Click here to switch to the map view.

The map label for this gene is algC [H]

Identifier: 92115099

GI number: 92115099

Start: 3321780

End: 3323183

Strand: Direct

Name: algC [H]

Synonym: Csal_2983

Alternate gene names: 92115099

Gene position: 3321780-3323183 (Clockwise)

Preceding gene: 92115098

Following gene: 92115100

Centisome position: 89.86

GC content: 66.88

Gene sequence:

>1404_bases
ATGAGTCAGCAAGCTTCCATCAGCGCTTCCATCTTCCGCGCCTATGACATCCGCGGCATCGTCGACGACACCCTGACCGA
GGAAGGCGTCGAGCTGATCGGTCGCGCCATCGGTGCCGAAGCCGCCAGCCGCGGCGAGTCCACGGTGGTCGTCGCACGCG
ATGGCCGGCATTCGGGCCAGCGCCTGCAGGCCGCCTTGATGCGCGGCCTGCGCCGCGCGGGGCGCGACGTCGTCGATATC
GGCATGGTGCCCACGCCGGTTCTCTACTTCGCCACCCACACGCTGGACGGCACGCGCTCCGGCGTCATGGTCACCGGCAG
CCATAACCCGCCCGACTACAATGGCTTCAAGATCGTGCTGGGCGGCGAAACCCTGTCCGGCGAGGCGATCACCGCACTCT
ACCAGCGCATCCAGGACGACGCGCTCGGCGATGGCGACGGCGGCCTGCGGGAGATGGATGTACGCGATGCCTATCTGGAA
CGCATCCTCGGTGATGTCGTCCTGAACGGACGCATCAAGGCCGTGGTCGACTGTGGCAACGGCGTGGCCGGCGAGCTGGG
GCCCAAGCTGATCGAGCGCCTGGGCGCCGAGACCGTACCGCTGTTCGCCGAGATCGACGGCGACTTCCCCAACCACCATC
CCGACCCCGGCAAGCTCGAAAACCTCGAGGACCTGATCCGCACCGTCAAGGAAACCGGCGCGGACATCGGCCTGGCCTTC
GACGGCGACGGCGACCGCCTCGGCGTGGTGACGCCCGCCGGCGAGGTGATCTATCCCGACCGTCTGATGATGGCCTTCGC
CGAGGACATGCTCGAGCGCAATCCCGGCGCCCGCGTGATCTTCGACGTCAAGTGCACCGGCAACCTGGCCCAGGTGATCG
AAAACGCCGGCGGCACGCCCGAGATGTGGCGCACCGGCCACTCGCTGATCAAGGCGCGCATGAAGGAAACCGGCGCGGCA
TTGGCCGGCGAGATGAGCGGCCACATCTTCTTCAAGGAACGCTGGTACGGTTTCGACGATGGCCTGTACGGCGCCGCGCG
GCTGCTGGAGATTCTTGCCAGGCAGCGCGCCGAGCACGACCTGGACGCCGATGCCTTCTTCGCTCGCTTTCCGCAGGACC
TGGGCACGCCGGAAATCAACGTCAAGGTGACCGACGACAACAAGTTCGACATCGTCGAGAAACTGGCCCGCGACGGCGAT
TTCGGCGACGACGGCGTCAAGACCACGCTCGACGGCATCCGTGTCGACTTCGCGGATGGCTGGGGGCTGTGCCGCGCCTC
CAACACCACGCCGATGCTGGTGCTGCGTTTCGAAGGCAAGAACCAGGACGCCTTGTCGCGCATCCAGGCCCAGTTTCGCG
CCGCCCTCAAGCAGGTCGCCCCCGAGGCCGATCTCCCGTTCTGA

Upstream 100 bases:

>100_bases
GCTTTGGCCATTCCGGCCGCCACTGAGTGCGGGCTGGGCGGCCAACGCCCCCGTCCCGATGTTCACGGCCACACGGCCAC
CGACTTGAAGGGATTCAATC

Downstream 100 bases:

>100_bases
CCCCCGCGGCCGGCGCTACGCGCCGGCCGTAGCCAATGGAGACAGCGCTCATGAGCGAAAACGCACGCGACCCGCGTCTA
GTGGTCGAGATCCTGTCCGA

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSQQASISASIFRAYDIRGIVDDTLTEEGVELIGRAIGAEAASRGESTVVVARDGRHSGQRLQAALMRGLRRAGRDVVDI
GMVPTPVLYFATHTLDGTRSGVMVTGSHNPPDYNGFKIVLGGETLSGEAITALYQRIQDDALGDGDGGLREMDVRDAYLE
RILGDVVLNGRIKAVVDCGNGVAGELGPKLIERLGAETVPLFAEIDGDFPNHHPDPGKLENLEDLIRTVKETGADIGLAF
DGDGDRLGVVTPAGEVIYPDRLMMAFAEDMLERNPGARVIFDVKCTGNLAQVIENAGGTPEMWRTGHSLIKARMKETGAA
LAGEMSGHIFFKERWYGFDDGLYGAARLLEILARQRAEHDLDADAFFARFPQDLGTPEINVKVTDDNKFDIVEKLARDGD
FGDDGVKTTLDGIRVDFADGWGLCRASNTTPMLVLRFEGKNQDALSRIQAQFRAALKQVAPEADLPF

Sequences:

>Translated_467_residues
MSQQASISASIFRAYDIRGIVDDTLTEEGVELIGRAIGAEAASRGESTVVVARDGRHSGQRLQAALMRGLRRAGRDVVDI
GMVPTPVLYFATHTLDGTRSGVMVTGSHNPPDYNGFKIVLGGETLSGEAITALYQRIQDDALGDGDGGLREMDVRDAYLE
RILGDVVLNGRIKAVVDCGNGVAGELGPKLIERLGAETVPLFAEIDGDFPNHHPDPGKLENLEDLIRTVKETGADIGLAF
DGDGDRLGVVTPAGEVIYPDRLMMAFAEDMLERNPGARVIFDVKCTGNLAQVIENAGGTPEMWRTGHSLIKARMKETGAA
LAGEMSGHIFFKERWYGFDDGLYGAARLLEILARQRAEHDLDADAFFARFPQDLGTPEINVKVTDDNKFDIVEKLARDGD
FGDDGVKTTLDGIRVDFADGWGLCRASNTTPMLVLRFEGKNQDALSRIQAQFRAALKQVAPEADLPF
>Mature_466_residues
SQQASISASIFRAYDIRGIVDDTLTEEGVELIGRAIGAEAASRGESTVVVARDGRHSGQRLQAALMRGLRRAGRDVVDIG
MVPTPVLYFATHTLDGTRSGVMVTGSHNPPDYNGFKIVLGGETLSGEAITALYQRIQDDALGDGDGGLREMDVRDAYLER
ILGDVVLNGRIKAVVDCGNGVAGELGPKLIERLGAETVPLFAEIDGDFPNHHPDPGKLENLEDLIRTVKETGADIGLAFD
GDGDRLGVVTPAGEVIYPDRLMMAFAEDMLERNPGARVIFDVKCTGNLAQVIENAGGTPEMWRTGHSLIKARMKETGAAL
AGEMSGHIFFKERWYGFDDGLYGAARLLEILARQRAEHDLDADAFFARFPQDLGTPEINVKVTDDNKFDIVEKLARDGDF
GDDGVKTTLDGIRVDFADGWGLCRASNTTPMLVLRFEGKNQDALSRIQAQFRAALKQVAPEADLPF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=463, Percent_Identity=34.9892008639309, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1789566, Length=461, Percent_Identity=27.114967462039, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50577; Mature: 50445

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQASISASIFRAYDIRGIVDDTLTEEGVELIGRAIGAEAASRGESTVVVARDGRHSGQ
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHH
RLQAALMRGLRRAGRDVVDIGMVPTPVLYFATHTLDGTRSGVMVTGSHNPPDYNGFKIVL
HHHHHHHHHHHHCCCCEEECCCCCCCHHHHEEECCCCCCCCEEEECCCCCCCCCCEEEEE
GGETLSGEAITALYQRIQDDALGDGDGGLREMDVRDAYLERILGDVVLNGRIKAVVDCGN
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCCEEEEEECCC
GVAGELGPKLIERLGAETVPLFAEIDGDFPNHHPDPGKLENLEDLIRTVKETGADIGLAF
CCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
DGDGDRLGVVTPAGEVIYPDRLMMAFAEDMLERNPGARVIFDVKCTGNLAQVIENAGGTP
CCCCCEEEEECCCCCEECCHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCCCH
EMWRTGHSLIKARMKETGAALAGEMSGHIFFKERWYGFDDGLYGAARLLEILARQRAEHD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
LDADAFFARFPQDLGTPEINVKVTDDNKFDIVEKLARDGDFGDDGVKTTLDGIRVDFADG
CCHHHHHHHCHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCC
WGLCRASNTTPMLVLRFEGKNQDALSRIQAQFRAALKQVAPEADLPF
CCEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SQQASISASIFRAYDIRGIVDDTLTEEGVELIGRAIGAEAASRGESTVVVARDGRHSGQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHH
RLQAALMRGLRRAGRDVVDIGMVPTPVLYFATHTLDGTRSGVMVTGSHNPPDYNGFKIVL
HHHHHHHHHHHHCCCCEEECCCCCCCHHHHEEECCCCCCCCEEEECCCCCCCCCCEEEEE
GGETLSGEAITALYQRIQDDALGDGDGGLREMDVRDAYLERILGDVVLNGRIKAVVDCGN
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCCEEEEEECCC
GVAGELGPKLIERLGAETVPLFAEIDGDFPNHHPDPGKLENLEDLIRTVKETGADIGLAF
CCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
DGDGDRLGVVTPAGEVIYPDRLMMAFAEDMLERNPGARVIFDVKCTGNLAQVIENAGGTP
CCCCCEEEEECCCCCEECCHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCCCH
EMWRTGHSLIKARMKETGAALAGEMSGHIFFKERWYGFDDGLYGAARLLEILARQRAEHD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
LDADAFFARFPQDLGTPEINVKVTDDNKFDIVEKLARDGDFGDDGVKTTLDGIRVDFADG
CCHHHHHHHCHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCC
WGLCRASNTTPMLVLRFEGKNQDALSRIQAQFRAALKQVAPEADLPF
CCEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]