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The map label for this gene is bioA [H]

Identifier: 94309059

GI number: 94309059

Start: 120229

End: 121695

Strand: Direct

Name: bioA [H]

Synonym: Rmet_0114

Alternate gene names: 94309059

Gene position: 120229-121695 (Clockwise)

Preceding gene: 94309058

Following gene: 94309060

Centisome position: 3.06

GC content: 68.03

Gene sequence:

>1467_bases
ATGAGCTTCCCACATCCGGCCGCGCGCGATGCGCGGGCGGACACTCATAGGAGAGTCCCTTTGACACATCCTGTCCTCGA
TTCCGGAGGCGGTGACACGTCGCTCGCGGCACGCAGCCAGCGCGCCGTGTGGCATCCGTGCACGCGCCTGCGTCCCGACG
CCAGCGCCAACGAGCCGCCGCTCGCCATTGTGCGTGGCGAAGGGCCCTGGTTGATCGACGCTGGCGACAAGCGCTACTTC
GATGCCATCAGCTCCTGGTGGGTCAATCTGTTCGGCCATGCCAACCCGGCCATCAACGCCGCCATCGGCGAACAACTGCA
GACACTGGAACACGTGATGCTGGCCGGCTGCACGCACGCACCGGCCGTGGAACTGGCCGAGCGGCTGACGGCGCTTACCG
GTGGCGCGCTCGGCAACGCGTTCTATGCGTCCGATGGTGCCTCTGCCGTCGAGATCGCGCTCAAGATGAGCTTCCACTAC
TGGCGCAACACCGGCCTCACGGCCAAGCGCGAGTTCATCTGCCTGCGCCATGGCTATCACGGCGAAACCGTGGGTGCACT
GGCCGTGACCGACGTGGAGATCTTCCGCGATGCCTACGATCCGCTGACGCGCCGCGCCCACGTGGTGATGTCTCCCGATG
CACGCCAGGCCGCGCGTAGCGAATCCGCCGCCGATGTGGCCACCCGGGCGCTGGCTGAACTCGAAGCACTGCTGCGCGAG
CGTGCCGGCCAGATCGCGGCGCTGATCGTCGAGCCGCTGGTGCAGGGCGCGGCCGGCATGGCGATGTACGACCCGTCGTA
TCTCGAAGGCGCGCGCGCGTTGTGCGATCGCTATCGCGTGCACCTGATCGCCGACGAGATCGCTGTGGGCTGTGGCCGCA
CCGGCACGTTCTTCGCCTGGGAGCAGGCACGCGGCGGCGACGCGGTGCCCGCACATGCCTGGCCGGACTTCCTGTGTCTG
TCGAAGGGCATTACCGGCGGCTACCTGCCGCTGTCGCTGGTGCTGTCGCGTCCCGAGATCCAGCGTGCGTTCGTGGCCGA
CGATATCGCGCGCAGCTTCCTGCATTCGCATTCGTACACGGGCAATCCGCTGGCCTGCCGGGCCGCGCTGGCCACGCTGG
ACCTGTTCGAATCCGAAGATGTGCTCGCCCGCAACCGCGAGCGCGCGCAATGGCTTGGCACGGCGATGGCCGGTATTGCC
GCCGACCCGCGCGTCAGCCACGTGCGCCAGCGCGGCATGATCTGGGCCGCCGACATCGACCCGCAGGCAGCGGGGGCGAA
CTTTGCCGGACGCTTCCATCTGGCCGCGCGCGAACGCGGCGTGCTGGCGCGCCCGATCGGGCACACGCTCTACGTGATGC
CGCCGTATGTTTTCGATGCCGAGCTGGCCAACTGGCTCGGTGAACAATTGCTGGACACGCTGCAGGCAGTGCTCGATCCG
GCGGAGGAGGCACGCCATGCTGCTTGA

Upstream 100 bases:

>100_bases
TGCACGGCACTGCGGGCGGCAAGATCGTCCAACGTCTGTGAAATTGCACTCAACTGGCTGAGTGCGGCCGGTTTGCCAAT
CCGGCGGGGACCTTTCTACC

Downstream 100 bases:

>100_bases
TCACCTGAAACGCGCGGCCGCGGAACGCGATGCCCAGTCGCTGACGCGCCGTCGCCGCATTGCTCACACGGCCTGCGCGC
CGCACCAGTCGGTGGGCGGG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSFPHPAARDARADTHRRVPLTHPVLDSGGGDTSLAARSQRAVWHPCTRLRPDASANEPPLAIVRGEGPWLIDAGDKRYF
DAISSWWVNLFGHANPAINAAIGEQLQTLEHVMLAGCTHAPAVELAERLTALTGGALGNAFYASDGASAVEIALKMSFHY
WRNTGLTAKREFICLRHGYHGETVGALAVTDVEIFRDAYDPLTRRAHVVMSPDARQAARSESAADVATRALAELEALLRE
RAGQIAALIVEPLVQGAAGMAMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAWEQARGGDAVPAHAWPDFLCL
SKGITGGYLPLSLVLSRPEIQRAFVADDIARSFLHSHSYTGNPLACRAALATLDLFESEDVLARNRERAQWLGTAMAGIA
ADPRVSHVRQRGMIWAADIDPQAAGANFAGRFHLAARERGVLARPIGHTLYVMPPYVFDAELANWLGEQLLDTLQAVLDP
AEEARHAA

Sequences:

>Translated_488_residues
MSFPHPAARDARADTHRRVPLTHPVLDSGGGDTSLAARSQRAVWHPCTRLRPDASANEPPLAIVRGEGPWLIDAGDKRYF
DAISSWWVNLFGHANPAINAAIGEQLQTLEHVMLAGCTHAPAVELAERLTALTGGALGNAFYASDGASAVEIALKMSFHY
WRNTGLTAKREFICLRHGYHGETVGALAVTDVEIFRDAYDPLTRRAHVVMSPDARQAARSESAADVATRALAELEALLRE
RAGQIAALIVEPLVQGAAGMAMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAWEQARGGDAVPAHAWPDFLCL
SKGITGGYLPLSLVLSRPEIQRAFVADDIARSFLHSHSYTGNPLACRAALATLDLFESEDVLARNRERAQWLGTAMAGIA
ADPRVSHVRQRGMIWAADIDPQAAGANFAGRFHLAARERGVLARPIGHTLYVMPPYVFDAELANWLGEQLLDTLQAVLDP
AEEARHAA
>Mature_487_residues
SFPHPAARDARADTHRRVPLTHPVLDSGGGDTSLAARSQRAVWHPCTRLRPDASANEPPLAIVRGEGPWLIDAGDKRYFD
AISSWWVNLFGHANPAINAAIGEQLQTLEHVMLAGCTHAPAVELAERLTALTGGALGNAFYASDGASAVEIALKMSFHYW
RNTGLTAKREFICLRHGYHGETVGALAVTDVEIFRDAYDPLTRRAHVVMSPDARQAARSESAADVATRALAELEALLRER
AGQIAALIVEPLVQGAAGMAMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAWEQARGGDAVPAHAWPDFLCLS
KGITGGYLPLSLVLSRPEIQRAFVADDIARSFLHSHSYTGNPLACRAALATLDLFESEDVLARNRERAQWLGTAMAGIAA
DPRVSHVRQRGMIWAADIDPQAAGANFAGRFHLAARERGVLARPIGHTLYVMPPYVFDAELANWLGEQLLDTLQAVLDPA
EEARHAA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=28.5012285012285, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI37574042, Length=436, Percent_Identity=25.6880733944954, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI13994255, Length=386, Percent_Identity=28.2383419689119, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=25.2293577981651, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI24119277, Length=465, Percent_Identity=26.2365591397849, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI226442709, Length=405, Percent_Identity=25.4320987654321, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI284507298, Length=228, Percent_Identity=34.2105263157895, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=36.6197183098592, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI145693181, Length=420, Percent_Identity=29.5238095238095, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789016, Length=437, Percent_Identity=28.1464530892449, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1789759, Length=380, Percent_Identity=28.1578947368421, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788044, Length=367, Percent_Identity=27.7929155313352, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787560, Length=362, Percent_Identity=29.0055248618785, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=419, Percent_Identity=25.5369928400955, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=27.6595744680851, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=250, Percent_Identity=28.4, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=22.196261682243, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=470, Percent_Identity=29.1489361702128, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323470, Length=413, Percent_Identity=29.7820823244552, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324432, Length=415, Percent_Identity=25.5421686746988, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=27.1604938271605, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI161085790, Length=394, Percent_Identity=27.1573604060914, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574759, Length=394, Percent_Identity=27.1573604060914, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356575, Length=327, Percent_Identity=27.82874617737, Blast_Score=105, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 52863; Mature: 52732

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPHPAARDARADTHRRVPLTHPVLDSGGGDTSLAARSQRAVWHPCTRLRPDASANEPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHCCHHHCCCCCCCCCCC
LAIVRGEGPWLIDAGDKRYFDAISSWWVNLFGHANPAINAAIGEQLQTLEHVMLAGCTHA
EEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PAVELAERLTALTGGALGNAFYASDGASAVEIALKMSFHYWRNTGLTAKREFICLRHGYH
CHHHHHHHHHHHHCCCCCCCEECCCCCHHEEHHHHHHHHHHHCCCCCCHHHEEEEECCCC
GETVGALAVTDVEIFRDAYDPLTRRAHVVMSPDARQAARSESAADVATRALAELEALLRE
CCCCCEEEEHHHHHHHHHHHHHHHCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
RAGQIAALIVEPLVQGAAGMAMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAW
HHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHEEHHHHHHCCCCCCCEEEE
EQARGGDAVPAHAWPDFLCLSKGITGGYLPLSLVLSRPEIQRAFVADDIARSFLHSHSYT
ECCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
GNPLACRAALATLDLFESEDVLARNRERAQWLGTAMAGIAADPRVSHVRQRGMIWAADID
CCCHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCC
PQAAGANFAGRFHLAARERGVLARPIGHTLYVMPPYVFDAELANWLGEQLLDTLQAVLDP
CCCCCCCCCCEEEEHHHCCCCEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
AEEARHAA
HHHHHCCC
>Mature Secondary Structure 
SFPHPAARDARADTHRRVPLTHPVLDSGGGDTSLAARSQRAVWHPCTRLRPDASANEPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHCCHHHCCCCCCCCCCC
LAIVRGEGPWLIDAGDKRYFDAISSWWVNLFGHANPAINAAIGEQLQTLEHVMLAGCTHA
EEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PAVELAERLTALTGGALGNAFYASDGASAVEIALKMSFHYWRNTGLTAKREFICLRHGYH
CHHHHHHHHHHHHCCCCCCCEECCCCCHHEEHHHHHHHHHHHCCCCCCHHHEEEEECCCC
GETVGALAVTDVEIFRDAYDPLTRRAHVVMSPDARQAARSESAADVATRALAELEALLRE
CCCCCEEEEHHHHHHHHHHHHHHHCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
RAGQIAALIVEPLVQGAAGMAMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAW
HHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHEEHHHHHHCCCCCCCEEEE
EQARGGDAVPAHAWPDFLCLSKGITGGYLPLSLVLSRPEIQRAFVADDIARSFLHSHSYT
ECCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
GNPLACRAALATLDLFESEDVLARNRERAQWLGTAMAGIAADPRVSHVRQRGMIWAADID
CCCHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCC
PQAAGANFAGRFHLAARERGVLARPIGHTLYVMPPYVFDAELANWLGEQLLDTLQAVLDP
CCCCCCCCCCEEEEHHHCCCCEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
AEEARHAA
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]