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The map label for this gene is hpd [H]

Identifier: 93006379

GI number: 93006379

Start: 1908270

End: 1909376

Strand: Reverse

Name: hpd [H]

Synonym: Pcryo_1555

Alternate gene names: 93006379

Gene position: 1909376-1908270 (Counterclockwise)

Preceding gene: 93006384

Following gene: 93006378

Centisome position: 62.4

GC content: 46.16

Gene sequence:

>1107_bases
ATGGCAGATTTATTTGACAACCCTATGGGTCTACAAGGCTTCGATTTTGTTGAGTTCGTCTCACAAGAGCCTGAGCTTGT
CGAAGAGCTGTTTCGCAACCTTGGCTTTACCCATGTCGCCAATCACCGCTCAAAAGATGTTTCCTTGTTTCGCCAAGGAG
ACATCAATCTCATATTAAACCGTGAGCCAAAAAGCCATGGCAGCTACTTTTTAGGTGAGCATGGTGCCGGCGCCTGTAGC
ATGGGTTTCCGTGTAAAAAATGCCCAGAAAGCTTATGATTTAGCGATCGAAAACGGTGCTGAACCAGTCGATGTGAAAAC
AGGGGTGATGGAGTTACGTCTGCCAGCGATCAAAGGTATCGGCGGCTCGCTCATTTATCTTATCGACCGCTTTACCGCTG
GTAACTCTATTTATGACATCGACTTTGAATATCTGCCTGATGTTGATAAGCATCCAAAAGGCTTTGGCTTCAAAGTCATC
GACCATCTAACGCATAACGTCTACCGTGGTCGCATGGCTTACTGGGCTGACTTCTACGAGCGTATCTTTAACTTCCGCGA
AATCCGTTATTTCGATATCAAAGGTGAATACACTGGCTTGACCAGTAAAGCGATGACTGCACCTGATGGCAAAATTCGTA
TCCCATTGAACGAAGAGTCAAAGCAGGGCGGCGGTCAAATCGAAGAGTACTTGATGCAATTTAATGGCGAAGGTATCCAG
CATATCGCGCTATTGAGTGATGATTTATTGTCTAGCATCGACAAATTGCGAGAGATGGGTATTCCACTCATGACGGCACC
AAATGATACTTATTATAAGATGCTTGATGAGCGTCTACCAGGTCATGGCGAGAATATCTCTGAGCTACAGATGCGCGGTA
TCTTGTTAGATGGCACGACGGAGGGCGATGTTCCGCGTCTGCTACTACAGATTTTCTCTGAAACCATCTTAGGCAGCCCA
GTATTCTTTGAGTTTATCCAGCGCAAAGGTGATTACGAAGAAGGCTTCGGCGAAGGTAACTTTAAAGCATTGTTTGAATC
AATCGAGCGCGATCAAGTACGCCGTGGCATGGTTGGTCAGACAGAGATAGAGACAGAAGCGCCATAA

Upstream 100 bases:

>100_bases
ATCTAATATAAATGAATCGTCAATAGGAATGATTGATGAAACTTATTTTTTGCTAATTTTTAGCGCTTTATACCACCAAT
TGCAATTAAGGATGATGACA

Downstream 100 bases:

>100_bases
TTTTCAGAGATTTCTTAAGAGTGCCTTTAAAAAAGCACTTTTAAACAAGTATCAAAAGGGCAAGATGAAAGGGGTTTATC
TTGTCCTTATTACCTTTGTT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MADLFDNPMGLQGFDFVEFVSQEPELVEELFRNLGFTHVANHRSKDVSLFRQGDINLILNREPKSHGSYFLGEHGAGACS
MGFRVKNAQKAYDLAIENGAEPVDVKTGVMELRLPAIKGIGGSLIYLIDRFTAGNSIYDIDFEYLPDVDKHPKGFGFKVI
DHLTHNVYRGRMAYWADFYERIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESKQGGGQIEEYLMQFNGEGIQ
HIALLSDDLLSSIDKLREMGIPLMTAPNDTYYKMLDERLPGHGENISELQMRGILLDGTTEGDVPRLLLQIFSETILGSP
VFFEFIQRKGDYEEGFGEGNFKALFESIERDQVRRGMVGQTEIETEAP

Sequences:

>Translated_368_residues
MADLFDNPMGLQGFDFVEFVSQEPELVEELFRNLGFTHVANHRSKDVSLFRQGDINLILNREPKSHGSYFLGEHGAGACS
MGFRVKNAQKAYDLAIENGAEPVDVKTGVMELRLPAIKGIGGSLIYLIDRFTAGNSIYDIDFEYLPDVDKHPKGFGFKVI
DHLTHNVYRGRMAYWADFYERIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESKQGGGQIEEYLMQFNGEGIQ
HIALLSDDLLSSIDKLREMGIPLMTAPNDTYYKMLDERLPGHGENISELQMRGILLDGTTEGDVPRLLLQIFSETILGSP
VFFEFIQRKGDYEEGFGEGNFKALFESIERDQVRRGMVGQTEIETEAP
>Mature_367_residues
ADLFDNPMGLQGFDFVEFVSQEPELVEELFRNLGFTHVANHRSKDVSLFRQGDINLILNREPKSHGSYFLGEHGAGACSM
GFRVKNAQKAYDLAIENGAEPVDVKTGVMELRLPAIKGIGGSLIYLIDRFTAGNSIYDIDFEYLPDVDKHPKGFGFKVID
HLTHNVYRGRMAYWADFYERIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESKQGGGQIEEYLMQFNGEGIQH
IALLSDDLLSSIDKLREMGIPLMTAPNDTYYKMLDERLPGHGENISELQMRGILLDGTTEGDVPRLLLQIFSETILGSPV
FFEFIQRKGDYEEGFGEGNFKALFESIERDQVRRGMVGQTEIETEAP

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=340, Percent_Identity=29.1176470588235, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4504477, Length=340, Percent_Identity=29.1176470588235, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI14249394, Length=131, Percent_Identity=32.0610687022901, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17555220, Length=226, Percent_Identity=37.1681415929204, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550752, Length=307, Percent_Identity=28.9902280130293, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24667510, Length=312, Percent_Identity=32.3717948717949, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356105, Length=304, Percent_Identity=32.5657894736842, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41643; Mature: 41512

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLFDNPMGLQGFDFVEFVSQEPELVEELFRNLGFTHVANHRSKDVSLFRQGDINLILN
CCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHCCCCCCHHEEECCCEEEEEE
REPKSHGSYFLGEHGAGACSMGFRVKNAQKAYDLAIENGAEPVDVKTGVMELRLPAIKGI
CCCCCCCCEEEECCCCCCEECCEEECCCHHHHHHHHHCCCCCCCHHHCHHHEECHHHHCC
GGSLIYLIDRFTAGNSIYDIDFEYLPDVDKHPKGFGFKVIDHLTHNVYRGRMAYWADFYE
CCCEEEEEEHHCCCCEEEEECHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESKQGGGQIEEYLMQFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCE
HIALLSDDLLSSIDKLREMGIPLMTAPNDTYYKMLDERLPGHGENISELQMRGILLDGTT
EHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHCEEEEECCC
EGDVPRLLLQIFSETILGSPVFFEFIQRKGDYEEGFGEGNFKALFESIERDQVRRGMVGQ
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
TEIETEAP
CCCCCCCC
>Mature Secondary Structure 
ADLFDNPMGLQGFDFVEFVSQEPELVEELFRNLGFTHVANHRSKDVSLFRQGDINLILN
CCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHCCCCCCHHEEECCCEEEEEE
REPKSHGSYFLGEHGAGACSMGFRVKNAQKAYDLAIENGAEPVDVKTGVMELRLPAIKGI
CCCCCCCCEEEECCCCCCEECCEEECCCHHHHHHHHHCCCCCCCHHHCHHHEECHHHHCC
GGSLIYLIDRFTAGNSIYDIDFEYLPDVDKHPKGFGFKVIDHLTHNVYRGRMAYWADFYE
CCCEEEEEEHHCCCCEEEEECHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESKQGGGQIEEYLMQFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCE
HIALLSDDLLSSIDKLREMGIPLMTAPNDTYYKMLDERLPGHGENISELQMRGILLDGTT
EHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHCEEEEECCC
EGDVPRLLLQIFSETILGSPVFFEFIQRKGDYEEGFGEGNFKALFESIERDQVRRGMVGQ
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
TEIETEAP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]