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The map label for this gene is phhA [H]

Identifier: 93006378

GI number: 93006378

Start: 1907190

End: 1908065

Strand: Reverse

Name: phhA [H]

Synonym: Pcryo_1554

Alternate gene names: 93006378

Gene position: 1908065-1907190 (Counterclockwise)

Preceding gene: 93006379

Following gene: 93006377

Centisome position: 62.36

GC content: 44.29

Gene sequence:

>876_bases
ATGGAAAGCCGTCACCAGACAACTGCGTACATAAAGCCTCTCAGTAGCAATTCGTTAAGCACTGAAGCTTCTACTCATCA
TTTAACTCAGAAGAAGCAACCTTACGTATCGCGCCAGCCAGATAATCATGGTCATATTCATTATAGTGACGATGAAAACG
CGATGTGGCAAGCACTGCTTGAACGTCAAGCCAAGCAAATACCCAATCGTGCCAGTTCAGCCTATCTTGAGGGTTTAGAG
AAACTCAAGCTACCAGCAACGCATATTCCGCAACTACAAGATATTGATGAAGTATTGCAAGCCAGTACTGGTTGGCAAAC
CGCTGCTGTACCGGCGTTAATCAGCTTCGGTAAATTCTTCAAACTCTTAGCTGATAAACGCTTTCCGGTTGCGACCTTTA
TCCGCCGCTTTGATGATATGGACTATATCGAAGAGCCAGATATTTTTCATGAAATCGTCGGGCATTGTCCGCTGCTGACC
CATCCTGCTTTTGCAACTTTTAATGAGACTTATGGCAAGCTTGGTCTCAATGCGACTAAGCAAGAGCGTCTTTATTTAGC
ACGCCTGTATTGGTTCACCATCGAATTTGGTCTAATGGGCGCGACCAAAGAAACCCGCAAGATTTATGGTGGCGGCATTT
TAAGCTCACCGTCTGAAACCATCTATGCCCTAAGCGATGATCCGGACTGTCGTGCGTTTGATTTGATTGACGTATTGCGC
ACGCCTTACCGTATTGATCAAATTCAGCCTATCTATTATGCAATTGACGATTTGGATACGTTATTTGATATCGTGAATAG
CGACATTATGGGCGCTGTAAAAAAGGCGATGAGCTTAGGATTGTTTGAGCCAACATATGCTATTAAGACGGCTTAA

Upstream 100 bases:

>100_bases
GGCTATTAATAATAAACGTTAAAAGCGAGGCAGACAAAGTGAATAAAGCAAATGACTGATACCAAGGTATTGGACTCATT
GCAATATAAGGAAACTAGGC

Downstream 100 bases:

>100_bases
TAGATAGTGCATTTTTTATAAGTAGTAAAAGAACCAACGTCAACACGGACGTACATTCATTAAAAAACCAATAGTTAATA
TAAAAGGATATTATCATGAC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MESRHQTTAYIKPLSSNSLSTEASTHHLTQKKQPYVSRQPDNHGHIHYSDDENAMWQALLERQAKQIPNRASSAYLEGLE
KLKLPATHIPQLQDIDEVLQASTGWQTAAVPALISFGKFFKLLADKRFPVATFIRRFDDMDYIEEPDIFHEIVGHCPLLT
HPAFATFNETYGKLGLNATKQERLYLARLYWFTIEFGLMGATKETRKIYGGGILSSPSETIYALSDDPDCRAFDLIDVLR
TPYRIDQIQPIYYAIDDLDTLFDIVNSDIMGAVKKAMSLGLFEPTYAIKTA

Sequences:

>Translated_291_residues
MESRHQTTAYIKPLSSNSLSTEASTHHLTQKKQPYVSRQPDNHGHIHYSDDENAMWQALLERQAKQIPNRASSAYLEGLE
KLKLPATHIPQLQDIDEVLQASTGWQTAAVPALISFGKFFKLLADKRFPVATFIRRFDDMDYIEEPDIFHEIVGHCPLLT
HPAFATFNETYGKLGLNATKQERLYLARLYWFTIEFGLMGATKETRKIYGGGILSSPSETIYALSDDPDCRAFDLIDVLR
TPYRIDQIQPIYYAIDDLDTLFDIVNSDIMGAVKKAMSLGLFEPTYAIKTA
>Mature_291_residues
MESRHQTTAYIKPLSSNSLSTEASTHHLTQKKQPYVSRQPDNHGHIHYSDDENAMWQALLERQAKQIPNRASSAYLEGLE
KLKLPATHIPQLQDIDEVLQASTGWQTAAVPALISFGKFFKLLADKRFPVATFIRRFDDMDYIEEPDIFHEIVGHCPLLT
HPAFATFNETYGKLGLNATKQERLYLARLYWFTIEFGLMGATKETRKIYGGGILSSPSETIYALSDDPDCRAFDLIDVLR
TPYRIDQIQPIYYAIDDLDTLFDIVNSDIMGAVKKAMSLGLFEPTYAIKTA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=234, Percent_Identity=32.4786324786325, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI88900505, Length=234, Percent_Identity=32.4786324786325, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI88900501, Length=234, Percent_Identity=32.4786324786325, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4759248, Length=240, Percent_Identity=30, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4557819, Length=218, Percent_Identity=32.5688073394495, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI31795563, Length=219, Percent_Identity=31.9634703196347, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980736, Length=222, Percent_Identity=30.6306306306306, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=212, Percent_Identity=37.2641509433962, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI115532103, Length=222, Percent_Identity=30.6306306306306, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI115533973, Length=223, Percent_Identity=30.9417040358744, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=29.0322580645161, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136774, Length=218, Percent_Identity=33.4862385321101, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136776, Length=222, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24660393, Length=220, Percent_Identity=32.7272727272727, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI62472054, Length=220, Percent_Identity=32.7272727272727, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24654994, Length=172, Percent_Identity=36.046511627907, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33012; Mature: 33012

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESRHQTTAYIKPLSSNSLSTEASTHHLTQKKQPYVSRQPDNHGHIHYSDDENAMWQALL
CCCCCCCHHEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHHHHHH
ERQAKQIPNRASSAYLEGLEKLKLPATHIPQLQDIDEVLQASTGWQTAAVPALISFGKFF
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
KLLADKRFPVATFIRRFDDMDYIEEPDIFHEIVGHCPLLTHPAFATFNETYGKLGLNATK
HHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCH
QERLYLARLYWFTIEFGLMGATKETRKIYGGGILSSPSETIYALSDDPDCRAFDLIDVLR
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
TPYRIDQIQPIYYAIDDLDTLFDIVNSDIMGAVKKAMSLGLFEPTYAIKTA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MESRHQTTAYIKPLSSNSLSTEASTHHLTQKKQPYVSRQPDNHGHIHYSDDENAMWQALL
CCCCCCCHHEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHHHHHH
ERQAKQIPNRASSAYLEGLEKLKLPATHIPQLQDIDEVLQASTGWQTAAVPALISFGKFF
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
KLLADKRFPVATFIRRFDDMDYIEEPDIFHEIVGHCPLLTHPAFATFNETYGKLGLNATK
HHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCH
QERLYLARLYWFTIEFGLMGATKETRKIYGGGILSSPSETIYALSDDPDCRAFDLIDVLR
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
TPYRIDQIQPIYYAIDDLDTLFDIVNSDIMGAVKKAMSLGLFEPTYAIKTA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]