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The map label for this gene is 93004969

Identifier: 93004969

GI number: 93004969

Start: 162270

End: 163568

Strand: Reverse

Name: 93004969

Synonym: Pcryo_0138

Alternate gene names: NA

Gene position: 163568-162270 (Counterclockwise)

Preceding gene: 93004971

Following gene: 93004968

Centisome position: 5.35

GC content: 43.19

Gene sequence:

>1299_bases
ATGAATACGGATATATCAAAGAGTACCAACTCATCAGGTGATAACAAAAAAATTAATAGTGAAAAACGAGCTTATGCGGT
GGTTTTATATGGGGCAACCAGCTTTGTTGGGCAAATCACTGCTCATTATCTGGCAGAGTTTTTGTCTGCTAACAAAGATA
AGAGCGGCTCTGAAATTAATTGGGCGATAGCAGGTCGTGATCAAGAGAAGCTCAACGAGTTGCAGTCTAACCTTACTAGC
AAAGTAGATATTATCATTGCCAATAGCGACGATCCGGCAAGCCTTGATGCAATGACCGAGCAAACACAAGTCATTATCTC
AACCGTTGGACCTTATCTTAAATACGGCGAACCGCTTATCAAATCGTGTGTTGATAATGGCACAGATTATGTTGATCTCA
CTGGTGAGGCAATATTTATCAAAGACATGATGGATAAGTATCAAGAGGCGGCAAAACAAAGCGGCGCCCGTATCGTCAAC
TCTTGTGGCTTTGATTCTATTCCATCAGATTTAGGCGTTTACTTTACGCAAAAGCAAGCTGAAGCGAAGTTTGACAGTGC
TTGTGATGTGATTCATATGCGCGTGAAAGCCGCGAAAGGCGGACTATCAGGCGGTACGATTGCCTCAATGGCAACCATCT
TTGAGGAAGTTGGACAAGATAAATCTCGTCGTAAGCAAGTGGCAAATCCTTATTTGCTGAACGATGATAAAAATGCGCCA
AACGTACGTCAGAGCAATGTCAGTAAACCAGAATACGATAGCGAACATAAGCGCTGGCTTGCACCTTTTGTGATGGCAAG
TATCAATACGCGCATTGTGCATCGCAGTAATCAGTTGCTTGGTTATGAATATGGACGCGAATTTAAATATGATGAAGCAA
TGTGGATGAAAGATGGTCTCAAAGGTAAGCTTACGAGTTATGCCTTGAGTGCAGGCTTGCTCGGCTTTGCCACTGCCATG
ATGATTACGCCAAGCCGCGAGTTATTATCCAAGCACGTATTGCCTAAATCAGGTTCAGGGCCTTCTAAAGAAGAGCAAGA
AAACGGCTATTTTGATATTCGTCTCTTTGGACAAACAGCTAACAAAGACAGTATTACTACCAAAGTAACGGGTGATAAAG
ATCCAGGCTATGGCAGCACTTCACGTATGTTGTCGCAAGCGGCATTATGTCTAGCACAAGATATCAGCAAAGAAGAAGTG
AAGGGTGGTTTTTGGACACCTGCTTCAGCAATGGGCGACAAGCTACTTGCTCGTTTAGAGAAACACGCTGGTCTGAGCTT
TGATGTGATTGATAGCTAA

Upstream 100 bases:

>100_bases
TATAAATATTATTTATGATGCTTTTTTAAGCTCAATTGAACTTAACGATCATTTTCTTATAACAATCATTTGACAAAGCA
CACTAACAAGGAAGATAGCG

Downstream 100 bases:

>100_bases
ACCTATGTCTTAAAAAGCAGTTTCTAGAATATCAATCAGTAGTATTAAAATAACCGTATTTTGGTCACAAGGTGCGGTTT
TTATCTCACAATAACACTAC

Product: saccharopine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNTDISKSTNSSGDNKKINSEKRAYAVVLYGATSFVGQITAHYLAEFLSANKDKSGSEINWAIAGRDQEKLNELQSNLTS
KVDIIIANSDDPASLDAMTEQTQVIISTVGPYLKYGEPLIKSCVDNGTDYVDLTGEAIFIKDMMDKYQEAAKQSGARIVN
SCGFDSIPSDLGVYFTQKQAEAKFDSACDVIHMRVKAAKGGLSGGTIASMATIFEEVGQDKSRRKQVANPYLLNDDKNAP
NVRQSNVSKPEYDSEHKRWLAPFVMASINTRIVHRSNQLLGYEYGREFKYDEAMWMKDGLKGKLTSYALSAGLLGFATAM
MITPSRELLSKHVLPKSGSGPSKEEQENGYFDIRLFGQTANKDSITTKVTGDKDPGYGSTSRMLSQAALCLAQDISKEEV
KGGFWTPASAMGDKLLARLEKHAGLSFDVIDS

Sequences:

>Translated_432_residues
MNTDISKSTNSSGDNKKINSEKRAYAVVLYGATSFVGQITAHYLAEFLSANKDKSGSEINWAIAGRDQEKLNELQSNLTS
KVDIIIANSDDPASLDAMTEQTQVIISTVGPYLKYGEPLIKSCVDNGTDYVDLTGEAIFIKDMMDKYQEAAKQSGARIVN
SCGFDSIPSDLGVYFTQKQAEAKFDSACDVIHMRVKAAKGGLSGGTIASMATIFEEVGQDKSRRKQVANPYLLNDDKNAP
NVRQSNVSKPEYDSEHKRWLAPFVMASINTRIVHRSNQLLGYEYGREFKYDEAMWMKDGLKGKLTSYALSAGLLGFATAM
MITPSRELLSKHVLPKSGSGPSKEEQENGYFDIRLFGQTANKDSITTKVTGDKDPGYGSTSRMLSQAALCLAQDISKEEV
KGGFWTPASAMGDKLLARLEKHAGLSFDVIDS
>Mature_432_residues
MNTDISKSTNSSGDNKKINSEKRAYAVVLYGATSFVGQITAHYLAEFLSANKDKSGSEINWAIAGRDQEKLNELQSNLTS
KVDIIIANSDDPASLDAMTEQTQVIISTVGPYLKYGEPLIKSCVDNGTDYVDLTGEAIFIKDMMDKYQEAAKQSGARIVN
SCGFDSIPSDLGVYFTQKQAEAKFDSACDVIHMRVKAAKGGLSGGTIASMATIFEEVGQDKSRRKQVANPYLLNDDKNAP
NVRQSNVSKPEYDSEHKRWLAPFVMASINTRIVHRSNQLLGYEYGREFKYDEAMWMKDGLKGKLTSYALSAGLLGFATAM
MITPSRELLSKHVLPKSGSGPSKEEQENGYFDIRLFGQTANKDSITTKVTGDKDPGYGSTSRMLSQAALCLAQDISKEEV
KGGFWTPASAMGDKLLARLEKHAGLSFDVIDS

Specific function: Unknown

COG id: COG3268

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770836, Length=445, Percent_Identity=31.0112359550562, Blast_Score=175, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17560066, Length=454, Percent_Identity=26.431718061674, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32567112, Length=419, Percent_Identity=26.9689737470167, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71991033, Length=429, Percent_Identity=25.4079254079254, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644140, Length=446, Percent_Identity=27.3542600896861, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24644142, Length=446, Percent_Identity=27.3542600896861, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21356081, Length=446, Percent_Identity=27.3542600896861, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24646278, Length=438, Percent_Identity=26.2557077625571, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR005097 [H]

Pfam domain/function: PF03435 Saccharop_dh [H]

EC number: NA

Molecular weight: Translated: 47248; Mature: 47248

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDISKSTNSSGDNKKINSEKRAYAVVLYGATSFVGQITAHYLAEFLSANKDKSGSEIN
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
WAIAGRDQEKLNELQSNLTSKVDIIIANSDDPASLDAMTEQTQVIISTVGPYLKYGEPLI
EEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHCCCHHH
KSCVDNGTDYVDLTGEAIFIKDMMDKYQEAAKQSGARIVNSCGFDSIPSDLGVYFTQKQA
HHHHHCCCCEEEECCCEEEHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHCEEEECHHH
EAKFDSACDVIHMRVKAAKGGLSGGTIASMATIFEEVGQDKSRRKQVANPYLLNDDKNAP
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCC
NVRQSNVSKPEYDSEHKRWLAPFVMASINTRIVHRSNQLLGYEYGREFKYDEAMWMKDGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCEECHHCCCCCCCCHHHHHHCCC
KGKLTSYALSAGLLGFATAMMITPSRELLSKHVLPKSGSGPSKEEQENGYFDIRLFGQTA
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHCCCEEEEEEEECCC
NKDSITTKVTGDKDPGYGSTSRMLSQAALCLAQDISKEEVKGGFWTPASAMGDKLLARLE
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHH
KHAGLSFDVIDS
HHCCCCEEECCC
>Mature Secondary Structure
MNTDISKSTNSSGDNKKINSEKRAYAVVLYGATSFVGQITAHYLAEFLSANKDKSGSEIN
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
WAIAGRDQEKLNELQSNLTSKVDIIIANSDDPASLDAMTEQTQVIISTVGPYLKYGEPLI
EEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHCCCHHH
KSCVDNGTDYVDLTGEAIFIKDMMDKYQEAAKQSGARIVNSCGFDSIPSDLGVYFTQKQA
HHHHHCCCCEEEECCCEEEHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHCEEEECHHH
EAKFDSACDVIHMRVKAAKGGLSGGTIASMATIFEEVGQDKSRRKQVANPYLLNDDKNAP
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCC
NVRQSNVSKPEYDSEHKRWLAPFVMASINTRIVHRSNQLLGYEYGREFKYDEAMWMKDGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCEECHHCCCCCCCCHHHHHHCCC
KGKLTSYALSAGLLGFATAMMITPSRELLSKHVLPKSGSGPSKEEQENGYFDIRLFGQTA
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHCCCEEEEEEEECCC
NKDSITTKVTGDKDPGYGSTSRMLSQAALCLAQDISKEEVKGGFWTPASAMGDKLLARLE
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHH
KHAGLSFDVIDS
HHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]