Click here to switch to the map view.

The map label for this gene is paaH [H]

Identifier: 94309919

GI number: 94309919

Start: 1059600

End: 1061123

Strand: Reverse

Name: paaH [H]

Synonym: Rmet_0974

Alternate gene names: 94309919

Gene position: 1061123-1059600 (Counterclockwise)

Preceding gene: 94309921

Following gene: 94309918

Centisome position: 27.01

GC content: 66.93

Gene sequence:

>1524_bases
ATGAGCAATTCCACCATCCAAACGCTCGGCATCGTCGGCACTGGCGCCATGGGCCGCGGTATCGCCCAGATCGCCGCGCA
GGCTGGCCTGACCGTCAACCTGTTCGACACGAATGCCCAGGCCGTGGCGGCAGCACGCCAGTATCTGCAGGATACCTTCA
CCAAGCTGGCCGAGAAAGGCAAGATGAGCGCCGCCGACGGCGAGGCCGCGCTGGCCCGCGTGAAGGCCTGCGCCGCGCTG
GAAGACCTGACCGCGTGCGACATGGTGCTGGAAGCCATCGTCGAGAGGCTCGATGTCAAGCGTGACCTGGTGGCCAAGCT
CGAAGCCGTCGTGCGCGAAGATGCCGTGATCGCGTCGAACACTTCGTCGCTGTCGATCACGGCCATCGCCGTGGGCGCGA
AGAAGCCCGGTCGCGTGGTCGGCTATCACTTCTTCAATCCGGTGCCGCTGATGAAGGTGGTGGAAGTCGTGGACGGCATC
TCGGGCGACCCGGCCGTGGGCGACCGCCTGATGGAACTGTCGCGCCGCATGGGCCATACGCCGGTGCGCTGCAAGGACAT
GCCCGGCTTCATCGTCAATCACGCCGGCCGCGGCATGAACATCGAAGGGCTCAAGGTTGCGCAGGAAGGCGTGGCCGAGT
TCGTCGACATCGACAACATCATGCGCGAGCAGGCTGGCTTCCGCATGGGCCCGTTCGAGCTGATGGACCTGACCGGTCTT
GACGTGTCGCACCCGGTGATGGAGTCGATCTACAACCAGTTCTACCAGGAGCCCCGTTACCGTCCGTCGCCGATCACGTC
GCTGCGTTCGGTCGGTGGCCTGCTCGGCCGCAAGACCGGCGCGGGCTTCTACGCCTACCCCAACGGCCAGAAACAGGTAC
CCGCCGCCGCGCCGGTGCCGGATGCGCGCCCTGCCAGCGTGTGGGTGAGCCGCGCCAACGCGCGTGGCCATGCGATGACC
GTCAAGCTGCTGACCGCCCTGGGTGTCACGGTCGAGGCTGGCAACCAGCCGCCGGCTGACGCGCTGATCGTGGTGACGCC
GCTGGGTCTGGACGCGACCTCCGCTGCACTCGAGGAAGGCCTTGACGCCACGCGCGTGGTGGCCATCGACACCCTGATGC
CGTTCGAAGCCACCAAGCGCCGCACGCTGATGACCACGCCGGCCACCAGCGCCGCCGCACGCGACGCCGCGCACGGATTG
TTCGCCAGCGACGGCGTGCCGGTGACAGTGATTCGCGATTCGGCCGGATTCGTCGCGCAGCGCGTGATCAGCTGCATCGT
CAACATCGCCAGCGACATCGCGCAGCAACGCATCGCCACTCCGACCGACATCGACCTGGCCGTGCACCTGGGCCTGGGCT
ATCCGAAAGGTCCGCTGGCACTCGGCGATACGATCGGCGCCGACTTGATCCTTGAAGTCCTGCGCAACCTGAACCGCCTG
ACCGGCGACATGCGCTACCGTCCGAGCCCGTGGCTGTGGCGCCGCGCCGGACTTGGCCTGTCGTTGCTGACCGAAGAAGC
CTGA

Upstream 100 bases:

>100_bases
CTGTCCGATCAGCGCACGCGGCGTGCGCGCCCCGTCTGTCGCGGCAAGTGCAAAAAACGTACGATCGTGCTAATTTAACC
ACATCTTTTTTGGACGAACG

Downstream 100 bases:

>100_bases
CCCCACGCAGGCGCCCCGACGAGACACGGGGCGCCTTTTTCATTTCCGCCAGATCAAGAGGCTGTCGTGACTGCCCAACT
ACTTTCCGAACGCGTCGACT

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSNSTIQTLGIVGTGAMGRGIAQIAAQAGLTVNLFDTNAQAVAAARQYLQDTFTKLAEKGKMSAADGEAALARVKACAAL
EDLTACDMVLEAIVERLDVKRDLVAKLEAVVREDAVIASNTSSLSITAIAVGAKKPGRVVGYHFFNPVPLMKVVEVVDGI
SGDPAVGDRLMELSRRMGHTPVRCKDMPGFIVNHAGRGMNIEGLKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGL
DVSHPVMESIYNQFYQEPRYRPSPITSLRSVGGLLGRKTGAGFYAYPNGQKQVPAAAPVPDARPASVWVSRANARGHAMT
VKLLTALGVTVEAGNQPPADALIVVTPLGLDATSAALEEGLDATRVVAIDTLMPFEATKRRTLMTTPATSAAARDAAHGL
FASDGVPVTVIRDSAGFVAQRVISCIVNIASDIAQQRIATPTDIDLAVHLGLGYPKGPLALGDTIGADLILEVLRNLNRL
TGDMRYRPSPWLWRRAGLGLSLLTEEA

Sequences:

>Translated_507_residues
MSNSTIQTLGIVGTGAMGRGIAQIAAQAGLTVNLFDTNAQAVAAARQYLQDTFTKLAEKGKMSAADGEAALARVKACAAL
EDLTACDMVLEAIVERLDVKRDLVAKLEAVVREDAVIASNTSSLSITAIAVGAKKPGRVVGYHFFNPVPLMKVVEVVDGI
SGDPAVGDRLMELSRRMGHTPVRCKDMPGFIVNHAGRGMNIEGLKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGL
DVSHPVMESIYNQFYQEPRYRPSPITSLRSVGGLLGRKTGAGFYAYPNGQKQVPAAAPVPDARPASVWVSRANARGHAMT
VKLLTALGVTVEAGNQPPADALIVVTPLGLDATSAALEEGLDATRVVAIDTLMPFEATKRRTLMTTPATSAAARDAAHGL
FASDGVPVTVIRDSAGFVAQRVISCIVNIASDIAQQRIATPTDIDLAVHLGLGYPKGPLALGDTIGADLILEVLRNLNRL
TGDMRYRPSPWLWRRAGLGLSLLTEEA
>Mature_506_residues
SNSTIQTLGIVGTGAMGRGIAQIAAQAGLTVNLFDTNAQAVAAARQYLQDTFTKLAEKGKMSAADGEAALARVKACAALE
DLTACDMVLEAIVERLDVKRDLVAKLEAVVREDAVIASNTSSLSITAIAVGAKKPGRVVGYHFFNPVPLMKVVEVVDGIS
GDPAVGDRLMELSRRMGHTPVRCKDMPGFIVNHAGRGMNIEGLKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGLD
VSHPVMESIYNQFYQEPRYRPSPITSLRSVGGLLGRKTGAGFYAYPNGQKQVPAAAPVPDARPASVWVSRANARGHAMTV
KLLTALGVTVEAGNQPPADALIVVTPLGLDATSAALEEGLDATRVVAIDTLMPFEATKRRTLMTTPATSAAARDAAHGLF
ASDGVPVTVIRDSAGFVAQRVISCIVNIASDIAQQRIATPTDIDLAVHLGLGYPKGPLALGDTIGADLILEVLRNLNRLT
GDMRYRPSPWLWRRAGLGLSLLTEEA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=36.9337979094077, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=36.1842105263158, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=29.6928327645051, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI261878539, Length=297, Percent_Identity=29.6296296296296, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI20127408, Length=290, Percent_Identity=30, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI115430219, Length=245, Percent_Identity=26.1224489795918, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1787661, Length=494, Percent_Identity=36.0323886639676, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1790281, Length=273, Percent_Identity=30.7692307692308, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=30.7407407407407, Blast_Score=126, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=38.7543252595156, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=36.3321799307958, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=33.1034482758621, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=299, Percent_Identity=27.0903010033445, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17508951, Length=290, Percent_Identity=30, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144276, Length=290, Percent_Identity=30, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17508953, Length=363, Percent_Identity=28.099173553719, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17558304, Length=290, Percent_Identity=29.6551724137931, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71985930, Length=281, Percent_Identity=26.6903914590747, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583077, Length=291, Percent_Identity=30.5841924398625, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24583079, Length=291, Percent_Identity=30.5841924398625, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI19921000, Length=291, Percent_Identity=30.5841924398625, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI20129993, Length=228, Percent_Identity=28.0701754385965, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=28.3333333333333, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53744; Mature: 53612

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSTIQTLGIVGTGAMGRGIAQIAAQAGLTVNLFDTNAQAVAAARQYLQDTFTKLAEKG
CCCCCEEEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
KMSAADGEAALARVKACAALEDLTACDMVLEAIVERLDVKRDLVAKLEAVVREDAVIASN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
TSSLSITAIAVGAKKPGRVVGYHFFNPVPLMKVVEVVDGISGDPAVGDRLMELSRRMGHT
CCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
PVRCKDMPGFIVNHAGRGMNIEGLKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGL
CCEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCC
DVSHPVMESIYNQFYQEPRYRPSPITSLRSVGGLLGRKTGAGFYAYPNGQKQVPAAAPVP
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCC
DARPASVWVSRANARGHAMTVKLLTALGVTVEAGNQPPADALIVVTPLGLDATSAALEEG
CCCCHHHHEECCCCCCHHHHHHHHHHHCCEEECCCCCCCCEEEEEEECCCCHHHHHHHCC
LDATRVVAIDTLMPFEATKRRTLMTTPATSAAARDAAHGLFASDGVPVTVIRDSAGFVAQ
CCCEEEEEEECCCCCHHHCCCEEEECCCCHHHHHHHHCCCEECCCCEEEEEECCCCHHHH
RVISCIVNIASDIAQQRIATPTDIDLAVHLGLGYPKGPLALGDTIGADLILEVLRNLNRL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TGDMRYRPSPWLWRRAGLGLSLLTEEA
CCCCCCCCCCCHHHHHCCCCEECCCCC
>Mature Secondary Structure 
SNSTIQTLGIVGTGAMGRGIAQIAAQAGLTVNLFDTNAQAVAAARQYLQDTFTKLAEKG
CCCCEEEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
KMSAADGEAALARVKACAALEDLTACDMVLEAIVERLDVKRDLVAKLEAVVREDAVIASN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
TSSLSITAIAVGAKKPGRVVGYHFFNPVPLMKVVEVVDGISGDPAVGDRLMELSRRMGHT
CCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
PVRCKDMPGFIVNHAGRGMNIEGLKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGL
CCEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCC
DVSHPVMESIYNQFYQEPRYRPSPITSLRSVGGLLGRKTGAGFYAYPNGQKQVPAAAPVP
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCC
DARPASVWVSRANARGHAMTVKLLTALGVTVEAGNQPPADALIVVTPLGLDATSAALEEG
CCCCHHHHEECCCCCCHHHHHHHHHHHCCEEECCCCCCCCEEEEEEECCCCHHHHHHHCC
LDATRVVAIDTLMPFEATKRRTLMTTPATSAAARDAAHGLFASDGVPVTVIRDSAGFVAQ
CCCEEEEEEECCCCCHHHCCCEEEECCCCHHHHHHHHCCCEECCCCEEEEEECCCCHHHH
RVISCIVNIASDIAQQRIATPTDIDLAVHLGLGYPKGPLALGDTIGADLILEVLRNLNRL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TGDMRYRPSPWLWRRAGLGLSLLTEEA
CCCCCCCCCCCHHHHHCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]