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The map label for this gene is dnaA

Identifier: 94308946

GI number: 94308946

Start: 104

End: 1843

Strand: Direct

Name: dnaA

Synonym: Rmet_0001

Alternate gene names: 94308946

Gene position: 104-1843 (Clockwise)

Preceding gene: NA

Following gene: 94308947

Centisome position: 0.0

GC content: 63.33

Gene sequence:

>1740_bases
ATGCAAGATTTCTGGCAGGCAGCAGCCGCGCAACTCGAGCGCGAACTGACGCCGCAACAGTTCAAGACCTGGATCAAGCC
GTTGGCGCCCGTGGCCTTCGACGAGGAAGCGCATGCGCTGCGGATTGCCGCGCCCAATCGCTTCAAGCTTGACTGGGTCA
AGAGCCAATTTTCGGGTCGGATCACGGCCCTTGCGTGCGAGTACTGGGAAACGCAGGTTAGCGTTCACTTCGTGCTCGAC
CCCGCTGCATCGGGGCGCGCGGCCGCATATACCCAGCAAGCAATGCAACAGGGCCAGGATGCGCCCGCTGCAATGGGTAC
GGCCATGGGCGCAGGCCATGCGCCTTATCCGGGCATGGCTGGCATGGCCGGAGGCCAATCCTACGGGCCGGCTGGCGCGC
AGGTTCCCGGCGCGCATCCGAACCAGATGGCTGGATATCCCGACTATCCCAGCCAGTCCAATGGCGCGCCCGCTGGCTAT
GGCGGCGCGGCGGGTGGACAAACGCCCTATTCCCAGTCGCAGCAGTCCGCGCAGGGACGCGGCGCGGCACCCACCGGGCA
TCCGCTTCAGGGCAATTCGGCCGCGCATTTGCCGGACATGGGCGAGATCGACGTGGCCCAGATGGACCCGGCCGAAGCCA
GCGCCCGCTCCTATCGCGTGCCGTCGCCGCAGCCGGCAGCGCCGGCCGGGGCGCAGCAGCAGAGCGACACGGTGCACGAG
CGCTCGCGCCTGAACCCGATCCTGACGTTCGACAACTTCGTCACCGGCAAGGCCAACCAGCTCGCGCGTGCCGCGGCGAT
CCAGGTGGCCAACAACCCGGGCAAGTCGTACAACCCGCTCTACCTGTACGGCGGCGTTGGCCTCGGCAAGACTCACCTGA
TTCACGCGATTGGCAACTTCATGCTGATGGAGAACCCGCGCGCGCGCATCCGGTACATCCATGCGGAGCAGTACGTTTCC
GACGTGGTGAAGGCCTACCAGCGCAAGGCGTTCGACGAGTTCAAGCGCTATTACCACTCGCTGGACCTGCTGCTGATCGA
TGATATTCAGTTCTTCTCCGGCAAGAACCGCACGCAGGAAGAATTCTTCTACGCATTCGAGGCGCTGATCGCCAATCGCG
CCCAGGTGATCATCACCAGTGATACCTATCCGAAGGAGATCACCGGCATCGACGACCGGCTGATTTCGCGTTTCGACTCC
GGCCTGACTGTGGCGATCGAGCCGCCCGAGCTGGAGATGCGCGTCGCCATTCTGATGAAGAAGGCCGCCGCCGAGAACGT
GAGCGTGCCCGAGGAAGTGGCCTTCTTCGTGGCCAAGCACCTGCGGTCGAACGTGCGCGAGCTGGAAGGCGCGCTGCGCA
AGATCCTGGCGTTCTCGAACTTCCATGGCAAGGACATCACGATCGATGTCACGCGTGAAGCGCTGAAGGACCTGCTGACC
GTGCAGAATCGCCAGATCTCCGTGGAGAACATCCAGAAGACCTGCGCAGATTTCTACAACATCAAGGTCGCGGACATGTA
TTCCAAGAAGCGGCCCGCCAATATCGCGCGGCCGCGCCAGATCGCGATGTATCTGGCGAAGGAACTGACGCAGAAGAGTC
TGCCGGAGATCGGCGAGTTGTTCGGCGGGCGCGATCACACCACGGTGCTTCACGCCGTGCGCAAGATTGCCGAAGAGCGT
AGCAAGGACGCGCAGCTCAATCACGAGTTGCACGTGCTGGAACAGACGCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
GGAATGACGCGGAGACGGCTTGGCAGGGCAGAGTCCGTGGCGCGCGTACGTTGCGATACTCGTGACACGTCCGCAAGGAT
GTGATCACTTAGAAGAACAC

Downstream 100 bases:

>100_bases
CACACGTGCAGGTTGCGTGCGCCGAATGCGGCGCCGCAGCCTGCCGAAAGCGGCTCATCGACGATTTCGAGAGCCAGCCT
TGCCGGGCTGGCATACTACT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MQDFWQAAAAQLERELTPQQFKTWIKPLAPVAFDEEAHALRIAAPNRFKLDWVKSQFSGRITALACEYWETQVSVHFVLD
PAASGRAAAYTQQAMQQGQDAPAAMGTAMGAGHAPYPGMAGMAGGQSYGPAGAQVPGAHPNQMAGYPDYPSQSNGAPAGY
GGAAGGQTPYSQSQQSAQGRGAAPTGHPLQGNSAAHLPDMGEIDVAQMDPAEASARSYRVPSPQPAAPAGAQQQSDTVHE
RSRLNPILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGKTHLIHAIGNFMLMENPRARIRYIHAEQYVS
DVVKAYQRKAFDEFKRYYHSLDLLLIDDIQFFSGKNRTQEEFFYAFEALIANRAQVIITSDTYPKEITGIDDRLISRFDS
GLTVAIEPPELEMRVAILMKKAAAENVSVPEEVAFFVAKHLRSNVRELEGALRKILAFSNFHGKDITIDVTREALKDLLT
VQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIAEER
SKDAQLNHELHVLEQTLKG

Sequences:

>Translated_579_residues
MQDFWQAAAAQLERELTPQQFKTWIKPLAPVAFDEEAHALRIAAPNRFKLDWVKSQFSGRITALACEYWETQVSVHFVLD
PAASGRAAAYTQQAMQQGQDAPAAMGTAMGAGHAPYPGMAGMAGGQSYGPAGAQVPGAHPNQMAGYPDYPSQSNGAPAGY
GGAAGGQTPYSQSQQSAQGRGAAPTGHPLQGNSAAHLPDMGEIDVAQMDPAEASARSYRVPSPQPAAPAGAQQQSDTVHE
RSRLNPILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGKTHLIHAIGNFMLMENPRARIRYIHAEQYVS
DVVKAYQRKAFDEFKRYYHSLDLLLIDDIQFFSGKNRTQEEFFYAFEALIANRAQVIITSDTYPKEITGIDDRLISRFDS
GLTVAIEPPELEMRVAILMKKAAAENVSVPEEVAFFVAKHLRSNVRELEGALRKILAFSNFHGKDITIDVTREALKDLLT
VQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIAEER
SKDAQLNHELHVLEQTLKG
>Mature_579_residues
MQDFWQAAAAQLERELTPQQFKTWIKPLAPVAFDEEAHALRIAAPNRFKLDWVKSQFSGRITALACEYWETQVSVHFVLD
PAASGRAAAYTQQAMQQGQDAPAAMGTAMGAGHAPYPGMAGMAGGQSYGPAGAQVPGAHPNQMAGYPDYPSQSNGAPAGY
GGAAGGQTPYSQSQQSAQGRGAAPTGHPLQGNSAAHLPDMGEIDVAQMDPAEASARSYRVPSPQPAAPAGAQQQSDTVHE
RSRLNPILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGKTHLIHAIGNFMLMENPRARIRYIHAEQYVS
DVVKAYQRKAFDEFKRYYHSLDLLLIDDIQFFSGKNRTQEEFFYAFEALIANRAQVIITSDTYPKEITGIDDRLISRFDS
GLTVAIEPPELEMRVAILMKKAAAENVSVPEEVAFFVAKHLRSNVRELEGALRKILAFSNFHGKDITIDVTREALKDLLT
VQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIAEER
SKDAQLNHELHVLEQTLKG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=438, Percent_Identity=53.6529680365297, Blast_Score=447, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_RALME (Q1LSI9)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_582156.1
- ProteinModelPortal:   Q1LSI9
- STRING:   Q1LSI9
- GeneID:   4036785
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_0001
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   ALACEYW
- PhylomeDB:   Q1LSI9
- ProtClustDB:   PRK00149
- BioCyc:   RMET266264:RMET_0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 63552; Mature: 63552

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDFWQAAAAQLERELTPQQFKTWIKPLAPVAFDEEAHALRIAAPNRFKLDWVKSQFSGR
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEHHHHHHHHCCC
ITALACEYWETQVSVHFVLDPAASGRAAAYTQQAMQQGQDAPAAMGTAMGAGHAPYPGMA
EEEEEEEHHHCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
GMAGGQSYGPAGAQVPGAHPNQMAGYPDYPSQSNGAPAGYGGAAGGQTPYSQSQQSAQGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
GAAPTGHPLQGNSAAHLPDMGEIDVAQMDPAEASARSYRVPSPQPAAPAGAQQQSDTVHE
CCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
RSRLNPILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGKTHLIHAIGNF
HHHCCCEEEECCCCCCCHHHHHHHHHHEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHH
MLMENPRARIRYIHAEQYVSDVVKAYQRKAFDEFKRYYHSLDLLLIDDIQFFSGKNRTQE
HEECCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHCCCCCCHH
EFFYAFEALIANRAQVIITSDTYPKEITGIDDRLISRFDSGLTVAIEPPELEMRVAILMK
HHHHHHHHHHHCCCEEEEECCCCCCHHCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
KAAAENVSVPEEVAFFVAKHLRSNVRELEGALRKILAFSNFHGKDITIDVTREALKDLLT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHH
VQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGEL
HCCCCCCHHHHHHHHHHHHCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHH
FGGRDHTTVLHAVRKIAEERSKDAQLNHELHVLEQTLKG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDFWQAAAAQLERELTPQQFKTWIKPLAPVAFDEEAHALRIAAPNRFKLDWVKSQFSGR
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEHHHHHHHHCCC
ITALACEYWETQVSVHFVLDPAASGRAAAYTQQAMQQGQDAPAAMGTAMGAGHAPYPGMA
EEEEEEEHHHCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
GMAGGQSYGPAGAQVPGAHPNQMAGYPDYPSQSNGAPAGYGGAAGGQTPYSQSQQSAQGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
GAAPTGHPLQGNSAAHLPDMGEIDVAQMDPAEASARSYRVPSPQPAAPAGAQQQSDTVHE
CCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
RSRLNPILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGKTHLIHAIGNF
HHHCCCEEEECCCCCCCHHHHHHHHHHEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHH
MLMENPRARIRYIHAEQYVSDVVKAYQRKAFDEFKRYYHSLDLLLIDDIQFFSGKNRTQE
HEECCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHCCCCCCHH
EFFYAFEALIANRAQVIITSDTYPKEITGIDDRLISRFDSGLTVAIEPPELEMRVAILMK
HHHHHHHHHHHCCCEEEEECCCCCCHHCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
KAAAENVSVPEEVAFFVAKHLRSNVRELEGALRKILAFSNFHGKDITIDVTREALKDLLT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHH
VQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGEL
HCCCCCCHHHHHHHHHHHHCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHH
FGGRDHTTVLHAVRKIAEERSKDAQLNHELHVLEQTLKG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA