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The map label for this gene is hemL

Identifier: 92115419

GI number: 92115419

Start: 3680165

End: 3681454

Strand: Direct

Name: hemL

Synonym: Csal_3304

Alternate gene names: 92115419

Gene position: 3680165-3681454 (Clockwise)

Preceding gene: 92115418

Following gene: 92115420

Centisome position: 99.55

GC content: 66.05

Gene sequence:

>1290_bases
ATGACCACGTCCGCACAACTCTTCGAGCAGGCTTGCCGTCACATCCCCGGCGGTGTGAATTCCCCCGTGCGTGCCTTCAA
GGGCATGGAACGCGCGCCGGTCTTCGTGGAACGCGCCCAGGGGGCTTATCTCTACGATGTCGAAGGGCAGCGCTATATCG
ATTACGTCGGCTCCTGGGGGCCGCTGATCACCGGCCACGCCGATCCCGACGTGCTGGGTGCGGTCCGCAGCCGTCTCGAC
GATGGCTTGTCCTTCGGCACGCCGACCGCCATCGAGACGCGCATGGCGGAGTTGATCTGCGAGATCATGCCGTCGATCGA
CATGGTGCGCATGGTCAACTCGGGCACCGAGGCCACCATGTCGGCGATCCGCCTGGCGCGCGGCCATACCGGCCGTGACA
AGATCGTCAAGTTCGAGGGCAACTACCACGGGCACTCCGACTCGCTGCTGGTCAAGGCCGGTTCCGGCGCGCTGACCCAC
GGCGAGCCCAGCTCGCCCGGTGTGCCCGCGTCCCTGGCCGAACACACCGTGACGCTGCCCTACAACGACCTGGACGCGGT
ACGCGCGTGTTTCGCCGAACTGGGCGACGAGATCGCCGGTATCATCGTCGAACCGGTGGCGGGCAACATGAACTGCATTC
CGCCGCAGCCCGACTTCCTCAAGGGATTGCGCGAGATCTGCGATGTGCATGGCAGCGTCTTGATCTTCGACGAGGTGATG
ACCGGCTTTCGCGTGGCGCTGGGCGGCGCTCAGGCGCATTTCGGCGTCACCCCGGATTTGACCTGCCTGGGCAAGATCGT
CGGCGGCGGCATGCCGGTGGGCGCCTTCGGCGGCACGCGCGAGATCATGGAGCAGCTCTCGCCGCTGGGACCGATTTACC
AGGCAGGCACGCTGGCCGGCAATCCGCTGGCCATGGCCGCCGGTATCGCGCTGCTGGAGAAGATTCGCCAGCCGGGCTTT
CACGACGCGCTCGCCGAACGCGTGGCAACCCTCTGCGACGGCCTGGAAGCCCGTGCTCGGGAGGCCGGTGTCGACCTGAT
CACGCAACGTGCGGGTGGCATGTTCGGGGTCTTCTTCACCGCCCAGCAACGTGTCGATAATTTCGCGCAAGCGACGGCCT
GCAACGCCGATACCTTCCGGCGTTTCTTCCTCGGCATGCTCGAACACGGCGTCTATCTTGCGCCGTCACCGTTCGAGGCG
GGCTTCATGTCCAGCGCGCACACGCCCGACGATATCCAGGCCACGCTGGATGCCGCCGAGCAGGTATTGGCGACGCTCGA
GAACGCCTGA

Upstream 100 bases:

>100_bases
ATCCACAGAGTCGAGCGGCGAGTTGTTCGACCTGTCCAGAGAGTTATCCACAGTTTCTTTTGCGACACGTTATCTTAGCC
ACACACAGCCAGAGGAAGTC

Downstream 100 bases:

>100_bases
GGTGGCGGATGAACGGGCAATGGAACGACGGGACGCGGGGGAACGCTCAGTGAGCCAGGCATTGATCGAGGCATTGCGCC
AGGGCCGGGGATTCGACCAT

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTTSAQLFEQACRHIPGGVNSPVRAFKGMERAPVFVERAQGAYLYDVEGQRYIDYVGSWGPLITGHADPDVLGAVRSRLD
DGLSFGTPTAIETRMAELICEIMPSIDMVRMVNSGTEATMSAIRLARGHTGRDKIVKFEGNYHGHSDSLLVKAGSGALTH
GEPSSPGVPASLAEHTVTLPYNDLDAVRACFAELGDEIAGIIVEPVAGNMNCIPPQPDFLKGLREICDVHGSVLIFDEVM
TGFRVALGGAQAHFGVTPDLTCLGKIVGGGMPVGAFGGTREIMEQLSPLGPIYQAGTLAGNPLAMAAGIALLEKIRQPGF
HDALAERVATLCDGLEARAREAGVDLITQRAGGMFGVFFTAQQRVDNFAQATACNADTFRRFFLGMLEHGVYLAPSPFEA
GFMSSAHTPDDIQATLDAAEQVLATLENA

Sequences:

>Translated_429_residues
MTTSAQLFEQACRHIPGGVNSPVRAFKGMERAPVFVERAQGAYLYDVEGQRYIDYVGSWGPLITGHADPDVLGAVRSRLD
DGLSFGTPTAIETRMAELICEIMPSIDMVRMVNSGTEATMSAIRLARGHTGRDKIVKFEGNYHGHSDSLLVKAGSGALTH
GEPSSPGVPASLAEHTVTLPYNDLDAVRACFAELGDEIAGIIVEPVAGNMNCIPPQPDFLKGLREICDVHGSVLIFDEVM
TGFRVALGGAQAHFGVTPDLTCLGKIVGGGMPVGAFGGTREIMEQLSPLGPIYQAGTLAGNPLAMAAGIALLEKIRQPGF
HDALAERVATLCDGLEARAREAGVDLITQRAGGMFGVFFTAQQRVDNFAQATACNADTFRRFFLGMLEHGVYLAPSPFEA
GFMSSAHTPDDIQATLDAAEQVLATLENA
>Mature_428_residues
TTSAQLFEQACRHIPGGVNSPVRAFKGMERAPVFVERAQGAYLYDVEGQRYIDYVGSWGPLITGHADPDVLGAVRSRLDD
GLSFGTPTAIETRMAELICEIMPSIDMVRMVNSGTEATMSAIRLARGHTGRDKIVKFEGNYHGHSDSLLVKAGSGALTHG
EPSSPGVPASLAEHTVTLPYNDLDAVRACFAELGDEIAGIIVEPVAGNMNCIPPQPDFLKGLREICDVHGSVLIFDEVMT
GFRVALGGAQAHFGVTPDLTCLGKIVGGGMPVGAFGGTREIMEQLSPLGPIYQAGTLAGNPLAMAAGIALLEKIRQPGFH
DALAERVATLCDGLEARAREAGVDLITQRAGGMFGVFFTAQQRVDNFAQATACNADTFRRFFLGMLEHGVYLAPSPFEAG
FMSSAHTPDDIQATLDAAEQVLATLENA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=346, Percent_Identity=29.4797687861272, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI13994255, Length=332, Percent_Identity=27.1084337349398, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI24119277, Length=333, Percent_Identity=26.7267267267267, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI37574042, Length=426, Percent_Identity=25.5868544600939, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI226442705, Length=425, Percent_Identity=24.7058823529412, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI284507298, Length=265, Percent_Identity=29.811320754717, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=25.3807106598985, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=62.4413145539906, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1789016, Length=359, Percent_Identity=30.6406685236769, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788044, Length=316, Percent_Identity=33.2278481012658, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI145693181, Length=360, Percent_Identity=30.8333333333333, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1789759, Length=308, Percent_Identity=31.1688311688312, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787560, Length=283, Percent_Identity=33.2155477031802, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786991, Length=422, Percent_Identity=29.3838862559242, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=337, Percent_Identity=28.486646884273, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=181, Percent_Identity=32.5966850828729, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323470, Length=342, Percent_Identity=28.0701754385965, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324432, Length=327, Percent_Identity=28.1345565749235, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21357415, Length=353, Percent_Identity=26.3456090651558, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21356575, Length=320, Percent_Identity=28.125, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_CHRSD (Q1QSB0)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_575347.1
- ProteinModelPortal:   Q1QSB0
- SMR:   Q1QSB0
- STRING:   Q1QSB0
- GeneID:   4028849
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_3304
- NMPDR:   fig|290398.4.peg.2581
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- BioCyc:   CSAL290398:CSAL_3304-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45522; Mature: 45391

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSAQLFEQACRHIPGGVNSPVRAFKGMERAPVFVERAQGAYLYDVEGQRYIDYVGSWG
CCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHCCCCEEEECCCCHHHHHHCCCC
PLITGHADPDVLGAVRSRLDDGLSFGTPTAIETRMAELICEIMPSIDMVRMVNSGTEATM
CEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
SAIRLARGHTGRDKIVKFEGNYHGHSDSLLVKAGSGALTHGEPSSPGVPASLAEHTVTLP
HHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCEEECC
YNDLDAVRACFAELGDEIAGIIVEPVAGNMNCIPPQPDFLKGLREICDVHGSVLIFDEVM
CCHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHH
TGFRVALGGAQAHFGVTPDLTCLGKIVGGGMPVGAFGGTREIMEQLSPLGPIYQAGTLAG
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCCCC
NPLAMAAGIALLEKIRQPGFHDALAERVATLCDGLEARAREAGVDLITQRAGGMFGVFFT
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
AQQRVDNFAQATACNADTFRRFFLGMLEHGVYLAPSPFEAGFMSSAHTPDDIQATLDAAE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECCCCCCHHCCCCCCCCHHHHHHHHHHH
QVLATLENA
HHHHHHCCC
>Mature Secondary Structure 
TTSAQLFEQACRHIPGGVNSPVRAFKGMERAPVFVERAQGAYLYDVEGQRYIDYVGSWG
CCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHCCCCEEEECCCCHHHHHHCCCC
PLITGHADPDVLGAVRSRLDDGLSFGTPTAIETRMAELICEIMPSIDMVRMVNSGTEATM
CEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
SAIRLARGHTGRDKIVKFEGNYHGHSDSLLVKAGSGALTHGEPSSPGVPASLAEHTVTLP
HHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCEEECC
YNDLDAVRACFAELGDEIAGIIVEPVAGNMNCIPPQPDFLKGLREICDVHGSVLIFDEVM
CCHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHH
TGFRVALGGAQAHFGVTPDLTCLGKIVGGGMPVGAFGGTREIMEQLSPLGPIYQAGTLAG
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCCCC
NPLAMAAGIALLEKIRQPGFHDALAERVATLCDGLEARAREAGVDLITQRAGGMFGVFFT
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
AQQRVDNFAQATACNADTFRRFFLGMLEHGVYLAPSPFEAGFMSSAHTPDDIQATLDAAE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECCCCCCHHCCCCCCCCHHHHHHHHHHH
QVLATLENA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA