Click here to switch to the map view.

The map label for this gene is tpm [H]

Identifier: 93006161

GI number: 93006161

Start: 1631143

End: 1631835

Strand: Reverse

Name: tpm [H]

Synonym: Pcryo_1333

Alternate gene names: 93006161

Gene position: 1631835-1631143 (Counterclockwise)

Preceding gene: 93006163

Following gene: 93006160

Centisome position: 53.33

GC content: 38.82

Gene sequence:

>693_bases
ATGACTCCTGAATTTTGGAAAAATGCATGGCAAAAGAGCCAAACTAATTTTACTCAGAAAAAACCAAATCCCATGCTAGT
ACATCATTTCAAAGCACTCAACACCCCTAAAAATGGTCGCGTTTTTGTGCCTTTATGCGGTAAGAGCGTGGATATGCTAT
GGTTTATAAGTCAGGGTTTTGACGTTATTGGTGTTGAGCTGTCAGAAATAGCAGTCATACAGTTTTTTGCCGAAAACGAT
TTGCAAGCGACAGTATCGCTACATCCAACTACCCCTAGCCTCACTTGTTATCAAGCTGAACACGAAGGACAAACTCTCAA
AATCTGGGTGGGTGATATTTTTGATTTAAGTCCTATTGATATTGGAATAATAGATGCTGTGTATGATCGTGGTGCATTAG
TAGCGCTTCCAGATATGAAGCCTGATAATCTACGTACACGCTATACACAGAAACTGATGGCGCTTAGTAATAAAGCAAGC
CAACTTCTCTTATCTTTTGCTTATGACGGCGAAAAGCAGTGCAGCGATAATCATAAAAACTTACCTCCTTTCTTAGTGAC
ACGATCTCAACTTGAACAATATTATGCTGAGTACTATGAGATAAACTTGATCGCACAAGAGAAAGTAGACTATGTTTCTA
CCGCAGGTGATTCAGGATATCGTCTTGTCTATACCTTACTATCTAAAAATTAA

Upstream 100 bases:

>100_bases
ATATCTATTTTATCAAAGTGGATACATCTTGAGACAGCTTAGAGGTGTCCATAGTAAAATAACAAGGCAGACTCAGTCTA
ATATAATAAAGGTTGATTTT

Downstream 100 bases:

>100_bases
TCCCTAATCTACATCTGGCTTTTCTAATCAAGAAGTTATCTAGAATTTTTGATGTTTTAGTAAAGAGTCTTTCGGGTAAG
ATTTATATTAAAAATTTTAC

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MTPEFWKNAWQKSQTNFTQKKPNPMLVHHFKALNTPKNGRVFVPLCGKSVDMLWFISQGFDVIGVELSEIAVIQFFAEND
LQATVSLHPTTPSLTCYQAEHEGQTLKIWVGDIFDLSPIDIGIIDAVYDRGALVALPDMKPDNLRTRYTQKLMALSNKAS
QLLLSFAYDGEKQCSDNHKNLPPFLVTRSQLEQYYAEYYEINLIAQEKVDYVSTAGDSGYRLVYTLLSKN

Sequences:

>Translated_230_residues
MTPEFWKNAWQKSQTNFTQKKPNPMLVHHFKALNTPKNGRVFVPLCGKSVDMLWFISQGFDVIGVELSEIAVIQFFAEND
LQATVSLHPTTPSLTCYQAEHEGQTLKIWVGDIFDLSPIDIGIIDAVYDRGALVALPDMKPDNLRTRYTQKLMALSNKAS
QLLLSFAYDGEKQCSDNHKNLPPFLVTRSQLEQYYAEYYEINLIAQEKVDYVSTAGDSGYRLVYTLLSKN
>Mature_229_residues
TPEFWKNAWQKSQTNFTQKKPNPMLVHHFKALNTPKNGRVFVPLCGKSVDMLWFISQGFDVIGVELSEIAVIQFFAENDL
QATVSLHPTTPSLTCYQAEHEGQTLKIWVGDIFDLSPIDIGIIDAVYDRGALVALPDMKPDNLRTRYTQKLMALSNKASQ
LLLSFAYDGEKQCSDNHKNLPPFLVTRSQLEQYYAEYYEINLIAQEKVDYVSTAGDSGYRLVYTLLSKN

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=212, Percent_Identity=33.0188679245283, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 26137; Mature: 26006

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEFWKNAWQKSQTNFTQKKPNPMLVHHFKALNTPKNGRVFVPLCGKSVDMLWFISQGF
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEEEECCCC
DVIGVELSEIAVIQFFAENDLQATVSLHPTTPSLTCYQAEHEGQTLKIWVGDIFDLSPID
EEEEEEHHHEEEEEEEECCCEEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCC
IGIIDAVYDRGALVALPDMKPDNLRTRYTQKLMALSNKASQLLLSFAYDGEKQCSDNHKN
EEHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCHHHHEEEEEECCCCHHCCCCCCC
LPPFLVTRSQLEQYYAEYYEINLIAQEKVDYVSTAGDSGYRLVYTLLSKN
CCHHEEEHHHHHHHHHHHEEEEEEECCCCCHHCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TPEFWKNAWQKSQTNFTQKKPNPMLVHHFKALNTPKNGRVFVPLCGKSVDMLWFISQGF
CCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEEEECCCC
DVIGVELSEIAVIQFFAENDLQATVSLHPTTPSLTCYQAEHEGQTLKIWVGDIFDLSPID
EEEEEEHHHEEEEEEEECCCEEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCC
IGIIDAVYDRGALVALPDMKPDNLRTRYTQKLMALSNKASQLLLSFAYDGEKQCSDNHKN
EEHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCHHHHEEEEEECCCCHHCCCCCCC
LPPFLVTRSQLEQYYAEYYEINLIAQEKVDYVSTAGDSGYRLVYTLLSKN
CCHHEEEHHHHHHHHHHHEEEEEEECCCCCHHCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA