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The map label for this gene is argH

Identifier: 92115225

GI number: 92115225

Start: 3465370

End: 3466773

Strand: Direct

Name: argH

Synonym: Csal_3110

Alternate gene names: 92115225

Gene position: 3465370-3466773 (Clockwise)

Preceding gene: 92115219

Following gene: 92115226

Centisome position: 93.74

GC content: 66.03

Gene sequence:

>1404_bases
ATGAGCAACACGACCAACCAATCCTGGGGCGGACGCTTCAGCGAGCCCACCGACGCTTTCGTCGCACGTTTCACGGCCTC
GGTGGACTTCGACCGGCGCCTCTATCACCACGACATCCGGGGCTCGATCGCCCACGCCACCATGCTCGAGCGTGTCGGCG
TGCTCACCGCCGACGAGCGCGACGCCATCCTGCAGGGGCTCGGCGAGATCGAGCAGGAAATCGACGCCGGCACCTTCGAA
TGGTCGGTGGACCTGGAAGACGTGCACATGAATCTCGAGGCCCGGCTGACCGAGAAGATCGGCATCACCGGCAAGAAGCT
GCACACCGGTCGCTCGCGCAACGATCAGATCGCCACCGACATCCGCCTCTATCTGCGCGACGCGATCGACGTCGTCGATG
CCGAGCTTGCCCGACTGCGCGAGGGATTGATCGAACTCGCCGCCCGCGAAGCCGACACCATCATGCCCGGCTTCACGCAT
CTTCAGACGGCCCAGCCGGTGACCTTCGGGCATCACCTGCTGGCCTGGCAGGAAATGCTGGCCCGCGATCACGAGCGCCT
GCGCGACTGCCGCAAGCGGGTCAACGTCATGCCACTGGGCGCCGCTGCCCTGGCCGGCACCACCTATCCCATCGATCGCC
ACATCACTGCCGAGCTGCTGGGCTTCGAGCGCCCCGCCGAAAACAGCCTCGACGCGGTGAGCGATCGCGATTTCGCCATC
GAGTTCGGCGCCTTCGCCAGCGTGCTGCTGATGCACATGTCGCGCATGAGCGAGGAACTGGTGTTGTGGACCAGCGCCCA
GTTCGACTTCATCGACCTGCCCGACCGCTTCTGCACCGGCTCGTCGATCATGCCGCAGAAGAAAAACCCGGATGTCCCCG
AGCTGGTGCGCGGCAAGACCGGCCGCGTCTACGGCCACCTGATGGGGCTGCTGACGTTGATGAAGTCGCAGCCGCTGGCT
TACAACAAGGACAATCAGGAAGACAAGGAGCCGTTGTTCGACACCCTCGACACCGTGCAGGGCTGCCTCAAGGCCTTCGC
CGACATGGTGCCGGCCATCGAGGCCAAGGCGGACAACATGTTCGAGGCGGCGCGCAAGGGCTTCTCCACCGCCACCGACC
TGGCGGACTACCTGGTGCGGGCGGGCGTGGCCTTCCGCGATGCGCACGAGATCGTCGGCCAGGCCGTGGCACTCGGCCTG
CGCGAGAAAAAGGATCTCTCGGAGATGACCCTCGACGAGTTGCGCCAGTTTTCCGACGCCATCGGCGAAGACGTCTTCGA
GGTGCTGACCCTGGAGGGCTCGGTGGCGGCACGCAACCATATCGGCGGCACCGCCCCGGATCAGGTCCGCGCCGCTGCCC
AGCGCGCGCGCGACGCCCTGGCAACGCTGCGACAGGAGGCATGA

Upstream 100 bases:

>100_bases
CCGCGCCCCGGTGCACCTGGCGCACCCGGCGCCTCGCCAGGCGCGCCGACTCTGGTACACTCGGAGCATCATCATCTCGA
CCAGCAGGACGCCACGCCCG

Downstream 100 bases:

>100_bases
TGCGCTCACTTCCCCTGCTGGCCGCACTCGGCATGGCCATGCTCACCCTCGCCGGGTGCGGCCAGAAAGGTCCGTTGTAC
ATGCCCGATGACGAACAGGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSNTTNQSWGGRFSEPTDAFVARFTASVDFDRRLYHHDIRGSIAHATMLERVGVLTADERDAILQGLGEIEQEIDAGTFE
WSVDLEDVHMNLEARLTEKIGITGKKLHTGRSRNDQIATDIRLYLRDAIDVVDAELARLREGLIELAAREADTIMPGFTH
LQTAQPVTFGHHLLAWQEMLARDHERLRDCRKRVNVMPLGAAALAGTTYPIDRHITAELLGFERPAENSLDAVSDRDFAI
EFGAFASVLLMHMSRMSEELVLWTSAQFDFIDLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVYGHLMGLLTLMKSQPLA
YNKDNQEDKEPLFDTLDTVQGCLKAFADMVPAIEAKADNMFEAARKGFSTATDLADYLVRAGVAFRDAHEIVGQAVALGL
REKKDLSEMTLDELRQFSDAIGEDVFEVLTLEGSVAARNHIGGTAPDQVRAAAQRARDALATLRQEA

Sequences:

>Translated_467_residues
MSNTTNQSWGGRFSEPTDAFVARFTASVDFDRRLYHHDIRGSIAHATMLERVGVLTADERDAILQGLGEIEQEIDAGTFE
WSVDLEDVHMNLEARLTEKIGITGKKLHTGRSRNDQIATDIRLYLRDAIDVVDAELARLREGLIELAAREADTIMPGFTH
LQTAQPVTFGHHLLAWQEMLARDHERLRDCRKRVNVMPLGAAALAGTTYPIDRHITAELLGFERPAENSLDAVSDRDFAI
EFGAFASVLLMHMSRMSEELVLWTSAQFDFIDLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVYGHLMGLLTLMKSQPLA
YNKDNQEDKEPLFDTLDTVQGCLKAFADMVPAIEAKADNMFEAARKGFSTATDLADYLVRAGVAFRDAHEIVGQAVALGL
REKKDLSEMTLDELRQFSDAIGEDVFEVLTLEGSVAARNHIGGTAPDQVRAAAQRARDALATLRQEA
>Mature_466_residues
SNTTNQSWGGRFSEPTDAFVARFTASVDFDRRLYHHDIRGSIAHATMLERVGVLTADERDAILQGLGEIEQEIDAGTFEW
SVDLEDVHMNLEARLTEKIGITGKKLHTGRSRNDQIATDIRLYLRDAIDVVDAELARLREGLIELAAREADTIMPGFTHL
QTAQPVTFGHHLLAWQEMLARDHERLRDCRKRVNVMPLGAAALAGTTYPIDRHITAELLGFERPAENSLDAVSDRDFAIE
FGAFASVLLMHMSRMSEELVLWTSAQFDFIDLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVYGHLMGLLTLMKSQPLAY
NKDNQEDKEPLFDTLDTVQGCLKAFADMVPAIEAKADNMFEAARKGFSTATDLADYLVRAGVAFRDAHEIVGQAVALGLR
EKKDLSEMTLDELRQFSDAIGEDVFEVLTLEGSVAARNHIGGTAPDQVRAAAQRARDALATLRQEA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=460, Percent_Identity=42.1739130434783, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=460, Percent_Identity=42.1739130434783, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI68303547, Length=460, Percent_Identity=40, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI68303549, Length=460, Percent_Identity=39.1304347826087, Blast_Score=330, Evalue=2e-90,
Organism=Escherichia coli, GI1790398, Length=445, Percent_Identity=47.6404494382022, Blast_Score=417, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321806, Length=456, Percent_Identity=44.5175438596491, Blast_Score=366, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221473854, Length=458, Percent_Identity=41.0480349344978, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI78706858, Length=458, Percent_Identity=41.0480349344978, Blast_Score=330, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_CHRSD (Q1QSV4)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_575153.1
- ProteinModelPortal:   Q1QSV4
- SMR:   Q1QSV4
- STRING:   Q1QSV4
- GeneID:   4028751
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_3110
- NMPDR:   fig|290398.4.peg.2813
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   CSAL290398:CSAL_3110-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51882; Mature: 51751

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTTNQSWGGRFSEPTDAFVARFTASVDFDRRLYHHDIRGSIAHATMLERVGVLTADER
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DAILQGLGEIEQEIDAGTFEWSVDLEDVHMNLEARLTEKIGITGKKLHTGRSRNDQIATD
HHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
IRLYLRDAIDVVDAELARLREGLIELAAREADTIMPGFTHLQTAQPVTFGHHLLAWQEML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHH
ARDHERLRDCRKRVNVMPLGAAALAGTTYPIDRHITAELLGFERPAENSLDAVSDRDFAI
HHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCEE
EFGAFASVLLMHMSRMSEELVLWTSAQFDFIDLPDRFCTGSSIMPQKKNPDVPELVRGKT
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCHHHCCCCCCCCCCCCCCCHHHHCCCC
GRVYGHLMGLLTLMKSQPLAYNKDNQEDKEPLFDTLDTVQGCLKAFADMVPAIEAKADNM
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEAARKGFSTATDLADYLVRAGVAFRDAHEIVGQAVALGLREKKDLSEMTLDELRQFSDA
HHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGEDVFEVLTLEGSVAARNHIGGTAPDQVRAAAQRARDALATLRQEA
HHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNTTNQSWGGRFSEPTDAFVARFTASVDFDRRLYHHDIRGSIAHATMLERVGVLTADER
CCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DAILQGLGEIEQEIDAGTFEWSVDLEDVHMNLEARLTEKIGITGKKLHTGRSRNDQIATD
HHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
IRLYLRDAIDVVDAELARLREGLIELAAREADTIMPGFTHLQTAQPVTFGHHLLAWQEML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHH
ARDHERLRDCRKRVNVMPLGAAALAGTTYPIDRHITAELLGFERPAENSLDAVSDRDFAI
HHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCEE
EFGAFASVLLMHMSRMSEELVLWTSAQFDFIDLPDRFCTGSSIMPQKKNPDVPELVRGKT
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCHHHCCCCCCCCCCCCCCCHHHHCCCC
GRVYGHLMGLLTLMKSQPLAYNKDNQEDKEPLFDTLDTVQGCLKAFADMVPAIEAKADNM
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEAARKGFSTATDLADYLVRAGVAFRDAHEIVGQAVALGLREKKDLSEMTLDELRQFSDA
HHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGEDVFEVLTLEGSVAARNHIGGTAPDQVRAAAQRARDALATLRQEA
HHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA