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The map label for this gene is cvrA [H]

Identifier: 94309772

GI number: 94309772

Start: 901073

End: 902890

Strand: Direct

Name: cvrA [H]

Synonym: Rmet_0827

Alternate gene names: 94309772

Gene position: 901073-902890 (Clockwise)

Preceding gene: 94309769

Following gene: 94309776

Centisome position: 22.94

GC content: 67.93

Gene sequence:

>1818_bases
ATGGAAAGCATTGACCACGCCATTCTGCTCGGTGCCGTCGTGATGACGGCGGGCATCCTGCTTGGGGTTTTCTCGTCGCG
CTTCGGTGTCCCGTTCCTGCTGGTCTTCTTGGGCGTAGGCATGGCGGCCGGGGTCGACGGCCCCGGTGGCATCCGCTTCT
CCAACACCTGGCTCAGCTTCCTGGTGGGCAATATCGCGCTGGCCGTGATCCTGCTCGATGGGGGCTTGCGCACGCGCCTT
GCCACCTTCCGCGTGGCGCTGCGGCCGTCCTTGTCCCTGGCCACGCTGGGGGTGGTCATCACGGCGGTGCTGGTCGGCGC
GTTTGCTTCCTGGTTGCTCGGGATCGACTGGAAGCTCGGGCTGTTGCTAGGCGCCATCGTAGGCTCCACCGATGCCGCCG
CCGTCTTCTCCCTGCTCAACGGTAGCGGTGTGCGGCTCACGGAGCGCGTGGCCAGCGTGCTCGAGATCGAGTCGGGTATC
AACGATCCCATGGCGATCTTCCTGACCCTGACGTTGATCGAGTGGATCACCTCGCCGCAGGGGCTGTCGCCCGGCGCGCT
GGTGACGCGGCTGGTCGTGCAGTTCGGGGTGGGCGGGATACTTGGCGCGGCGCTGGGCTACTGTCTGGCCAACGTGATGG
AACGCGTCAACGTGGCCGAGGGCCTGCAGGCCATTCTGGTCTGTTCGGGCGGCTGCATGGTCTGGGCGATCGTGCAGACT
GCCGGCGGCAGTGGCTTCCTGGCGGTCTACCTGACCGGGATGATCGTCGGCAACCGGGAACACGCGGTCGGCGGCGACAC
GATGCGGGCGATGGATGGCATGGCCTGGCTGGCGCAGTCGGCGATGTTCCTGCTGCTTGGGCTGCTGGTGTCTCCGCACC
GGATCTGGGACATCGCGCTGCCCGCCGCGGCCGTGGCGTTGTTTCTGATGTGCGTGGCGCGGCCCGTATCCGTCTGGATC
TCGTTGCTGCCGTTCCGGTTCAACGCGCGCGAGAAGGGTTTCGTGGCGTGGGTGGGGTTGCGCGGCGCGGTGCCGATCGT
GCTGTCGTTGTTCCCGATGCTGCAGGGCATGAAGGATTCGGGGTTGCTGTTTCGCGTGGCGTTCGCGGTGGTGCTGGCCA
GCCTGCTGTGCCAGGGCACCACGGTCGCCCTGGCTGCACGGCTGGCGCGCGTGCTGCGGCCGCTCTACAACGAACCGCTA
TCGCGTGAGCGGATGCGCGGCACCCAGGCGCCGGCACTGGAGTTGATGCAGTTCGAGGTGGCCGCTAATTCACCGGTGGA
CAGCTTGCGCGCGGACCAACTCGAATTGCCAATGCGCAGCCGCCTGATGACCGTGGCGCGTGACGGGGCGCTGGTGCCGC
TCGACCGCGCCATCCTGCGTGCTGGCGATACCGTCTCGGTGCTGGCGCCTGGCGGTGTTCTGCCGGTGCTTTCTCGCCTG
TTCCTGACGTCAGGACCCCCGCCTGCCTGGGACCAGGTGACCTACGATTTTCTGCTTGCCGGACAGGCGAGTCTGGCCGA
TGTCGCCGCGCTCTATGGCACCCGGGCGCTGCTGCCGCACGAGCAGTTGAGCACGCTCGAACAGGCGATGCTGGCAGTGT
TCCGGTCGCCGCCGGTAGAGGGGGATGCGCTGGAGATTGCCGGCTTGCGGCTGACGGTGACCCGCATGGACGGGCCCCGC
ATCGTGCAGGTGGGATTGCTGCTGCCGCGCCCGGTGGCGGCGGGCGCTGGCGATGGCACTAACCATCGCTGGCGCCGGCG
TCACCGGGCACGGCCGGGGCTGGACCGGGTCAGTCGACCTTCGCGCCGGAAACCTTGA

Upstream 100 bases:

>100_bases
TGGACGTCCGGCAGCAGGGCGTGGAGCCGGCCTCGGCGTGCACTATCATCGACAGAACCGGTCGGTATATCGACGGTAAG
ACGGTACGGGGAGCCACGGG

Downstream 100 bases:

>100_bases
CGATCTGGCTGTACTTCTTCAGTTCGCGCTGGATCAGGGTGGCGAACTGGTCAGGCGTGGTCGGCGCCGGCTGCGCGCCA
ATGCGTGCCAGCTTCGCCTT

Product: putative cation/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MESIDHAILLGAVVMTAGILLGVFSSRFGVPFLLVFLGVGMAAGVDGPGGIRFSNTWLSFLVGNIALAVILLDGGLRTRL
ATFRVALRPSLSLATLGVVITAVLVGAFASWLLGIDWKLGLLLGAIVGSTDAAAVFSLLNGSGVRLTERVASVLEIESGI
NDPMAIFLTLTLIEWITSPQGLSPGALVTRLVVQFGVGGILGAALGYCLANVMERVNVAEGLQAILVCSGGCMVWAIVQT
AGGSGFLAVYLTGMIVGNREHAVGGDTMRAMDGMAWLAQSAMFLLLGLLVSPHRIWDIALPAAAVALFLMCVARPVSVWI
SLLPFRFNAREKGFVAWVGLRGAVPIVLSLFPMLQGMKDSGLLFRVAFAVVLASLLCQGTTVALAARLARVLRPLYNEPL
SRERMRGTQAPALELMQFEVAANSPVDSLRADQLELPMRSRLMTVARDGALVPLDRAILRAGDTVSVLAPGGVLPVLSRL
FLTSGPPPAWDQVTYDFLLAGQASLADVAALYGTRALLPHEQLSTLEQAMLAVFRSPPVEGDALEIAGLRLTVTRMDGPR
IVQVGLLLPRPVAAGAGDGTNHRWRRRHRARPGLDRVSRPSRRKP

Sequences:

>Translated_605_residues
MESIDHAILLGAVVMTAGILLGVFSSRFGVPFLLVFLGVGMAAGVDGPGGIRFSNTWLSFLVGNIALAVILLDGGLRTRL
ATFRVALRPSLSLATLGVVITAVLVGAFASWLLGIDWKLGLLLGAIVGSTDAAAVFSLLNGSGVRLTERVASVLEIESGI
NDPMAIFLTLTLIEWITSPQGLSPGALVTRLVVQFGVGGILGAALGYCLANVMERVNVAEGLQAILVCSGGCMVWAIVQT
AGGSGFLAVYLTGMIVGNREHAVGGDTMRAMDGMAWLAQSAMFLLLGLLVSPHRIWDIALPAAAVALFLMCVARPVSVWI
SLLPFRFNAREKGFVAWVGLRGAVPIVLSLFPMLQGMKDSGLLFRVAFAVVLASLLCQGTTVALAARLARVLRPLYNEPL
SRERMRGTQAPALELMQFEVAANSPVDSLRADQLELPMRSRLMTVARDGALVPLDRAILRAGDTVSVLAPGGVLPVLSRL
FLTSGPPPAWDQVTYDFLLAGQASLADVAALYGTRALLPHEQLSTLEQAMLAVFRSPPVEGDALEIAGLRLTVTRMDGPR
IVQVGLLLPRPVAAGAGDGTNHRWRRRHRARPGLDRVSRPSRRKP
>Mature_605_residues
MESIDHAILLGAVVMTAGILLGVFSSRFGVPFLLVFLGVGMAAGVDGPGGIRFSNTWLSFLVGNIALAVILLDGGLRTRL
ATFRVALRPSLSLATLGVVITAVLVGAFASWLLGIDWKLGLLLGAIVGSTDAAAVFSLLNGSGVRLTERVASVLEIESGI
NDPMAIFLTLTLIEWITSPQGLSPGALVTRLVVQFGVGGILGAALGYCLANVMERVNVAEGLQAILVCSGGCMVWAIVQT
AGGSGFLAVYLTGMIVGNREHAVGGDTMRAMDGMAWLAQSAMFLLLGLLVSPHRIWDIALPAAAVALFLMCVARPVSVWI
SLLPFRFNAREKGFVAWVGLRGAVPIVLSLFPMLQGMKDSGLLFRVAFAVVLASLLCQGTTVALAARLARVLRPLYNEPL
SRERMRGTQAPALELMQFEVAANSPVDSLRADQLELPMRSRLMTVARDGALVPLDRAILRAGDTVSVLAPGGVLPVLSRL
FLTSGPPPAWDQVTYDFLLAGQASLADVAALYGTRALLPHEQLSTLEQAMLAVFRSPPVEGDALEIAGLRLTVTRMDGPR
IVQVGLLLPRPVAAGAGDGTNHRWRRRHRARPGLDRVSRPSRRKP

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=568, Percent_Identity=44.5422535211268, Blast_Score=392, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 64142; Mature: 64142

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESIDHAILLGAVVMTAGILLGVFSSRFGVPFLLVFLGVGMAAGVDGPGGIRFSNTWLSF
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHH
LVGNIALAVILLDGGLRTRLATFRVALRPSLSLATLGVVITAVLVGAFASWLLGIDWKLG
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLLGAIVGSTDAAAVFSLLNGSGVRLTERVASVLEIESGINDPMAIFLTLTLIEWITSPQ
HHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
GLSPGALVTRLVVQFGVGGILGAALGYCLANVMERVNVAEGLQAILVCSGGCMVWAIVQT
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCCEEEEEEEC
AGGSGFLAVYLTGMIVGNREHAVGGDTMRAMDGMAWLAQSAMFLLLGLLVSPHRIWDIAL
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PAAAVALFLMCVARPVSVWISLLPFRFNAREKGFVAWVGLRGAVPIVLSLFPMLQGMKDS
HHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCC
GLLFRVAFAVVLASLLCQGTTVALAARLARVLRPLYNEPLSRERMRGTQAPALELMQFEV
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHH
AANSPVDSLRADQLELPMRSRLMTVARDGALVPLDRAILRAGDTVSVLAPGGVLPVLSRL
HCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHH
FLTSGPPPAWDQVTYDFLLAGQASLADVAALYGTRALLPHEQLSTLEQAMLAVFRSPPVE
HHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
GDALEIAGLRLTVTRMDGPRIVQVGLLLPRPVAAGAGDGTNHRWRRRHRARPGLDRVSRP
CCCEEEECEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHCCCC
SRRKP
CCCCC
>Mature Secondary Structure
MESIDHAILLGAVVMTAGILLGVFSSRFGVPFLLVFLGVGMAAGVDGPGGIRFSNTWLSF
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHH
LVGNIALAVILLDGGLRTRLATFRVALRPSLSLATLGVVITAVLVGAFASWLLGIDWKLG
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLLGAIVGSTDAAAVFSLLNGSGVRLTERVASVLEIESGINDPMAIFLTLTLIEWITSPQ
HHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
GLSPGALVTRLVVQFGVGGILGAALGYCLANVMERVNVAEGLQAILVCSGGCMVWAIVQT
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCCEEEEEEEC
AGGSGFLAVYLTGMIVGNREHAVGGDTMRAMDGMAWLAQSAMFLLLGLLVSPHRIWDIAL
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PAAAVALFLMCVARPVSVWISLLPFRFNAREKGFVAWVGLRGAVPIVLSLFPMLQGMKDS
HHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCC
GLLFRVAFAVVLASLLCQGTTVALAARLARVLRPLYNEPLSRERMRGTQAPALELMQFEV
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHH
AANSPVDSLRADQLELPMRSRLMTVARDGALVPLDRAILRAGDTVSVLAPGGVLPVLSRL
HCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHH
FLTSGPPPAWDQVTYDFLLAGQASLADVAALYGTRALLPHEQLSTLEQAMLAVFRSPPVE
HHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
GDALEIAGLRLTVTRMDGPRIVQVGLLLPRPVAAGAGDGTNHRWRRRHRARPGLDRVSRP
CCCEEEECEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHCCCC
SRRKP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]