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The map label for this gene is mip [H]

Identifier: 92115256

GI number: 92115256

Start: 3497868

End: 3498587

Strand: Direct

Name: mip [H]

Synonym: Csal_3141

Alternate gene names: 92115256

Gene position: 3497868-3498587 (Clockwise)

Preceding gene: 92115254

Following gene: 92115258

Centisome position: 94.62

GC content: 62.64

Gene sequence:

>720_bases
ATGAAGCGTTTGATGACGGCCGTGGTATTCGGCGGCCTCGTGGCAACGCCGCTGGTGGCCATGGCCGCCCCGGAAAGCGA
CAACGCCAAGCTGGGCTACAGCCTTGGCGCCACGCTCGGTCAAAGCATGAAGCAGGACGTCTCGGATCTCGATACCGACG
CCTTCACCCAAGCGATCAAGGATGTCTACGCCGGTGACGATCTGCAGATGAGCGACGAGGAAATCGCCGCCACGCTTTCC
GACTACCAGCAGCAGAAGATGGCCGAACAACAGGCCGAGAAGGCAAAAGTCGCCGAGGAAAACCGCAAGGCGAGCGAGCA
GTTTCTCGCCGAAAACGCCGAGAAAGAGGGCGTGAAGGTCACCGATTCGGGACTGCAGTACAAGGTGCTCGAGTCCGGGG
ATGGCGACACCCCCAGCGCCGGCGATACCGTGAAGGTCAACTACGAGGGCAAGCTGCCCGACGGTACCGTGTTCGACAGC
TCCTACGAGCGCGGCGAGCCGATCACCTTCCAGGTCGGCCAGGTCATCGAGGGCTGGCAGGAAGCGCTGCAGAAGATGCA
GGTCGGCGATACCTGGATGCTGTACGTGCCCGCCGACCTCGCCTACGGCAAGGGCGGCACCGGTGGCCCGATCGGTCCCA
ATCAGGCCCTCGTGTTCAAGATCGAACTGCTGGGCATCGAAGACGGCAACGATCAGGACGCCTCCTCGAACGGCGAATGA

Upstream 100 bases:

>100_bases
CGCTTCAATGTCAAGAGAGCCCCGCCGCGTGGGTGCGCAACGCCGCGCGTGCTGGTAGAGTTGAACGGCGGTGTTTTTGT
TTACCTGTTAAGGAGTTTTC

Downstream 100 bases:

>100_bases
CGTCCGTCACCCACGGCGCCCGTCCACGGGCGCCGTTTCGTTTTTCCCGCCGACATCCGCAGACGTCTTTTCCACATCCC
CATCGCCCCGCCTGCCTGTG

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKRLMTAVVFGGLVATPLVAMAAPESDNAKLGYSLGATLGQSMKQDVSDLDTDAFTQAIKDVYAGDDLQMSDEEIAATLS
DYQQQKMAEQQAEKAKVAEENRKASEQFLAENAEKEGVKVTDSGLQYKVLESGDGDTPSAGDTVKVNYEGKLPDGTVFDS
SYERGEPITFQVGQVIEGWQEALQKMQVGDTWMLYVPADLAYGKGGTGGPIGPNQALVFKIELLGIEDGNDQDASSNGE

Sequences:

>Translated_239_residues
MKRLMTAVVFGGLVATPLVAMAAPESDNAKLGYSLGATLGQSMKQDVSDLDTDAFTQAIKDVYAGDDLQMSDEEIAATLS
DYQQQKMAEQQAEKAKVAEENRKASEQFLAENAEKEGVKVTDSGLQYKVLESGDGDTPSAGDTVKVNYEGKLPDGTVFDS
SYERGEPITFQVGQVIEGWQEALQKMQVGDTWMLYVPADLAYGKGGTGGPIGPNQALVFKIELLGIEDGNDQDASSNGE
>Mature_239_residues
MKRLMTAVVFGGLVATPLVAMAAPESDNAKLGYSLGATLGQSMKQDVSDLDTDAFTQAIKDVYAGDDLQMSDEEIAATLS
DYQQQKMAEQQAEKAKVAEENRKASEQFLAENAEKEGVKVTDSGLQYKVLESGDGDTPSAGDTVKVNYEGKLPDGTVFDS
SYERGEPITFQVGQVIEGWQEALQKMQVGDTWMLYVPADLAYGKGGTGGPIGPNQALVFKIELLGIEDGNDQDASSNGE

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=43.9252336448598, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=43.9252336448598, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI224809329, Length=106, Percent_Identity=41.5094339622642, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI224809327, Length=106, Percent_Identity=41.5094339622642, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4758384, Length=106, Percent_Identity=41.5094339622642, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI224809331, Length=130, Percent_Identity=38.4615384615385, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4503729, Length=115, Percent_Identity=38.2608695652174, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=43.8202247191011, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=43.8202247191011, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=43.8202247191011, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4503727, Length=110, Percent_Identity=40, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI33469985, Length=100, Percent_Identity=42, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI8923659, Length=94, Percent_Identity=41.4893617021277, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI192448443, Length=94, Percent_Identity=36.1702127659575, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=220, Percent_Identity=39.0909090909091, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI87082390, Length=209, Percent_Identity=40.1913875598086, Blast_Score=144, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=40.5660377358491, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=89, Percent_Identity=43.8202247191011, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=89, Percent_Identity=38.2022471910112, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=90, Percent_Identity=50, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=41.0714285714286, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=43.9252336448598, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=38.3177570093458, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281363946, Length=89, Percent_Identity=44.9438202247191, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17352457, Length=89, Percent_Identity=44.9438202247191, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21356629, Length=90, Percent_Identity=47.7777777777778, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647110, Length=114, Percent_Identity=35.0877192982456, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25550; Mature: 25550

Theoretical pI: Translated: 3.95; Mature: 3.95

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLMTAVVFGGLVATPLVAMAAPESDNAKLGYSLGATLGQSMKQDVSDLDTDAFTQAIK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DVYAGDDLQMSDEEIAATLSDYQQQKMAEQQAEKAKVAEENRKASEQFLAENAEKEGVKV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCEE
TDSGLQYKVLESGDGDTPSAGDTVKVNYEGKLPDGTVFDSSYERGEPITFQVGQVIEGWQ
ECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCEEEHHHHHHHHHH
EALQKMQVGDTWMLYVPADLAYGKGGTGGPIGPNQALVFKIELLGIEDGNDQDASSNGE
HHHHHHHCCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKRLMTAVVFGGLVATPLVAMAAPESDNAKLGYSLGATLGQSMKQDVSDLDTDAFTQAIK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DVYAGDDLQMSDEEIAATLSDYQQQKMAEQQAEKAKVAEENRKASEQFLAENAEKEGVKV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCEE
TDSGLQYKVLESGDGDTPSAGDTVKVNYEGKLPDGTVFDSSYERGEPITFQVGQVIEGWQ
ECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCEEEHHHHHHHHHH
EALQKMQVGDTWMLYVPADLAYGKGGTGGPIGPNQALVFKIELLGIEDGNDQDASSNGE
HHHHHHHCCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7516906 [H]