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The map label for this gene is pepA [H]

Identifier: 93004882

GI number: 93004882

Start: 59445

End: 61124

Strand: Reverse

Name: pepA [H]

Synonym: Pcryo_0051

Alternate gene names: 93004882

Gene position: 61124-59445 (Counterclockwise)

Preceding gene: 93004883

Following gene: 93004881

Centisome position: 2.0

GC content: 43.75

Gene sequence:

>1680_bases
ATGAATATTAAATTAACGCAAAGTTTACCGAAAACCCATACACAAAAAATTCTTAAAAAAGAAGCTAAAAGCAAAGATGC
CGCTTGCCTCGTCGTCTTAATTGATGATAAGAAAAATATCTTAGCTGAGTCGGTATTAAGTGATTATCAAACCCGTATTG
AGCAATTGATTGAAGTATCGCACTTTAATGGCAAAGCTTGTGAGACGGTTGCTGACTATGCGCTGGCTGGCGATAAAAAA
ACCACCAAAGAAAATCCAGTACAGCTGTTATTGGTCGGTGTGGGTAATGTTGATAAATTACGTCATAGCGTTCTAGAAAA
AATTGCCAATACCATTTATAAGAGCACGCAAAAGCGTGTTGACTCTATCACTGTTGCGCTGGGCGATGCTTTAGAAGAAA
ACCATTTTAGTCAATTCGCGTTGAGCCTACTGGCAGCAAGCTATCGTTTTGATAAGTACAAATCTGAGCAGCAAACGCCT
GTTTTAACGGATATTTACTTACTGGCAGAGCCATCTTTAGAGGAATCGTTAAACTTTGCACAAGCGGTCTTTACTGGTCA
AAGCTTAACCCGTGATGTCGCCAATGAGCCGGGTAATATCTGTTTCCCAGCGTATATGGCTGAGCAAGCACAGGAATTGG
CAGCCACTTATCCTGACCTCTTAAAAGTCACCGTATTAGGTGAAAAAGAGATGTCAGCATTAGGTATGAACTGCTTCTTA
TCGGTCGCGCAAGGCTCGACCAAAGAGGGCAAGCTGGTGTTAATGGAATATCGTGGCAAGTCTAATTTTAGCGTCAATGC
TGATGGCGATACTAGCAAAGCCATTATCAACAGCGCAAAAGTAGCGGGTGGTCTAAAAGCATTGGCTGATAAGTTACCTA
GCAAAGCTACTAGCAAAAAAGCCGCTAAAAATGCGAAACAAGATAGTAATGACGATGTGCAAGTTGCAAATGACGACTCG
CCTATCGTATTGGTTGGTAAAGGCGTCACCTTCGATTCAGGTGGTATCTCAATCAAACCGGGTGCGGCGATGGATGAGAT
GAAATTTGATATGGGCGGTTCTGCTGCGGTAATCGGTACCCTAAAAGCATTATGTGAAGCGCGTCTACCTATCAACGTCG
TCGGTGCGCTAGCTTGTGCTGAAAATATGCCATCAGGAGAGGCGACGCGTCCTGGCGATATCATCATAGCAATGAACGGT
AAGTCAGTTGAGATATTAAATACCGATGCTGAAGGTCGTTTAGTACTGTGCGATACCTTGTGCTATGTACAGAAGTATTA
TCAGCCAAAAGCCATCATCGATGTCGCAACCTTGACTGGTGCTTGTGTGGTTGCGCTAGGTCACGTCCGCTCAGCGGTCT
TTAGTAATGACGAAGATGTGTTGTTTGACTTAGAAAACGCGAGTCATTTATCGGGTGATCTTATCTGGCACATGCCAATG
GATGACGAGTATCAAGCGCAGATTGACTCGCCTATTGCTGATATTCAAAATATCGGTGGTAAAGGTGCTGGCGCTGTTAC
TGCTGCATGTTTCTTATCGCGCTTTATAGAAGAAGGCCAAGCATGGGCGCATTTAGACATCGCTGGTACGGCATGGATTT
CAGGTCAAGACAAAGCTGCGACTGGTCGTCCTGTACCGTTATTTATGCAATATCTGAGAAATAGTGCAAACATGGCATAA

Upstream 100 bases:

>100_bases
AAATGCGTTAGCAGTTAAAATTTGATATCTTTTTAAATTTGACACCTTACTGTATTCACGCTTTTAAAAAAATGCATTCA
TCTAATAAGGATAACAATAT

Downstream 100 bases:

>100_bases
CTTATTAATGAGAACCAATTAATGAAAACCAATTAATGAAAATCAGTTTATGAACGTTAGCTTCTATGTATTAACTGAGA
ATAAAGCCCAAGATTTCTTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MNIKLTQSLPKTHTQKILKKEAKSKDAACLVVLIDDKKNILAESVLSDYQTRIEQLIEVSHFNGKACETVADYALAGDKK
TTKENPVQLLLVGVGNVDKLRHSVLEKIANTIYKSTQKRVDSITVALGDALEENHFSQFALSLLAASYRFDKYKSEQQTP
VLTDIYLLAEPSLEESLNFAQAVFTGQSLTRDVANEPGNICFPAYMAEQAQELAATYPDLLKVTVLGEKEMSALGMNCFL
SVAQGSTKEGKLVLMEYRGKSNFSVNADGDTSKAIINSAKVAGGLKALADKLPSKATSKKAAKNAKQDSNDDVQVANDDS
PIVLVGKGVTFDSGGISIKPGAAMDEMKFDMGGSAAVIGTLKALCEARLPINVVGALACAENMPSGEATRPGDIIIAMNG
KSVEILNTDAEGRLVLCDTLCYVQKYYQPKAIIDVATLTGACVVALGHVRSAVFSNDEDVLFDLENASHLSGDLIWHMPM
DDEYQAQIDSPIADIQNIGGKGAGAVTAACFLSRFIEEGQAWAHLDIAGTAWISGQDKAATGRPVPLFMQYLRNSANMA

Sequences:

>Translated_559_residues
MNIKLTQSLPKTHTQKILKKEAKSKDAACLVVLIDDKKNILAESVLSDYQTRIEQLIEVSHFNGKACETVADYALAGDKK
TTKENPVQLLLVGVGNVDKLRHSVLEKIANTIYKSTQKRVDSITVALGDALEENHFSQFALSLLAASYRFDKYKSEQQTP
VLTDIYLLAEPSLEESLNFAQAVFTGQSLTRDVANEPGNICFPAYMAEQAQELAATYPDLLKVTVLGEKEMSALGMNCFL
SVAQGSTKEGKLVLMEYRGKSNFSVNADGDTSKAIINSAKVAGGLKALADKLPSKATSKKAAKNAKQDSNDDVQVANDDS
PIVLVGKGVTFDSGGISIKPGAAMDEMKFDMGGSAAVIGTLKALCEARLPINVVGALACAENMPSGEATRPGDIIIAMNG
KSVEILNTDAEGRLVLCDTLCYVQKYYQPKAIIDVATLTGACVVALGHVRSAVFSNDEDVLFDLENASHLSGDLIWHMPM
DDEYQAQIDSPIADIQNIGGKGAGAVTAACFLSRFIEEGQAWAHLDIAGTAWISGQDKAATGRPVPLFMQYLRNSANMA
>Mature_559_residues
MNIKLTQSLPKTHTQKILKKEAKSKDAACLVVLIDDKKNILAESVLSDYQTRIEQLIEVSHFNGKACETVADYALAGDKK
TTKENPVQLLLVGVGNVDKLRHSVLEKIANTIYKSTQKRVDSITVALGDALEENHFSQFALSLLAASYRFDKYKSEQQTP
VLTDIYLLAEPSLEESLNFAQAVFTGQSLTRDVANEPGNICFPAYMAEQAQELAATYPDLLKVTVLGEKEMSALGMNCFL
SVAQGSTKEGKLVLMEYRGKSNFSVNADGDTSKAIINSAKVAGGLKALADKLPSKATSKKAAKNAKQDSNDDVQVANDDS
PIVLVGKGVTFDSGGISIKPGAAMDEMKFDMGGSAAVIGTLKALCEARLPINVVGALACAENMPSGEATRPGDIIIAMNG
KSVEILNTDAEGRLVLCDTLCYVQKYYQPKAIIDVATLTGACVVALGHVRSAVFSNDEDVLFDLENASHLSGDLIWHMPM
DDEYQAQIDSPIADIQNIGGKGAGAVTAACFLSRFIEEGQAWAHLDIAGTAWISGQDKAATGRPVPLFMQYLRNSANMA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=413, Percent_Identity=34.3825665859564, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI47155554, Length=212, Percent_Identity=38.2075471698113, Blast_Score=120, Evalue=5e-27,
Organism=Escherichia coli, GI1790710, Length=553, Percent_Identity=38.1555153707052, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI87082123, Length=210, Percent_Identity=46.6666666666667, Blast_Score=163, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17556903, Length=245, Percent_Identity=37.9591836734694, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=132, Percent_Identity=37.1212121212121, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129969, Length=249, Percent_Identity=35.3413654618474, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24661038, Length=245, Percent_Identity=35.9183673469388, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21355725, Length=242, Percent_Identity=35.5371900826446, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24662227, Length=247, Percent_Identity=34.412955465587, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21355645, Length=245, Percent_Identity=32.2448979591837, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24662223, Length=245, Percent_Identity=32.2448979591837, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI161077148, Length=247, Percent_Identity=31.9838056680162, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI20130057, Length=247, Percent_Identity=31.9838056680162, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19922386, Length=248, Percent_Identity=32.258064516129, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20129963, Length=250, Percent_Identity=32, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21357381, Length=233, Percent_Identity=38.6266094420601, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI221379063, Length=233, Percent_Identity=38.6266094420601, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221379062, Length=233, Percent_Identity=38.6266094420601, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646701, Length=142, Percent_Identity=36.6197183098592, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646703, Length=142, Percent_Identity=36.6197183098592, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21358201, Length=142, Percent_Identity=36.6197183098592, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 59958; Mature: 59958

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKLTQSLPKTHTQKILKKEAKSKDAACLVVLIDDKKNILAESVLSDYQTRIEQLIEVS
CCEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
HFNGKACETVADYALAGDKKTTKENPVQLLLVGVGNVDKLRHSVLEKIANTIYKSTQKRV
CCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
DSITVALGDALEENHFSQFALSLLAASYRFDKYKSEQQTPVLTDIYLLAEPSLEESLNFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHH
QAVFTGQSLTRDVANEPGNICFPAYMAEQAQELAATYPDLLKVTVLGEKEMSALGMNCFL
HHHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCHHHHE
SVAQGSTKEGKLVLMEYRGKSNFSVNADGDTSKAIINSAKVAGGLKALADKLPSKATSKK
EECCCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AAKNAKQDSNDDVQVANDDSPIVLVGKGVTFDSGGISIKPGAAMDEMKFDMGGSAAVIGT
HHHCCCCCCCCCEEEECCCCCEEEEECCEEECCCCEEECCCCCHHHHHHCCCCCHHHHHH
LKALCEARLPINVVGALACAENMPSGEATRPGDIIIAMNGKSVEILNTDAEGRLVLCDTL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCEEEEHHH
CYVQKYYQPKAIIDVATLTGACVVALGHVRSAVFSNDEDVLFDLENASHLSGDLIWHMPM
HHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCC
DDEYQAQIDSPIADIQNIGGKGAGAVTAACFLSRFIEEGQAWAHLDIAGTAWISGQDKAA
CCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECEEEEECCCCCCC
TGRPVPLFMQYLRNSANMA
CCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIKLTQSLPKTHTQKILKKEAKSKDAACLVVLIDDKKNILAESVLSDYQTRIEQLIEVS
CCEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
HFNGKACETVADYALAGDKKTTKENPVQLLLVGVGNVDKLRHSVLEKIANTIYKSTQKRV
CCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
DSITVALGDALEENHFSQFALSLLAASYRFDKYKSEQQTPVLTDIYLLAEPSLEESLNFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHH
QAVFTGQSLTRDVANEPGNICFPAYMAEQAQELAATYPDLLKVTVLGEKEMSALGMNCFL
HHHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCHHHHE
SVAQGSTKEGKLVLMEYRGKSNFSVNADGDTSKAIINSAKVAGGLKALADKLPSKATSKK
EECCCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AAKNAKQDSNDDVQVANDDSPIVLVGKGVTFDSGGISIKPGAAMDEMKFDMGGSAAVIGT
HHHCCCCCCCCCEEEECCCCCEEEEECCEEECCCCEEECCCCCHHHHHHCCCCCHHHHHH
LKALCEARLPINVVGALACAENMPSGEATRPGDIIIAMNGKSVEILNTDAEGRLVLCDTL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCEEEEHHH
CYVQKYYQPKAIIDVATLTGACVVALGHVRSAVFSNDEDVLFDLENASHLSGDLIWHMPM
HHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCC
DDEYQAQIDSPIADIQNIGGKGAGAVTAACFLSRFIEEGQAWAHLDIAGTAWISGQDKAA
CCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECEEEEECCCCCCC
TGRPVPLFMQYLRNSANMA
CCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]