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The map label for this gene is hbdA [H]

Identifier: 94309157

GI number: 94309157

Start: 224897

End: 225751

Strand: Direct

Name: hbdA [H]

Synonym: Rmet_0212

Alternate gene names: 94309157

Gene position: 224897-225751 (Clockwise)

Preceding gene: 94309156

Following gene: 94309159

Centisome position: 5.73

GC content: 61.99

Gene sequence:

>855_bases
ATGGCAATCAAGACAGTGGGCATCGTTGGTGCCGGCACGATGGGTAACGGCATTGCGCAGGCCTGCGCGGTGGTCGGCAT
CGACGTGGTGATGATCGACATCAGCGACGCCGCCGTCCAGAAGGGCATCGCCACCGTGGCCGGCAGCCTCGACCGTCTGA
TCAAGAAGGAAAAGGCCACCGAGGCGGACAAGGCCGCGGCGCTGGCACGTATCCACGGCAGCACGTCGTACGACGATCTG
AAGCGCGCCGACATCGTGATCGAGGCGGCCACCGAAAACTTCGACCTGAAGGTCAAGATCCTGAAGCAGATCGATGGCAT
CGTCGGCCCCGACGTGATCGTTGCATCGAACACCTCGTCGATCTCGATCACCAAGCTGGCCGCTGTAACGTCGCGCGCGG
ACCGCTTTATCGGCATGCACTTCTTCAACCCGGTGCCGATGATGGCGTTGGTCGAACTGATTCGTGGCCTGCAGACCAGC
GATGCCGCGCACGCCGACGTCGAGGACCTCGCCAAGCGTCTGGGCAAGTACCCGATCACGGTCAAGAACAGCCCGGGTTT
CGTGGTCAACCGCATTCTCTGCCCGATGATCAACGAAGCGTTCTGCGTGCTCGGTGAAGGCCTGGCCTCGCCCGAGGAAA
TCGACGAAGGCATGAAGCTCGGCTGCAATCATCCGATCGGTCCGCTGGCGCTGGCCGACATGATCGGTCTGGACACGATG
CTTGCCGTCATGGAAGTGCTCTACACCGAGTTCGCCGATCCGAAGTACCGTCCGGCCATGCTGATGCGCGAAATGGTGGC
CGCAGGCTATCTGGGCCGCAAGACGGGCCGTGGCGTGTACGTGTACAGCAAGTAA

Upstream 100 bases:

>100_bases
ACGCCGAGCGCGTCATTGCCGCGCTGGCGAAGCTCAAGGGCTGAGCGCGCCCGAAAATCGAATCACCAAACAACTGGAAA
CTGAAGGAAGGAAGACAGAC

Downstream 100 bases:

>100_bases
GTCTCACGCGCGCGTTGCGCGCTGATCCGGCCCCTTCCGCCACGGCGAGGAGGGGCCGAAGGTGGCGAAAGGCCTACCGG
AAATGGCTGCGCAGCGCTGG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MAIKTVGIVGAGTMGNGIAQACAVVGIDVVMIDISDAAVQKGIATVAGSLDRLIKKEKATEADKAAALARIHGSTSYDDL
KRADIVIEAATENFDLKVKILKQIDGIVGPDVIVASNTSSISITKLAAVTSRADRFIGMHFFNPVPMMALVELIRGLQTS
DAAHADVEDLAKRLGKYPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
LAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK

Sequences:

>Translated_284_residues
MAIKTVGIVGAGTMGNGIAQACAVVGIDVVMIDISDAAVQKGIATVAGSLDRLIKKEKATEADKAAALARIHGSTSYDDL
KRADIVIEAATENFDLKVKILKQIDGIVGPDVIVASNTSSISITKLAAVTSRADRFIGMHFFNPVPMMALVELIRGLQTS
DAAHADVEDLAKRLGKYPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
LAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK
>Mature_283_residues
AIKTVGIVGAGTMGNGIAQACAVVGIDVVMIDISDAAVQKGIATVAGSLDRLIKKEKATEADKAAALARIHGSTSYDDLK
RADIVIEAATENFDLKVKILKQIDGIVGPDVIVASNTSSISITKLAAVTSRADRFIGMHFFNPVPMMALVELIRGLQTSD
AAHADVEDLAKRLGKYPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTML
AVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=39.5833333333333, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=38.0327868852459, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=34.7368421052632, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI261878539, Length=297, Percent_Identity=30.6397306397306, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI68989263, Length=296, Percent_Identity=30.4054054054054, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI115430219, Length=231, Percent_Identity=29.8701298701299, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=37.3665480427046, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=36.8421052631579, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1788682, Length=267, Percent_Identity=37.4531835205993, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=39.7212543554007, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=41.5807560137457, Blast_Score=212, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=38.1625441696113, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=38.7323943661972, Blast_Score=190, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=38.7323943661972, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=38.7323943661972, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=34.7222222222222, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71985923, Length=286, Percent_Identity=30.7692307692308, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=27.8571428571429, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI193203623, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=36.8794326241135, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=36.8794326241135, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=36.8794326241135, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=29.5833333333333, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20129993, Length=225, Percent_Identity=28, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30200; Mature: 30069

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKTVGIVGAGTMGNGIAQACAVVGIDVVMIDISDAAVQKGIATVAGSLDRLIKKEKAT
CCEEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
EADKAAALARIHGSTSYDDLKRADIVIEAATENFDLKVKILKQIDGIVGPDVIVASNTSS
HHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCCEEHHHHHHHCCCCCCCEEEECCCCC
ISITKLAAVTSRADRFIGMHFFNPVPMMALVELIRGLQTSDAAHADVEDLAKRLGKYPIT
EEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEE
VKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure 
AIKTVGIVGAGTMGNGIAQACAVVGIDVVMIDISDAAVQKGIATVAGSLDRLIKKEKAT
CEEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
EADKAAALARIHGSTSYDDLKRADIVIEAATENFDLKVKILKQIDGIVGPDVIVASNTSS
HHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCCEEHHHHHHHCCCCCCCEEEECCCCC
ISITKLAAVTSRADRFIGMHFFNPVPMMALVELIRGLQTSDAAHADVEDLAKRLGKYPIT
EEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEE
VKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA