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The map label for this gene is apt [H]

Identifier: 94309256

GI number: 94309256

Start: 326669

End: 327241

Strand: Direct

Name: apt [H]

Synonym: Rmet_0311

Alternate gene names: 94309256

Gene position: 326669-327241 (Clockwise)

Preceding gene: 94309253

Following gene: 94309257

Centisome position: 8.32

GC content: 64.22

Gene sequence:

>573_bases
ATGTCGAACTCCATCATCCAGTCCCCCGATCTTGGCGATGTCACCGGTTACCTGCGTGACCGCATCCGCACCGTGCCGGA
CTGGCCGCAGCCGGGCGTGATGTTCCGCGACATCACGCCGCTGCTGCAGAACCCCAAGACGCTGCGCGTGCTGATCGACG
TCTTCGTGCACCGCTACATGGACCAGAACCTGGACCTCGTGGCTGGCATCGACGCGCGCGGCTTCATCCTCGGGTCGATC
ATCGCGTACGAGCTGAACCTGGGCTTCGTGCCGATCCGCAAGAAGGGCAAGTTGCCGTTCCAGACGGTGGCCGAGGAATA
CGAGCTCGAGTATGGCAGCGCCACCGTGGAGATCCATGCCGATGCCTGCAAGCCGGGAGACCGCGTGCTGCTGATCGACG
ACCTGATCGCCACGGGTGGCACGATGATGGCGGGACGCAAGCTGCTGGAGCGTCTTGGCGCAACGGTGGTGGAAGGCGGG
GCGATCGTCGACCTGCCTGAGCTCGGCGGCTCCAAGCTTTTGCAAGCCAGCGGCCTGTCGCTGTTCACGGTCTGCAATTT
CGACGGCCACTAG

Upstream 100 bases:

>100_bases
GCGGATGTTCAAACTGCCGGGCCATTGTGCGGCGATGGTTTTGGACACGGGTGGTAGCCCGTTACCGCATCGCGCGTAAT
TTCACTTTCCAGTTTCTTTC

Downstream 100 bases:

>100_bases
AAAGCCCTAGGAAGCCATTAGGAAGTCGTTTCAAAAGGATTCCGGCGTCGTTGCGGGGCCTTGCCGTACCGCTTGTACTG
TCTGCGGCCCCGCTCCAGGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MSNSIIQSPDLGDVTGYLRDRIRTVPDWPQPGVMFRDITPLLQNPKTLRVLIDVFVHRYMDQNLDLVAGIDARGFILGSI
IAYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAGRKLLERLGATVVEGG
AIVDLPELGGSKLLQASGLSLFTVCNFDGH

Sequences:

>Translated_190_residues
MSNSIIQSPDLGDVTGYLRDRIRTVPDWPQPGVMFRDITPLLQNPKTLRVLIDVFVHRYMDQNLDLVAGIDARGFILGSI
IAYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAGRKLLERLGATVVEGG
AIVDLPELGGSKLLQASGLSLFTVCNFDGH
>Mature_189_residues
SNSIIQSPDLGDVTGYLRDRIRTVPDWPQPGVMFRDITPLLQNPKTLRVLIDVFVHRYMDQNLDLVAGIDARGFILGSII
AYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAGRKLLERLGATVVEGGA
IVDLPELGGSKLLQASGLSLFTVCNFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=44.2528735632184, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=48, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=47.1264367816092, Blast_Score=184, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17509087, Length=182, Percent_Identity=41.2087912087912, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=36.9942196531792, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=168, Percent_Identity=30.952380952381, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136334, Length=172, Percent_Identity=40.1162790697674, Blast_Score=130, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20740; Mature: 20609

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSIIQSPDLGDVTGYLRDRIRTVPDWPQPGVMFRDITPLLQNPKTLRVLIDVFVHRYM
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEHHCCCHHHCCCHHHHHHHHHHHHHHH
DQNLDLVAGIDARGFILGSIIAYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHA
CCCCCEEECCCCCHHHHHHHHEEEECCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEE
DACKPGDRVLLIDDLIATGGTMMAGRKLLERLGATVVEGGAIVDLPELGGSKLLQASGLS
CCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCCEEECCCEEEECCCCCCCCEEHHCCCE
LFTVCNFDGH
EEEEECCCCC
>Mature Secondary Structure 
SNSIIQSPDLGDVTGYLRDRIRTVPDWPQPGVMFRDITPLLQNPKTLRVLIDVFVHRYM
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEHHCCCHHHCCCHHHHHHHHHHHHHHH
DQNLDLVAGIDARGFILGSIIAYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHA
CCCCCEEECCCCCHHHHHHHHEEEECCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEE
DACKPGDRVLLIDDLIATGGTMMAGRKLLERLGATVVEGGAIVDLPELGGSKLLQASGLS
CCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCCEEECCCEEEECCCCCCCCEEHHCCCE
LFTVCNFDGH
EEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA