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The map label for this gene is pyrC [H]

Identifier: 94309351

GI number: 94309351

Start: 433818

End: 434852

Strand: Direct

Name: pyrC [H]

Synonym: Rmet_0406

Alternate gene names: 94309351

Gene position: 433818-434852 (Clockwise)

Preceding gene: 94309350

Following gene: 94309352

Centisome position: 11.04

GC content: 67.73

Gene sequence:

>1035_bases
ATGACCCAGAAACTCACCATCACCCGCCCGGACGACTGGCACCTGCACCTGCGCGATGGCGCGGCGCTGGCGGCCGTACT
GCCCGACACGGCACGCCAGTTCGCACGTGCCATCATCATGCCGAACCTGAAGCCGCCCGTGACCACGGTGGATCAGGCCA
GTGCCTACCGCGCGCGCATTCTGGCCGCGCTGCCGGCCGGCATGGCGTTCGAGCCGCTGATGACGCTGTACCTGACCGAC
AACACGCCGCCGGAGGAAATCGTCGCGGCCCGTGCCAGCGGTTTCGTCCACGGCGTCAAGCTGTATCCGGCCGGCGCCAC
CACCAACAGCGATGCCGGCGTGACCGATATCCGCCGCTGCGCCGCCACGCTTGAGGCGATGCAGCGTGAAGGTGTGCCGC
TGCTGGTCCACGGCGAGGTCACTGATGGCGACATCGACATCTTCGATCGCGAGGCCGTGTTCATCGACCGCGTGATGAAG
CCGCTGCGCCGCGACTTCCCGGAGCTCAAGGTGGTGTTCGAACACATCACCACCCGCGATGCGGCCCAGTACGTGGCCGA
GGCCGAAGGCCCGGTCGGCGCGACGATTACCGCGCACCACCTGCTGTACAACCGTAATGCGATCTTCACGGGCGGGATTC
GTCCGCACTACTACTGCCTGCCGGTGCTCAAGCGCGAGATCCACCGCGAGGCGCTGGTCAAGGCCGCGACGTCGGGCAGC
CCGCGTTTCTTCCTTGGCACTGACAGCGCACCCCACGCACGCGGCCTCAAGGAGCACGCATGCGGCTGCGCCGGCTGCTA
CACGGCGCTCCATGCGATGGAGCTCTATGCCGAAGCGTTCGACGCTGCCGGCGCGCTGGACAAGCTCGAGGCATTCTCCA
GCTTCAACGGCCCGGCCTTCTACGGCCTGCCGCGCAATAGCGGCACGCTGACGCTGACGCGCGAAGACTGGGAACTGCCG
GCCGAGCTGCCGTACGGTGATACCACGCTGGTGCCGCTGCGCGCCGGCGAAACGCTGCGCTGGAAGGCGAGCTGA

Upstream 100 bases:

>100_bases
GCGACCTGGTCGTGACCGGCCCGACGCGTACCAATGTGAATGACTACCGCGCCATTCTGATTCTCTAGATTTCCCCGTCT
TACTCGTTTCGCTCGTCCCC

Downstream 100 bases:

>100_bases
GTCGGTTGCTGTCGACGATCGACTGGACGCGGCCGTGGTTCCTGCCATTCGCCGCGTCCGCATCCTGCCTCGATGGCAGT
GACCTGCGCGAGGCTTTCAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTQKLTITRPDDWHLHLRDGAALAAVLPDTARQFARAIIMPNLKPPVTTVDQASAYRARILAALPAGMAFEPLMTLYLTD
NTPPEEIVAARASGFVHGVKLYPAGATTNSDAGVTDIRRCAATLEAMQREGVPLLVHGEVTDGDIDIFDREAVFIDRVMK
PLRRDFPELKVVFEHITTRDAAQYVAEAEGPVGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKREIHREALVKAATSGS
PRFFLGTDSAPHARGLKEHACGCAGCYTALHAMELYAEAFDAAGALDKLEAFSSFNGPAFYGLPRNSGTLTLTREDWELP
AELPYGDTTLVPLRAGETLRWKAS

Sequences:

>Translated_344_residues
MTQKLTITRPDDWHLHLRDGAALAAVLPDTARQFARAIIMPNLKPPVTTVDQASAYRARILAALPAGMAFEPLMTLYLTD
NTPPEEIVAARASGFVHGVKLYPAGATTNSDAGVTDIRRCAATLEAMQREGVPLLVHGEVTDGDIDIFDREAVFIDRVMK
PLRRDFPELKVVFEHITTRDAAQYVAEAEGPVGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKREIHREALVKAATSGS
PRFFLGTDSAPHARGLKEHACGCAGCYTALHAMELYAEAFDAAGALDKLEAFSSFNGPAFYGLPRNSGTLTLTREDWELP
AELPYGDTTLVPLRAGETLRWKAS
>Mature_343_residues
TQKLTITRPDDWHLHLRDGAALAAVLPDTARQFARAIIMPNLKPPVTTVDQASAYRARILAALPAGMAFEPLMTLYLTDN
TPPEEIVAARASGFVHGVKLYPAGATTNSDAGVTDIRRCAATLEAMQREGVPLLVHGEVTDGDIDIFDREAVFIDRVMKP
LRRDFPELKVVFEHITTRDAAQYVAEAEGPVGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKREIHREALVKAATSGSP
RFFLGTDSAPHARGLKEHACGCAGCYTALHAMELYAEAFDAAGALDKLEAFSSFNGPAFYGLPRNSGTLTLTREDWELPA
ELPYGDTTLVPLRAGETLRWKAS

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=343, Percent_Identity=56.5597667638484, Blast_Score=393, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6323452, Length=364, Percent_Identity=35.989010989011, Blast_Score=192, Evalue=5e-50,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37551; Mature: 37420

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKLTITRPDDWHLHLRDGAALAAVLPDTARQFARAIIMPNLKPPVTTVDQASAYRARI
CCCEEEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LAALPAGMAFEPLMTLYLTDNTPPEEIVAARASGFVHGVKLYPAGATTNSDAGVTDIRRC
HHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHH
AATLEAMQREGVPLLVHGEVTDGDIDIFDREAVFIDRVMKPLRRDFPELKVVFEHITTRD
HHHHHHHHHCCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAQYVAEAEGPVGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKREIHREALVKAATSGS
HHHHHHHCCCCCCCEEEEEHEEEECCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHCCCC
PRFFLGTDSAPHARGLKEHACGCAGCYTALHAMELYAEAFDAAGALDKLEAFSSFNGPAF
CEEEEECCCCCHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEE
YGLPRNSGTLTLTREDWELPAELPYGDTTLVPLRAGETLRWKAS
EECCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCEEEEECC
>Mature Secondary Structure 
TQKLTITRPDDWHLHLRDGAALAAVLPDTARQFARAIIMPNLKPPVTTVDQASAYRARI
CCEEEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LAALPAGMAFEPLMTLYLTDNTPPEEIVAARASGFVHGVKLYPAGATTNSDAGVTDIRRC
HHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHH
AATLEAMQREGVPLLVHGEVTDGDIDIFDREAVFIDRVMKPLRRDFPELKVVFEHITTRD
HHHHHHHHHCCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAQYVAEAEGPVGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKREIHREALVKAATSGS
HHHHHHHCCCCCCCEEEEEHEEEECCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHCCCC
PRFFLGTDSAPHARGLKEHACGCAGCYTALHAMELYAEAFDAAGALDKLEAFSSFNGPAF
CEEEEECCCCCHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEE
YGLPRNSGTLTLTREDWELPAELPYGDTTLVPLRAGETLRWKAS
EECCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA