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The map label for this gene is ivd1 [H]

Identifier: 94309048

GI number: 94309048

Start: 109418

End: 110599

Strand: Direct

Name: ivd1 [H]

Synonym: Rmet_0103

Alternate gene names: 94309048

Gene position: 109418-110599 (Clockwise)

Preceding gene: 94309047

Following gene: 94309049

Centisome position: 2.79

GC content: 65.06

Gene sequence:

>1182_bases
ATGACCGAACTACCCGGCCTGAAATTCGACCTTGGCGAAGACATCGAGATGCTGCGCGAATCGGTGCGCAACTGGGCGCA
GGCCGAACTGGCGCCGCGCGCCGCCGAGATCGACCGGACCGACCAGTTTCCGATGGATGCATGGCGGAAGATGGGCGACC
TCGGCGTGCTGGGCATCACGGTGGCCGAGGAGTACGGCGGCGCCAACATGGGGTACCTGGCCCACATGATCGCGATGGAG
GAGATCAGCCGCGCGTCGGCGTCGGTCGGCCTGTCGTACGGCGCCCATTCGAACCTGTGCGTGAACCAGATCCACCGCAA
CGGCACGGCGGCCCAGAAGGCGAAGTACCTGCCGAAGCTGGTTTCCGGCGAATGGATCGGCGCGCTGGCCATGAGCGAGC
CGAACGCCGGATCGGACGTGGTCAGCATGAAGCTGCGCGCCGATTTCAAGGGTGACCGCTACGTGCTCAACGGCACCAAG
ATGTGGATCACGAACGGGCCGGACTGCGACGTGCTGGTGGTCTACGCCAAGACCGAGCCGGACCTGGGCGCGCGCGGCAT
GACCGCCTTCATCGTCGAGAAGGGCATGAAGGGCTTCTCGGTAGCCCAGAAGCTGGACAAGCTCGGCATGCGCGGTTCGC
ACACCGGCGAACTGGTGTTCCAGGACGTGGAAGTGCCGGTCGAGAACATTCTCGGGGCCGAGAACGGGGGCGCCAAGGTG
CTGATGAGCGGCCTGGACTACGAGCGCGCCGTGCTGTCGGGCGGCCCGGTCGGCATCATGCAGGCCTGCATGGACGTGAT
CACGCCGTACATCCACGATCGCAAGCAGTTTGGCCAGAGCATCGGCGAGTTCCAGCTGATCCAGGGCAAGGTGGCCGACA
TGTACACCACGCTGCAGGCCGCGCGCAGCTACCTGTACACCGTGGGCAAGAACCTGGACTCGCTGGGCACGGACCACGTG
CGCCAGGTCCGCAAGGACTGCGCCGCCGTGATTCTGTACACCGCGGAGAAGGCCACGTGGATGGCGGGCGAGTCGGTGCA
GATCCTGGGCGGTAACGGCTACATCAACGAATACCCGGTCGGCCGCCTGTGGCGTGATGCCAAGCTGTACGAGATCGGCG
CGGGCACTTCGGAGATCCGCCGCATGCTGATTGGCCGCGAATTGTTCTCCGAAACGATGTAA

Upstream 100 bases:

>100_bases
CATGCGACTTCTAATTGACGTTTACGTAAACGTCAATAAAATAGCCGACACCGACCTCATCGAACCCATCGAACCCATCG
AACTAACAGGAGACACCACC

Downstream 100 bases:

>100_bases
TCCGCCCAGTCGACTGAAAAGTGCTCTATGAGGCGTTCGGTGCCGCCATTGGGCCGGCACCGAACGCCTTTACAATCTCA
ACATCGCCGCCTGCCCGATT

Product: isovaleryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTELPGLKFDLGEDIEMLRESVRNWAQAELAPRAAEIDRTDQFPMDAWRKMGDLGVLGITVAEEYGGANMGYLAHMIAME
EISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRYVLNGTK
MWITNGPDCDVLVVYAKTEPDLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPVENILGAENGGAKV
LMSGLDYERAVLSGGPVGIMQACMDVITPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGTDHV
RQVRKDCAAVILYTAEKATWMAGESVQILGGNGYINEYPVGRLWRDAKLYEIGAGTSEIRRMLIGRELFSETM

Sequences:

>Translated_393_residues
MTELPGLKFDLGEDIEMLRESVRNWAQAELAPRAAEIDRTDQFPMDAWRKMGDLGVLGITVAEEYGGANMGYLAHMIAME
EISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRYVLNGTK
MWITNGPDCDVLVVYAKTEPDLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPVENILGAENGGAKV
LMSGLDYERAVLSGGPVGIMQACMDVITPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGTDHV
RQVRKDCAAVILYTAEKATWMAGESVQILGGNGYINEYPVGRLWRDAKLYEIGAGTSEIRRMLIGRELFSETM
>Mature_392_residues
TELPGLKFDLGEDIEMLRESVRNWAQAELAPRAAEIDRTDQFPMDAWRKMGDLGVLGITVAEEYGGANMGYLAHMIAMEE
ISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRYVLNGTKM
WITNGPDCDVLVVYAKTEPDLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPVENILGAENGGAKVL
MSGLDYERAVLSGGPVGIMQACMDVITPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGTDHVR
QVRKDCAAVILYTAEKATWMAGESVQILGGNGYINEYPVGRLWRDAKLYEIGAGTSEIRRMLIGRELFSETM

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=382, Percent_Identity=62.82722513089, Blast_Score=490, Evalue=1e-139,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=65.8892128279883, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=39.2105263157895, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=34.4, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=35.0649350649351, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=35.0649350649351, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI21361497, Length=393, Percent_Identity=36.6412213740458, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4501857, Length=386, Percent_Identity=32.1243523316062, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4557235, Length=380, Percent_Identity=33.6842105263158, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI76496475, Length=380, Percent_Identity=33.6842105263158, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=30.1298701298701, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI4503943, Length=388, Percent_Identity=34.020618556701, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=34.6260387811634, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=24.6527777777778, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=24.6527777777778, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI38505218, Length=285, Percent_Identity=20.7017543859649, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=28.3505154639175, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=27.720207253886, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI87082384, Length=253, Percent_Identity=24.5059288537549, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081702, Length=272, Percent_Identity=24.6323529411765, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=387, Percent_Identity=61.7571059431525, Blast_Score=477, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17569725, Length=388, Percent_Identity=34.7938144329897, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17506239, Length=381, Percent_Identity=33.8582677165354, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=34.7150259067358, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=390, Percent_Identity=32.3076923076923, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=32.2916666666667, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=30.8900523560209, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=33.8028169014084, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=286, Percent_Identity=37.7622377622378, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=31.266149870801, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.961038961039, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=36.9718309859155, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.5766423357664, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=373, Percent_Identity=29.2225201072386, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=27.4193548387097, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=249, Percent_Identity=27.3092369477912, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=21.875, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=64.5244215938303, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=39.8950131233596, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=36.745406824147, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=34.625322997416, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24666513, Length=382, Percent_Identity=34.5549738219895, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI281363737, Length=367, Percent_Identity=34.0599455040872, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=32.4742268041237, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24652780, Length=316, Percent_Identity=22.4683544303797, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550141, Length=327, Percent_Identity=24.4648318042813, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221473076, Length=327, Percent_Identity=24.4648318042813, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 42959; Mature: 42828

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELPGLKFDLGEDIEMLRESVRNWAQAELAPRAAEIDRTDQFPMDAWRKMGDLGVLGIT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHCCCCCEEEEE
VAEEYGGANMGYLAHMIAMEEISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKL
EEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRYVLNGTKMWITNGPDCDVLVVYAKTEP
HCCCCEEEEEECCCCCCCCEEEEEEEECCCCCEEEECCEEEEEECCCCCCEEEEEEECCC
DLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPVENILGAENGGAKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHCCCCCCCCEE
LMSGLDYERAVLSGGPVGIMQACMDVITPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQA
EEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHH
ARSYLYTVGKNLDSLGTDHVRQVRKDCAAVILYTAEKATWMAGESVQILGGNGYINEYPV
HHHHHHHHHCCHHHCCHHHHHHHHHHHHEEEEEECCCCEEECCCEEEEEECCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELFSETM
CHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TELPGLKFDLGEDIEMLRESVRNWAQAELAPRAAEIDRTDQFPMDAWRKMGDLGVLGIT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHCCCCCEEEEE
VAEEYGGANMGYLAHMIAMEEISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKL
EEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRYVLNGTKMWITNGPDCDVLVVYAKTEP
HCCCCEEEEEECCCCCCCCEEEEEEEECCCCCEEEECCEEEEEECCCCCCEEEEEEECCC
DLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPVENILGAENGGAKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHCCCCCCCCEE
LMSGLDYERAVLSGGPVGIMQACMDVITPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQA
EEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHH
ARSYLYTVGKNLDSLGTDHVRQVRKDCAAVILYTAEKATWMAGESVQILGGNGYINEYPV
HHHHHHHHHCCHHHCCHHHHHHHHHHHHEEEEEECCCCEEECCCEEEEEECCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELFSETM
CHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]