Click here to switch to the map view.

The map label for this gene is pepP [H]

Identifier: 94309377

GI number: 94309377

Start: 456183

End: 457580

Strand: Reverse

Name: pepP [H]

Synonym: Rmet_0432

Alternate gene names: 94309377

Gene position: 457580-456183 (Counterclockwise)

Preceding gene: 94309378

Following gene: 94309376

Centisome position: 11.65

GC content: 68.1

Gene sequence:

>1398_bases
ATGTCCGCACCCGACTCCGCCCTCCTCGGCGCGTGCAGCGATCGCCGCGCCCGTGTGCTGAAACATCTGCGCGCCAACGG
CGGCGGCGTGGCCATCGTGCCAACCGCGCCGGAGGCCATGCGCAATCGCGACAGCGACTATCCGTACCGGCACGACAGCT
ATTTCTATTACCTGACCGGATTCACCGAGCCAGAAGCAGTGCTCGTGCTGGTGGCGGGCGGCCCGGGCGACGACACCAAC
AGCAGCATCCTGTTCTGCCGACCCAAGCACGAAGAACGCGAGATCTGGGATGGCTTCCGCTATGGCCCAGAAGGCGCGCG
CGCGATGTTCGGCTTCGACGAGGCGCATTCGGTCGAAGACATCGACAAGCTGCTGCCGCCGATGCTGGCCAATCGCGCCA
CGCTGGCCTACCCGCTGGCCGCCACCGCAGACTTCGACGCCCGCGTGCGTGGCTGGCTGGACGCGGTACGGATGCAGGGC
CGCGCCGGGGTGTCCTCCCCGTCGGCCGCGCTCGACGTTCGCGCACTACTCGACGAGATGCGCCTGTTCAAGGATGCGGG
CGAACTGGTCACGATGCGCCGTGCCGCCGAGATCTCGGCCCAGGCGCATGTTCGTGCGATGCGCACGTCGCGCCACGGCT
TGCGCGAGTACCACCTCGAAGCCGAACTGCTCTACGAATTCCGCCGCCACGGCGCCCAGAGCGTGGCCTACAACTCGATC
GTCGCCACGGGCCCCAACGCTTGCGTGCTGCACTACCGGGCTGGTCCGGCCGAACTGCGCGACGGCGACCTGTGCCTGAT
CGACGCGGGTTGCGAACTCGACGGCTACGCGTCGGACATTACGCGCACATTCCCGGTCAACGGCCGATTCACGCCGGCGC
AGCGCGAGCTCTATGACCTCGTGCAGGCCGCGCAGGACGCCGCCATCGCCGAGACACGCGCGGGCGTGCCATACAACGTC
CCGCACGACGCGGCGGTGCGTGTGCTGGCGCAAGGCATGCTGGACACCGGCCTGCTCGACCGCAACAAGGAAGGCACGCT
CGACGACGTGCTGGCCAGCGGCAGCTATCGCCGCTTCTACATGCACCGCACGGGCCACTGGCTCGGCATGGACGTGCACG
ACGTGGGTGAATACCGCGTGCCCGGCCCGCTGCCGGCAGGCCACGAGGGCGAGCGGGCATGGCGTCCGCTTGAGGCGGGC
ATGGTGGTAACCATCGAGCCGGGCATCTACGTGCGCCCGGCCGAAGACGTACCCGAACGCTACTGGCACATCGGCATCCG
CATCGAGGACGACGCCGTGGTGACTTCGGGAGATTGCGAACTGATCACGCGCGGCGTGCCTGTGAAGGCCGACGAGATCG
AGGCACTGATGCGCGACAACGGAGGCATGTCGCGATGA

Upstream 100 bases:

>100_bases
CCGGACGCGCCCACTTTTGCGCCGCATCGTGCGCACGCGCGGCCCGCTTTCCCCGCCGACGGGTTTAGAATCGGGGCATT
CCCCTCACCGTCTTTCATCC

Downstream 100 bases:

>100_bases
AGGCATTGTTGAGCAAACTGTTCGGAACCGGCGTCACGAAGACCCACACGACACGAGCAGTCGATCCGAACGAACCATTC
GTGATCAATATTTATGACGA

Product: proline aminopeptidase P II

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSAPDSALLGACSDRRARVLKHLRANGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPEAVLVLVAGGPGDDTN
SSILFCRPKHEEREIWDGFRYGPEGARAMFGFDEAHSVEDIDKLLPPMLANRATLAYPLAATADFDARVRGWLDAVRMQG
RAGVSSPSAALDVRALLDEMRLFKDAGELVTMRRAAEISAQAHVRAMRTSRHGLREYHLEAELLYEFRRHGAQSVAYNSI
VATGPNACVLHYRAGPAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTPAQRELYDLVQAAQDAAIAETRAGVPYNV
PHDAAVRVLAQGMLDTGLLDRNKEGTLDDVLASGSYRRFYMHRTGHWLGMDVHDVGEYRVPGPLPAGHEGERAWRPLEAG
MVVTIEPGIYVRPAEDVPERYWHIGIRIEDDAVVTSGDCELITRGVPVKADEIEALMRDNGGMSR

Sequences:

>Translated_465_residues
MSAPDSALLGACSDRRARVLKHLRANGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPEAVLVLVAGGPGDDTN
SSILFCRPKHEEREIWDGFRYGPEGARAMFGFDEAHSVEDIDKLLPPMLANRATLAYPLAATADFDARVRGWLDAVRMQG
RAGVSSPSAALDVRALLDEMRLFKDAGELVTMRRAAEISAQAHVRAMRTSRHGLREYHLEAELLYEFRRHGAQSVAYNSI
VATGPNACVLHYRAGPAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTPAQRELYDLVQAAQDAAIAETRAGVPYNV
PHDAAVRVLAQGMLDTGLLDRNKEGTLDDVLASGSYRRFYMHRTGHWLGMDVHDVGEYRVPGPLPAGHEGERAWRPLEAG
MVVTIEPGIYVRPAEDVPERYWHIGIRIEDDAVVTSGDCELITRGVPVKADEIEALMRDNGGMSR
>Mature_464_residues
SAPDSALLGACSDRRARVLKHLRANGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPEAVLVLVAGGPGDDTNS
SILFCRPKHEEREIWDGFRYGPEGARAMFGFDEAHSVEDIDKLLPPMLANRATLAYPLAATADFDARVRGWLDAVRMQGR
AGVSSPSAALDVRALLDEMRLFKDAGELVTMRRAAEISAQAHVRAMRTSRHGLREYHLEAELLYEFRRHGAQSVAYNSIV
ATGPNACVLHYRAGPAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTPAQRELYDLVQAAQDAAIAETRAGVPYNVP
HDAAVRVLAQGMLDTGLLDRNKEGTLDDVLASGSYRRFYMHRTGHWLGMDVHDVGEYRVPGPLPAGHEGERAWRPLEAGM
VVTIEPGIYVRPAEDVPERYWHIGIRIEDDAVVTSGDCELITRGVPVKADEIEALMRDNGGMSR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=453, Percent_Identity=33.7748344370861, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI149589008, Length=475, Percent_Identity=29.6842105263158, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI260593665, Length=306, Percent_Identity=35.9477124183007, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI260593663, Length=475, Percent_Identity=28.2105263157895, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1789275, Length=444, Percent_Identity=44.3693693693694, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1790282, Length=320, Percent_Identity=31.25, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788728, Length=305, Percent_Identity=28.8524590163934, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=481, Percent_Identity=29.5218295218295, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71989583, Length=289, Percent_Identity=29.757785467128, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320922, Length=422, Percent_Identity=29.3838862559242, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6321118, Length=442, Percent_Identity=31.6742081447964, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19920384, Length=478, Percent_Identity=33.8912133891213, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21357079, Length=466, Percent_Identity=31.7596566523605, Blast_Score=182, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 51237; Mature: 51106

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPDSALLGACSDRRARVLKHLRANGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTG
CCCCCCHHHHCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEEEC
FTEPEAVLVLVAGGPGDDTNSSILFCRPKHEEREIWDGFRYGPEGARAMFGFDEAHSVED
CCCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCCCEEECCCCCCCHHH
IDKLLPPMLANRATLAYPLAATADFDARVRGWLDAVRMQGRAGVSSPSAALDVRALLDEM
HHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RLFKDAGELVTMRRAAEISAQAHVRAMRTSRHGLREYHLEAELLYEFRRHGAQSVAYNSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCE
VATGPNACVLHYRAGPAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTPAQRELYDL
EECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHCEEEECCCCCCCHHHHHHHHH
VQAAQDAAIAETRAGVPYNVPHDAAVRVLAQGMLDTGLLDRNKEGTLDDVLASGSYRRFY
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEE
MHRTGHWLGMDVHDVGEYRVPGPLPAGHEGERAWRPLEAGMVVTIEPGIYVRPAEDVPER
EEECCCEECCCHHHCCCCCCCCCCCCCCCCCHHCCHHHCCEEEEECCCEEEECCHHHCCC
YWHIGIRIEDDAVVTSGDCELITRGVPVKADEIEALMRDNGGMSR
CEEEEEEEECCEEEECCCCEEEECCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAPDSALLGACSDRRARVLKHLRANGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTG
CCCCCHHHHCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEEEC
FTEPEAVLVLVAGGPGDDTNSSILFCRPKHEEREIWDGFRYGPEGARAMFGFDEAHSVED
CCCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCCCEEECCCCCCCHHH
IDKLLPPMLANRATLAYPLAATADFDARVRGWLDAVRMQGRAGVSSPSAALDVRALLDEM
HHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RLFKDAGELVTMRRAAEISAQAHVRAMRTSRHGLREYHLEAELLYEFRRHGAQSVAYNSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCE
VATGPNACVLHYRAGPAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTPAQRELYDL
EECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHCEEEECCCCCCCHHHHHHHHH
VQAAQDAAIAETRAGVPYNVPHDAAVRVLAQGMLDTGLLDRNKEGTLDDVLASGSYRRFY
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEE
MHRTGHWLGMDVHDVGEYRVPGPLPAGHEGERAWRPLEAGMVVTIEPGIYVRPAEDVPER
EEECCCEECCCHHHCCCCCCCCCCCCCCCCCHHCCHHHCCEEEEECCCEEEECCHHHCCC
YWHIGIRIEDDAVVTSGDCELITRGVPVKADEIEALMRDNGGMSR
CEEEEEEEECCEEEECCCCEEEECCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]