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The map label for this gene is ethA [H]

Identifier: 94309957

GI number: 94309957

Start: 1101744

End: 1103261

Strand: Reverse

Name: ethA [H]

Synonym: Rmet_1012

Alternate gene names: 94309957

Gene position: 1103261-1101744 (Counterclockwise)

Preceding gene: 94309959

Following gene: 94309956

Centisome position: 28.09

GC content: 65.61

Gene sequence:

>1518_bases
ATGACCGCCCCCACTTCTGATGACGCAGTCCTTGATGTTCTGATCGTCGGCGCCGGCCTGTCCGGTATCGGCGCCGCCCG
ACAATTGCAGGACCGCTGCCCCGGCAAGCGCTACGCCATCCTGGAAGCCCGGCAGGCCATGGGCGGTACCTGGGATCTGT
TCCGCTACCCGGGCATCCGTTCCGACTCGGACATGTACACCCTGGGGTACCGCTTCAAGCCCTGGAGAGGCGCCAAGGCA
ATTGCCGATGGCCCGTCGATCCTGTCGTACATTCGCGAGACCGCCGACGAGGCGGGTATCACAAAGCACATCCGCTACGG
GCACAAGGTGGTCAGCGCGGCTTGGGATAGCCGCTCTGCCTGCTGGACGATCGAGGCCGAGCGCACCGCCGATGGCAGCC
GGGTCCGCCTGCGCGCGCATTTCCTTTACGTCTGCGCCGGCTACTACAGCTACGCGGAGGGACACCGGCCAACGTTTCCG
GGCGAGGAGAACTTCCGTGGCCGCATGGTGCATCCACAGTTCTGGGACCCGTCGATCGACTATGCCGGCAAACGCGTGGT
GGTAATCGGCAGCGGCGCTACGGCCGTCACGCTGGTACCGTCCATGTCGCAAACCGCGGCCCACGTGACGATGCTGCAGC
GGTCGCCCACGTATATCGTCACGCGTCCAGGCCAGGATGCGATCGCTCACAAGCTGCGCCGGATGCTGCCCGAAGGGCTG
GCCTACGCGGCCACGCGCTGGAAGAACGTGCTGCTGGGGATGTTCTTCTTCCAGCTTGCCCGCCGCAAACCCGAGAAGGT
CAAGGCCCGGATGATCGGCATGGCGGCCGAGCAGCTTGCGCCCGGCTATGACGTCGACACCCATTTCACGCCGCGCTACA
AGCCGTGGGACCAGCGCGTCTGCCTGGTGCCCGACGGCGACCTGTTCCGCGAGATCCGCGAGGGCCGCGCCTCGATCGTG
ACCGACACCATCGAGCGTTTCACCGAGGACGGCATCGTGCTGGCCTCGGGTCAGACCTTGCCGGCCGACATCGTGGTGAT
GGCCACCGGCCTGAAGCTGAACATGCTGGGCGACATCGTCGTCACCGTGGATGGCGTGCCGCGCCGCCCGGCCGAGGCGA
TGGCCTACAAAGGCATGATGCTCAGCGATGTGCCCAATCTCGTGCTGGCCTTCGGCTACACCAATGCATCGTGGACGCTC
AAGGCGGACCTGACCGCCGAATACGTCTGCCGGCTGCTGCGTTACATGGATCGCCACGGCTACCGCTCCGCCGTGCCGCA
CGTTGATCCAACCGTGCAGACCATGCCATTCCTCGACTTCTCTTCGGGCTACGTGCAACGCGCCGCCAGCGTGCTGCCCC
GGCAGGGCGACCGCCGGCCGTGGCGCGTCTACCAGAACTACTTCATGGATATGATGACCATTCGCCATGGCCGCATCGCG
GATGGCGTGCTGCAGTTTGATAGACAAGGCGCCGCGACCTTGCCGCAGGAAGATGCCCTGGCGGAGGTGCAGTCGTGA

Upstream 100 bases:

>100_bases
GAGAGCTCGGTAGTCATGGGCGCCATTATGACATTCCCTATTGTCAGATTGCTTCTGACAACCTATGTTGTCAGAAATGC
CACTGATCCGGGTTCCCGTC

Downstream 100 bases:

>100_bases
ACGCCCTGCTCTCCGTCGTCGTCGCCGTCGTTGGGCTGCTGGTACTGATCGGCCTCGCGCTGTTCCTGTACACGTGGCGC
ACCACCCGGAAGATCGAAGC

Product: flavin-binding monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTAPTSDDAVLDVLIVGAGLSGIGAARQLQDRCPGKRYAILEARQAMGGTWDLFRYPGIRSDSDMYTLGYRFKPWRGAKA
IADGPSILSYIRETADEAGITKHIRYGHKVVSAAWDSRSACWTIEAERTADGSRVRLRAHFLYVCAGYYSYAEGHRPTFP
GEENFRGRMVHPQFWDPSIDYAGKRVVVIGSGATAVTLVPSMSQTAAHVTMLQRSPTYIVTRPGQDAIAHKLRRMLPEGL
AYAATRWKNVLLGMFFFQLARRKPEKVKARMIGMAAEQLAPGYDVDTHFTPRYKPWDQRVCLVPDGDLFREIREGRASIV
TDTIERFTEDGIVLASGQTLPADIVVMATGLKLNMLGDIVVTVDGVPRRPAEAMAYKGMMLSDVPNLVLAFGYTNASWTL
KADLTAEYVCRLLRYMDRHGYRSAVPHVDPTVQTMPFLDFSSGYVQRAASVLPRQGDRRPWRVYQNYFMDMMTIRHGRIA
DGVLQFDRQGAATLPQEDALAEVQS

Sequences:

>Translated_505_residues
MTAPTSDDAVLDVLIVGAGLSGIGAARQLQDRCPGKRYAILEARQAMGGTWDLFRYPGIRSDSDMYTLGYRFKPWRGAKA
IADGPSILSYIRETADEAGITKHIRYGHKVVSAAWDSRSACWTIEAERTADGSRVRLRAHFLYVCAGYYSYAEGHRPTFP
GEENFRGRMVHPQFWDPSIDYAGKRVVVIGSGATAVTLVPSMSQTAAHVTMLQRSPTYIVTRPGQDAIAHKLRRMLPEGL
AYAATRWKNVLLGMFFFQLARRKPEKVKARMIGMAAEQLAPGYDVDTHFTPRYKPWDQRVCLVPDGDLFREIREGRASIV
TDTIERFTEDGIVLASGQTLPADIVVMATGLKLNMLGDIVVTVDGVPRRPAEAMAYKGMMLSDVPNLVLAFGYTNASWTL
KADLTAEYVCRLLRYMDRHGYRSAVPHVDPTVQTMPFLDFSSGYVQRAASVLPRQGDRRPWRVYQNYFMDMMTIRHGRIA
DGVLQFDRQGAATLPQEDALAEVQS
>Mature_504_residues
TAPTSDDAVLDVLIVGAGLSGIGAARQLQDRCPGKRYAILEARQAMGGTWDLFRYPGIRSDSDMYTLGYRFKPWRGAKAI
ADGPSILSYIRETADEAGITKHIRYGHKVVSAAWDSRSACWTIEAERTADGSRVRLRAHFLYVCAGYYSYAEGHRPTFPG
EENFRGRMVHPQFWDPSIDYAGKRVVVIGSGATAVTLVPSMSQTAAHVTMLQRSPTYIVTRPGQDAIAHKLRRMLPEGLA
YAATRWKNVLLGMFFFQLARRKPEKVKARMIGMAAEQLAPGYDVDTHFTPRYKPWDQRVCLVPDGDLFREIREGRASIVT
DTIERFTEDGIVLASGQTLPADIVVMATGLKLNMLGDIVVTVDGVPRRPAEAMAYKGMMLSDVPNLVLAFGYTNASWTLK
ADLTAEYVCRLLRYMDRHGYRSAVPHVDPTVQTMPFLDFSSGYVQRAASVLPRQGDRRPWRVYQNYFMDMMTIRHGRIAD
GVLQFDRQGAATLPQEDALAEVQS

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI50541965, Length=254, Percent_Identity=23.6220472440945, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI50541961, Length=254, Percent_Identity=23.6220472440945, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503759, Length=228, Percent_Identity=25, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541300, Length=384, Percent_Identity=23.6979166666667, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17506045, Length=217, Percent_Identity=26.2672811059908, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56394; Mature: 56263

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTSDDAVLDVLIVGAGLSGIGAARQLQDRCPGKRYAILEARQAMGGTWDLFRYPGIR
CCCCCCCCHHEEEEEECCCCCCCHHHHHHHHHCCCCEEEHHHHHHHCCCCEEHHCCCCCC
SDSDMYTLGYRFKPWRGAKAIADGPSILSYIRETADEAGITKHIRYGHKVVSAAWDSRSA
CCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCE
CWTIEAERTADGSRVRLRAHFLYVCAGYYSYAEGHRPTFPGEENFRGRMVHPQFWDPSID
EEEEEECCCCCCCEEEEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
YAGKRVVVIGSGATAVTLVPSMSQTAAHVTMLQRSPTYIVTRPGQDAIAHKLRRMLPEGL
CCCCEEEEEECCCEEEEEECCCHHHHHHHHHEECCCCEEEECCCHHHHHHHHHHHHHHHH
AYAATRWKNVLLGMFFFQLARRKPEKVKARMIGMAAEQLAPGYDVDTHFTPRYKPWDQRV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
CLVPDGDLFREIREGRASIVTDTIERFTEDGIVLASGQTLPADIVVMATGLKLNMLGDIV
EEECCHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCEEEEECEEE
VTVDGVPRRPAEAMAYKGMMLSDVPNLVLAFGYTNASWTLKADLTAEYVCRLLRYMDRHG
EEECCCCCCCHHHHHHCCCHHHCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCC
YRSAVPHVDPTVQTMPFLDFSSGYVQRAASVLPRQGDRRPWRVYQNYFMDMMTIRHGRIA
CCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
DGVLQFDRQGAATLPQEDALAEVQS
HHHHHHCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
TAPTSDDAVLDVLIVGAGLSGIGAARQLQDRCPGKRYAILEARQAMGGTWDLFRYPGIR
CCCCCCCHHEEEEEECCCCCCCHHHHHHHHHCCCCEEEHHHHHHHCCCCEEHHCCCCCC
SDSDMYTLGYRFKPWRGAKAIADGPSILSYIRETADEAGITKHIRYGHKVVSAAWDSRSA
CCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCE
CWTIEAERTADGSRVRLRAHFLYVCAGYYSYAEGHRPTFPGEENFRGRMVHPQFWDPSID
EEEEEECCCCCCCEEEEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
YAGKRVVVIGSGATAVTLVPSMSQTAAHVTMLQRSPTYIVTRPGQDAIAHKLRRMLPEGL
CCCCEEEEEECCCEEEEEECCCHHHHHHHHHEECCCCEEEECCCHHHHHHHHHHHHHHHH
AYAATRWKNVLLGMFFFQLARRKPEKVKARMIGMAAEQLAPGYDVDTHFTPRYKPWDQRV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
CLVPDGDLFREIREGRASIVTDTIERFTEDGIVLASGQTLPADIVVMATGLKLNMLGDIV
EEECCHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCEEEEECEEE
VTVDGVPRRPAEAMAYKGMMLSDVPNLVLAFGYTNASWTLKADLTAEYVCRLLRYMDRHG
EEECCCCCCCHHHHHHCCCHHHCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCC
YRSAVPHVDPTVQTMPFLDFSSGYVQRAASVLPRQGDRRPWRVYQNYFMDMMTIRHGRIA
CCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
DGVLQFDRQGAATLPQEDALAEVQS
HHHHHHCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA