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The map label for this gene is gcvT [H]

Identifier: 93005636

GI number: 93005636

Start: 950110

End: 951282

Strand: Reverse

Name: gcvT [H]

Synonym: Pcryo_0806

Alternate gene names: 93005636

Gene position: 951282-950110 (Counterclockwise)

Preceding gene: 93005641

Following gene: 93005635

Centisome position: 31.09

GC content: 45.95

Gene sequence:

>1173_bases
ATGACCGATACTCAAAATACTAACAGCCAAGCTCCTCAACGCACACCCCTTTATCAGTCTCATGTCGAGAGTGATGGCAA
ACTGGTGGATTTTTCTGGTTGGGAATTGCCAATCCATTATGGCTCACAAATCGAAGAGCACGAAGCGGTGCGTACTGATG
CCGGTATGTTTGACGTCTCTCATATGGTTATTGTCGATATCAAAGGCACGGATGCCAAAGCATGGCTACAGAAGCTATTA
GCTAACGATGTCGATAAACTAAAAACAGCTGGTAAAGCCCTTTATTCTCCTATGCTAAATGAAGAAGGCGGCATCATCGA
TGATTTAATCGTTTATCTATCAAATTCTGATGAAACTGAATACCGTATCGTCTCAAACGCTGCTACTCGCGATAAAGACA
TGGCGCAATTTGACAAAGTCGCTGAAGGTTTTGACATCAGCATCACTGAGCGGCCAGAGCTTGCCATGATTGCCGTGCAA
GGACCAAACGCCGTTGAAAAACTGGCGCACACCAAACCTAGCTGGGCAGATACCTTAGCTGGTCTTAAGCCTTTCGTTGG
TGCTGATTTAACAGACATCGAAGGTACAGATTGGTTCGTCGCTCGTACGGGCTACACCGGTGAAGATGGCGTCGAAGTCA
TTATGCATGGCGATGATGCGCCGGCGTTCTTTGAGCAATTAAAAGCCAATGGTATAAAGCCTGCCGGTCTTGGCGCTCGT
GATACTTTGCGTATGGAAGCTGGCATGAACCTCTATGGTCATGATATGAATGAAGATGTTAGCCCTTATGAGTGCAACAT
GGGCTGGACACTGGCGCTAAAAGACGATCGTGACTTTATTGGTCGCGATGCTATGGTCAGCAAACGCAAACAGTCAAAAG
ATGACAATACTGCTATGAAGCAAGTGGGCTTATTAATGACTAGCCGTGGCGTATTACGTGAAGGTATGGAAGTGACCATT
AATCAAGGCACTGATAAAGAGCAAAAAGGTATCATTACTAGTGGTACTTTCTCTCCTAGCCTCAAAAATTCTATCGCTAT
CGCCCGTGTTCCTGCTACCCTAGCAGAAGATGACAATGTGCAAATTGATCTGCGCGGTAAAGGTAAGTTCGTCGATGTAC
GCGTGCTTAAACTACCGTTTGTCCGTAATGGCAAGCAGCAGTTTGACTCGTAG

Upstream 100 bases:

>100_bases
AATGCTTGTACCCTGCAATATTGCTTCTCGCTACTATGATCATGTACATCAGCCCTAATACTTTTACTAAGTATAGCTAA
TGTCCACATAAGGATTTGTT

Downstream 100 bases:

>100_bases
GCAACAGAAAATTTATTATTAGCTTTCTTTTTCATTAATTAACCTCTATCACCTAGGAGAGAAACCATGAGTAATATCCC
AGCAGAACTAAAATACATCG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTDTQNTNSQAPQRTPLYQSHVESDGKLVDFSGWELPIHYGSQIEEHEAVRTDAGMFDVSHMVIVDIKGTDAKAWLQKLL
ANDVDKLKTAGKALYSPMLNEEGGIIDDLIVYLSNSDETEYRIVSNAATRDKDMAQFDKVAEGFDISITERPELAMIAVQ
GPNAVEKLAHTKPSWADTLAGLKPFVGADLTDIEGTDWFVARTGYTGEDGVEVIMHGDDAPAFFEQLKANGIKPAGLGAR
DTLRMEAGMNLYGHDMNEDVSPYECNMGWTLALKDDRDFIGRDAMVSKRKQSKDDNTAMKQVGLLMTSRGVLREGMEVTI
NQGTDKEQKGIITSGTFSPSLKNSIAIARVPATLAEDDNVQIDLRGKGKFVDVRVLKLPFVRNGKQQFDS

Sequences:

>Translated_390_residues
MTDTQNTNSQAPQRTPLYQSHVESDGKLVDFSGWELPIHYGSQIEEHEAVRTDAGMFDVSHMVIVDIKGTDAKAWLQKLL
ANDVDKLKTAGKALYSPMLNEEGGIIDDLIVYLSNSDETEYRIVSNAATRDKDMAQFDKVAEGFDISITERPELAMIAVQ
GPNAVEKLAHTKPSWADTLAGLKPFVGADLTDIEGTDWFVARTGYTGEDGVEVIMHGDDAPAFFEQLKANGIKPAGLGAR
DTLRMEAGMNLYGHDMNEDVSPYECNMGWTLALKDDRDFIGRDAMVSKRKQSKDDNTAMKQVGLLMTSRGVLREGMEVTI
NQGTDKEQKGIITSGTFSPSLKNSIAIARVPATLAEDDNVQIDLRGKGKFVDVRVLKLPFVRNGKQQFDS
>Mature_389_residues
TDTQNTNSQAPQRTPLYQSHVESDGKLVDFSGWELPIHYGSQIEEHEAVRTDAGMFDVSHMVIVDIKGTDAKAWLQKLLA
NDVDKLKTAGKALYSPMLNEEGGIIDDLIVYLSNSDETEYRIVSNAATRDKDMAQFDKVAEGFDISITERPELAMIAVQG
PNAVEKLAHTKPSWADTLAGLKPFVGADLTDIEGTDWFVARTGYTGEDGVEVIMHGDDAPAFFEQLKANGIKPAGLGARD
TLRMEAGMNLYGHDMNEDVSPYECNMGWTLALKDDRDFIGRDAMVSKRKQSKDDNTAMKQVGLLMTSRGVLREGMEVTIN
QGTDKEQKGIITSGTFSPSLKNSIAIARVPATLAEDDNVQIDLRGKGKFVDVRVLKLPFVRNGKQQFDS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=381, Percent_Identity=36.745406824147, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI257796258, Length=350, Percent_Identity=37.4285714285714, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI257796254, Length=376, Percent_Identity=31.9148936170213, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI257796256, Length=326, Percent_Identity=35.5828220858896, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI24797151, Length=330, Percent_Identity=27.8787878787879, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789272, Length=375, Percent_Identity=51.4666666666667, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17560118, Length=389, Percent_Identity=33.9331619537275, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71994052, Length=373, Percent_Identity=24.1286863270777, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994045, Length=373, Percent_Identity=24.1286863270777, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320222, Length=386, Percent_Identity=32.6424870466321, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20129441, Length=388, Percent_Identity=35.8247422680412, Blast_Score=194, Evalue=9e-50,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42927; Mature: 42796

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTQNTNSQAPQRTPLYQSHVESDGKLVDFSGWELPIHYGSQIEEHEAVRTDAGMFDVS
CCCCCCCCCCCCCCCCCHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHHCCCEEEEC
HMVIVDIKGTDAKAWLQKLLANDVDKLKTAGKALYSPMLNEEGGIIDDLIVYLSNSDETE
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEECCCCCCE
YRIVSNAATRDKDMAQFDKVAEGFDISITERPELAMIAVQGPNAVEKLAHTKPSWADTLA
EEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCHHHHHHCCCCCHHHHHH
GLKPFVGADLTDIEGTDWFVARTGYTGEDGVEVIMHGDDAPAFFEQLKANGIKPAGLGAR
CCCHHHCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCC
DTLRMEAGMNLYGHDMNEDVSPYECNMGWTLALKDDRDFIGRDAMVSKRKQSKDDNTAMK
CEEEHHCCCCEECCCCCCCCCCEECCCCEEEEEECCCHHHCCHHHHHHHHCCCCHHHHHH
QVGLLMTSRGVLREGMEVTINQGTDKEQKGIITSGTFSPSLKNSIAIARVPATLAEDDNV
HHHHHHHCCHHHHCCCEEEEECCCCHHHCCCEEECCCCCCHHCCEEEEECCCCCCCCCCE
QIDLRGKGKFVDVRVLKLPFVRNGKQQFDS
EEEEECCCCEEEEEEEECCCCCCCHHHCCC
>Mature Secondary Structure 
TDTQNTNSQAPQRTPLYQSHVESDGKLVDFSGWELPIHYGSQIEEHEAVRTDAGMFDVS
CCCCCCCCCCCCCCCCHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHHCCCEEEEC
HMVIVDIKGTDAKAWLQKLLANDVDKLKTAGKALYSPMLNEEGGIIDDLIVYLSNSDETE
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEECCCCCCE
YRIVSNAATRDKDMAQFDKVAEGFDISITERPELAMIAVQGPNAVEKLAHTKPSWADTLA
EEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCHHHHHHCCCCCHHHHHH
GLKPFVGADLTDIEGTDWFVARTGYTGEDGVEVIMHGDDAPAFFEQLKANGIKPAGLGAR
CCCHHHCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCC
DTLRMEAGMNLYGHDMNEDVSPYECNMGWTLALKDDRDFIGRDAMVSKRKQSKDDNTAMK
CEEEHHCCCCEECCCCCCCCCCEECCCCEEEEEECCCHHHCCHHHHHHHHCCCCHHHHHH
QVGLLMTSRGVLREGMEVTINQGTDKEQKGIITSGTFSPSLKNSIAIARVPATLAEDDNV
HHHHHHHCCHHHHCCCEEEEECCCCHHHCCCEEECCCCCCHHCCEEEEECCCCCCCCCCE
QIDLRGKGKFVDVRVLKLPFVRNGKQQFDS
EEEEECCCCEEEEEEEECCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]