Click here to switch to the map view.

The map label for this gene is crt [H]

Identifier: 93006341

GI number: 93006341

Start: 1862302

End: 1863084

Strand: Reverse

Name: crt [H]

Synonym: Pcryo_1515

Alternate gene names: 93006341

Gene position: 1863084-1862302 (Counterclockwise)

Preceding gene: 93006342

Following gene: 93006340

Centisome position: 60.89

GC content: 46.49

Gene sequence:

>783_bases
ATGACGGATTATACCAACTTAAAACTATCGATTGATGGTCATACTGCGACATTAACCCTAAACAACCCACCTGCTCATAC
ATGGACGATGGACAGTCTTAAGGCGCTTAAGCAACTGGTCACTGATCTCAATGCCAATGATGAGGTATATGCACTAATCG
TTCATGGTGATGGTGATAAATTCTTTTCAGCGGGCGCCGATCTAAATAATTTTGCAGATGGTGATAAAGGTCGCGCAATC
AGTATGGCGATAGCGTTTGGTGAAGCATTTGAAGCACTGTCAGCCTATCGCGGCGTTAGCATTGCAGTGATCAATGGCTA
TGCGATGGGCGGCGGTCTTGAGTGTGCGCTTGCTTGTGATATCCGTATCGCAGAAGATCATGCTCAAATGGCGCTACCTG
AGACAGGCGTTGGCTTGTTGCCGTGTGCCGGTGGTACACAAAATCTAACGGCTTTGGTAGGCGAAGGGTGGGCAAAGCGT
ATGATATTATGCGGTGAGCGCGTCGATGCCGAGACTGCGCTACGCATTGGCTTAGTCGAAGAAGTTGCTGCGAAAGGTGA
AGGATTACAAACAGCACAAGCATTGGCGCAAAAAGCTGCTAAACAATCACCAGTTGCAGTCAGTTATTCCAAAAAACTTA
TTCAAGCAGCAAGACACACACCACCTGCGCAAAACCTTATCCATGAGCGTGAAGCCTTTGTTAAATTGTTCGATACTGAA
GATCAGCGCGAAGGTGTGCAAGCATTTTTAGAGAAGCGTAAGCCTGTTTGGCAAAATAAATAA

Upstream 100 bases:

>100_bases
CGTGATTGTCTCGCGTCAGCTATTACAAGACGATGCATTGAGCCAACTGCGCTAACCTATTTATATGAATAAAATGATTT
TATGATAAGGATGTTTGATC

Downstream 100 bases:

>100_bases
ACGCCATAGAATCAAACTTAATGATACTATTTTTCTTTTAATATTTGTAGGTCACATTTATGACAGCAGCTATAGAAGGC
ACACTAGAGGCGCCGGTATT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTDYTNLKLSIDGHTATLTLNNPPAHTWTMDSLKALKQLVTDLNANDEVYALIVHGDGDKFFSAGADLNNFADGDKGRAI
SMAIAFGEAFEALSAYRGVSIAVINGYAMGGGLECALACDIRIAEDHAQMALPETGVGLLPCAGGTQNLTALVGEGWAKR
MILCGERVDAETALRIGLVEEVAAKGEGLQTAQALAQKAAKQSPVAVSYSKKLIQAARHTPPAQNLIHEREAFVKLFDTE
DQREGVQAFLEKRKPVWQNK

Sequences:

>Translated_260_residues
MTDYTNLKLSIDGHTATLTLNNPPAHTWTMDSLKALKQLVTDLNANDEVYALIVHGDGDKFFSAGADLNNFADGDKGRAI
SMAIAFGEAFEALSAYRGVSIAVINGYAMGGGLECALACDIRIAEDHAQMALPETGVGLLPCAGGTQNLTALVGEGWAKR
MILCGERVDAETALRIGLVEEVAAKGEGLQTAQALAQKAAKQSPVAVSYSKKLIQAARHTPPAQNLIHEREAFVKLFDTE
DQREGVQAFLEKRKPVWQNK
>Mature_259_residues
TDYTNLKLSIDGHTATLTLNNPPAHTWTMDSLKALKQLVTDLNANDEVYALIVHGDGDKFFSAGADLNNFADGDKGRAIS
MAIAFGEAFEALSAYRGVSIAVINGYAMGGGLECALACDIRIAEDHAQMALPETGVGLLPCAGGTQNLTALVGEGWAKRM
ILCGERVDAETALRIGLVEEVAAKGEGLQTAQALAQKAAKQSPVAVSYSKKLIQAARHTPPAQNLIHEREAFVKLFDTED
QREGVQAFLEKRKPVWQNK

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=244, Percent_Identity=34.8360655737705, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI68989263, Length=216, Percent_Identity=31.9444444444444, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502327, Length=239, Percent_Identity=30.1255230125523, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI31542718, Length=248, Percent_Identity=29.0322580645161, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI20127408, Length=215, Percent_Identity=28.8372093023256, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI157694516, Length=227, Percent_Identity=27.7533039647577, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI213417737, Length=227, Percent_Identity=27.7533039647577, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI157694520, Length=198, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI150378541, Length=258, Percent_Identity=29.8449612403101, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI37594471, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI37594469, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI62530384, Length=246, Percent_Identity=24.7967479674797, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI261878539, Length=109, Percent_Identity=40.3669724770642, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI70995211, Length=267, Percent_Identity=26.9662921348315, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787659, Length=258, Percent_Identity=36.8217054263566, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI221142681, Length=259, Percent_Identity=32.046332046332, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1788682, Length=216, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790281, Length=100, Percent_Identity=40, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082183, Length=223, Percent_Identity=25.5605381165919, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787660, Length=249, Percent_Identity=30.5220883534137, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=25.8964143426295, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=259, Percent_Identity=35.1351351351351, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=33.0708661417323, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17540714, Length=230, Percent_Identity=28.695652173913, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17536985, Length=268, Percent_Identity=25, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=175, Percent_Identity=31.4285714285714, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=237, Percent_Identity=27.4261603375527, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25144157, Length=184, Percent_Identity=27.7173913043478, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144160, Length=184, Percent_Identity=27.7173913043478, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144276, Length=161, Percent_Identity=33.5403726708075, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=225, Percent_Identity=27.5555555555556, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=161, Percent_Identity=33.5403726708075, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=161, Percent_Identity=33.5403726708075, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20129971, Length=263, Percent_Identity=33.4600760456274, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24653477, Length=263, Percent_Identity=33.4600760456274, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24653139, Length=260, Percent_Identity=30, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583165, Length=251, Percent_Identity=25.4980079681275, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550169, Length=247, Percent_Identity=27.9352226720648, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921018, Length=256, Percent_Identity=25, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24650670, Length=243, Percent_Identity=27.9835390946502, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357171, Length=256, Percent_Identity=26.953125, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922422, Length=247, Percent_Identity=21.4574898785425, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 27853; Mature: 27722

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYTNLKLSIDGHTATLTLNNPPAHTWTMDSLKALKQLVTDLNANDEVYALIVHGDGDK
CCCCEEEEEEECCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
FFSAGADLNNFADGDKGRAISMAIAFGEAFEALSAYRGVSIAVINGYAMGGGLECALACD
EEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEEEE
IRIAEDHAQMALPETGVGLLPCAGGTQNLTALVGEGWAKRMILCGERVDAETALRIGLVE
EEEECCHHHHCCCCCCCEEEECCCCCCCHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHH
EVAAKGEGLQTAQALAQKAAKQSPVAVSYSKKLIQAARHTPPAQNLIHEREAFVKLFDTE
HHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCC
DQREGVQAFLEKRKPVWQNK
CHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDYTNLKLSIDGHTATLTLNNPPAHTWTMDSLKALKQLVTDLNANDEVYALIVHGDGDK
CCCEEEEEEECCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
FFSAGADLNNFADGDKGRAISMAIAFGEAFEALSAYRGVSIAVINGYAMGGGLECALACD
EEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEEEE
IRIAEDHAQMALPETGVGLLPCAGGTQNLTALVGEGWAKRMILCGERVDAETALRIGLVE
EEEECCHHHHCCCCCCCEEEECCCCCCCHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHH
EVAAKGEGLQTAQALAQKAAKQSPVAVSYSKKLIQAARHTPPAQNLIHEREAFVKLFDTE
HHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCC
DQREGVQAFLEKRKPVWQNK
CHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]