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The map label for this gene is cysG [H]

Identifier: 93006152

GI number: 93006152

Start: 1621260

End: 1622189

Strand: Direct

Name: cysG [H]

Synonym: Pcryo_1324

Alternate gene names: 93006152

Gene position: 1621260-1622189 (Clockwise)

Preceding gene: 93006151

Following gene: 93006154

Centisome position: 52.98

GC content: 47.31

Gene sequence:

>930_bases
ATGACGGATTCATCTGCCTTTATCGCAACACTACCTCCAAACGATTTATCTAATAAAAAGTGTGTCGTCAATGCGCTAAA
CACGCCATTAAACAGAGCAGCTGCAAAAGTAGGCATTGTGCATTTAGTCGGTGCAGGCTCTGGTGATCCTGAGCTGCTCA
CACTAAAAGCTTTGCGAATCATGCAGCGCGCTGATGTGGTGCTTTACGATAGCCTAGTCTCAGAGGATATATTGGATATG
TGCGAACCAACAGCGGAAAAGATATTTGTTGGTAAACGCCGAGCCAATCATGCGCTGCCGCAAGAAGGCATCAATGAGCT
GTTGGTCAAGCACGCGCTGGCAGGTAAAACAGTTGTAAGACTCAAAGGCGGCGACCCTTTTATCTTTGGGCGCGGCGGAG
AGGAGCTTCAAGAAGTGGTGCGCCATGGTATCTTTTTTGAATCTATCCCTGGCATTACTGCCGCCAGTGCCGCTGCTAGT
AGTGCAGGTATTCCATTGACGCATCGCGACCATGCGCAGGCAGTGAAGTTTGTAACGGCATATAAGAAATCAGGAGCGCC
AAATAATAACTATGACGAGCATTTAGATAGCACCCAAACGGTTGTTTTTTATATGGGATTGCATCAGCTAGATGAATTGA
CTGAAGGGTTGATAGCAGCGGGACGAGATAGCGCGACGCCTTTTGCGGTGATTAGCCATGCCAGCTTGCCCACGCAGCAA
CTGCTCATCGGCACGCTTGGTAGTATCGCTAAGCAGCAAGCTGAAGCGAAATTGCCAACCCCAGCATTACTGATTATGGG
CGATGTGGTGACGCTATATCATGAATTTGCAGACTACAACCTTGGTGCATTTGGTAAGCGTGCAGTCTGCAATATTAAGC
AATCCATCACTGATAAACATCTTATACCTACTTTTGAGAGTATTGCATAA

Upstream 100 bases:

>100_bases
AGCTGTCTTATAACCGCCTTATGAAATACAACCAATTGATCAATATGGCATAGGGCTTGCACCGTATATTGCACTAACAG
CATCATTAGGAGTCACCGTC

Downstream 100 bases:

>100_bases
AATATAGGGTTAGTCTAAATGCTCAATAAGATAACTTTAAGACAGGCTAATCCTATAACTATAAATTTCGTAATTGCTCA
ATTAACCAGCGATGTATACC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTDSSAFIATLPPNDLSNKKCVVNALNTPLNRAAAKVGIVHLVGAGSGDPELLTLKALRIMQRADVVLYDSLVSEDILDM
CEPTAEKIFVGKRRANHALPQEGINELLVKHALAGKTVVRLKGGDPFIFGRGGEELQEVVRHGIFFESIPGITAASAAAS
SAGIPLTHRDHAQAVKFVTAYKKSGAPNNNYDEHLDSTQTVVFYMGLHQLDELTEGLIAAGRDSATPFAVISHASLPTQQ
LLIGTLGSIAKQQAEAKLPTPALLIMGDVVTLYHEFADYNLGAFGKRAVCNIKQSITDKHLIPTFESIA

Sequences:

>Translated_309_residues
MTDSSAFIATLPPNDLSNKKCVVNALNTPLNRAAAKVGIVHLVGAGSGDPELLTLKALRIMQRADVVLYDSLVSEDILDM
CEPTAEKIFVGKRRANHALPQEGINELLVKHALAGKTVVRLKGGDPFIFGRGGEELQEVVRHGIFFESIPGITAASAAAS
SAGIPLTHRDHAQAVKFVTAYKKSGAPNNNYDEHLDSTQTVVFYMGLHQLDELTEGLIAAGRDSATPFAVISHASLPTQQ
LLIGTLGSIAKQQAEAKLPTPALLIMGDVVTLYHEFADYNLGAFGKRAVCNIKQSITDKHLIPTFESIA
>Mature_308_residues
TDSSAFIATLPPNDLSNKKCVVNALNTPLNRAAAKVGIVHLVGAGSGDPELLTLKALRIMQRADVVLYDSLVSEDILDMC
EPTAEKIFVGKRRANHALPQEGINELLVKHALAGKTVVRLKGGDPFIFGRGGEELQEVVRHGIFFESIPGITAASAAASS
AGIPLTHRDHAQAVKFVTAYKKSGAPNNNYDEHLDSTQTVVFYMGLHQLDELTEGLIAAGRDSATPFAVISHASLPTQQL
LIGTLGSIAKQQAEAKLPTPALLIMGDVVTLYHEFADYNLGAFGKRAVCNIKQSITDKHLIPTFESIA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=267, Percent_Identity=43.8202247191011, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322922, Length=242, Percent_Identity=36.3636363636364, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 33056; Mature: 32925

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSSAFIATLPPNDLSNKKCVVNALNTPLNRAAAKVGIVHLVGAGSGDPELLTLKALRI
CCCCCCEEEECCCCCCCCCCEEHHHHCCCHHHHHHHHCEEEEEECCCCCCCHHHHHHHHH
MQRADVVLYDSLVSEDILDMCEPTAEKIFVGKRRANHALPQEGINELLVKHALAGKTVVR
HHHCCHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCEEEE
LKGGDPFIFGRGGEELQEVVRHGIFFESIPGITAASAAASSAGIPLTHRDHAQAVKFVTA
EECCCEEEECCCCHHHHHHHHHCCHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
YKKSGAPNNNYDEHLDSTQTVVFYMGLHQLDELTEGLIAAGRDSATPFAVISHASLPTQQ
HHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHH
LLIGTLGSIAKQQAEAKLPTPALLIMGDVVTLYHEFADYNLGAFGKRAVCNIKQSITDKH
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCC
LIPTFESIA
CCCCHHHCC
>Mature Secondary Structure 
TDSSAFIATLPPNDLSNKKCVVNALNTPLNRAAAKVGIVHLVGAGSGDPELLTLKALRI
CCCCCEEEECCCCCCCCCCEEHHHHCCCHHHHHHHHCEEEEEECCCCCCCHHHHHHHHH
MQRADVVLYDSLVSEDILDMCEPTAEKIFVGKRRANHALPQEGINELLVKHALAGKTVVR
HHHCCHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCEEEE
LKGGDPFIFGRGGEELQEVVRHGIFFESIPGITAASAAASSAGIPLTHRDHAQAVKFVTA
EECCCEEEECCCCHHHHHHHHHCCHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
YKKSGAPNNNYDEHLDSTQTVVFYMGLHQLDELTEGLIAAGRDSATPFAVISHASLPTQQ
HHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHH
LLIGTLGSIAKQQAEAKLPTPALLIMGDVVTLYHEFADYNLGAFGKRAVCNIKQSITDKH
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCC
LIPTFESIA
CCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA