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The map label for this gene is gltP2 [H]

Identifier: 94309535

GI number: 94309535

Start: 634211

End: 635518

Strand: Reverse

Name: gltP2 [H]

Synonym: Rmet_0590

Alternate gene names: 94309535

Gene position: 635518-634211 (Counterclockwise)

Preceding gene: 94309536

Following gene: 94309534

Centisome position: 16.18

GC content: 64.6

Gene sequence:

>1308_bases
ATGACAAAACGACTGCCAACCCTGATCTTCGTCGCGATGCTGCTAGGCGTGCTCGTCGGCGCTGCCGTGCACAACATGTC
GCCGGACGCCGCAACCGCGAAGTCGATCGCCGATCACCTGTCGATCCTGACCGACGTGTTCCTGCGGATGATCAAGATGA
TCATCGGCCCGCTGGTGTTCGCCACACTGGTTTCCGGCATTGCCAGCATGGGCGACGGCAAGACCGTCGGCCGCATCGGC
CTGAAGGCGATGGCCTGGTTCATGGCCGCGTCGATCACGTCGCTGCTGCTGGGCTTGCTGATGGCCAACCTGCTGGCCCC
GGGCCACGGCATGAACCTGCCGCTGCCGGCCGCCGACGCCGCGTCGAACCTGAAGACCGGTGCGCTGAACCTGCGCGACT
TCATCGCCCACATGTTCCCGAAGAGCTTCGTGGAAGCGATGGCCACCAACGAAGTGCTGCAGATCGTGGTGTTCTCGCTG
TTCTTCGGCTTCGCGCTGGGTACCCTCAAGGACGGCGTGGGCAAGCCCGTGCTGGCCGGTATCGATGGCCTGGGCCACAT
CATGCTCAAGGTCACCAACTACGTGATGGCCTTCGCGCCGCTGGGCGTGTTCGGCGCCGTCTCCGCCGTGATCTCGGCGC
AGGGCCTGGGCGTGCTGGTGGTCTACGCCAAGCTGCTGGGCAGCGTGTACGCGGCGCTGGCACTGCTGTGGCTGGCACTG
ATCGCGGGTGGCTACTTCTTCCTGGGTCGTGACGTCTTCCGCCTGATGCGCACGCTGCGCACGCCGCTGATGATCGGCTT
CGCCACGGCCAGCAGCGAATCGGCCTACCCGAAGGTGATCGACCAACTCACGCGCTTCGGCGTCAAGCCGCGCATCACGA
ACTTCGTGCTGCCGCTGGGCTACTCGTTCAACCTTGACGGCTCGATCATGTACACCTCCTTTGCCGCCCTGTTCGTGGCG
CAGGTGTACGGGATCCAGCTTTCGCTGACCCAGCAGATCACCATGCTGCTGGTGCTGCTGGTCACCAGCAAGGGCATCGC
CGGCGTGCCGCGCGCCTCGCTGGTGGTGGTAGCCGCCGTTCTGCCGATGTTCGGTCTGCCCGAAGCCGGCATCCTGCTCG
TCCTCGGTATCGACCATATCCTCGATATGGGCCGGACCGTGACCAATGTGCTTGGCAATGCCATTGCCACGACCGTCGTC
GCCAAAAGCGAAGGCGCGATCGGCGCGCCGGAACTCTCCGAGGAGGCAGACACCTCCGAGGACAGCAATACCGGCCTGAC
ACCCGCTCAGGTCCTGGCGAGCAAGTAA

Upstream 100 bases:

>100_bases
CGTGCGATTTAGGCGCCGCCGTAGGGCACACAAGCGCGGCCGCACCATCCCCAAGAGGAAACACGCGGGCCGCCACAGTA
CAAAGGAGGATGTACCCACG

Downstream 100 bases:

>100_bases
GACATTGCTCCCAGGCGTGCCAGGGCCCGGTTGCCGATCAGGTAACCGGGCCTTTTTTGCTTTTTGGCGGCTGTAACGCC
GGGTGTGGTAAAACGTCGCC

Product: Sodium:dicarboxylate symporter: DAACS family

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTKRLPTLIFVAMLLGVLVGAAVHNMSPDAATAKSIADHLSILTDVFLRMIKMIIGPLVFATLVSGIASMGDGKTVGRIG
LKAMAWFMAASITSLLLGLLMANLLAPGHGMNLPLPAADAASNLKTGALNLRDFIAHMFPKSFVEAMATNEVLQIVVFSL
FFGFALGTLKDGVGKPVLAGIDGLGHIMLKVTNYVMAFAPLGVFGAVSAVISAQGLGVLVVYAKLLGSVYAALALLWLAL
IAGGYFFLGRDVFRLMRTLRTPLMIGFATASSESAYPKVIDQLTRFGVKPRITNFVLPLGYSFNLDGSIMYTSFAALFVA
QVYGIQLSLTQQITMLLVLLVTSKGIAGVPRASLVVVAAVLPMFGLPEAGILLVLGIDHILDMGRTVTNVLGNAIATTVV
AKSEGAIGAPELSEEADTSEDSNTGLTPAQVLASK

Sequences:

>Translated_435_residues
MTKRLPTLIFVAMLLGVLVGAAVHNMSPDAATAKSIADHLSILTDVFLRMIKMIIGPLVFATLVSGIASMGDGKTVGRIG
LKAMAWFMAASITSLLLGLLMANLLAPGHGMNLPLPAADAASNLKTGALNLRDFIAHMFPKSFVEAMATNEVLQIVVFSL
FFGFALGTLKDGVGKPVLAGIDGLGHIMLKVTNYVMAFAPLGVFGAVSAVISAQGLGVLVVYAKLLGSVYAALALLWLAL
IAGGYFFLGRDVFRLMRTLRTPLMIGFATASSESAYPKVIDQLTRFGVKPRITNFVLPLGYSFNLDGSIMYTSFAALFVA
QVYGIQLSLTQQITMLLVLLVTSKGIAGVPRASLVVVAAVLPMFGLPEAGILLVLGIDHILDMGRTVTNVLGNAIATTVV
AKSEGAIGAPELSEEADTSEDSNTGLTPAQVLASK
>Mature_434_residues
TKRLPTLIFVAMLLGVLVGAAVHNMSPDAATAKSIADHLSILTDVFLRMIKMIIGPLVFATLVSGIASMGDGKTVGRIGL
KAMAWFMAASITSLLLGLLMANLLAPGHGMNLPLPAADAASNLKTGALNLRDFIAHMFPKSFVEAMATNEVLQIVVFSLF
FGFALGTLKDGVGKPVLAGIDGLGHIMLKVTNYVMAFAPLGVFGAVSAVISAQGLGVLVVYAKLLGSVYAALALLWLALI
AGGYFFLGRDVFRLMRTLRTPLMIGFATASSESAYPKVIDQLTRFGVKPRITNFVLPLGYSFNLDGSIMYTSFAALFVAQ
VYGIQLSLTQQITMLLVLLVTSKGIAGVPRASLVVVAAVLPMFGLPEAGILLVLGIDHILDMGRTVTNVLGNAIATTVVA
KSEGAIGAPELSEEADTSEDSNTGLTPAQVLASK

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=492, Percent_Identity=25.8130081300813, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI66773030, Length=466, Percent_Identity=25.9656652360515, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI21314632, Length=450, Percent_Identity=28, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI40254478, Length=426, Percent_Identity=28.169014084507, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI5032093, Length=402, Percent_Identity=28.3582089552239, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4827012, Length=258, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI194239697, Length=262, Percent_Identity=32.4427480916031, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI223468566, Length=283, Percent_Identity=29.6819787985866, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=29.3478260869565, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI262359914, Length=403, Percent_Identity=24.0694789081886, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI301601644, Length=150, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790514, Length=405, Percent_Identity=39.7530864197531, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1789947, Length=406, Percent_Identity=36.6995073891626, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1788024, Length=419, Percent_Identity=26.7303102625298, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17537407, Length=465, Percent_Identity=26.6666666666667, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71996953, Length=464, Percent_Identity=26.2931034482759, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=429, Percent_Identity=26.5734265734266, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71983106, Length=412, Percent_Identity=26.9417475728155, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983099, Length=418, Percent_Identity=26.7942583732057, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=436, Percent_Identity=25.6880733944954, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=405, Percent_Identity=25.4320987654321, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24583025, Length=435, Percent_Identity=26.2068965517241, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI17137668, Length=435, Percent_Identity=26.2068965517241, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24583023, Length=435, Percent_Identity=26.2068965517241, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI281360481, Length=454, Percent_Identity=26.8722466960352, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360483, Length=454, Percent_Identity=26.8722466960352, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137666, Length=454, Percent_Identity=26.8722466960352, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45558; Mature: 45427

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCHHHHHCCC
>Mature Secondary Structure 
TKRLPTLIFVAMLLGVLVGAAVHNMSPDAATAKSIADHLSILTDVFLRMIKMIIGPLVF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATLVSGIASMGDGKTVGRIGLKAMAWFMAASITSLLLGLLMANLLAPGHGMNLPLPAADA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ASNLKTGALNLRDFIAHMFPKSFVEAMATNEVLQIVVFSLFFGFALGTLKDGVGKPVLAG
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IDGLGHIMLKVTNYVMAFAPLGVFGAVSAVISAQGLGVLVVYAKLLGSVYAALALLWLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IAGGYFFLGRDVFRLMRTLRTPLMIGFATASSESAYPKVIDQLTRFGVKPRITNFVLPLG
HHCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHEEEECC
YSFNLDGSIMYTSFAALFVAQVYGIQLSLTQQITMLLVLLVTSKGIAGVPRASLVVVAAV
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LPMFGLPEAGILLVLGIDHILDMGRTVTNVLGNAIATTVVAKSEGAIGAPELSEEADTSE
HHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DSNTGLTPAQVLASK
CCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]