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The map label for this gene is mutL [H]

Identifier: 93006321

GI number: 93006321

Start: 1838534

End: 1840276

Strand: Reverse

Name: mutL [H]

Synonym: Pcryo_1495

Alternate gene names: 93006321

Gene position: 1840276-1838534 (Counterclockwise)

Preceding gene: 93006322

Following gene: 93006320

Centisome position: 60.14

GC content: 42.28

Gene sequence:

>1743_bases
ATGCTACATAGCCACACCAATACACGCATTAAAAAACTATCACCGCTGCTTATTAATCAATTAGCGGCGGGTGAAGTCGT
GACGCGTCCAGCAGCGGTGGTTAAAGAGCTCCTCGAGAATGCAATTGATGCTCATGCCACAGATATCGAGGTCCGCATTA
CCCAAGGTGGCATGGGTATGATTGAGGTGATTGATAATGGCGTTGGGATTCATCCTGATGATATGGTCATGGCAGTCACG
CGTCATGCCACTAGCAAAGTCGCTGATGTGGCACACTTGCATGGTATTACAACGTTGGGTTTTCGCGGGGAAGCACTGGC
AGCGACGGCTGCTGTTTCCCGTTTGACCTTAACCAGTAGTCATAATGACAGCGGTATTGGTCGTCAGTTGCAAGTTGCCG
GTATATTGGGCGATACGCCAAAATTAATACCCGTTGTGCATCATCGCGGTACTACTATTACAGTCAAAGATTTATATTTC
AACGTACCAGCACGCCGCGGTAATTTGAAATCTATCGCGACTGAGTTCAGTCATATCGAAACGATTGTCCGTGAAGTGGC
TTTAGCACGCGCTGATGTGGCGCTGACGCTTTTTCATGATAATAAAAAACGGCTATCACTATCGGTAAACACTATAAATA
AAGTTACTGAAAAGTATCTGCCGTTATCACGTTTGGAACAAGCGACTGGATTGGCACTTGCAGAGCAGGCAATTGAAATC
GCGGTTGATTTATCTAGCCTAACGCAGCAATTTGGAAGTTCTTCTGCTACTAATGCTAATGGTGAATATGCTGATAATGT
ACGCACTATGCAAGCGGCGAGTATTGGCGGTTGGTTGTGGGCAAGTTATGATGCCAACCATAGTTTACCAAAGCTCATTT
ATGTAAATGGCAGATTGGTAAAAGAGGCATTAATTAGCAATCAGCTTCGTCAAATGGTTCAAAGTGTACAGCTAGCAGGT
ATGGGTTATGCGCTTTATTTTGAGTTACCAACTCAGTGGCTCAATGTTAATGTTCATCCTTCCAAGCAGCGTATCAAGAT
TAGCCCACTGAACAATATCATGGCGCATTTAAGTCATGCGATTCGTGCGAAGTTAAGAGGGCTTAATACCGCGAAAATTG
TTCGCTCTAAAGAGCGAGCACCAAATGATAATATCTCCACAAGAAAGTCGTTTAATGCGTTAGACGCAATAGCATCATAT
ACCAACAATGCAACGGCAAGTCAGCAAGTTCAAGCTCCTAAGCAACCATATCAGCTGTCAGAAAATGAGTCGTTATTCGA
AAGTATTAAAGACTTACATATTGATGAGCCTGTAGAAGACAGTCGTCATGCTGTTAACAGTTACCCTGTAAACACACCAC
CTTTACCAGTTTGCTTACAAGTTATAGATAGTGTCACTGGTCTGGTAGCTTCTTCAGTTATATATAGCAATGACGATAAA
GCGCTGCCTTGGTTGCTATTTTATTATCAAGGACAGTGTGCGCTAATTAGTGCTGAGAGATGGCAGTCAAGATTAAAAGT
ATTGTTTGAGTCAAGTGTCTTTAGCAGCACTATGTATGACAAAGCCAAAGAATTAAATAGCACTACTATTAATCAGCAAT
TGGCGAAGATAATCAAGCAGATGTCATCACAAGATGTACAAGCTTTTGTATCAGATATGGAAGCTATACTGAGCAAATAT
GCTATCCACTCTATAGATAGTCATCAATTAGTCACATTGATGTTATCATCTGCGCTTAAATAG

Upstream 100 bases:

>100_bases
GTTTTGACTTATCCAGTCTAAATCTTTAGTCCAAATCGTGCTACAGATGTTTAAAGGCTTAAAATCCGCCTCTATTATTT
TCAATATATGATACCCATCA

Downstream 100 bases:

>100_bases
CGCTATTGTGAAAATAACGTATTTTCTATAGTTAGGACATATCGCTGAGCTATCAATAATTTACCTTATTGTTCTTAAAA
CCATGACCATCAAAGGCAAG

Product: ATP-binding region, ATPase-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MLHSHTNTRIKKLSPLLINQLAAGEVVTRPAAVVKELLENAIDAHATDIEVRITQGGMGMIEVIDNGVGIHPDDMVMAVT
RHATSKVADVAHLHGITTLGFRGEALAATAAVSRLTLTSSHNDSGIGRQLQVAGILGDTPKLIPVVHHRGTTITVKDLYF
NVPARRGNLKSIATEFSHIETIVREVALARADVALTLFHDNKKRLSLSVNTINKVTEKYLPLSRLEQATGLALAEQAIEI
AVDLSSLTQQFGSSSATNANGEYADNVRTMQAASIGGWLWASYDANHSLPKLIYVNGRLVKEALISNQLRQMVQSVQLAG
MGYALYFELPTQWLNVNVHPSKQRIKISPLNNIMAHLSHAIRAKLRGLNTAKIVRSKERAPNDNISTRKSFNALDAIASY
TNNATASQQVQAPKQPYQLSENESLFESIKDLHIDEPVEDSRHAVNSYPVNTPPLPVCLQVIDSVTGLVASSVIYSNDDK
ALPWLLFYYQGQCALISAERWQSRLKVLFESSVFSSTMYDKAKELNSTTINQQLAKIIKQMSSQDVQAFVSDMEAILSKY
AIHSIDSHQLVTLMLSSALK

Sequences:

>Translated_580_residues
MLHSHTNTRIKKLSPLLINQLAAGEVVTRPAAVVKELLENAIDAHATDIEVRITQGGMGMIEVIDNGVGIHPDDMVMAVT
RHATSKVADVAHLHGITTLGFRGEALAATAAVSRLTLTSSHNDSGIGRQLQVAGILGDTPKLIPVVHHRGTTITVKDLYF
NVPARRGNLKSIATEFSHIETIVREVALARADVALTLFHDNKKRLSLSVNTINKVTEKYLPLSRLEQATGLALAEQAIEI
AVDLSSLTQQFGSSSATNANGEYADNVRTMQAASIGGWLWASYDANHSLPKLIYVNGRLVKEALISNQLRQMVQSVQLAG
MGYALYFELPTQWLNVNVHPSKQRIKISPLNNIMAHLSHAIRAKLRGLNTAKIVRSKERAPNDNISTRKSFNALDAIASY
TNNATASQQVQAPKQPYQLSENESLFESIKDLHIDEPVEDSRHAVNSYPVNTPPLPVCLQVIDSVTGLVASSVIYSNDDK
ALPWLLFYYQGQCALISAERWQSRLKVLFESSVFSSTMYDKAKELNSTTINQQLAKIIKQMSSQDVQAFVSDMEAILSKY
AIHSIDSHQLVTLMLSSALK
>Mature_580_residues
MLHSHTNTRIKKLSPLLINQLAAGEVVTRPAAVVKELLENAIDAHATDIEVRITQGGMGMIEVIDNGVGIHPDDMVMAVT
RHATSKVADVAHLHGITTLGFRGEALAATAAVSRLTLTSSHNDSGIGRQLQVAGILGDTPKLIPVVHHRGTTITVKDLYF
NVPARRGNLKSIATEFSHIETIVREVALARADVALTLFHDNKKRLSLSVNTINKVTEKYLPLSRLEQATGLALAEQAIEI
AVDLSSLTQQFGSSSATNANGEYADNVRTMQAASIGGWLWASYDANHSLPKLIYVNGRLVKEALISNQLRQMVQSVQLAG
MGYALYFELPTQWLNVNVHPSKQRIKISPLNNIMAHLSHAIRAKLRGLNTAKIVRSKERAPNDNISTRKSFNALDAIASY
TNNATASQQVQAPKQPYQLSENESLFESIKDLHIDEPVEDSRHAVNSYPVNTPPLPVCLQVIDSVTGLVASSVIYSNDDK
ALPWLLFYYQGQCALISAERWQSRLKVLFESSVFSSTMYDKAKELNSTTINQQLAKIIKQMSSQDVQAFVSDMEAILSKY
AIHSIDSHQLVTLMLSSALK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=386, Percent_Identity=29.5336787564767, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI310128478, Length=192, Percent_Identity=31.25, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI4505913, Length=192, Percent_Identity=31.25, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI4505911, Length=197, Percent_Identity=29.4416243654822, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI189458896, Length=203, Percent_Identity=30.5418719211823, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI189458898, Length=197, Percent_Identity=29.4416243654822, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI91992162, Length=267, Percent_Identity=26.5917602996255, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI91992160, Length=265, Percent_Identity=26.7924528301887, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI310128480, Length=145, Percent_Identity=29.6551724137931, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI1790612, Length=345, Percent_Identity=39.1304347826087, Blast_Score=219, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71991825, Length=341, Percent_Identity=27.2727272727273, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562796, Length=366, Percent_Identity=24.5901639344262, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323819, Length=372, Percent_Identity=27.9569892473118, Blast_Score=158, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324247, Length=351, Percent_Identity=25.9259259259259, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=214, Percent_Identity=26.1682242990654, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136968, Length=389, Percent_Identity=29.0488431876607, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI17136970, Length=181, Percent_Identity=31.4917127071823, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 63589; Mature: 63589

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHSHTNTRIKKLSPLLINQLAAGEVVTRPAAVVKELLENAIDAHATDIEVRITQGGMGM
CCCCCCCCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEE
IEVIDNGVGIHPDDMVMAVTRHATSKVADVAHLHGITTLGFRGEALAATAAVSRLTLTSS
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHEEEECC
HNDSGIGRQLQVAGILGDTPKLIPVVHHRGTTITVKDLYFNVPARRGNLKSIATEFSHIE
CCCCCCCCEEEEEEEECCCCCEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHH
TIVREVALARADVALTLFHDNKKRLSLSVNTINKVTEKYLPLSRLEQATGLALAEQAIEI
HHHHHHHHHHCCEEEEEEECCCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AVDLSSLTQQFGSSSATNANGEYADNVRTMQAASIGGWLWASYDANHSLPKLIYVNGRLV
HHHHHHHHHHHCCCCCCCCCCCHHHCHHHHHHHCCCCEEEEECCCCCCCCEEEEECCHHH
KEALISNQLRQMVQSVQLAGMGYALYFELPTQWLNVNVHPSKQRIKISPLNNIMAHLSHA
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCEEEECCHHHHHHHHHHH
IRAKLRGLNTAKIVRSKERAPNDNISTRKSFNALDAIASYTNNATASQQVQAPKQPYQLS
HHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCC
ENESLFESIKDLHIDEPVEDSRHAVNSYPVNTPPLPVCLQVIDSVTGLVASSVIYSNDDK
CCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCC
ALPWLLFYYQGQCALISAERWQSRLKVLFESSVFSSTMYDKAKELNSTTINQQLAKIIKQ
CCCEEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
MSSQDVQAFVSDMEAILSKYAIHSIDSHQLVTLMLSSALK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLHSHTNTRIKKLSPLLINQLAAGEVVTRPAAVVKELLENAIDAHATDIEVRITQGGMGM
CCCCCCCCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEE
IEVIDNGVGIHPDDMVMAVTRHATSKVADVAHLHGITTLGFRGEALAATAAVSRLTLTSS
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHEEEECC
HNDSGIGRQLQVAGILGDTPKLIPVVHHRGTTITVKDLYFNVPARRGNLKSIATEFSHIE
CCCCCCCCEEEEEEEECCCCCEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHH
TIVREVALARADVALTLFHDNKKRLSLSVNTINKVTEKYLPLSRLEQATGLALAEQAIEI
HHHHHHHHHHCCEEEEEEECCCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AVDLSSLTQQFGSSSATNANGEYADNVRTMQAASIGGWLWASYDANHSLPKLIYVNGRLV
HHHHHHHHHHHCCCCCCCCCCCHHHCHHHHHHHCCCCEEEEECCCCCCCCEEEEECCHHH
KEALISNQLRQMVQSVQLAGMGYALYFELPTQWLNVNVHPSKQRIKISPLNNIMAHLSHA
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCEEEECCHHHHHHHHHHH
IRAKLRGLNTAKIVRSKERAPNDNISTRKSFNALDAIASYTNNATASQQVQAPKQPYQLS
HHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCC
ENESLFESIKDLHIDEPVEDSRHAVNSYPVNTPPLPVCLQVIDSVTGLVASSVIYSNDDK
CCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCC
ALPWLLFYYQGQCALISAERWQSRLKVLFESSVFSSTMYDKAKELNSTTINQQLAKIIKQ
CCCEEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
MSSQDVQAFVSDMEAILSKYAIHSIDSHQLVTLMLSSALK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA