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The map label for this gene is ffh [H]

Identifier: 93006809

GI number: 93006809

Start: 2444406

End: 2445953

Strand: Reverse

Name: ffh [H]

Synonym: Pcryo_1985

Alternate gene names: 93006809

Gene position: 2445953-2444406 (Counterclockwise)

Preceding gene: 93006811

Following gene: 93006808

Centisome position: 79.94

GC content: 47.16

Gene sequence:

>1548_bases
ATGTTTGATACCTTAACAGAACGATTGTCGTCTAGTCTGCGCAATATCGCAGGCACGGGGCAATTGACCGAAGACAATAT
CAAAGACACTTTACGTGAAGTACGTATGGCGCTGCTGGAAGCCGATGTGGCATTGCCAGTCACTCGTGATTTTGTGAAGC
GTGTCAAAGAGCAAGCGCTTGGCGCTGAAGTGCTTAAAGAATTAGCACCAGGACAGGCATTTGTCAAAATCGTCCATGAC
GAGCTGACTGAAATGATGGGCAGTGCCAATCAGCAGCTTGAGATGACAGGTAAGCCGCCGGTTATTTATCTGCTAGCGGG
TCTGCAAGGTGCTGGTAAAACTACTACTGCCGGTAAATTGGCCAAGTTCTTACAAGAACGTCATAAGAAAAAAGTCATGC
TGGTATCTGCTGACGTTTACCGTCCCGCAGCGATTGCCCAGCTTGAGCAAGTCGCTGGACAAGTAAATGCCAAGTTCGTC
AATTCAAGTAGCGACGAAAACCCGATTGATATCGCCTTGCGTGCTATCGAAGAAGCTAAAATCCAATATCAAGATATCTT
GATTATTGATACAGCTGGTCGTTTGGCTATTGATGAAACCATGATGGATGAAATCAAGGCGTTAACCGCTGCGGTCAATC
CTTCTGAGACACTGTTTGTTGTTGATGCGATGACTGGTCAGGATGCGGCAAATACTGCCAAAGCCTTTAACGATGCGCTG
CCATTAACGGGCGTTATTTTGACCAAGACTGACGGCGATGCTCGTGGCGGTGCGGCGCTTTCTGTACGCGCCATCACAGG
TAAGCCAATTAAATTCTTGGGTCGCGGTGAGAAACTAGATGCGCTAGAGCTATTCCATCCTGAACGTATTGCCCAGCGTA
TTCTTGGTATGGGTGACGTCTTAAGTCTGGTTGAAGAAGTTGAGCAAAAGATTGACCGTGATAAAGCCGAAAAAATGGCG
AAAAAGATGCAAAAGGGCGGCGAGTTCGACCTTGAAGATCTATTGACCCAGTTTCAGCAAATGAAAAGCATGGGCGGTAT
GGCGGGCTTCTTAGATAAGATGCCAGGTATGGGTGGCTCGGATATGCAAAAAGCGGTCGAAGATGCTAAGCCTGAAGAAA
AAGTGCGTGAGATGGAAGCACTGATCAATTCGATGACACCATTTGAGCGCAAAAATCCTGATAAAATCAATCCAAGTCGT
AAGCGCCGTATTGCTGCAGGCTCAGGTCGTGAGATTCAAGACGTCAATCGTTTGCTCAAGCAGCACAAGCAAATGGCAAA
AATGATGAAAATGATTTCAAAGCCAGAAGGCATCAGTAAAATGATGAAATCGATGCAAGGGTTGATGGGCGGCGGCGGTG
GAGCAGGCGGCGGCGGTCCATTATTCGGCGGTGGCGGTCAGCAAGGTGGTGTTAAAGATGTGAACCCACAGCAAATGGCA
AAGCAGATGGGACTTGACCCAAATAATATGCCTAGCACTGAAGAGATGCAAAAACAGATGCAAGAGCTACAAAACCAAGC
GCCGAAGAAGTTTAAAACACGTTTTTAA

Upstream 100 bases:

>100_bases
GCTTGAATACCTGCGATCGCATACCCTAATAGTATTTATCAACTCTTTTATTTATGAAGAGTTAAGCTTAATCTAGAATT
ATTTTAACTGAGAGTTATTT

Downstream 100 bases:

>100_bases
ATGATTTAGTGCTACTGGGAAATATTGATAATAAAAACCTCAAAGCTAAATGAGTTTTGAGGTTTTTTCATATTTTGAAT
ATTTGAGTGAATTCTCACAA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MFDTLTERLSSSLRNIAGTGQLTEDNIKDTLREVRMALLEADVALPVTRDFVKRVKEQALGAEVLKELAPGQAFVKIVHD
ELTEMMGSANQQLEMTGKPPVIYLLAGLQGAGKTTTAGKLAKFLQERHKKKVMLVSADVYRPAAIAQLEQVAGQVNAKFV
NSSSDENPIDIALRAIEEAKIQYQDILIIDTAGRLAIDETMMDEIKALTAAVNPSETLFVVDAMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGRGEKLDALELFHPERIAQRILGMGDVLSLVEEVEQKIDRDKAEKMA
KKMQKGGEFDLEDLLTQFQQMKSMGGMAGFLDKMPGMGGSDMQKAVEDAKPEEKVREMEALINSMTPFERKNPDKINPSR
KRRIAAGSGREIQDVNRLLKQHKQMAKMMKMISKPEGISKMMKSMQGLMGGGGGAGGGGPLFGGGGQQGGVKDVNPQQMA
KQMGLDPNNMPSTEEMQKQMQELQNQAPKKFKTRF

Sequences:

