCAATAGCTAAGTCGTACTGGATATTTCGGCGCATAGGCCTCATCTTGCACGTGTGATGCCGCATCCCGGCA
GCCAATCGGAATTTGCCACC

Downstream 100 bases:

>100_bases
CCGCCACCCACCCCGCCCTGCCCCCAGGCGCCCGGACCATGAACATTCCTTTCCCGATTCGCAAGGAATGTCCACCGGGC
GCCTGTGTCTGCAATCGCGA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 700; Mature: 699

Protein sequence:

>700_residues
MTDTTDRASNPLLDFSDLPRFAEIRPEHIGPALDVLLAQAQAAVARAEDPATPATWASAVEALEVATEPLGRAWGVVGHL
SAVADTPELRKAHADNLPRMTEFWSSLGQSLALYEKYKAVAAGPEFAGLSPARKQLLENELRGFRLGGAELAEDKKPRFA
EIQEQQAQLSKAFSDHVLDATNGYALYIEDEARLSGIPADAKEAAALAAQKDGKAGWKFTLHFPSYFPVLQYADDRALRQ
TMYEASVTRASELGPQHGNGQADWDNTANMREQLTLRREEAHMLGYANYGEVSLVPKMAESPAEVLKFLDELAVKARPFA
EHDWTELREFAAAELGLNDVAPWDVAYASEKLRQKRYSFSDDEVKQYFQEPKVLEGLFGVAEKLFSVRIQPDTTQTWHKD
VRFFRVVSPQGALLAQFYIDLYAREGKRGGAWMDDARGRKERGNGTVQTPVAYLTCNFTAPVGDKPALFTHDEVITMFHE
FGHGLHHMLTQVGDLGVSGINGVEWDAVELPSQFMENFCWEYEVLSTMTAHVETGAPLPRALFDRMLAAKNFQNGMMTLR
QIVFSSFDMHLHTDYDPQGAVSVLELSRQINDAKHVVPQSPLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEE
AAQLSGSVLDSATGERYRREILSVGGSRPAMESFVAFRGRAPQIDALLRHGGMTEAAVAA

Sequences:

>Translated_700_residues
MTDTTDRASNPLLDFSDLPRFAEIRPEHIGPALDVLLAQAQAAVARAEDPATPATWASAVEALEVATEPLGRAWGVVGHL
SAVADTPELRKAHADNLPRMTEFWSSLGQSLALYEKYKAVAAGPEFAGLSPARKQLLENELRGFRLGGAELAEDKKPRFA
EIQEQQAQLSKAFSDHVLDATNGYALYIEDEARLSGIPADAKEAAALAAQKDGKAGWKFTLHFPSYFPVLQYADDRALRQ
TMYEASVTRASELGPQHGNGQADWDNTANMREQLTLRREEAHMLGYANYGEVSLVPKMAESPAEVLKFLDELAVKARPFA
EHDWTELREFAAAELGLNDVAPWDVAYASEKLRQKRYSFSDDEVKQYFQEPKVLEGLFGVAEKLFSVRIQPDTTQTWHKD
VRFFRVVSPQGALLAQFYIDLYAREGKRGGAWMDDARGRKERGNGTVQTPVAYLTCNFTAPVGDKPALFTHDEVITMFHE
FGHGLHHMLTQVGDLGVSGINGVEWDAVELPSQFMENFCWEYEVLSTMTAHVETGAPLPRALFDRMLAAKNFQNGMMTLR
QIVFSSFDMHLHTDYDPQGAVSVLELSRQINDAKHVVPQSPLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEE
AAQLSGSVLDSATGERYRREILSVGGSRPAMESFVAFRGRAPQIDALLRHGGMTEAAVAA
>Mature_699_residues
TDTTDRASNPLLDFSDLPRFAEIRPEHIGPALDVLLAQAQAAVARAEDPATPATWASAVEALEVATEPLGRAWGVVGHLS
AVADTPELRKAHADNLPRMTEFWSSLGQSLALYEKYKAVAAGPEFAGLSPARKQLLENELRGFRLGGAELAEDKKPRFAE
IQEQQAQLSKAFSDHVLDATNGYALYIEDEARLSGIPADAKEAAALAAQKDGKAGWKFTLHFPSYFPVLQYADDRALRQT
MYEASVTRASELGPQHGNGQADWDNTANMREQLTLRREEAHMLGYANYGEVSLVPKMAESPAEVLKFLDELAVKARPFAE
HDWTELREFAAAELGLNDVAPWDVAYASEKLRQKRYSFSDDEVKQYFQEPKVLEGLFGVAEKLFSVRIQPDTTQTWHKDV
RFFRVVSPQGALLAQFYIDLYAREGKRGGAWMDDARGRKERGNGTVQTPVAYLTCNFTAPVGDKPALFTHDEVITMFHEF
GHGLHHMLTQVGDLGVSGINGVEWDAVELPSQFMENFCWEYEVLSTMTAHVETGAPLPRALFDRMLAAKNFQNGMMTLRQ
IVFSSFDMHLHTDYDPQGAVSVLELSRQINDAKHVVPQSPLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEEA
AQLSGSVLDSATGERYRREILSVGGSRPAMESFVAFRGRAPQIDALLRHGGMTEAAVAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=620, Percent_Identity=31.6129032258064, Blast_Score=293, Evalue=5e-79,
Organism=Homo sapiens, GI14149738, Length=620, Percent_Identity=29.3548387096774, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI156105687, Length=669, Percent_Identity=24.3647234678625, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=47.2303206997085, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=694, Percent_Identity=29.971181556196, Blast_Score=257, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71999758, Length=576, Percent_Identity=24.1319444444444, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32565901, Length=632, Percent_Identity=21.0443037974684, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319793, Length=670, Percent_Identity=27.1641791044776, Blast_Score=247, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6322715, Length=685, Percent_Identity=23.7956204379562, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21356111, Length=647, Percent_Identity=26.8933539412674, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI20129717, Length=407, Percent_Identity=28.992628992629, Blast_Score=170, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77525; Mature: 77394

