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The map label for this gene is dxr [H]

Identifier: 93006534

GI number: 93006534

Start: 2117367

End: 2118575

Strand: Reverse

Name: dxr [H]

Synonym: Pcryo_1710

Alternate gene names: 93006534

Gene position: 2118575-2117367 (Counterclockwise)

Preceding gene: 93006535

Following gene: 93006533

Centisome position: 69.24

GC content: 47.23

Gene sequence:

>1209_bases
ATGGTTATGACCCAACGTATCGCCGTATTAGGCGCGACAGGCTCGATTGGCGACAGTACGTTAGCCATCTTGGCGGCACA
ACCACAGCATTACGATGTTTATGCCTTATCTGGATATCACCGTTTAGATAAGCTGCTTGCGCTTTGTCAGCAGTTTGCTC
CTAAGCGGGTAGGCGTACCGACAGCTGCGGTTGATGAGTTTGCCAAGCGTCTTAGCGAGGCAGGACTTGATATCGAAGTA
GTCGGTGGCGAAACAGGCCTCGTAGATATCGCTACCGATTCACAAACTGATACTGTCGTTGCTGCTATTGTTGGCGCCGC
AGGCTTGCCTTCTACTCTAGCTGCTGCCCGTGCAGGCAAGCGTATCTTACTAGCGAACAAAGAAGCGCTGGTGATGGCAG
GGCAAGTGATGATCAATGCGGTCAAAACGCATCATGCAACTTTGCTGCCGCTTGATTCTGAACATAACGCTATCTTTCAG
TGTTTACCATTTGCCATTCAGCAGGATAATACCCAAATTCACCGACTAAATCATGGCGTGCGTAAGCTATGGCTAACCGC
TTCTGGTGGACCGTTCTTACAGCAGTCATTTACGCAGATGCAGCAAGCTAGTGTCGCTGAAGCGGTCAAACACCCAAACT
GGTCGATGGGACAAAAGATATCTGTCGATTCTGCCACGATGATGAACAAGGGGCTTGAGCTGATTGAAGCCTGTCATTTA
TTTGATTTGCCTGAAAATAAGATAAATGTGGTGATTCATCCACAAAGTATCATTCACTCAATGGTAGAATATAGCGACGG
CAGCTTTTTGGCGCAGCTTGGCAGCCCAGATATGAAAACGCCCATCGCTCATGCGCTAAGCTACCCTGACCGTATTGACA
GTGGCTCGCAGCCATTAGACTTATTTGCATTAAGTGGTTTAGAGTTTATCGAGCCTGATTTGCAAAAATTTGCCTGCTTA
CGTCTGGCACGAGAGGCGATGCAAACGGGTACTCACGCGACCATCATTCTAAATGCGGCGAATGAGATTGCAGTATCGGC
ATTTTTGAATAATCAAATTCGTCTGACGGATATTGCTGATATTAATGAGCAAGCATTGAATGAGATACAAGTGTCGGCAT
TAACTGAGACGGCTGATATTGATGAGATTTTAGCAATCGATAACCTAGCGCGTCAGCATACTGAGAAGCTGGTGGCAAGA
TTGGTTTAG

Upstream 100 bases:

>100_bases
TAATACGATCAAAATCGCTTATGTAGTTATCTGACAGAACATAAGCTTAGCTGCTCATTTAATTTTCATCTTATTACTAC
CGTATCATTTATAGGCACCC

Downstream 100 bases:

>100_bases
ATGTATCAAGTGCTATCGCCTTTATAATGATGTTAAGAGTACCTACTGAGAAAAGATCATGACGTTTCTATTAACACTCC
TTGCGGCAATATTTGTCTTA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MVMTQRIAVLGATGSIGDSTLAILAAQPQHYDVYALSGYHRLDKLLALCQQFAPKRVGVPTAAVDEFAKRLSEAGLDIEV
VGGETGLVDIATDSQTDTVVAAIVGAAGLPSTLAAARAGKRILLANKEALVMAGQVMINAVKTHHATLLPLDSEHNAIFQ
CLPFAIQQDNTQIHRLNHGVRKLWLTASGGPFLQQSFTQMQQASVAEAVKHPNWSMGQKISVDSATMMNKGLELIEACHL
FDLPENKINVVIHPQSIIHSMVEYSDGSFLAQLGSPDMKTPIAHALSYPDRIDSGSQPLDLFALSGLEFIEPDLQKFACL
RLAREAMQTGTHATIILNAANEIAVSAFLNNQIRLTDIADINEQALNEIQVSALTETADIDEILAIDNLARQHTEKLVAR
LV

