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The map label for this gene is gmk

Identifier: 92115348

GI number: 92115348

Start: 3603003

End: 3603650

Strand: Direct

Name: gmk

Synonym: Csal_3233

Alternate gene names: 92115348

Gene position: 3603003-3603650 (Clockwise)

Preceding gene: 92115345

Following gene: 92115349

Centisome position: 97.47

GC content: 66.05

Gene sequence:

>648_bases
ATGCCCATCCAGCCTCCGTCAAAAGGGACACTCTACATCGTCTCGGCGCCTTCCGGCGCAGGCAAGACCAGCCTGGTGCG
CGCCCTGCTCGAACGCGTCGCGGGCATCCAGGTCAGCGTCTCGCACACCACCCGGGCCATGCGCCCCGGCGAGCAGAATG
GCATCAACTATCACTTCGTCGACGTCGCCACCTTCGAGCGCCTGATCGAAAGCGGCGATTTCATCGAGCATGCGCGGGTC
TTCGACAATTATTACGGCACCTCGCGCGCCGCCGTGCAGGCCCTGCTCGACGCCGGCCAGGACGTCATCCTGGAGATCGA
CTGGCAAGGTGCCCGCCAGGTACGCGAGGCCTTCGACGAGGCCGTCTCGATCTTCATTCTCCCGCCCTCGCGGGAAGCGC
TCCACGCACGGCTTGCCGGGCGCGGCACCGACGACGCGGCGACCATCGCCCGGCGCATGCGCGACGCGGTCGACGAAATG
TCGCATTACGACGAATACGAGCATGTCATCATCAACGACACCTTCGACCATGCGCTCGACGAACTGAGCTGCCTGGTGCA
TGCCCAGCGTACCCGCATGCCGCGGGTGCAGGCAGAGCACGCCCCGCTGCTGGCGGCGCTCTTGTCACGCGTGGAAGACG
TCGAGTAG

Upstream 100 bases:

>100_bases
TTCCTTATCGTGAAGGCGCAAGAGACCCGATATCGGCAGGGCACGAAGTCTATGCGATAATGCCCGATTACCCCAGAAGC
GGCTCAACCGGACACGCCAT

Downstream 100 bases:

>100_bases
ACTCGAGGGTCCTTCCGCAGGTCCGGCTTATGCCGTTTTCATTTCTCGATCAGGGTTCACACTCATGGCACGCGTTACCG
TAGAAGATTGCCTCGACAAC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MPIQPPSKGTLYIVSAPSGAGKTSLVRALLERVAGIQVSVSHTTRAMRPGEQNGINYHFVDVATFERLIESGDFIEHARV
FDNYYGTSRAAVQALLDAGQDVILEIDWQGARQVREAFDEAVSIFILPPSREALHARLAGRGTDDAATIARRMRDAVDEM
SHYDEYEHVIINDTFDHALDELSCLVHAQRTRMPRVQAEHAPLLAALLSRVEDVE

Sequences:

>Translated_215_residues
MPIQPPSKGTLYIVSAPSGAGKTSLVRALLERVAGIQVSVSHTTRAMRPGEQNGINYHFVDVATFERLIESGDFIEHARV
FDNYYGTSRAAVQALLDAGQDVILEIDWQGARQVREAFDEAVSIFILPPSREALHARLAGRGTDDAATIARRMRDAVDEM
SHYDEYEHVIINDTFDHALDELSCLVHAQRTRMPRVQAEHAPLLAALLSRVEDVE
>Mature_214_residues
PIQPPSKGTLYIVSAPSGAGKTSLVRALLERVAGIQVSVSHTTRAMRPGEQNGINYHFVDVATFERLIESGDFIEHARVF
DNYYGTSRAAVQALLDAGQDVILEIDWQGARQVREAFDEAVSIFILPPSREALHARLAGRGTDDAATIARRMRDAVDEMS
HYDEYEHVIINDTFDHALDELSCLVHAQRTRMPRVQAEHAPLLAALLSRVEDVE

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=40.9574468085106, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=40.9574468085106, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=40.9574468085106, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI38570142, Length=193, Percent_Identity=32.1243523316062, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI14780902, Length=190, Percent_Identity=30, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI111154074, Length=160, Percent_Identity=30, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21361598, Length=201, Percent_Identity=26.865671641791, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21536464, Length=130, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI261862237, Length=151, Percent_Identity=28.476821192053, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI119943108, Length=151, Percent_Identity=28.476821192053, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI119943106, Length=152, Percent_Identity=28.2894736842105, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1790080, Length=205, Percent_Identity=54.1463414634146, Blast_Score=219, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI193203132, Length=191, Percent_Identity=32.4607329842932, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=187, Percent_Identity=32.620320855615, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=40.4371584699454, Blast_Score=132, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21356141, Length=178, Percent_Identity=33.7078651685393, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45554489, Length=174, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85724806, Length=174, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007136, Length=174, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640542, Length=174, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161077626, Length=174, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554481, Length=174, Percent_Identity=26.4367816091954, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330162, Length=127, Percent_Identity=33.0708661417323, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330166, Length=127, Percent_Identity=33.0708661417323, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330164, Length=127, Percent_Identity=33.0708661417323, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CHRSD (Q1QSI1)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_575276.1
- ProteinModelPortal:   Q1QSI1
- SMR:   Q1QSI1
- STRING:   Q1QSI1
- GeneID:   4028567
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_3233
- NMPDR:   fig|290398.4.peg.1959
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   CSAL290398:CSAL_3233-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23861; Mature: 23730

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQPPSKGTLYIVSAPSGAGKTSLVRALLERVAGIQVSVSHTTRAMRPGEQNGINYHFV
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECHHHHHCCCCCCCCCCEEEE
DVATFERLIESGDFIEHARVFDNYYGTSRAAVQALLDAGQDVILEIDWQGARQVREAFDE
HHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
AVSIFILPPSREALHARLAGRGTDDAATIARRMRDAVDEMSHYDEYEHVIINDTFDHALD
HEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHH
ELSCLVHAQRTRMPRVQAEHAPLLAALLSRVEDVE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIQPPSKGTLYIVSAPSGAGKTSLVRALLERVAGIQVSVSHTTRAMRPGEQNGINYHFV
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECHHHHHCCCCCCCCCCEEEE
DVATFERLIESGDFIEHARVFDNYYGTSRAAVQALLDAGQDVILEIDWQGARQVREAFDE
HHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
AVSIFILPPSREALHARLAGRGTDDAATIARRMRDAVDEMSHYDEYEHVIINDTFDHALD
HEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHH
ELSCLVHAQRTRMPRVQAEHAPLLAALLSRVEDVE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA