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The map label for this gene is argH [H]

Identifier: 93004926

GI number: 93004926

Start: 109881

End: 111254

Strand: Reverse

Name: argH [H]

Synonym: Pcryo_0095

Alternate gene names: 93004926

Gene position: 111254-109881 (Counterclockwise)

Preceding gene: 93004933

Following gene: 93004925

Centisome position: 3.64

GC content: 48.62

Gene sequence:

>1374_bases
ATGTGGGGAGGACGCTTTAGTGAAGCGACCGACAGCTTTGTGGCAGCCTTTACCGCATCGGTTGGCTTTGACCAGCGCTT
TGCCCGCCACGATATTCAAGGCTCAATTGCCCATGCGACCATGCTCAGAGAATGCGGTATCTTGGAAGCTGATGACGTTG
CAACGATCATTGATGGTTTGCATCAAGTGCTACGCGAAATCGAAGCCGGTGAGTTTAATTGGTCGATTGCGTTAGAGGAC
GTGCATATGAACGTCGAATCGCGCCTGACCGATATCGTCGGCGCGGTGGGCAAAAAGCTGCATACCGGTCGCAGCCGTAA
TGACCAAGTGGCGACTGATATTCGTCTTTGGTTACGCGAAGAGACTGATAATATCATTGCGCTATTGGTGCGCTTGCAAA
GTGGCTTGCTAGATTTGGCTGAGCAACATACTGATACCATCATGCCAGGCTTCACCCATTTGCAAACCGCGCAGCCGGTC
AGCTTTGGTCATCATGTCATGGCATGGTTTGAGATGCTATACCGTGATACCGAGCGCCTAGTCGATGCCCGTCGCCGCAT
TAACCAAATGCCGCTTGGTAGCGCGGCACTTGCTGGTACGACTTTTCCAATTGACCGTACCATTACCGCTGAGCTATTAG
GTTTCGAAGGTATTTGCCAAAACTCGCTAGATGCGGTATCAGATCGTGATTTTGCCATCGAATTTACTTCGGCAGCATCT
ATTTTAATGATGCATATGTCACGCATGAGCGAAGAGATTATTCTTTGGATGTCAGCGCAATTTAACTTTGTGCAGATTCC
TGACCGCTTTTGTACCGGCTCATCTATCATGCCGCAAAAGAAAAACCCTGATGTACCAGAGTTGGTTCGTGGTAAAGCCG
CACGGGTATTTGGTCAATTAATGACGCTACTTAGCCTCATGAAAAGCCAGCCGCTTGCTTATAATAAAGACAATCAAGAA
GACAAAGAACCGCTATTTGATTGTGTTGATACCTTGACCGGTTCATTACTAGCATTTGCTGATATGCTACCAAATATCAC
GCCGAATAAAGAAAATATGCGCGCCGCCACGATGAAAGGTTATGCAACTGCAACTGATTTAGCGGATTATCTGGTGCGCC
GTGGCGTAGCGTTCCGTGATGCTCATGAAGTGGTCGGTAATGCCGTCGCTTTGGGCATTGCTGAGGGCGTTGATTTAAGC
GACTTATCTCTTGCGCAACTCCAGCAGTTTAGCGATGCGATTGGTGAAGACGTGTTTGAGTATTTAACCTTAGAAGGCTC
ACTTGCCGCGCGTGATCATTTGGGCGGTACTGCGCCGAATCAAGTCAAACAAGCCGTCAGCCGTGGTCGTACTCGATTGG
AATTATTCGCTTAA

Upstream 100 bases:

>100_bases
TTCAAATAAAAATTCATCTGCTTCTGAGTTTAGCACAGATGCTTCTATAACAAACGCTGCCGCACAGAACAGCCCTACTA
CTAGTAGTCAGGGTCAACAG

Downstream 100 bases:

>100_bases
TATCTGTTTAATAGTATTAGCGCTTTATTATTAAAAATGCCCGCCTTCGTTGCGGGTGTTTTTTTGAGCATAATCAGGTA
CAGTATTAGGTAATATCATT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MWGGRFSEATDSFVAAFTASVGFDQRFARHDIQGSIAHATMLRECGILEADDVATIIDGLHQVLREIEAGEFNWSIALED
VHMNVESRLTDIVGAVGKKLHTGRSRNDQVATDIRLWLREETDNIIALLVRLQSGLLDLAEQHTDTIMPGFTHLQTAQPV
SFGHHVMAWFEMLYRDTERLVDARRRINQMPLGSAALAGTTFPIDRTITAELLGFEGICQNSLDAVSDRDFAIEFTSAAS
ILMMHMSRMSEEIILWMSAQFNFVQIPDRFCTGSSIMPQKKNPDVPELVRGKAARVFGQLMTLLSLMKSQPLAYNKDNQE
DKEPLFDCVDTLTGSLLAFADMLPNITPNKENMRAATMKGYATATDLADYLVRRGVAFRDAHEVVGNAVALGIAEGVDLS
DLSLAQLQQFSDAIGEDVFEYLTLEGSLAARDHLGGTAPNQVKQAVSRGRTRLELFA

Sequences:

>Translated_457_residues
MWGGRFSEATDSFVAAFTASVGFDQRFARHDIQGSIAHATMLRECGILEADDVATIIDGLHQVLREIEAGEFNWSIALED
VHMNVESRLTDIVGAVGKKLHTGRSRNDQVATDIRLWLREETDNIIALLVRLQSGLLDLAEQHTDTIMPGFTHLQTAQPV
SFGHHVMAWFEMLYRDTERLVDARRRINQMPLGSAALAGTTFPIDRTITAELLGFEGICQNSLDAVSDRDFAIEFTSAAS
ILMMHMSRMSEEIILWMSAQFNFVQIPDRFCTGSSIMPQKKNPDVPELVRGKAARVFGQLMTLLSLMKSQPLAYNKDNQE
DKEPLFDCVDTLTGSLLAFADMLPNITPNKENMRAATMKGYATATDLADYLVRRGVAFRDAHEVVGNAVALGIAEGVDLS
DLSLAQLQQFSDAIGEDVFEYLTLEGSLAARDHLGGTAPNQVKQAVSRGRTRLELFA
>Mature_457_residues
MWGGRFSEATDSFVAAFTASVGFDQRFARHDIQGSIAHATMLRECGILEADDVATIIDGLHQVLREIEAGEFNWSIALED
VHMNVESRLTDIVGAVGKKLHTGRSRNDQVATDIRLWLREETDNIIALLVRLQSGLLDLAEQHTDTIMPGFTHLQTAQPV
SFGHHVMAWFEMLYRDTERLVDARRRINQMPLGSAALAGTTFPIDRTITAELLGFEGICQNSLDAVSDRDFAIEFTSAAS
ILMMHMSRMSEEIILWMSAQFNFVQIPDRFCTGSSIMPQKKNPDVPELVRGKAARVFGQLMTLLSLMKSQPLAYNKDNQE
DKEPLFDCVDTLTGSLLAFADMLPNITPNKENMRAATMKGYATATDLADYLVRRGVAFRDAHEVVGNAVALGIAEGVDLS
DLSLAQLQQFSDAIGEDVFEYLTLEGSLAARDHLGGTAPNQVKQAVSRGRTRLELFA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=43.1718061674009, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=43.1718061674009, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=41.1894273127753, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=40.3083700440529, Blast_Score=332, Evalue=4e-91,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=47.4725274725275, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321806, Length=460, Percent_Identity=42.1739130434783, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221473854, Length=442, Percent_Identity=38.2352941176471, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI78706858, Length=442, Percent_Identity=38.2352941176471, Blast_Score=319, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50543; Mature: 50543

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWGGRFSEATDSFVAAFTASVGFDQRFARHDIQGSIAHATMLRECGILEADDVATIIDGL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
HQVLREIEAGEFNWSIALEDVHMNVESRLTDIVGAVGKKLHTGRSRNDQVATDIRLWLRE
HHHHHHHHCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ETDNIIALLVRLQSGLLDLAEQHTDTIMPGFTHLQTAQPVSFGHHVMAWFEMLYRDTERL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VDARRRINQMPLGSAALAGTTFPIDRTITAELLGFEGICQNSLDAVSDRDFAIEFTSAAS
HHHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHCHHHHHHHHHHHCCCCCEEEEEHHHHH
ILMMHMSRMSEEIILWMSAQFNFVQIPDRFCTGSSIMPQKKNPDVPELVRGKAARVFGQL
HHHHHHHHHHHHEEEEEECCCCEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MTLLSLMKSQPLAYNKDNQEDKEPLFDCVDTLTGSLLAFADMLPNITPNKENMRAATMKG
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
YATATDLADYLVRRGVAFRDAHEVVGNAVALGIAEGVDLSDLSLAQLQQFSDAIGEDVFE
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
YLTLEGSLAARDHLGGTAPNQVKQAVSRGRTRLELFA
HHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MWGGRFSEATDSFVAAFTASVGFDQRFARHDIQGSIAHATMLRECGILEADDVATIIDGL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
HQVLREIEAGEFNWSIALEDVHMNVESRLTDIVGAVGKKLHTGRSRNDQVATDIRLWLRE
HHHHHHHHCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ETDNIIALLVRLQSGLLDLAEQHTDTIMPGFTHLQTAQPVSFGHHVMAWFEMLYRDTERL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VDARRRINQMPLGSAALAGTTFPIDRTITAELLGFEGICQNSLDAVSDRDFAIEFTSAAS
HHHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHCHHHHHHHHHHHCCCCCEEEEEHHHHH
ILMMHMSRMSEEIILWMSAQFNFVQIPDRFCTGSSIMPQKKNPDVPELVRGKAARVFGQL
HHHHHHHHHHHHEEEEEECCCCEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MTLLSLMKSQPLAYNKDNQEDKEPLFDCVDTLTGSLLAFADMLPNITPNKENMRAATMKG
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
YATATDLADYLVRRGVAFRDAHEVVGNAVALGIAEGVDLSDLSLAQLQQFSDAIGEDVFE
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
YLTLEGSLAARDHLGGTAPNQVKQAVSRGRTRLELFA
HHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA