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The map label for this gene is strD [H]

Identifier: 94309378

GI number: 94309378

Start: 457709

End: 458407

Strand: Reverse

Name: strD [H]

Synonym: Rmet_0433

Alternate gene names: 94309378

Gene position: 458407-457709 (Counterclockwise)

Preceding gene: 335055491

Following gene: 94309377

Centisome position: 11.67

GC content: 68.24

Gene sequence:

>699_bases
ATGATCTTCGCCGCCGGCCGCGGCGATCGTATGCGACCGTTGACCGATGCCTGCCCAAAGCCGTTGCTGGCCGTGGGGGG
CAAGCCGCTGATCGTGTGGCAGGTCGAGGCGCTGGTGCGCGCTGGCCTCACCGATATCGTCATCAATCACGCCTGGCTCG
GCGAGCAGCTCGAGTCGGCACTGGGCGATGGCTCGCAATTCGGCGCGCGCATCCATTGGTCGGCCGAAGGCACGGCGCTG
GAAACGGCCGGCGGCATCGCCCACGCGCTGCCCCTGCTGACCGGCAAGACCGACGCCGACGACGTGTTCCTGGCCGTATC
GGGCGACATCTTCTGCGACTTCGACTACCGCACCCTGTTGCCACGCGCCCGCGCCATGGCCATGGCCCCGCGACCGCACA
TGCATCTGGTGATGGTGCCGAACCCGCCCTTCCATCCGCGCGGCGATTTCGTGCTGGATACGGCCGGGCTGCTGCGGATG
CCCAGCGCCGACGCCCACGCGCTGACGTTCGGCAATATCGGCCTGTACGACACCCGCCTGTTCCGCGAAATCGAACGCGG
AGCGAAGGTGGCGATGTCGCCCTACTATCGGGAGTCCATCGCCGCAGGCCTGGCCACGGGCGAGCGCTTCGACGGCCGCT
GGGAAAACGTTGGCACTCCTGCGCAACTGGCGGCGCTTGATCGCTCGCTGCGGGCATAG

Upstream 100 bases:

>100_bases
TGGTGGCCATCGTCATCGCCGCGCGCACGCGCAGCGTTGGCTGGACCATCGCCGGAGGCATGGCCGCCCTGATTGCCCTG
GAGGCCCTGATTTGAAAGCG

Downstream 100 bases:

>100_bases
CGGCGCGTTCCCGAACGTTACCAAAGCCCCGGACGCGCCCACTTTTGCGCCGCATCGTGCGCACGCGCGGCCCGCTTTCC
CCGCCGACGGGTTTAGAATC

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MIFAAGRGDRMRPLTDACPKPLLAVGGKPLIVWQVEALVRAGLTDIVINHAWLGEQLESALGDGSQFGARIHWSAEGTAL
ETAGGIAHALPLLTGKTDADDVFLAVSGDIFCDFDYRTLLPRARAMAMAPRPHMHLVMVPNPPFHPRGDFVLDTAGLLRM
PSADAHALTFGNIGLYDTRLFREIERGAKVAMSPYYRESIAAGLATGERFDGRWENVGTPAQLAALDRSLRA

Sequences:

>Translated_232_residues
MIFAAGRGDRMRPLTDACPKPLLAVGGKPLIVWQVEALVRAGLTDIVINHAWLGEQLESALGDGSQFGARIHWSAEGTAL
ETAGGIAHALPLLTGKTDADDVFLAVSGDIFCDFDYRTLLPRARAMAMAPRPHMHLVMVPNPPFHPRGDFVLDTAGLLRM
PSADAHALTFGNIGLYDTRLFREIERGAKVAMSPYYRESIAAGLATGERFDGRWENVGTPAQLAALDRSLRA
>Mature_232_residues
MIFAAGRGDRMRPLTDACPKPLLAVGGKPLIVWQVEALVRAGLTDIVINHAWLGEQLESALGDGSQFGARIHWSAEGTAL
ETAGGIAHALPLLTGKTDADDVFLAVSGDIFCDFDYRTLLPRARAMAMAPRPHMHLVMVPNPPFHPRGDFVLDTAGLLRM
PSADAHALTFGNIGLYDTRLFREIERGAKVAMSPYYRESIAAGLATGERFDGRWENVGTPAQLAALDRSLRA

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=121, Percent_Identity=35.5371900826446, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI11761619, Length=121, Percent_Identity=35.5371900826446, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=120, Percent_Identity=35.8333333333333, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355443, Length=121, Percent_Identity=33.8842975206612, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644084, Length=121, Percent_Identity=33.8842975206612, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25086; Mature: 25086

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFAAGRGDRMRPLTDACPKPLLAVGGKPLIVWQVEALVRAGLTDIVINHAWLGEQLESA
CEEECCCCCCCCCCHHHCCCCHHHHCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHH
LGDGSQFGARIHWSAEGTALETAGGIAHALPLLTGKTDADDVFLAVSGDIFCDFDYRTLL
HCCCCCCCEEEEECCCCCEEECCCCHHHHHHHHCCCCCCCCEEEEEECCEEEECCHHHHH
PRARAMAMAPRPHMHLVMVPNPPFHPRGDFVLDTAGLLRMPSADAHALTFGNIGLYDTRL
HHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEECCCCEECCCCCCCEEEECCCCCHHHHH
FREIERGAKVAMSPYYRESIAAGLATGERFDGRWENVGTPAQLAALDRSLRA
HHHHHHCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIFAAGRGDRMRPLTDACPKPLLAVGGKPLIVWQVEALVRAGLTDIVINHAWLGEQLESA
CEEECCCCCCCCCCHHHCCCCHHHHCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHH
LGDGSQFGARIHWSAEGTALETAGGIAHALPLLTGKTDADDVFLAVSGDIFCDFDYRTLL
HCCCCCCCEEEEECCCCCEEECCCCHHHHHHHHCCCCCCCCEEEEEECCEEEECCHHHHH
PRARAMAMAPRPHMHLVMVPNPPFHPRGDFVLDTAGLLRMPSADAHALTFGNIGLYDTRL
HHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEECCCCEECCCCCCCEEEECCCCCHHHHH
FREIERGAKVAMSPYYRESIAAGLATGERFDGRWENVGTPAQLAALDRSLRA
HHHHHHCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]