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The map label for this gene is mutY [H]

Identifier: 93007108

GI number: 93007108

Start: 2806167

End: 2807528

Strand: Direct

Name: mutY [H]

Synonym: Pcryo_2284

Alternate gene names: 93007108

Gene position: 2806167-2807528 (Clockwise)

Preceding gene: 93007107

Following gene: 93007111

Centisome position: 91.71

GC content: 44.35

Gene sequence:

>1362_bases
ATGGTGCTCACAACTAAGCTCACCTACTGTTGTCTTGTATCAATCGTATTACACCCCATAAATAACCTTAATCCCAAATT
TTATACATCCCTGTTAAATTTACAAGGAATACTCTTGCATACTCAATTTTCTCACTCATTAACTTCTTTAGACGCATTCG
CCCCGCGCCTCCTCGCTTGGTTCGCCGATAATGGTCGCCATGACCTGCCTTGGCAACAGCACCAGACCGATACGCCAAAT
CCTTATATTGTTTGGCTATCAGAAGTCATGCTACAACAGACGCAAGTGACCACCGTGCTGCCCTACTTTGCCCGTTTTAT
GGACTCCTTTCCGACCGTGCAAGATTTAGCAGCAGCAGAATGGGACACCATCGCGGAGCATTGGGCGGGGCTAGGTTACT
ATGCGCGTGCACGTAATTTGCATAAAGGTGCGAAGCAATTGGTCGCTGTGATTGACGAGACTGGCGACTTTCCGCAAACC
TTGGCAGGTTGGGAAGCGATATCAGGTGTTGGTCCTTCGACCGCTGGGGCGATTATGTCAATGGGCTTGCATCGTTATGG
CGTCATTTGCGATGGTAATGTTAAACGGGTACTGACACGCTGGGCAGCAATTGATGGCGATATCACTAAGTCCGCGACGA
CTAAAGATTTATGGGCATTGGCAGAGCGTCTAACGCCTAGAGAACAATCAGGATTGTTTGCGCAAGCAATGATGGATATG
GGTGCAACTTTATGCACGCGTAGCAAGCCTGCTTGTCTACTATGTCCACTACAAGATGATTGCTTAGCGCATGCGCAAGG
TCGTGAAACGGAATATCCAGTGAAGGCTAAGAAACAGCCTAAACCGAGTAAATTTAGTAATGCACTGCTTATTGAAAACG
AAAATGGCGAAATACTTTGGCTACAGCGCCCTGACAATGGCATTTGGGGCGGACTGTGGAGTTTGCCGCTAGCATTTATA
GAAAAAATTAGTGGAAAAGTTGCCGTGAAGGATGCTGACAAGAATAAAAATAAGGGACCAATTGCAGCGAATGATAATCA
GCTTTTAGAAGTAGCTAGTAATGAAAAAATATACGAGACAGAATTTACTACTGCTGAGCAAATTATTAATGAGTGGTTGG
ATAAGAATAAATTGAGCGCAAAATCAGTTAGCAACACACTGCTTGATGACGCACCGATTAAACATTCATTGACCCATTTT
CATTGGTATTTAACCCCGCAATCGGTAACTTTAAACGATAAACAGGTGACTGAGATAACCAAGGCATTGCAAGCAGCTGA
AATTAATATTAATTGGTTGAATACTGATGATGCACAGGCAACGCTAGGCTTACCAAGAGCGATGGTGAAAATTTTAGAAT
AG

Upstream 100 bases:

>100_bases
CCTAGCGCACCTGTTTTATCTTTATAATTCACCTTTAACTTATCTGAAAATCCTCACAATCTCACTTGGCAAACAATACA
GTTAATTGCCATTTTATCCA

Downstream 100 bases:

>100_bases
GATTACATATATAATCATTAAAAAATCCGCTTAAAATAACGATTGTATACGCCATAAAAAAGCGACTCAGAATAATTCTA
AGTCGCTTTTTCTATTTATA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MVLTTKLTYCCLVSIVLHPINNLNPKFYTSLLNLQGILLHTQFSHSLTSLDAFAPRLLAWFADNGRHDLPWQQHQTDTPN
PYIVWLSEVMLQQTQVTTVLPYFARFMDSFPTVQDLAAAEWDTIAEHWAGLGYYARARNLHKGAKQLVAVIDETGDFPQT
LAGWEAISGVGPSTAGAIMSMGLHRYGVICDGNVKRVLTRWAAIDGDITKSATTKDLWALAERLTPREQSGLFAQAMMDM
GATLCTRSKPACLLCPLQDDCLAHAQGRETEYPVKAKKQPKPSKFSNALLIENENGEILWLQRPDNGIWGGLWSLPLAFI
EKISGKVAVKDADKNKNKGPIAANDNQLLEVASNEKIYETEFTTAEQIINEWLDKNKLSAKSVSNTLLDDAPIKHSLTHF
HWYLTPQSVTLNDKQVTEITKALQAAEININWLNTDDAQATLGLPRAMVKILE

Sequences:

>Translated_453_residues
MVLTTKLTYCCLVSIVLHPINNLNPKFYTSLLNLQGILLHTQFSHSLTSLDAFAPRLLAWFADNGRHDLPWQQHQTDTPN
PYIVWLSEVMLQQTQVTTVLPYFARFMDSFPTVQDLAAAEWDTIAEHWAGLGYYARARNLHKGAKQLVAVIDETGDFPQT
LAGWEAISGVGPSTAGAIMSMGLHRYGVICDGNVKRVLTRWAAIDGDITKSATTKDLWALAERLTPREQSGLFAQAMMDM
GATLCTRSKPACLLCPLQDDCLAHAQGRETEYPVKAKKQPKPSKFSNALLIENENGEILWLQRPDNGIWGGLWSLPLAFI
EKISGKVAVKDADKNKNKGPIAANDNQLLEVASNEKIYETEFTTAEQIINEWLDKNKLSAKSVSNTLLDDAPIKHSLTHF
HWYLTPQSVTLNDKQVTEITKALQAAEININWLNTDDAQATLGLPRAMVKILE
>Mature_453_residues
MVLTTKLTYCCLVSIVLHPINNLNPKFYTSLLNLQGILLHTQFSHSLTSLDAFAPRLLAWFADNGRHDLPWQQHQTDTPN
PYIVWLSEVMLQQTQVTTVLPYFARFMDSFPTVQDLAAAEWDTIAEHWAGLGYYARARNLHKGAKQLVAVIDETGDFPQT
LAGWEAISGVGPSTAGAIMSMGLHRYGVICDGNVKRVLTRWAAIDGDITKSATTKDLWALAERLTPREQSGLFAQAMMDM
GATLCTRSKPACLLCPLQDDCLAHAQGRETEYPVKAKKQPKPSKFSNALLIENENGEILWLQRPDNGIWGGLWSLPLAFI
EKISGKVAVKDADKNKNKGPIAANDNQLLEVASNEKIYETEFTTAEQIINEWLDKNKLSAKSVSNTLLDDAPIKHSLTHF
HWYLTPQSVTLNDKQVTEITKALQAAEININWLNTDDAQATLGLPRAMVKILE

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=333, Percent_Identity=33.6336336336336, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI115298654, Length=333, Percent_Identity=33.6336336336336, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI115298652, Length=333, Percent_Identity=33.6336336336336, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI190358497, Length=333, Percent_Identity=33.6336336336336, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI115298650, Length=333, Percent_Identity=33.6336336336336, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI6912520, Length=333, Percent_Identity=33.6336336336336, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1789331, Length=264, Percent_Identity=51.5151515151515, Blast_Score=259, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 50435; Mature: 50435

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLTTKLTYCCLVSIVLHPINNLNPKFYTSLLNLQGILLHTQFSHSLTSLDAFAPRLLAW
CEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHH
FADNGRHDLPWQQHQTDTPNPYIVWLSEVMLQQTQVTTVLPYFARFMDSFPTVQDLAAAE
HHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
WDTIAEHWAGLGYYARARNLHKGAKQLVAVIDETGDFPQTLAGWEAISGVGPSTAGAIMS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHH
MGLHRYGVICDGNVKRVLTRWAAIDGDITKSATTKDLWALAERLTPREQSGLFAQAMMDM
HCHHHEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHCCHHHHHHHHC
GATLCTRSKPACLLCPLQDDCLAHAQGRETEYPVKAKKQPKPSKFSNALLIENENGEILW
CHHHHCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEE
LQRPDNGIWGGLWSLPLAFIEKISGKVAVKDADKNKNKGPIAANDNQLLEVASNEKIYET
EECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEC
EFTTAEQIINEWLDKNKLSAKSVSNTLLDDAPIKHSLTHFHWYLTPQSVTLNDKQVTEIT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHCCEEEEEEECCCEEECCHHHHHHHH
KALQAAEININWLNTDDAQATLGLPRAMVKILE
HHHHHHEEEEEEECCCCCHHHHCCHHHHHHHCC
>Mature Secondary Structure
MVLTTKLTYCCLVSIVLHPINNLNPKFYTSLLNLQGILLHTQFSHSLTSLDAFAPRLLAW
CEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHH
FADNGRHDLPWQQHQTDTPNPYIVWLSEVMLQQTQVTTVLPYFARFMDSFPTVQDLAAAE
HHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
WDTIAEHWAGLGYYARARNLHKGAKQLVAVIDETGDFPQTLAGWEAISGVGPSTAGAIMS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHH
MGLHRYGVICDGNVKRVLTRWAAIDGDITKSATTKDLWALAERLTPREQSGLFAQAMMDM
HCHHHEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHCCHHHHHHHHC
GATLCTRSKPACLLCPLQDDCLAHAQGRETEYPVKAKKQPKPSKFSNALLIENENGEILW
CHHHHCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEE
LQRPDNGIWGGLWSLPLAFIEKISGKVAVKDADKNKNKGPIAANDNQLLEVASNEKIYET
EECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEC
EFTTAEQIINEWLDKNKLSAKSVSNTLLDDAPIKHSLTHFHWYLTPQSVTLNDKQVTEIT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHCCEEEEEEECCCEEECCHHHHHHHH
KALQAAEININWLNTDDAQATLGLPRAMVKILE
HHHHHHEEEEEEECCCCCHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]