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The map label for this gene is ada [H]

Identifier: 92114912

GI number: 92114912

Start: 3125240

End: 3126601

Strand: Direct

Name: ada [H]

Synonym: Csal_2795

Alternate gene names: 92114912

Gene position: 3125240-3126601 (Clockwise)

Preceding gene: 92114910

Following gene: 92114913

Centisome position: 84.54

GC content: 68.94

Gene sequence:

>1362_bases
ATGCTAGACCCCGAACGCTGCCGAGTGGCCCGCCTGTCGCGCGATGCACGCTTCGACGGTCGCTTCTTCGTCGGCGTGGT
CACCACCGGGATCTACTGTCGGCCGATCTGTCCCTCGCGGCCGCCGCGGGACGACAATGTGCGCTATTTCCCCAGCGCCG
TGGCCGCCGCCCAGGCGGGGTTCCGCCCTTGCCTGCGCTGCCGCCCGGACAGCGCTCCGGAGTCGCCCGCCTGGCATGGC
AACCACACCACGCTGCACCGCGCCGTGCGGCTGATCGACGAAGGCGCCTTGAACCAGGCCTCCCTGGGCGCGCTATGCGA
CCGGCTCGGCATCGGCGAGCGCTACCTGCGCCTGCTTTTTCAGCAGCATCTTGGCATCTCGCCCAAGGCCTACGCCCTGC
ACCGCCAGTGTCTGTTCGCCAAGCAGCTGTTGCATCAGAGCACGCTGCCGATTGCCGATATCGCCCATGCCAGCGGCTTC
ACCAGCCTGCGACGCTTCAACGACGCCTTCCGCCGCCATGTGGGCCAGGCACCGCGCACGTTGCGCCGCACGCCGCGAGC
ACCGAGCCAGGACGTCACGCTGATGCTGGCCTATCGCCCGCCGTACGCCTGGGAATGGCTGCGAGACTTTCTTGCCGCCC
GGCGTATCGACAGGCTGGAATGGGGCGACGAGCACCGCTACGGGCGCCATATCCAGTGGGGCTCGGCAAGCGGCCATTTC
ACGGCCGTGCACGTGCCCGAGCGACATGGCTTTCGCGTTACGCTGTCGCTCGACGATCTCGGTGCGCTCTTGCCGGTGGT
ACGTCACATCCGCCGCGTGCTCGATCTGGACGCCGATACGGCACTCATCGAGGCGCAGCTTCGTCAGACGCTTCCGGACA
CGTTCCCGCTTGTCGAGGGCTTGCGCCTGCCCGGCGTGTGGACGCCCTTCGAGGCCGGGGTGCGCGCGGTCCTCGGACAG
CAAGTCTCGATATCGGCAGCACGTGGGCATGTCACACGGCTGGTCGAGGCGCTCGGCGAACCCACCGGCGATGACGGCCG
CCAGTTCCCCACAGCCGCGCGAATAGCCGCCAGCGACCTGGCGTTTCTGCGCATGCCCCAGGCGCGCCGCGACTGTCTGC
GTGGCCTGGCGCAGGCCGCGTGCGATCGGCGCCTCGACGATGACCCGCGCCAGTGGACCGCGCTGAAGGGAATCGGCCCC
TGGAGTGCCGATTACGCCGCCCTGCGTGGCACCAGCCATCCCGATATCTGGCTGGGCGGCGACCTGGGCGTCAAGCGAGC
GCTGTCGGCGCTGGGTACGGTCGAGCCGGCCCATGCCACGCCATGGCGCAGTTACCTCACCCTGCAACTCTGGAGCCTTT
GA

Upstream 100 bases:

>100_bases
ATCGCGGGATATCGGTGCCATGCATGTCACTGCCGAATCCGGCGAGTCACGCGCCGGCGACGAGTTACACTGATGGCGTC
ACCTTTCGAGGAGCCCTGTC

Downstream 100 bases:

>100_bases
CATGTCGTCCCTCGAGTCCGCCATCGACTACGTCGTCACGCCCGTACCGGCCTCGCCGCTGGGCACGATACGCATCCGCG
CCAGTGCACGTGGCATTCGC

Product: transcriptional regulator Ada / DNA-3-methyladenine glycosylase II / DNA-O6-methylguanine--protein-cysteine S-methyltransferase

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MLDPERCRVARLSRDARFDGRFFVGVVTTGIYCRPICPSRPPRDDNVRYFPSAVAAAQAGFRPCLRCRPDSAPESPAWHG
NHTTLHRAVRLIDEGALNQASLGALCDRLGIGERYLRLLFQQHLGISPKAYALHRQCLFAKQLLHQSTLPIADIAHASGF
TSLRRFNDAFRRHVGQAPRTLRRTPRAPSQDVTLMLAYRPPYAWEWLRDFLAARRIDRLEWGDEHRYGRHIQWGSASGHF
TAVHVPERHGFRVTLSLDDLGALLPVVRHIRRVLDLDADTALIEAQLRQTLPDTFPLVEGLRLPGVWTPFEAGVRAVLGQ
QVSISAARGHVTRLVEALGEPTGDDGRQFPTAARIAASDLAFLRMPQARRDCLRGLAQAACDRRLDDDPRQWTALKGIGP
WSADYAALRGTSHPDIWLGGDLGVKRALSALGTVEPAHATPWRSYLTLQLWSL

Sequences:

>Translated_453_residues
MLDPERCRVARLSRDARFDGRFFVGVVTTGIYCRPICPSRPPRDDNVRYFPSAVAAAQAGFRPCLRCRPDSAPESPAWHG
NHTTLHRAVRLIDEGALNQASLGALCDRLGIGERYLRLLFQQHLGISPKAYALHRQCLFAKQLLHQSTLPIADIAHASGF
TSLRRFNDAFRRHVGQAPRTLRRTPRAPSQDVTLMLAYRPPYAWEWLRDFLAARRIDRLEWGDEHRYGRHIQWGSASGHF
TAVHVPERHGFRVTLSLDDLGALLPVVRHIRRVLDLDADTALIEAQLRQTLPDTFPLVEGLRLPGVWTPFEAGVRAVLGQ
QVSISAARGHVTRLVEALGEPTGDDGRQFPTAARIAASDLAFLRMPQARRDCLRGLAQAACDRRLDDDPRQWTALKGIGP
WSADYAALRGTSHPDIWLGGDLGVKRALSALGTVEPAHATPWRSYLTLQLWSL
>Mature_453_residues
MLDPERCRVARLSRDARFDGRFFVGVVTTGIYCRPICPSRPPRDDNVRYFPSAVAAAQAGFRPCLRCRPDSAPESPAWHG
NHTTLHRAVRLIDEGALNQASLGALCDRLGIGERYLRLLFQQHLGISPKAYALHRQCLFAKQLLHQSTLPIADIAHASGF
TSLRRFNDAFRRHVGQAPRTLRRTPRAPSQDVTLMLAYRPPYAWEWLRDFLAARRIDRLEWGDEHRYGRHIQWGSASGHF
TAVHVPERHGFRVTLSLDDLGALLPVVRHIRRVLDLDADTALIEAQLRQTLPDTFPLVEGLRLPGVWTPFEAGVRAVLGQ
QVSISAARGHVTRLVEALGEPTGDDGRQFPTAARIAASDLAFLRMPQARRDCLRGLAQAACDRRLDDDPRQWTALKGIGP
WSADYAALRGTSHPDIWLGGDLGVKRALSALGTVEPAHATPWRSYLTLQLWSL

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=273, Percent_Identity=32.6007326007326, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788542, Length=120, Percent_Identity=37.5, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 50659; Mature: 50659

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPERCRVARLSRDARFDGRFFVGVVTTGIYCRPICPSRPPRDDNVRYFPSAVAAAQAG
CCCHHHHHHHHHCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHC
FRPCLRCRPDSAPESPAWHGNHTTLHRAVRLIDEGALNQASLGALCDRLGIGERYLRLLF
CCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHH
QQHLGISPKAYALHRQCLFAKQLLHQSTLPIADIAHASGFTSLRRFNDAFRRHVGQAPRT
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCHH
LRRTPRAPSQDVTLMLAYRPPYAWEWLRDFLAARRIDRLEWGDEHRYGRHIQWGSASGHF
HHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCE
TAVHVPERHGFRVTLSLDDLGALLPVVRHIRRVLDLDADTALIEAQLRQTLPDTFPLVEG
EEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHC
LRLPGVWTPFEAGVRAVLGQQVSISAARGHVTRLVEALGEPTGDDGRQFPTAARIAASDL
CCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AFLRMPQARRDCLRGLAQAACDRRLDDDPRQWTALKGIGPWSADYAALRGTSHPDIWLGG
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCEEECC
DLGVKRALSALGTVEPAHATPWRSYLTLQLWSL
CHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECC
>Mature Secondary Structure
MLDPERCRVARLSRDARFDGRFFVGVVTTGIYCRPICPSRPPRDDNVRYFPSAVAAAQAG
CCCHHHHHHHHHCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHC
FRPCLRCRPDSAPESPAWHGNHTTLHRAVRLIDEGALNQASLGALCDRLGIGERYLRLLF
CCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHH
QQHLGISPKAYALHRQCLFAKQLLHQSTLPIADIAHASGFTSLRRFNDAFRRHVGQAPRT
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCHH
LRRTPRAPSQDVTLMLAYRPPYAWEWLRDFLAARRIDRLEWGDEHRYGRHIQWGSASGHF
HHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCE
TAVHVPERHGFRVTLSLDDLGALLPVVRHIRRVLDLDADTALIEAQLRQTLPDTFPLVEG
EEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHC
LRLPGVWTPFEAGVRAVLGQQVSISAARGHVTRLVEALGEPTGDDGRQFPTAARIAASDL
CCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AFLRMPQARRDCLRGLAQAACDRRLDDDPRQWTALKGIGPWSADYAALRGTSHPDIWLGG
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCEEECC
DLGVKRALSALGTVEPAHATPWRSYLTLQLWSL
CHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]