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTDRASNPLLDFSDLPRFAEIRPEHIGPALDVLLAQAQAAVARAEDPATPATWASAV
CCCCCCCCCCCCCCHHCCCHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
EALEVATEPLGRAWGVVGHLSAVADTPELRKAHADNLPRMTEFWSSLGQSLALYEKYKAV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AAGPEFAGLSPARKQLLENELRGFRLGGAELAEDKKPRFAEIQEQQAQLSKAFSDHVLDA
HCCCCCCCCCHHHHHHHHHHHCCEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
TNGYALYIEDEARLSGIPADAKEAAALAAQKDGKAGWKFTLHFPSYFPVLQYADDRALRQ
CCCEEEEEECCHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCHHHHHH
TMYEASVTRASELGPQHGNGQADWDNTANMREQLTLRREEAHMLGYANYGEVSLVPKMAE
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHC
SPAEVLKFLDELAVKARPFAEHDWTELREFAAAELGLNDVAPWDVAYASEKLRQKRYSFS
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
DDEVKQYFQEPKVLEGLFGVAEKLFSVRIQPDTTQTWHKDVRFFRVVSPQGALLAQFYID
HHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCHHHHHCCCEEEEECCCCHHHHHHHHH
LYAREGKRGGAWMDDARGRKERGNGTVQTPVAYLTCNFTAPVGDKPALFTHDEVITMFHE
HHHHCCCCCCCCCHHCCCCHHCCCCCEECCEEEEEEEEECCCCCCCCEEEHHHHHHHHHH
FGHGLHHMLTQVGDLGVSGINGVEWDAVELPSQFMENFCWEYEVLSTMTAHVETGAPLPR
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALFDRMLAAKNFQNGMMTLRQIVFSSFDMHLHTDYDPQGAVSVLELSRQINDAKHVVPQS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
PLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEEAAQLSGSVLDSATGERYRRE
HHHHCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ILSVGGSRPAMESFVAFRGRAPQIDALLRHGGMTEAAVAA
HHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure 
TDTTDRASNPLLDFSDLPRFAEIRPEHIGPALDVLLAQAQAAVARAEDPATPATWASAV
CCCCCCCCCCCCCHHCCCHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
EALEVATEPLGRAWGVVGHLSAVADTPELRKAHADNLPRMTEFWSSLGQSLALYEKYKAV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AAGPEFAGLSPARKQLLENELRGFRLGGAELAEDKKPRFAEIQEQQAQLSKAFSDHVLDA
HCCCCCCCCCHHHHHHHHHHHCCEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
TNGYALYIEDEARLSGIPADAKEAAALAAQKDGKAGWKFTLHFPSYFPVLQYADDRALRQ
CCCEEEEEECCHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCHHHHHH
TMYEASVTRASELGPQHGNGQADWDNTANMREQLTLRREEAHMLGYANYGEVSLVPKMAE
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHC
SPAEVLKFLDELAVKARPFAEHDWTELREFAAAELGLNDVAPWDVAYASEKLRQKRYSFS
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
DDEVKQYFQEPKVLEGLFGVAEKLFSVRIQPDTTQTWHKDVRFFRVVSPQGALLAQFYID
HHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCHHHHHCCCEEEEECCCCHHHHHHHHH
LYAREGKRGGAWMDDARGRKERGNGTVQTPVAYLTCNFTAPVGDKPALFTHDEVITMFHE
HHHHCCCCCCCCCHHCCCCHHCCCCCEECCEEEEEEEEECCCCCCCCEEEHHHHHHHHHH
FGHGLHHMLTQVGDLGVSGINGVEWDAVELPSQFMENFCWEYEVLSTMTAHVETGAPLPR
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALFDRMLAAKNFQNGMMTLRQIVFSSFDMHLHTDYDPQGAVSVLELSRQINDAKHVVPQS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
PLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEEAAQLSGSVLDSATGERYRRE
HHHHCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ILSVGGSRPAMESFVAFRGRAPQIDALLRHGGMTEAAVAA
HHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]