Click here to switch to the map view.

The map label for this gene is grxD [H]

Identifier: 93005978

GI number: 93005978

Start: 1393434

End: 1393784

Strand: Direct

Name: grxD [H]

Synonym: Pcryo_1150

Alternate gene names: 93005978

Gene position: 1393434-1393784 (Clockwise)

Preceding gene: 93005977

Following gene: 93005979

Centisome position: 45.54

GC content: 41.88

Gene sequence:

>351_bases
ATGAGTGAGCAAACCCCAAATACTGCTGCCAACGATATTGAACAACTGATTCGTAACCAAATCAAAGACAACAAAGTCAT
TCTATATATGAAAGGCTCACCGCAGTTCCCACAGTGTGGTTTCTCTGCCAAAGCGATTGAAGTCTTGACACAAATTGGTC
GCCCATTTGCTTTCGTCAATATCTTAGAAAATCCAGAAATCCGCGCAACGTTACCACAAATTGCTAATTGGCCAACTTTT
CCGCAGCTATGGATTGATGGTGAATTGATGGGCGGATCAGACATTATTTTACAAATGTATCAATCAGGCGAGCTTAAGCC
TTTGGTTGAAGCAAATAGCCCAGCTGCTTAA

Upstream 100 bases:

>100_bases
CTGCTTGCAATATGGTTAAGATTGCCCCATGTAGCAGCCACATGATAAATTTAATGTTACCTGTCTTTTTTATAAATAGT
TTTAATTAATAGGAGTTTTT

Downstream 100 bases:

>100_bases
TATCGAAAGCACTTTATATCGACGTTTAATGCTTAAATATCTAAATGGCATTAAGATGTTAATATAATTGATATTCGAGC
CTAAGTACCCAAATCCGAGT

Product: glutaredoxin-like protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 116; Mature: 115

Protein sequence:

>116_residues
MSEQTPNTAANDIEQLIRNQIKDNKVILYMKGSPQFPQCGFSAKAIEVLTQIGRPFAFVNILENPEIRATLPQIANWPTF
PQLWIDGELMGGSDIILQMYQSGELKPLVEANSPAA

Sequences:

>Translated_116_residues
MSEQTPNTAANDIEQLIRNQIKDNKVILYMKGSPQFPQCGFSAKAIEVLTQIGRPFAFVNILENPEIRATLPQIANWPTF
PQLWIDGELMGGSDIILQMYQSGELKPLVEANSPAA
>Mature_115_residues
SEQTPNTAANDIEQLIRNQIKDNKVILYMKGSPQFPQCGFSAKAIEVLTQIGRPFAFVNILENPEIRATLPQIANWPTFP
QLWIDGELMGGSDIILQMYQSGELKPLVEANSPAA

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42516576, Length=86, Percent_Identity=45.3488372093023, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI95113651, Length=104, Percent_Identity=37.5, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1787943, Length=97, Percent_Identity=58.7628865979381, Blast_Score=137, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71988153, Length=90, Percent_Identity=35.5555555555556, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71988159, Length=80, Percent_Identity=38.75, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17556042, Length=100, Percent_Identity=33, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325198, Length=104, Percent_Identity=42.3076923076923, Blast_Score=97, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321022, Length=71, Percent_Identity=47.887323943662, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320303, Length=71, Percent_Identity=47.887323943662, Blast_Score=81, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24642023, Length=85, Percent_Identity=42.3529411764706, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921242, Length=113, Percent_Identity=30.9734513274336, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12873; Mature: 12742

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQTPNTAANDIEQLIRNQIKDNKVILYMKGSPQFPQCGFSAKAIEVLTQIGRPFAFVN
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
ILENPEIRATLPQIANWPTFPQLWIDGELMGGSDIILQMYQSGELKPLVEANSPAA
ECCCCCCEEECCHHCCCCCCCEEEECCEEECCHHHHHHHHCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SEQTPNTAANDIEQLIRNQIKDNKVILYMKGSPQFPQCGFSAKAIEVLTQIGRPFAFVN
CCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
ILENPEIRATLPQIANWPTFPQLWIDGELMGGSDIILQMYQSGELKPLVEANSPAA
ECCCCCCEEECCHHCCCCCCCEEEECCEEECCHHHHHHHHCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]