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The map label for this gene is ggt [H]

Identifier: 94309767

GI number: 94309767

Start: 894878

End: 896503

Strand: Reverse

Name: ggt [H]

Synonym: Rmet_0822

Alternate gene names: 94309767

Gene position: 896503-894878 (Counterclockwise)

Preceding gene: 94309768

Following gene: 94309766

Centisome position: 22.82

GC content: 64.51

Gene sequence:

>1626_bases
ATGCAGAACTTCAACTGGACCAACCCCTACCCCACCGTGCGCATTCCGCTGTTCGCGCGCAACGTTGTGTCGACCTCGCA
TCCGCTGGCGGCCCAGGCCGGCCTGCGGATGCTGCTCAAGGGTGGCAACGCAGTGGACGCCGCGATTGCCGCCGCCGCGG
CGATCACGCTGGTGGAACCGGTGTCGTGCGGCCTGGGCAGCGATGCCTTCGCGATCCTGTGGGACGGCAAGCAACTGCAC
GGCCTGAATTCGTCGGGCGTGGCACCGGCCGCGTGGAATCCGGACTACTTCAAGAACAAGTACGGCGCCGATGGCAACGG
CCTTGCGAACCGGCCGATCCGTGGCTGGGATTCGGTCACCGTGCCTGGTGTCATCGCCGGCTGGGCCGCGCTGCACGAAC
GCTTCGGCAAGCTGCCGTTCGAAGACCTGATGGAACCCGCGATCGAGATCGCGGAACGTGGCTATGCAGTGCCGCCGGTG
GTTGCGCACAAGTGGGCCGCCGCCGTGCCGGACCTCAAGAGCCAGCCCGGCTTTGCCGACACGTTCATGCCGAATGGCCG
CGCGCCGGCTGTCGGCGAGAAGTTCTTGTTCAAGGATGCCGCAGACACGCTGCGCAAGATCGGCGCCACTGGCGGCCGTG
CGTACTATGAAGGCGAAATCGCCGAGAAGATCGCCGCGTTCAGCAAGGCATGCGGTGGCGCGATGACGCTCGACGATCTG
CGCAACTACCGCCCCGAGTGGGTCACGCCGATCAGCAAGTCCTACCGTGGCTACGAAGTGCACGAGATTCCGCCGAACGG
CCAGGGCATTGCCGCGCTGATGGCGCTGGGTATCCTCGATCAGTTCGACGTCGGCTCGCTGCCGGTGGATTCGGTCGACT
CGCAGCACCTGCAGATCGAGGCGATGAAGCTTGCCTTCGCGGACCTGTACCGCTACGTGGCCGATCCGCGCAGCATGGAG
GTCACGCCCGAGCAGATGTTGGACGAGGCCTACCTGAAGTCCCGCGCCAAGCTGATCGACATGCAACGCGCGACGCATTT
CAACTTCGGCATGCCCCGCACGGGCGGCACGATCTACCTGACCGCGGCAGACGAGAACGGCATGATGATCTCGTTCATCC
AGTCGAACTACATGGGCTTCGGTTCCGGCGTCGTGGTGCCGGGCACCGGCATCAGCCTGCAGAACCGTGGCGTTGGATTC
TCGATGGATCCGAAGTCGGCCAACGTGGTGGAAGGCGGCAAGCGCCCGTTCCACACGATTATCCCGGCCTTCCTGACCAA
GCAAGGCAAGCCGGTGATGAGCTTCGGCGTCATGGGCGGCGATATGCAACCGCAAGGTCATCTGCAAACCGTTGTGCGCA
TGCTCGATTACAACCAGCAACCGCAGGCTGCCTGCTGCGCACCGCGCTGGAAGGTCAACCGCGACTTCACGCTGGACGTT
GAAGGCACCATGGACCCGAACACCGTGGCCGGGCTCAAGGAGCGCGGCCACAAGCTCAAATCCGTGGAAGACCCGTATAT
GGACTTCGGCTCCGGCCAGTTCATCTGGCGTTTGTCGGACGATGCCGAGCAAGGCTATGTGGCCGCCAGCGACAGCCGCC
GCGACGGTCAGGCCGTGGGCTTCTGA

Upstream 100 bases:

>100_bases
TCGGAAGATCCAGGTGGATTGATTCTTTGATCCCCAATTTTGCTCTGCTCTCCTGCGCGATGGGAGCGCAGAGAAAACAC
TAGGCATAGCGAGAGACACC

Downstream 100 bases:

>100_bases
GGCAGAGGTTTAGTTGTACCGCTGTAGGTAGTACGTAGTAGAAGTCCTGCGAGGCGCCATGGGGAAACCCATGGCGCCTA
TTTTCATTCCGGGATTGCCA

Product: Gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MQNFNWTNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAAAITLVEPVSCGLGSDAFAILWDGKQLH
GLNSSGVAPAAWNPDYFKNKYGADGNGLANRPIRGWDSVTVPGVIAGWAALHERFGKLPFEDLMEPAIEIAERGYAVPPV
VAHKWAAAVPDLKSQPGFADTFMPNGRAPAVGEKFLFKDAADTLRKIGATGGRAYYEGEIAEKIAAFSKACGGAMTLDDL
RNYRPEWVTPISKSYRGYEVHEIPPNGQGIAALMALGILDQFDVGSLPVDSVDSQHLQIEAMKLAFADLYRYVADPRSME
VTPEQMLDEAYLKSRAKLIDMQRATHFNFGMPRTGGTIYLTAADENGMMISFIQSNYMGFGSGVVVPGTGISLQNRGVGF
SMDPKSANVVEGGKRPFHTIIPAFLTKQGKPVMSFGVMGGDMQPQGHLQTVVRMLDYNQQPQAACCAPRWKVNRDFTLDV
EGTMDPNTVAGLKERGHKLKSVEDPYMDFGSGQFIWRLSDDAEQGYVAASDSRRDGQAVGF

Sequences:

>Translated_541_residues
MQNFNWTNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAAAITLVEPVSCGLGSDAFAILWDGKQLH
GLNSSGVAPAAWNPDYFKNKYGADGNGLANRPIRGWDSVTVPGVIAGWAALHERFGKLPFEDLMEPAIEIAERGYAVPPV
VAHKWAAAVPDLKSQPGFADTFMPNGRAPAVGEKFLFKDAADTLRKIGATGGRAYYEGEIAEKIAAFSKACGGAMTLDDL
RNYRPEWVTPISKSYRGYEVHEIPPNGQGIAALMALGILDQFDVGSLPVDSVDSQHLQIEAMKLAFADLYRYVADPRSME
VTPEQMLDEAYLKSRAKLIDMQRATHFNFGMPRTGGTIYLTAADENGMMISFIQSNYMGFGSGVVVPGTGISLQNRGVGF
SMDPKSANVVEGGKRPFHTIIPAFLTKQGKPVMSFGVMGGDMQPQGHLQTVVRMLDYNQQPQAACCAPRWKVNRDFTLDV
EGTMDPNTVAGLKERGHKLKSVEDPYMDFGSGQFIWRLSDDAEQGYVAASDSRRDGQAVGF
>Mature_541_residues
MQNFNWTNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAAAITLVEPVSCGLGSDAFAILWDGKQLH
GLNSSGVAPAAWNPDYFKNKYGADGNGLANRPIRGWDSVTVPGVIAGWAALHERFGKLPFEDLMEPAIEIAERGYAVPPV
VAHKWAAAVPDLKSQPGFADTFMPNGRAPAVGEKFLFKDAADTLRKIGATGGRAYYEGEIAEKIAAFSKACGGAMTLDDL
RNYRPEWVTPISKSYRGYEVHEIPPNGQGIAALMALGILDQFDVGSLPVDSVDSQHLQIEAMKLAFADLYRYVADPRSME
VTPEQMLDEAYLKSRAKLIDMQRATHFNFGMPRTGGTIYLTAADENGMMISFIQSNYMGFGSGVVVPGTGISLQNRGVGF
SMDPKSANVVEGGKRPFHTIIPAFLTKQGKPVMSFGVMGGDMQPQGHLQTVVRMLDYNQQPQAACCAPRWKVNRDFTLDV
EGTMDPNTVAGLKERGHKLKSVEDPYMDFGSGQFIWRLSDDAEQGYVAASDSRRDGQAVGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=553, Percent_Identity=26.7631103074141, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI73915090, Length=553, Percent_Identity=26.7631103074141, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI73915096, Length=553, Percent_Identity=26.7631103074141, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI73915094, Length=553, Percent_Identity=26.7631103074141, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI113429324, Length=551, Percent_Identity=25.9528130671506, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI113429326, Length=556, Percent_Identity=25.7194244604317, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI109148539, Length=520, Percent_Identity=26.3461538461538, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI153266885, Length=551, Percent_Identity=23.7749546279492, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI153266901, Length=552, Percent_Identity=23.731884057971, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI153266907, Length=549, Percent_Identity=23.1329690346084, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1789856, Length=506, Percent_Identity=28.4584980237154, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17506189, Length=555, Percent_Identity=24.1441441441441, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI72000294, Length=523, Percent_Identity=24.6653919694073, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI212646519, Length=523, Percent_Identity=24.6653919694073, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17542894, Length=559, Percent_Identity=25.0447227191413, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI193208245, Length=504, Percent_Identity=24.2063492063492, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193208247, Length=504, Percent_Identity=24.2063492063492, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859893, Length=522, Percent_Identity=26.8199233716475, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24642670, Length=555, Percent_Identity=25.7657657657658, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24642666, Length=555, Percent_Identity=25.7657657657658, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI161077880, Length=555, Percent_Identity=25.7657657657658, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI161077878, Length=555, Percent_Identity=25.7657657657658, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45551474, Length=555, Percent_Identity=25.7657657657658, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI18859741, Length=562, Percent_Identity=25.6227758007117, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077496, Length=507, Percent_Identity=26.0355029585799, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58595; Mature: 58595

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNFNWTNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAAAITLVEP
CCCCCCCCCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VSCGLGSDAFAILWDGKQLHGLNSSGVAPAAWNPDYFKNKYGADGNGLANRPIRGWDSVT
HCCCCCCCEEEEEECCHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
VPGVIAGWAALHERFGKLPFEDLMEPAIEIAERGYAVPPVVAHKWAAAVPDLKSQPGFAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCC
TFMPNGRAPAVGEKFLFKDAADTLRKIGATGGRAYYEGEIAEKIAAFSKACGGAMTLDDL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCHHHH
RNYRPEWVTPISKSYRGYEVHEIPPNGQGIAALMALGILDQFDVGSLPVDSVDSQHLQIE
HCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHH
AMKLAFADLYRYVADPRSMEVTPEQMLDEAYLKSRAKLIDMQRATHFNFGMPRTGGTIYL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
TAADENGMMISFIQSNYMGFGSGVVVPGTGISLQNRGVGFSMDPKSANVVEGGKRPFHTI
EEECCCCCEEEEEECCCCCCCCCEEECCCCCEECCCCCCCEECCCCCCCCCCCCCCHHHH
IPAFLTKQGKPVMSFGVMGGDMQPQGHLQTVVRMLDYNQQPQAACCAPRWKVNRDFTLDV
HHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEE
EGTMDPNTVAGLKERGHKLKSVEDPYMDFGSGQFIWRLSDDAEQGYVAASDSRRDGQAVG
CCCCCCHHHHHHHHHCCHHCCCCCCHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCC
F
C
>Mature Secondary Structure
MQNFNWTNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAAAITLVEP
CCCCCCCCCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VSCGLGSDAFAILWDGKQLHGLNSSGVAPAAWNPDYFKNKYGADGNGLANRPIRGWDSVT
HCCCCCCCEEEEEECCHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
VPGVIAGWAALHERFGKLPFEDLMEPAIEIAERGYAVPPVVAHKWAAAVPDLKSQPGFAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCC
TFMPNGRAPAVGEKFLFKDAADTLRKIGATGGRAYYEGEIAEKIAAFSKACGGAMTLDDL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCHHHH
RNYRPEWVTPISKSYRGYEVHEIPPNGQGIAALMALGILDQFDVGSLPVDSVDSQHLQIE
HCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHH
AMKLAFADLYRYVADPRSMEVTPEQMLDEAYLKSRAKLIDMQRATHFNFGMPRTGGTIYL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
TAADENGMMISFIQSNYMGFGSGVVVPGTGISLQNRGVGFSMDPKSANVVEGGKRPFHTI
EEECCCCCEEEEEECCCCCCCCCEEECCCCCEECCCCCCCEECCCCCCCCCCCCCCHHHH
IPAFLTKQGKPVMSFGVMGGDMQPQGHLQTVVRMLDYNQQPQAACCAPRWKVNRDFTLDV
HHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEE
EGTMDPNTVAGLKERGHKLKSVEDPYMDFGSGQFIWRLSDDAEQGYVAASDSRRDGQAVG
CCCCCCHHHHHHHHHCCHHCCCCCCHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]