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The map label for this gene is accC [H]

Identifier: 93005992

GI number: 93005992

Start: 1410877

End: 1412238

Strand: Reverse

Name: accC [H]

Synonym: Pcryo_1164

Alternate gene names: 93005992

Gene position: 1412238-1410877 (Counterclockwise)

Preceding gene: 93005993

Following gene: 93005989

Centisome position: 46.15

GC content: 42.44

Gene sequence:

>1362_bases
ATGATAAAAAAACTGCTCATCGCCAATAGAGGTGAGATTGCTCTACGTATCGTTCGCGCTTGTAAAGCCCTTGGTATTCA
AACCGTTGGAGTTTACTCTACGGCTGATGCCAATTTGATGCACTTACGCTTTGTTGATGAAGCCATTTGTATCGGCAAGC
CTAATGCCAATCAAAGCTATCTAAATATCAATACTATCTTGACTGCTGCTGAGATTACTGGCGCTGATGCCATTCACCCC
GGTTATGGTTTTTTGGCTGAAAATGCTGAATTTGCTGAACGTATTGAAGAAGCTGGATTAACCTTTGTAGGCCCTACTGC
AGATCATATTCGTCTGATGGGAAACAAGGTTTCCGCGATCAATGCCATGAAAAAAGCGGGTGTGCCGACAGTACCTGGTT
CAGTAGGTGCTGTGACGCTACACAATGCTGAAGAGCAAGCACGCAATATCGGTTTTCCCTTGTTGATTAAAGCGGCAGCG
GGTGGCGGTGGTCGTGGTATGCGTGTGGTTGAGCGCTTTGAAGAAATTATCGGTCAAGTGCAAGCGGCTAAGCAAGAAGC
TGAGCTATGGTTTGGTGATGACACGGTTTATATGGAACGTTATCTCCAAAACCCGCGACATGTAGAGATACAAGTACTTG
GCGATGGTAATGGTAATGCCATTCATTTATATGACAGAGATTGCTCATTGCAGCGTCGTCATCAAAAAGTTTTAGAAGAA
GCCCCTGCCCCTGATATTCCTGATGATGTACGTCAGCCTATCTTAGATGCTTGTGTAAAAGCTTGTAAGCTGGTCAAATA
CCGCGGTGCTGGTACTTTTGAGTTTTTATTTGAAAATAATGAATATTTCTTTATTGAGATGAACACTCGCGTACAAGTTG
AGCATACTATTACTGAGATGATTACAGGCATTGATGTGGTCGTTGAACAGTTAAAAATCGCAGCAGGCTACGGTCTATCG
TATCGCCAAAGTGAGATTGAAATTCAAGGTCATGCGATTGAATGTCGCATCAATGCTGAAGATCCAGTGACCTTTATGCC
ATCACCTGGTACGGTTACTCAGCTGTATTCACCTAGTGGGGCTGGTATCCGCTTTGACTCACATCTATATCCTGGCTATG
AGATTCCAAGTTACTATGACTCTTTGATTGGTAAGCTTATCTGTCATGGTCAAACCCGTCAGCAAGCGATTTCGAAAACG
CTACAGGCACTTGATGAGTTGGTTATCGAAGGTATCAAAACAAATATCCCGATGCATCGTGATGTAATTTTATCAGATGA
TAATTTTGTTCATGAAGCACAGAATATTCATTATCTTGAAAGAGAGTTGTTAACTGCTAATAAAGAAAAATCTAACTTGT
GA

Upstream 100 bases:

>100_bases
AGATTTTAAAGTTAGATAATCACTAGGCTTAATAATAAGTTTTGATATTGCTGAATATAGTGACTCCATTAAAAAACGCC
GCTTCAATAAGGATGATCCC

Downstream 100 bases:

>100_bases
ACTGATTAAATATTGATATCAAATATCTTTATTATCAAGATTTTTTCTCATTAAAAAAACCGCTATCCATGCAGATAGCG
GTTTTTTTATTGATGATTGT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MIKKLLIANRGEIALRIVRACKALGIQTVGVYSTADANLMHLRFVDEAICIGKPNANQSYLNINTILTAAEITGADAIHP
GYGFLAENAEFAERIEEAGLTFVGPTADHIRLMGNKVSAINAMKKAGVPTVPGSVGAVTLHNAEEQARNIGFPLLIKAAA
GGGGRGMRVVERFEEIIGQVQAAKQEAELWFGDDTVYMERYLQNPRHVEIQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
APAPDIPDDVRQPILDACVKACKLVKYRGAGTFEFLFENNEYFFIEMNTRVQVEHTITEMITGIDVVVEQLKIAAGYGLS
YRQSEIEIQGHAIECRINAEDPVTFMPSPGTVTQLYSPSGAGIRFDSHLYPGYEIPSYYDSLIGKLICHGQTRQQAISKT
LQALDELVIEGIKTNIPMHRDVILSDDNFVHEAQNIHYLERELLTANKEKSNL

Sequences:

>Translated_453_residues
MIKKLLIANRGEIALRIVRACKALGIQTVGVYSTADANLMHLRFVDEAICIGKPNANQSYLNINTILTAAEITGADAIHP
GYGFLAENAEFAERIEEAGLTFVGPTADHIRLMGNKVSAINAMKKAGVPTVPGSVGAVTLHNAEEQARNIGFPLLIKAAA
GGGGRGMRVVERFEEIIGQVQAAKQEAELWFGDDTVYMERYLQNPRHVEIQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
APAPDIPDDVRQPILDACVKACKLVKYRGAGTFEFLFENNEYFFIEMNTRVQVEHTITEMITGIDVVVEQLKIAAGYGLS
YRQSEIEIQGHAIECRINAEDPVTFMPSPGTVTQLYSPSGAGIRFDSHLYPGYEIPSYYDSLIGKLICHGQTRQQAISKT
LQALDELVIEGIKTNIPMHRDVILSDDNFVHEAQNIHYLERELLTANKEKSNL
>Mature_453_residues
MIKKLLIANRGEIALRIVRACKALGIQTVGVYSTADANLMHLRFVDEAICIGKPNANQSYLNINTILTAAEITGADAIHP
GYGFLAENAEFAERIEEAGLTFVGPTADHIRLMGNKVSAINAMKKAGVPTVPGSVGAVTLHNAEEQARNIGFPLLIKAAA
GGGGRGMRVVERFEEIIGQVQAAKQEAELWFGDDTVYMERYLQNPRHVEIQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
APAPDIPDDVRQPILDACVKACKLVKYRGAGTFEFLFENNEYFFIEMNTRVQVEHTITEMITGIDVVVEQLKIAAGYGLS
YRQSEIEIQGHAIECRINAEDPVTFMPSPGTVTQLYSPSGAGIRFDSHLYPGYEIPSYYDSLIGKLICHGQTRQQAISKT
LQALDELVIEGIKTNIPMHRDVILSDDNFVHEAQNIHYLERELLTANKEKSNL

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=47.3922902494331, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI189095269, Length=429, Percent_Identity=46.3869463869464, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI65506442, Length=429, Percent_Identity=46.3869463869464, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI295821183, Length=429, Percent_Identity=46.3869463869464, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=44.7427293064877, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=44.7427293064877, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=44.7427293064877, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI38679977, Length=477, Percent_Identity=31.2368972746331, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679967, Length=477, Percent_Identity=31.2368972746331, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679971, Length=477, Percent_Identity=31.2368972746331, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679960, Length=477, Percent_Identity=31.2368972746331, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679974, Length=477, Percent_Identity=31.2368972746331, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI134142062, Length=479, Percent_Identity=30.6889352818372, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=60, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI1786216, Length=325, Percent_Identity=24.9230769230769, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17567343, Length=425, Percent_Identity=44.9411764705882, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71987519, Length=426, Percent_Identity=45.0704225352113, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=43.4004474272931, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI133931226, Length=502, Percent_Identity=30.2788844621514, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=526, Percent_Identity=28.1368821292776, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=526, Percent_Identity=28.1368821292776, Blast_Score=211, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6319685, Length=429, Percent_Identity=43.8228438228438, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319695, Length=425, Percent_Identity=46.1176470588235, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=425, Percent_Identity=47.2941176470588, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=481, Percent_Identity=31.6008316008316, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=435, Percent_Identity=32.183908045977, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24651757, Length=420, Percent_Identity=45.7142857142857, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=45.5357142857143, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=382, Percent_Identity=45.2879581151832, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=30.6, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=30.6, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=30.6, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=30.6, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50075; Mature: 50075

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLLIANRGEIALRIVRACKALGIQTVGVYSTADANLMHLRFVDEAICIGKPNANQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCEECCCCCCCCE
LNINTILTAAEITGADAIHPGYGFLAENAEFAERIEEAGLTFVGPTADHIRLMGNKVSAI
EEEHHEEEEHHHCCCCCCCCCCCEEECCHHHHHHHHHCCCEEECCCHHHHHEECCCHHHH
NAMKKAGVPTVPGSVGAVTLHNAEEQARNIGFPLLIKAAAGGGGRGMRVVERFEEIIGQV
HHHHHCCCCCCCCCCCEEEEECCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
QAAKQEAELWFGDDTVYMERYLQNPRHVEIQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
HHHHHHCCEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHH
APAPDIPDDVRQPILDACVKACKLVKYRGAGTFEFLFENNEYFFIEMNTRVQVEHTITEM
CCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCEEEEEEECCEEEEHHHHHHH
ITGIDVVVEQLKIAAGYGLSYRQSEIEIQGHAIECRINAEDPVTFMPSPGTVTQLYSPSG
HHHHHHHHHHHHHHHCCCCCEECCEEEEECEEEEEEECCCCCEEECCCCCCEEEEECCCC
AGIRFDSHLYPGYEIPSYYDSLIGKLICHGQTRQQAISKTLQALDELVIEGIKTNIPMHR
CCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DVILSDDNFVHEAQNIHYLERELLTANKEKSNL
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIKKLLIANRGEIALRIVRACKALGIQTVGVYSTADANLMHLRFVDEAICIGKPNANQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCEECCCCCCCCE
LNINTILTAAEITGADAIHPGYGFLAENAEFAERIEEAGLTFVGPTADHIRLMGNKVSAI
EEEHHEEEEHHHCCCCCCCCCCCEEECCHHHHHHHHHCCCEEECCCHHHHHEECCCHHHH
NAMKKAGVPTVPGSVGAVTLHNAEEQARNIGFPLLIKAAAGGGGRGMRVVERFEEIIGQV
HHHHHCCCCCCCCCCCEEEEECCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
QAAKQEAELWFGDDTVYMERYLQNPRHVEIQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
HHHHHHCCEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHH
APAPDIPDDVRQPILDACVKACKLVKYRGAGTFEFLFENNEYFFIEMNTRVQVEHTITEM
CCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCEEEEEEECCEEEEHHHHHHH
ITGIDVVVEQLKIAAGYGLSYRQSEIEIQGHAIECRINAEDPVTFMPSPGTVTQLYSPSG
HHHHHHHHHHHHHHHCCCCCEECCEEEEECEEEEEEECCCCCEEECCCCCCEEEEECCCC
AGIRFDSHLYPGYEIPSYYDSLIGKLICHGQTRQQAISKTLQALDELVIEGIKTNIPMHR
CCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DVILSDDNFVHEAQNIHYLERELLTANKEKSNL
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]