>Translated_515_residues
MFDTLTERLSSSLRNIAGTGQLTEDNIKDTLREVRMALLEADVALPVTRDFVKRVKEQALGAEVLKELAPGQAFVKIVHD
ELTEMMGSANQQLEMTGKPPVIYLLAGLQGAGKTTTAGKLAKFLQERHKKKVMLVSADVYRPAAIAQLEQVAGQVNAKFV
NSSSDENPIDIALRAIEEAKIQYQDILIIDTAGRLAIDETMMDEIKALTAAVNPSETLFVVDAMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGRGEKLDALELFHPERIAQRILGMGDVLSLVEEVEQKIDRDKAEKMA
KKMQKGGEFDLEDLLTQFQQMKSMGGMAGFLDKMPGMGGSDMQKAVEDAKPEEKVREMEALINSMTPFERKNPDKINPSR
KRRIAAGSGREIQDVNRLLKQHKQMAKMMKMISKPEGISKMMKSMQGLMGGGGGAGGGGPLFGGGGQQGGVKDVNPQQMA
KQMGLDPNNMPSTEEMQKQMQELQNQAPKKFKTRF
>Mature_515_residues
MFDTLTERLSSSLRNIAGTGQLTEDNIKDTLREVRMALLEADVALPVTRDFVKRVKEQALGAEVLKELAPGQAFVKIVHD
ELTEMMGSANQQLEMTGKPPVIYLLAGLQGAGKTTTAGKLAKFLQERHKKKVMLVSADVYRPAAIAQLEQVAGQVNAKFV
NSSSDENPIDIALRAIEEAKIQYQDILIIDTAGRLAIDETMMDEIKALTAAVNPSETLFVVDAMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGRGEKLDALELFHPERIAQRILGMGDVLSLVEEVEQKIDRDKAEKMA
KKMQKGGEFDLEDLLTQFQQMKSMGGMAGFLDKMPGMGGSDMQKAVEDAKPEEKVREMEALINSMTPFERKNPDKINPSR
KRRIAAGSGREIQDVNRLLKQHKQMAKMMKMISKPEGISKMMKSMQGLMGGGGGAGGGGPLFGGGGQQGGVKDVNPQQMA
KQMGLDPNNMPSTEEMQKQMQELQNQAPKKFKTRF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=526, Percent_Identity=33.2699619771863, Blast_Score=232, Evalue=8e-61,
Organism=Homo sapiens, GI226371618, Length=349, Percent_Identity=36.1031518624642, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=35.7575757575758, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI23308697, Length=303, Percent_Identity=25.7425742574257, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI295424842, Length=303, Percent_Identity=25.7425742574257, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=64.1592920353982, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1789874, Length=266, Percent_Identity=35.3383458646617, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=439, Percent_Identity=32.5740318906606, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI193206261, Length=204, Percent_Identity=33.8235294117647, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=436, Percent_Identity=32.7981651376147, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=318, Percent_Identity=26.1006289308176, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17647949, Length=487, Percent_Identity=31.4168377823409, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24641198, Length=311, Percent_Identity=26.0450160771704, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 56107; Mature: 56107

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTLTERLSSSLRNIAGTGQLTEDNIKDTLREVRMALLEADVALPVTRDFVKRVKEQAL
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GAEVLKELAPGQAFVKIVHDELTEMMGSANQQLEMTGKPPVIYLLAGLQGAGKTTTAGKL
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHH
AKFLQERHKKKVMLVSADVYRPAAIAQLEQVAGQVNAKFVNSSSDENPIDIALRAIEEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHH
IQYQDILIIDTAGRLAIDETMMDEIKALTAAVNPSETLFVVDAMTGQDAANTAKAFNDAL
HEECCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCC
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGRGEKLDALELFHPERIAQRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEEECCCCHHHHCCCCCCCHHHHCCHHHHHHHHHCHHHH
LSLVEEVEQKIDRDKAEKMAKKMQKGGEFDLEDLLTQFQQMKSMGGMAGFLDKMPGMGGS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCH
DMQKAVEDAKPEEKVREMEALINSMTPFERKNPDKINPSRKRRIAAGSGREIQDVNRLLK
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHH
QHKQMAKMMKMISKPEGISKMMKSMQGLMGGGGGAGGGGPLFGGGGQQGGVKDVNPQQMA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KQMGLDPNNMPSTEEMQKQMQELQNQAPKKFKTRF
HHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCC
>Mature Secondary Structure
MFDTLTERLSSSLRNIAGTGQLTEDNIKDTLREVRMALLEADVALPVTRDFVKRVKEQAL
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GAEVLKELAPGQAFVKIVHDELTEMMGSANQQLEMTGKPPVIYLLAGLQGAGKTTTAGKL
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHH
AKFLQERHKKKVMLVSADVYRPAAIAQLEQVAGQVNAKFVNSSSDENPIDIALRAIEEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHH
IQYQDILIIDTAGRLAIDETMMDEIKALTAAVNPSETLFVVDAMTGQDAANTAKAFNDAL
HEECCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCC
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGRGEKLDALELFHPERIAQRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEEECCCCHHHHCCCCCCCHHHHCCHHHHHHHHHCHHHH
LSLVEEVEQKIDRDKAEKMAKKMQKGGEFDLEDLLTQFQQMKSMGGMAGFLDKMPGMGGS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCH
DMQKAVEDAKPEEKVREMEALINSMTPFERKNPDKINPSRKRRIAAGSGREIQDVNRLLK
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHH
QHKQMAKMMKMISKPEGISKMMKSMQGLMGGGGGAGGGGPLFGGGGQQGGVKDVNPQQMA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KQMGLDPNNMPSTEEMQKQMQELQNQAPKKFKTRF
HHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]