Sequences:

>Translated_402_residues
MVMTQRIAVLGATGSIGDSTLAILAAQPQHYDVYALSGYHRLDKLLALCQQFAPKRVGVPTAAVDEFAKRLSEAGLDIEV
VGGETGLVDIATDSQTDTVVAAIVGAAGLPSTLAAARAGKRILLANKEALVMAGQVMINAVKTHHATLLPLDSEHNAIFQ
CLPFAIQQDNTQIHRLNHGVRKLWLTASGGPFLQQSFTQMQQASVAEAVKHPNWSMGQKISVDSATMMNKGLELIEACHL
FDLPENKINVVIHPQSIIHSMVEYSDGSFLAQLGSPDMKTPIAHALSYPDRIDSGSQPLDLFALSGLEFIEPDLQKFACL
RLAREAMQTGTHATIILNAANEIAVSAFLNNQIRLTDIADINEQALNEIQVSALTETADIDEILAIDNLARQHTEKLVAR
LV
>Mature_402_residues
MVMTQRIAVLGATGSIGDSTLAILAAQPQHYDVYALSGYHRLDKLLALCQQFAPKRVGVPTAAVDEFAKRLSEAGLDIEV
VGGETGLVDIATDSQTDTVVAAIVGAAGLPSTLAAARAGKRILLANKEALVMAGQVMINAVKTHHATLLPLDSEHNAIFQ
CLPFAIQQDNTQIHRLNHGVRKLWLTASGGPFLQQSFTQMQQASVAEAVKHPNWSMGQKISVDSATMMNKGLELIEACHL
FDLPENKINVVIHPQSIIHSMVEYSDGSFLAQLGSPDMKTPIAHALSYPDRIDSGSQPLDLFALSGLEFIEPDLQKFACL
RLAREAMQTGTHATIILNAANEIAVSAFLNNQIRLTDIADINEQALNEIQVSALTETADIDEILAIDNLARQHTEKLVAR
LV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=398, Percent_Identity=48.4924623115578, Blast_Score=353, Evalue=8e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43358; Mature: 43358

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMTQRIAVLGATGSIGDSTLAILAAQPQHYDVYALSGYHRLDKLLALCQQFAPKRVGVP
CCCEEEEEEEECCCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCC
TAAVDEFAKRLSEAGLDIEVVGGETGLVDIATDSQTDTVVAAIVGAAGLPSTLAAARAGK
HHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHCCC
RILLANKEALVMAGQVMINAVKTHHATLLPLDSEHNAIFQCLPFAIQQDNTQIHRLNHGV
EEEEECCCHHEEHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHCCC
RKLWLTASGGPFLQQSFTQMQQASVAEAVKHPNWSMGQKISVDSATMMNKGLELIEACHL
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHH
FDLPENKINVVIHPQSIIHSMVEYSDGSFLAQLGSPDMKTPIAHALSYPDRIDSGSQPLD
CCCCCCCEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCCHHCCCCCCCHH
LFALSGLEFIEPDLQKFACLRLAREAMQTGTHATIILNAANEIAVSAFLNNQIRLTDIAD
HHEECCCHHHCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCEEEEEECC
INEQALNEIQVSALTETADIDEILAIDNLARQHTEKLVARLV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVMTQRIAVLGATGSIGDSTLAILAAQPQHYDVYALSGYHRLDKLLALCQQFAPKRVGVP
CCCEEEEEEEECCCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCC
TAAVDEFAKRLSEAGLDIEVVGGETGLVDIATDSQTDTVVAAIVGAAGLPSTLAAARAGK
HHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHCCC
RILLANKEALVMAGQVMINAVKTHHATLLPLDSEHNAIFQCLPFAIQQDNTQIHRLNHGV
EEEEECCCHHEEHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHCCC
RKLWLTASGGPFLQQSFTQMQQASVAEAVKHPNWSMGQKISVDSATMMNKGLELIEACHL
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHH
FDLPENKINVVIHPQSIIHSMVEYSDGSFLAQLGSPDMKTPIAHALSYPDRIDSGSQPLD
CCCCCCCEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCCHHCCCCCCCHH
LFALSGLEFIEPDLQKFACLRLAREAMQTGTHATIILNAANEIAVSAFLNNQIRLTDIAD
HHEECCCHHHCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCEEEEEECC
INEQALNEIQVSALTETADIDEILAIDNLARQHTEKLVARLV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA