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The map label for this gene is mutY [H]

Identifier: 94309240

GI number: 94309240

Start: 312751

End: 313968

Strand: Direct

Name: mutY [H]

Synonym: Rmet_0295

Alternate gene names: 94309240

Gene position: 312751-313968 (Clockwise)

Preceding gene: 94309239

Following gene: 94309253

Centisome position: 7.96

GC content: 65.35

Gene sequence:

>1218_bases
TTGCAACCGCCGATGTATCATGTGGCGCCGCCAGTGAGCGGCGCTTTTTCTTTTCAAGATCCCGCAATGCCCCGCAAGCC
TGCCGCCGCCCCCGCCATGCCCGAAACCATCGCCGTGCCATCCGATTTCGGTATGCGCGTGGTGACGTGGCAGCGCCAGC
ACGGACGGCACGACCTGCCCTGGCAGAACACACGCGATCCGTATCGCATCTGGCTGTCCGAGATCATGCTGCAGCAGACG
CAGGTGGCAGCGGTGATCGAGTATTTCCAGCGCTTCGTGACGGCGCTGCCCACGGTTGCCGCTCTGGCGGCAGCGTCTGC
CGACGAGGTCATGGCATTGTGGGCCGGGCTGGGCTACTACTCGCGCGCGCGCAATCTTCATCGCTGCGCCAAGACCGTGG
TGGATGAGCACGCTGGCGTGTTTCCGACCGACCCCGAGGTGCTCGTGACGCTGCCCGGCATCGGTCGCTCCACGGCTGCG
GCGATCGCGGCGTTCAGTGCCGGCGTTCGTTCTCCGATCCTTGACGGCAACGTCAAGCGCGTCTTCGCGCGGGTGTTCGG
CATTCACGGTTATCCCGGCGAGCGTGCGATCGAAAATCGGATGTGGGCGCTGGCCGAACAGGCGCTGCCGCCTGCCGGAC
GTCATCAGGCAGATCACATGGTGGCCTACACGCAGGGATTGATGGACCTCGGCGCCACGATTTGCTCGCGCGGCAAGCCA
GCCTGTCTGGCCGACGCAGAGGCGTGCCCGCTCGTAGCCGATTGCCTGGCCCGCAAGGACAACCTCACCGCCGTGCTGCC
CACGCCGAAGCCACGCGCGGCGATTCCGGAGCGCAGCACCGTGATGCTGATCGTCCGGCATGGACGTGATGTGCTGGTGC
AGTTGCGTCCCAGCCGCGGCATCTGGGGCGGGTTGTGGAGCCTGCCCGAAATGCCGGTCGACACGGTACCGTTCGATTCG
GAGGCCGCCGAGGAATCGGCGCTGGAGTTAGCCCGCGCGTATGGCTTGCCTGCGCGCGCATATCTGGCTGGCGAGCTGAC
GCACGTGTTTACTCATTTTCGCTTGCTGATTCGCGCGATTCGCGTCGATCTGGACACTGTCGCGCTTGAAGGTGATGCCG
CGAGCCGGTGGCTGTCTCTTGACGATCTCGATATGCTGGGCACCCCGGCCCCGGTGCGCAAGCTGCTGGAAGATCAGGCG
AGGCTCGGACTTTTCTGA

Upstream 100 bases:

>100_bases
GACGCGCCCCCGGAAGCAACGGCGCGCGCGGCGTAGTCGGTGCGTTCCCCCCTCGTCCACTTGTGGGGGAGGGGGCAGGC
CCGGCCATCTGGGAAGGGTA

Downstream 100 bases:

>100_bases
GTTGCCCGTTCAGAAAGCGGCTCAGACGATGTGGTGCTGTCGCATGTAGCGATGCACGATCTCGATGCGCACGCCGGCAT
CAGGTAGCTCCATCAGCATC

Product: A/G-specific adenine DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MQPPMYHVAPPVSGAFSFQDPAMPRKPAAAPAMPETIAVPSDFGMRVVTWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQT
QVAAVIEYFQRFVTALPTVAALAAASADEVMALWAGLGYYSRARNLHRCAKTVVDEHAGVFPTDPEVLVTLPGIGRSTAA
AIAAFSAGVRSPILDGNVKRVFARVFGIHGYPGERAIENRMWALAEQALPPAGRHQADHMVAYTQGLMDLGATICSRGKP
ACLADAEACPLVADCLARKDNLTAVLPTPKPRAAIPERSTVMLIVRHGRDVLVQLRPSRGIWGGLWSLPEMPVDTVPFDS
EAAEESALELARAYGLPARAYLAGELTHVFTHFRLLIRAIRVDLDTVALEGDAASRWLSLDDLDMLGTPAPVRKLLEDQA
RLGLF

Sequences:

>Translated_405_residues
MQPPMYHVAPPVSGAFSFQDPAMPRKPAAAPAMPETIAVPSDFGMRVVTWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQT
QVAAVIEYFQRFVTALPTVAALAAASADEVMALWAGLGYYSRARNLHRCAKTVVDEHAGVFPTDPEVLVTLPGIGRSTAA
AIAAFSAGVRSPILDGNVKRVFARVFGIHGYPGERAIENRMWALAEQALPPAGRHQADHMVAYTQGLMDLGATICSRGKP
ACLADAEACPLVADCLARKDNLTAVLPTPKPRAAIPERSTVMLIVRHGRDVLVQLRPSRGIWGGLWSLPEMPVDTVPFDS
EAAEESALELARAYGLPARAYLAGELTHVFTHFRLLIRAIRVDLDTVALEGDAASRWLSLDDLDMLGTPAPVRKLLEDQA
RLGLF
>Mature_405_residues
MQPPMYHVAPPVSGAFSFQDPAMPRKPAAAPAMPETIAVPSDFGMRVVTWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQT
QVAAVIEYFQRFVTALPTVAALAAASADEVMALWAGLGYYSRARNLHRCAKTVVDEHAGVFPTDPEVLVTLPGIGRSTAA
AIAAFSAGVRSPILDGNVKRVFARVFGIHGYPGERAIENRMWALAEQALPPAGRHQADHMVAYTQGLMDLGATICSRGKP
ACLADAEACPLVADCLARKDNLTAVLPTPKPRAAIPERSTVMLIVRHGRDVLVQLRPSRGIWGGLWSLPEMPVDTVPFDS
EAAEESALELARAYGLPARAYLAGELTHVFTHFRLLIRAIRVDLDTVALEGDAASRWLSLDDLDMLGTPAPVRKLLEDQA
RLGLF

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=425, Percent_Identity=31.7647058823529, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI115298654, Length=425, Percent_Identity=31.7647058823529, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI115298652, Length=425, Percent_Identity=31.7647058823529, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI6912520, Length=425, Percent_Identity=31.7647058823529, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI190358497, Length=425, Percent_Identity=31.7647058823529, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI115298648, Length=425, Percent_Identity=31.7647058823529, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1789331, Length=372, Percent_Identity=43.010752688172, Blast_Score=292, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 44213; Mature: 44213

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPPMYHVAPPVSGAFSFQDPAMPRKPAAAPAMPETIAVPSDFGMRVVTWQRQHGRHDLP
CCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEHHCCCCCCC
WQNTRDPYRIWLSEIMLQQTQVAAVIEYFQRFVTALPTVAALAAASADEVMALWAGLGYY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SRARNLHRCAKTVVDEHAGVFPTDPEVLVTLPGIGRSTAAAIAAFSAGVRSPILDGNVKR
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
VFARVFGIHGYPGERAIENRMWALAEQALPPAGRHQADHMVAYTQGLMDLGATICSRGKP
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
ACLADAEACPLVADCLARKDNLTAVLPTPKPRAAIPERSTVMLIVRHGRDVLVQLRPSRG
CEECCCCCCHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCC
IWGGLWSLPEMPVDTVPFDSEAAEESALELARAYGLPARAYLAGELTHVFTHFRLLIRAI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RVDLDTVALEGDAASRWLSLDDLDMLGTPAPVRKLLEDQARLGLF
HHHHHHEEECCCHHHHCCCCCCHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQPPMYHVAPPVSGAFSFQDPAMPRKPAAAPAMPETIAVPSDFGMRVVTWQRQHGRHDLP
CCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEHHCCCCCCC
WQNTRDPYRIWLSEIMLQQTQVAAVIEYFQRFVTALPTVAALAAASADEVMALWAGLGYY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SRARNLHRCAKTVVDEHAGVFPTDPEVLVTLPGIGRSTAAAIAAFSAGVRSPILDGNVKR
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
VFARVFGIHGYPGERAIENRMWALAEQALPPAGRHQADHMVAYTQGLMDLGATICSRGKP
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
ACLADAEACPLVADCLARKDNLTAVLPTPKPRAAIPERSTVMLIVRHGRDVLVQLRPSRG
CEECCCCCCHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCC
IWGGLWSLPEMPVDTVPFDSEAAEESALELARAYGLPARAYLAGELTHVFTHFRLLIRAI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RVDLDTVALEGDAASRWLSLDDLDMLGTPAPVRKLLEDQARLGLF
HHHHHHEEECCCHHHHCCCCCCHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]