Click here to switch to the map view.

The map label for this gene is murC [H]

Identifier: 93006855

GI number: 93006855

Start: 2496220

End: 2497659

Strand: Reverse

Name: murC [H]

Synonym: Pcryo_2031

Alternate gene names: 93006855

Gene position: 2497659-2496220 (Counterclockwise)

Preceding gene: 93006856

Following gene: 93006854

Centisome position: 81.63

GC content: 45.35

Gene sequence:

>1440_bases
ATGCCAACCTCTGCTAAAGCCTTAACCAAACGTTTGATTGAAATACCAGAAATGCGCCGTATTCAGCATTTACATTTTAT
TGGTATTGGTGGTTCGGGGATGTGTGGTATTGCTGAGGTTATGAATAATCAAGGCTATCAAGTCAGTGGTTCTGATATTA
CTGAGAGCTTAGTGACCAAACGTTTGGCGCAGATTGGTATTGATATTGCTATCGGTCATGATTCCAAAAACATTGCCAAT
GCTGATGTCATCGTTGTATCGTCTGCCATCGATCGTAGCAATCCCGAAGTAAAAGCAGCACTCGAAGCACGTCTTCCGGT
AGTGCGCCGTGCGGATATGCTTGGTGAATTGATGCGTTATCGTCACGGTATTGCTATTGCTGGGGCGCATGGTAAAACCA
CCACGACCAGTTTGCTGACCACTATGATGGCAGAAGGCAATTTAGATCCTACTTATGTGATTGGCGGTAAGCTTAATGCT
TCGGGTAAAAATGCCGCGCTTGGTAGCAGTCGTTTTCTAATTGCCGAGGCTGATGAGTCTGACGCCTCATTCTTGTCATT
GCATCCGATGGCGGCAATTGTCACCAATATTGATCAAGATCATATGGAAACTTATGGCAATAGTTTTGATAAATTAAAGG
CAGCTTATATTCAGTTTTTACAAAACATGCCGTTTTATGGTCTGGCAGTGGTCTGCGGTGATGATCCTGAGCTGTACGCG
ATGATTGATGATATTGGGCGTCCAGTCTTGACCTTTGGTCTTGAGCCATTTAATGATGTACAAGCCGTTGATTTGGTCAC
CGAAGGTACAAAAACCCATTTTACGGTACTACGTCGTGATCATGAACCATTGCGTCTGACACTGAATATTCCGGGCGTGC
ATAATGTCTACAATGCGCTTGCAGCCATTACTATGGCGACTGATGAAGGCGTCGATGATGCTGCAATTACCCGTGCGCTA
CAGAAGTTTGAAGGGGTTGGTCGTCGTTTTGAGCAACATGCCTCTGTGGAGATAGATGATGGTAATGTGCTGCTGATTGA
TGATTATGGTCATCATCCAAAAGAAGTTGATGCCACCATCAAAGCGGCGCGTCAAAGCTTCCCTGAGCGTCGTTTAGTCA
TGATGTTCCAGCCTCATCGTTACAGCCGTACCCGTGACTGCTTCGATGATTTTGTCGAAGTACTCTCAAGTGTTGATGAG
TTATTATTGTTGGATGTCTATTCTGCTGGTGAAAGCCCTATCGCTGGTGCGGACACCAAAGCCTTAGCACGTAGTATACG
TTTGCGCGGTGCCGTCGAGCCAACGATAGTAGATAAAGATAATATTGCCCCTGTCATGCAGCGATTATTGAAAGCAGGTG
ATATGCTGATCACCCAAGGCGCGGGTAATGTCGGGCAAATAGCTATCGATCTCGCCGCCAATAATCTTTATATCAAATAA

Upstream 100 bases:

>100_bases
CGTTGCCAATATTATCTGGCAAGCTTTGTAGATAAACAAATAAATACCTGATATTTTTGCCTTACTATATTTTATCCGTC
TTATAAAAAGAGAAAACCTT

Downstream 100 bases:

>100_bases
GCCTTAGAAGCATTGCTTTAAAAATATTAGGAGCACTAACAATGACCATGAATAATACTAAAGAAAATAATAATATTGAT
GAAGATGGCGTTAATGTTGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MPTSAKALTKRLIEIPEMRRIQHLHFIGIGGSGMCGIAEVMNNQGYQVSGSDITESLVTKRLAQIGIDIAIGHDSKNIAN
ADVIVVSSAIDRSNPEVKAALEARLPVVRRADMLGELMRYRHGIAIAGAHGKTTTTSLLTTMMAEGNLDPTYVIGGKLNA
SGKNAALGSSRFLIAEADESDASFLSLHPMAAIVTNIDQDHMETYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDPELYA
MIDDIGRPVLTFGLEPFNDVQAVDLVTEGTKTHFTVLRRDHEPLRLTLNIPGVHNVYNALAAITMATDEGVDDAAITRAL
QKFEGVGRRFEQHASVEIDDGNVLLIDDYGHHPKEVDATIKAARQSFPERRLVMMFQPHRYSRTRDCFDDFVEVLSSVDE
LLLLDVYSAGESPIAGADTKALARSIRLRGAVEPTIVDKDNIAPVMQRLLKAGDMLITQGAGNVGQIAIDLAANNLYIK

Sequences:

>Translated_479_residues
MPTSAKALTKRLIEIPEMRRIQHLHFIGIGGSGMCGIAEVMNNQGYQVSGSDITESLVTKRLAQIGIDIAIGHDSKNIAN
ADVIVVSSAIDRSNPEVKAALEARLPVVRRADMLGELMRYRHGIAIAGAHGKTTTTSLLTTMMAEGNLDPTYVIGGKLNA
SGKNAALGSSRFLIAEADESDASFLSLHPMAAIVTNIDQDHMETYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDPELYA
MIDDIGRPVLTFGLEPFNDVQAVDLVTEGTKTHFTVLRRDHEPLRLTLNIPGVHNVYNALAAITMATDEGVDDAAITRAL
QKFEGVGRRFEQHASVEIDDGNVLLIDDYGHHPKEVDATIKAARQSFPERRLVMMFQPHRYSRTRDCFDDFVEVLSSVDE
LLLLDVYSAGESPIAGADTKALARSIRLRGAVEPTIVDKDNIAPVMQRLLKAGDMLITQGAGNVGQIAIDLAANNLYIK
>Mature_478_residues
PTSAKALTKRLIEIPEMRRIQHLHFIGIGGSGMCGIAEVMNNQGYQVSGSDITESLVTKRLAQIGIDIAIGHDSKNIANA
DVIVVSSAIDRSNPEVKAALEARLPVVRRADMLGELMRYRHGIAIAGAHGKTTTTSLLTTMMAEGNLDPTYVIGGKLNAS
GKNAALGSSRFLIAEADESDASFLSLHPMAAIVTNIDQDHMETYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDPELYAM
IDDIGRPVLTFGLEPFNDVQAVDLVTEGTKTHFTVLRRDHEPLRLTLNIPGVHNVYNALAAITMATDEGVDDAAITRALQ
KFEGVGRRFEQHASVEIDDGNVLLIDDYGHHPKEVDATIKAARQSFPERRLVMMFQPHRYSRTRDCFDDFVEVLSSVDEL
LLLDVYSAGESPIAGADTKALARSIRLRGAVEPTIVDKDNIAPVMQRLLKAGDMLITQGAGNVGQIAIDLAANNLYIK

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=464, Percent_Identity=54.7413793103448, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1790680, Length=464, Percent_Identity=27.5862068965517, Blast_Score=144, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 52126; Mature: 51995

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTSAKALTKRLIEIPEMRRIQHLHFIGIGGSGMCGIAEVMNNQGYQVSGSDITESLVTK
CCCCHHHHHHHHHHCHHHHHHCEEEEEEECCCCCHHHHHHHCCCCCEECCHHHHHHHHHH
RLAQIGIDIAIGHDSKNIANADVIVVSSAIDRSNPEVKAALEARLPVVRRADMLGELMRY
HHHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
RHGIAIAGAHGKTTTTSLLTTMMAEGNLDPTYVIGGKLNASGKNAALGSSRFLIAEADES
HCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCEECCCCCCCCCCCCEEEEEECCCC
DASFLSLHPMAAIVTNIDQDHMETYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDPELYA
CCCEEEHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEH
MIDDIGRPVLTFGLEPFNDVQAVDLVTEGTKTHFTVLRRDHEPLRLTLNIPGVHNVYNAL
HHHHHCCCEEEECCCCCCCCEEEHEEECCCCCEEEEEECCCCCEEEEEECCCHHHHHHHH
AAITMATDEGVDDAAITRALQKFEGVGRRFEQHASVEIDDGNVLLIDDYGHHPKEVDATI
HHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCHHHHHHH
KAARQSFPERRLVMMFQPHRYSRTRDCFDDFVEVLSSVDELLLLDVYSAGESPIAGADTK
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCCCCCCHH
ALARSIRLRGAVEPTIVDKDNIAPVMQRLLKAGDMLITQGAGNVGQIAIDLAANNLYIK
HHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCEEEC
>Mature Secondary Structure 
PTSAKALTKRLIEIPEMRRIQHLHFIGIGGSGMCGIAEVMNNQGYQVSGSDITESLVTK
CCCHHHHHHHHHHCHHHHHHCEEEEEEECCCCCHHHHHHHCCCCCEECCHHHHHHHHHH
RLAQIGIDIAIGHDSKNIANADVIVVSSAIDRSNPEVKAALEARLPVVRRADMLGELMRY
HHHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
RHGIAIAGAHGKTTTTSLLTTMMAEGNLDPTYVIGGKLNASGKNAALGSSRFLIAEADES
HCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCEECCCCCCCCCCCCEEEEEECCCC
DASFLSLHPMAAIVTNIDQDHMETYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDPELYA
CCCEEEHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEH
MIDDIGRPVLTFGLEPFNDVQAVDLVTEGTKTHFTVLRRDHEPLRLTLNIPGVHNVYNAL
HHHHHCCCEEEECCCCCCCCEEEHEEECCCCCEEEEEECCCCCEEEEEECCCHHHHHHHH
AAITMATDEGVDDAAITRALQKFEGVGRRFEQHASVEIDDGNVLLIDDYGHHPKEVDATI
HHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCHHHHHHH
KAARQSFPERRLVMMFQPHRYSRTRDCFDDFVEVLSSVDELLLLDVYSAGESPIAGADTK
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCCCCCCHH
ALARSIRLRGAVEPTIVDKDNIAPVMQRLLKAGDMLITQGAGNVGQIAIDLAANNLYIK
HHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA