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The map label for this gene is lpxB [H]

Identifier: 93006332

GI number: 93006332

Start: 1850251

End: 1851561

Strand: Reverse

Name: lpxB [H]

Synonym: Pcryo_1506

Alternate gene names: 93006332

Gene position: 1851561-1850251 (Counterclockwise)

Preceding gene: 93006334

Following gene: 93006331

Centisome position: 60.51

GC content: 47.52

Gene sequence:

>1311_bases
ATGACCGATAACCATACGCTTCAGCCTGATTTAACTGTACCATTTGATACTTACGAGATCGCTAATGTAGCGCGTGAGCC
GCTCGTTATCGGTATCGTCGCTGGTGAAGTATCAGGAGACAGTCTGGGTGCAGACTTCATGCAGCAGATGAACAATCTAC
GTGATGACATCGTTTGGGTTGGAGTAGGCGGTACCAAAATGCAGGCACAAGGGCTTAATAGTATTTTTCCATTGTCTCGT
TTGGCAGTGATGGGTCTGGTAGAAGTCATAGGACAGTTGTCTGATTTGCTTAGGGCGCGTCGTGAGTTGCTGGCTGCTTT
TAAAAAGGCGGATATTGATTGGTTTATTGGCATAGATGCCCCTGATTTTAATCTACGAGTCTCTAAAAAATTAAAGCCTA
AAGGCGTGTTTTGCGTGCAGTATGTTAGTCCTTCTATCTGGGCTTGGCGCGAGTCACGTATTCATAATATTAAAGCGGCA
ACCCACTTGGTATTGTGCCTGTTTCCGTTTGAGCTGCCTGTTTACGAGCGTTATAAGCATCCGGCGATATGCGTTGGGCA
TCCACTGATGCATACCATTGACCAGTCACTGCTCGACATACCAATCAATCAGCGCCGTAGTGAGCTGGTCTGGCACAACG
ATGGCTTACAGCAGTTTTTTATCGAACGCTTTGATGAAGTCAGTCAGCTTATTTGTGTGATGCCGGGCTCACGCCGCGGT
GAAATAACGGCTATTTTACCCTTGATGCTAGACGGTATCCAAAAGCTGCTTTTATTGGACCCAAAGCTTTGCTTTATCAT
CCCAACTGTCGATCAAAACCATCAGTATATCGTCCAAGACGTGATTGATCAGCGCTCAGAGCAGCTGCGTGCCGCCATCG
TGGTGGTCTATGATGATAGCCAGCCAACCTTTAGTCAGCAGGCGATGGCGGCATCAGATATTGTGATGTTAGCCTCAGGT
ACCGCAACGCTTGAGGCGATGCTACTTGAGCGTCCGATGGTCGTCGTCTATCAGCTGAATCAGCTAACCTATCAGATTGC
TAAACGTCTGGTCAAAGTGCCCTATGTGGGTTTGCCAAATATTTTGGCAGCTACCGCGATCGTACCGGAGCTTATTCAAG
AGCAAGCAAGTGGTGACAATATCTGCCGTACCGTCATGCGCCTTTTGCAGCCACGTGCTTATGCGGAGCAATTGAATGCG
CTGATTCAGACCAAGCATCTTTTGCAACAGCAAAGCAATCATCAACCTGCCAATAGCGTGATTGAACAATGGTATCTGCA
AAATTATCCGTCGAAAACGCCGCAGATCTAG

Upstream 100 bases:

>100_bases
TGCGTATCCTATAATAGATACCCCATGTTATATTTTATAATATCCATGTTTTCTCCCTTGTACGACTTTCACTGTTACAC
TTTATTATTAAGAGCTTGTC

Downstream 100 bases:

>100_bases
TAAGAAAATTCATTACATACCTTTTCATTTCATAAAATAAGACAATAAAATTAATGAATAGCATGCTACATATAGAGAGT
AATCTTTTACAGATTGAACG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTDNHTLQPDLTVPFDTYEIANVAREPLVIGIVAGEVSGDSLGADFMQQMNNLRDDIVWVGVGGTKMQAQGLNSIFPLSR
LAVMGLVEVIGQLSDLLRARRELLAAFKKADIDWFIGIDAPDFNLRVSKKLKPKGVFCVQYVSPSIWAWRESRIHNIKAA
THLVLCLFPFELPVYERYKHPAICVGHPLMHTIDQSLLDIPINQRRSELVWHNDGLQQFFIERFDEVSQLICVMPGSRRG
EITAILPLMLDGIQKLLLLDPKLCFIIPTVDQNHQYIVQDVIDQRSEQLRAAIVVVYDDSQPTFSQQAMAASDIVMLASG
TATLEAMLLERPMVVVYQLNQLTYQIAKRLVKVPYVGLPNILAATAIVPELIQEQASGDNICRTVMRLLQPRAYAEQLNA
LIQTKHLLQQQSNHQPANSVIEQWYLQNYPSKTPQI

Sequences:

>Translated_436_residues
MTDNHTLQPDLTVPFDTYEIANVAREPLVIGIVAGEVSGDSLGADFMQQMNNLRDDIVWVGVGGTKMQAQGLNSIFPLSR
LAVMGLVEVIGQLSDLLRARRELLAAFKKADIDWFIGIDAPDFNLRVSKKLKPKGVFCVQYVSPSIWAWRESRIHNIKAA
THLVLCLFPFELPVYERYKHPAICVGHPLMHTIDQSLLDIPINQRRSELVWHNDGLQQFFIERFDEVSQLICVMPGSRRG
EITAILPLMLDGIQKLLLLDPKLCFIIPTVDQNHQYIVQDVIDQRSEQLRAAIVVVYDDSQPTFSQQAMAASDIVMLASG
TATLEAMLLERPMVVVYQLNQLTYQIAKRLVKVPYVGLPNILAATAIVPELIQEQASGDNICRTVMRLLQPRAYAEQLNA
LIQTKHLLQQQSNHQPANSVIEQWYLQNYPSKTPQI
>Mature_435_residues
TDNHTLQPDLTVPFDTYEIANVAREPLVIGIVAGEVSGDSLGADFMQQMNNLRDDIVWVGVGGTKMQAQGLNSIFPLSRL
AVMGLVEVIGQLSDLLRARRELLAAFKKADIDWFIGIDAPDFNLRVSKKLKPKGVFCVQYVSPSIWAWRESRIHNIKAAT
HLVLCLFPFELPVYERYKHPAICVGHPLMHTIDQSLLDIPINQRRSELVWHNDGLQQFFIERFDEVSQLICVMPGSRRGE
ITAILPLMLDGIQKLLLLDPKLCFIIPTVDQNHQYIVQDVIDQRSEQLRAAIVVVYDDSQPTFSQQAMAASDIVMLASGT
ATLEAMLLERPMVVVYQLNQLTYQIAKRLVKVPYVGLPNILAATAIVPELIQEQASGDNICRTVMRLLQPRAYAEQLNAL
IQTKHLLQQQSNHQPANSVIEQWYLQNYPSKTPQI

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=349, Percent_Identity=37.8223495702006, Blast_Score=228, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 49154; Mature: 49023

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNHTLQPDLTVPFDTYEIANVAREPLVIGIVAGEVSGDSLGADFMQQMNNLRDDIVWV
CCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEE
GVGGTKMQAQGLNSIFPLSRLAVMGLVEVIGQLSDLLRARRELLAAFKKADIDWFIGIDA
ECCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
PDFNLRVSKKLKPKGVFCVQYVSPSIWAWRESRIHNIKAATHLVLCLFPFELPVYERYKH
CCCCEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
PAICVGHPLMHTIDQSLLDIPINQRRSELVWHNDGLQQFFIERFDEVSQLICVMPGSRRG
CEEEECCHHHHHHHHHHHCCCCCCCCCHHEEECCCHHHHHHHHHHHHHHEEEECCCCCCC
EITAILPLMLDGIQKLLLLDPKLCFIIPTVDQNHQYIVQDVIDQRSEQLRAAIVVVYDDS
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEEEEECCC
QPTFSQQAMAASDIVMLASGTATLEAMLLERPMVVVYQLNQLTYQIAKRLVKVPYVGLPN
CCCHHHHHHHHHCEEEEECCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCH
ILAATAIVPELIQEQASGDNICRTVMRLLQPRAYAEQLNALIQTKHLLQQQSNHQPANSV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IEQWYLQNYPSKTPQI
HHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TDNHTLQPDLTVPFDTYEIANVAREPLVIGIVAGEVSGDSLGADFMQQMNNLRDDIVWV
CCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEE
GVGGTKMQAQGLNSIFPLSRLAVMGLVEVIGQLSDLLRARRELLAAFKKADIDWFIGIDA
ECCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
PDFNLRVSKKLKPKGVFCVQYVSPSIWAWRESRIHNIKAATHLVLCLFPFELPVYERYKH
CCCCEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
PAICVGHPLMHTIDQSLLDIPINQRRSELVWHNDGLQQFFIERFDEVSQLICVMPGSRRG
CEEEECCHHHHHHHHHHHCCCCCCCCCHHEEECCCHHHHHHHHHHHHHHEEEECCCCCCC
EITAILPLMLDGIQKLLLLDPKLCFIIPTVDQNHQYIVQDVIDQRSEQLRAAIVVVYDDS
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEEEEECCC
QPTFSQQAMAASDIVMLASGTATLEAMLLERPMVVVYQLNQLTYQIAKRLVKVPYVGLPN
CCCHHHHHHHHHCEEEEECCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCH
ILAATAIVPELIQEQASGDNICRTVMRLLQPRAYAEQLNALIQTKHLLQQQSNHQPANSV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IEQWYLQNYPSKTPQI
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA