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The map label for this gene is hisC1 [H]

Identifier: 94309662

GI number: 94309662

Start: 794484

End: 795608

Strand: Direct

Name: hisC1 [H]

Synonym: Rmet_0717

Alternate gene names: 94309662

Gene position: 794484-795608 (Clockwise)

Preceding gene: 94309661

Following gene: 94309663

Centisome position: 20.23

GC content: 62.58

Gene sequence:

>1125_bases
ATGGCAGGGCAGGACAACGCGGCTGACTACTTTGGTCCGTCCTATGTGCGCAAGATCTCGCCGTATATCGCGGGCAAGCC
GATCTCGGAAGTGGCTCGCGAGTTCGGACTCGACGAGGCAAGAATCGTCAAGCTGGCGTCGAACGAGAACCCGCTCGGCA
TGCCCGCCTCGGCAAAAGCGGCTATCGCCGCCGCGACGGAGGATCTGGGGCGCTATCCGGACAGCAACGGCTTCGAACTG
AAGGCGAAACTGTCAGAAAAATACGATGTGCCGGCCGAGTGGCTGACGCTTGGCAACGGTAGCAACGACATTCTGGAACT
GGCCGCGCATGCATTGGTGCGCAATGGCGAGTCGATCGTCTACGCCGAGTACTCGTTTGCGGTCTACGCGCTGGCTACGC
AGGAAGTTGGCGCGCGCGCCATCGAGGTCAAGTCGCGCGCGTATGGTCATGATCTCGATGCGATGGCTGCGGCGATTGCG
CCCGACACCAAGCTCGTCTTCATCGCCAACCCGAACAATCCGACTGGCACATTCGTGTCCGCCGCCGAGATCGAGGCTTT
CTTGGCCAAGGTGCCGCCGCATGTGGTGGTTGTGCTGGACGAGGCCTACAACGAGTATCTCGATGCGGGCCAGCAGTACG
AATCGGTTGCCTGGGTGCGCAAGTATCCGAACCTGATGGTGTCGCGGACGTTCTCGAAGGCCTATGGGCTGGCGGGGCTG
CGGGTCGGCTATGGCGTGGCACAGCCCCAGCTTACCGATTTGCTGAATCGCGTGCGCCAGCCGTTCAACGTCAACAGCCT
GGCGCAGGCTGCAGCCGTGGCAGCGCTCGACGATACGGCATTTCTGCAACGCAGCGCCGAACTGAATCGTCAGGGCAAGG
CGCGGCTGGTGGAAGCGTTCGAGCGAAGTGGGCTCGAATACGTGAAGTCGTCCGGCAACTTTGTCATGGTTCGCGTGGGT
GGCGACGATGGCGCTGGCGCGCGGGTCAATCTGGCGCTGCTGAAGCAAGGTGTGATCGTGCGCCCCGTGGCCAACTACGG
CCTGCCGCAGTGGCTGCGCGTGACGATCGGCCTGCCAGAAGAGAACGACGCGTTCATCGCGGCGCTGGAACAGGCCCTGA
AGTGA

Upstream 100 bases:

>100_bases
GCCGTGACGCGCGCGATCGAGATGCTGCGTCGCAATGCCGCGTACCTGAAGGTCCTGGGTTCGTATCCATCCAGCAAATA
ACGGCAGCGAGGAGACAGAC

Downstream 100 bases:

>100_bases
AACTCAAGCATGTCTGAAACCGTGAGCGCATTGCATTTTTCGAAAGTCGTGATTGTCGGCGTTGGCCTGATTGGCGGATC
GCTGGCGCTGTCGCTCAAGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MAGQDNAADYFGPSYVRKISPYIAGKPISEVAREFGLDEARIVKLASNENPLGMPASAKAAIAAATEDLGRYPDSNGFEL
KAKLSEKYDVPAEWLTLGNGSNDILELAAHALVRNGESIVYAEYSFAVYALATQEVGARAIEVKSRAYGHDLDAMAAAIA
PDTKLVFIANPNNPTGTFVSAAEIEAFLAKVPPHVVVVLDEAYNEYLDAGQQYESVAWVRKYPNLMVSRTFSKAYGLAGL
RVGYGVAQPQLTDLLNRVRQPFNVNSLAQAAAVAALDDTAFLQRSAELNRQGKARLVEAFERSGLEYVKSSGNFVMVRVG
GDDGAGARVNLALLKQGVIVRPVANYGLPQWLRVTIGLPEENDAFIAALEQALK

Sequences:

>Translated_374_residues
MAGQDNAADYFGPSYVRKISPYIAGKPISEVAREFGLDEARIVKLASNENPLGMPASAKAAIAAATEDLGRYPDSNGFEL
KAKLSEKYDVPAEWLTLGNGSNDILELAAHALVRNGESIVYAEYSFAVYALATQEVGARAIEVKSRAYGHDLDAMAAAIA
PDTKLVFIANPNNPTGTFVSAAEIEAFLAKVPPHVVVVLDEAYNEYLDAGQQYESVAWVRKYPNLMVSRTFSKAYGLAGL
RVGYGVAQPQLTDLLNRVRQPFNVNSLAQAAAVAALDDTAFLQRSAELNRQGKARLVEAFERSGLEYVKSSGNFVMVRVG
GDDGAGARVNLALLKQGVIVRPVANYGLPQWLRVTIGLPEENDAFIAALEQALK
>Mature_373_residues
AGQDNAADYFGPSYVRKISPYIAGKPISEVAREFGLDEARIVKLASNENPLGMPASAKAAIAAATEDLGRYPDSNGFELK
AKLSEKYDVPAEWLTLGNGSNDILELAAHALVRNGESIVYAEYSFAVYALATQEVGARAIEVKSRAYGHDLDAMAAAIAP
DTKLVFIANPNNPTGTFVSAAEIEAFLAKVPPHVVVVLDEAYNEYLDAGQQYESVAWVRKYPNLMVSRTFSKAYGLAGLR
VGYGVAQPQLTDLLNRVRQPFNVNSLAQAAAVAALDDTAFLQRSAELNRQGKARLVEAFERSGLEYVKSSGNFVMVRVGG
DDGAGARVNLALLKQGVIVRPVANYGLPQWLRVTIGLPEENDAFIAALEQALK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=361, Percent_Identity=26.5927977839335, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786816, Length=270, Percent_Identity=27.4074074074074, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788627, Length=189, Percent_Identity=28.042328042328, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=362, Percent_Identity=29.0055248618785, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40258; Mature: 40127

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS00599 AA_TRANSFER_CLASS_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGQDNAADYFGPSYVRKISPYIAGKPISEVAREFGLDEARIVKLASNENPLGMPASAKA
CCCCCCCCCCCCHHHHHHHCHHHCCCCHHHHHHHHCCCHHEEEEEECCCCCCCCCCCCHH
AIAAATEDLGRYPDSNGFELKAKLSEKYDVPAEWLTLGNGSNDILELAAHALVRNGESIV
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHEEECCCCHHHHHHHHHHHHHCCCEEE
YAEYSFAVYALATQEVGARAIEVKSRAYGHDLDAMAAAIAPDTKLVFIANPNNPTGTFVS
EEEECEEEEEEEHHHHCCEEEEEHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEE
AAEIEAFLAKVPPHVVVVLDEAYNEYLDAGQQYESVAWVRKYPNLMVSRTFSKAYGLAGL
HHHHHHHHHHCCCEEEEEEHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
RVGYGVAQPQLTDLLNRVRQPFNVNSLAQAAAVAALDDTAFLQRSAELNRQGKARLVEAF
EECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHH
ERSGLEYVKSSGNFVMVRVGGDDGAGARVNLALLKQGVIVRPVANYGLPQWLRVTIGLPE
HHCCHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHCCCEEEEHHHCCCCCEEEEEECCCC
ENDAFIAALEQALK
CCCHHHHHHHHHHC
>Mature Secondary Structure 
AGQDNAADYFGPSYVRKISPYIAGKPISEVAREFGLDEARIVKLASNENPLGMPASAKA
CCCCCCCCCCCHHHHHHHCHHHCCCCHHHHHHHHCCCHHEEEEEECCCCCCCCCCCCHH
AIAAATEDLGRYPDSNGFELKAKLSEKYDVPAEWLTLGNGSNDILELAAHALVRNGESIV
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHEEECCCCHHHHHHHHHHHHHCCCEEE
YAEYSFAVYALATQEVGARAIEVKSRAYGHDLDAMAAAIAPDTKLVFIANPNNPTGTFVS
EEEECEEEEEEEHHHHCCEEEEEHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEE
AAEIEAFLAKVPPHVVVVLDEAYNEYLDAGQQYESVAWVRKYPNLMVSRTFSKAYGLAGL
HHHHHHHHHHCCCEEEEEEHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
RVGYGVAQPQLTDLLNRVRQPFNVNSLAQAAAVAALDDTAFLQRSAELNRQGKARLVEAF
EECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHH
ERSGLEYVKSSGNFVMVRVGGDDGAGARVNLALLKQGVIVRPVANYGLPQWLRVTIGLPE
HHCCHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHCCCEEEEHHHCCCCCEEEEEECCCC
ENDAFIAALEQALK
CCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA