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The map label for this gene is hisM [H]

Identifier: 92114901

GI number: 92114901

Start: 3115236

End: 3115967

Strand: Direct

Name: hisM [H]

Synonym: Csal_2783

Alternate gene names: 92114901

Gene position: 3115236-3115967 (Clockwise)

Preceding gene: 92114900

Following gene: 92114902

Centisome position: 84.27

GC content: 60.93

Gene sequence:

>732_bases
ATGGAACAACTGAACGCCTGGTTCACCGAACTGCTCGCGGACAACGCCATCTTCACGGCCAACACCCTGGGGTATTACCT
CGACGGGCTGGGCAATACCGTGCGGCTGGTCTTCTTGTCCCTCGTCATCGGCCTGCTGCTGGCCGTGCCGCTCGCCATTG
CCCGCGGCTCGCGCCGCAAGTGGATCAAATGGCCGGTGTTCTTCTACACCTACGTGTTTCGCGGCACGCCGCTGCTGATT
CAGCTATACATGATCTATTACGGCGTGGTGTTCATCGAGGGTATTCAGGACACCATTCTGTGGGTGGTGCTCAAGGATGC
CTTCTTCCCCGCACTGATCGCCTTCACGCTCAATACCGCCGCCTATACCACCGAGATCTTTCATGGCGCGATCAAGGCCA
CCTCGCGCGGCGAGATCGAGGCTGCAAGGGCATACGGCATGTCGCGCGGGCTCATGATGCGCCGCATCATCCTGCCCAGC
GCCTTTCGTCGCGCCCTGCCCGCCTACGGCAACGAGGTGATCTTCATGCTCCATGCCAGCGCCATCGCCAGCGTGGTGAC
GATCATGGACCTCACGGGGGCCGCCCGCTTCGTCTATGCCCGCTTCTACGCGCCCTTCGACGCCTTCCTGTTCGTGGCGG
CGATCTACCTGTGCTTGACCTTCGCCATCCTGTATCTCTTCCGCTACCTGGAAAAGAAACTCCTGGCGCACCTCAAGCCG
ATCAACGGTTGA

Upstream 100 bases:

>100_bases
TCCCGGTCGCCGTCATCTATCTGCTGATCGCGAGCGTGTCGGAGTGGGGCGTGGCGCGACTGCAAAAACGCTATAACGTC
GGTTTCGGGGAGGCGGACGA

Downstream 100 bases:

>100_bases
AGCATTGCGCTTCACGACAACACGACGACCGCGAGATTGTTGACATGAAAAAGCTGCTCACGCTGACCCTGCTGGGAATG
TTCCTGGCGACCGGCACCGC

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MEQLNAWFTELLADNAIFTANTLGYYLDGLGNTVRLVFLSLVIGLLLAVPLAIARGSRRKWIKWPVFFYTYVFRGTPLLI
QLYMIYYGVVFIEGIQDTILWVVLKDAFFPALIAFTLNTAAYTTEIFHGAIKATSRGEIEAARAYGMSRGLMMRRIILPS
AFRRALPAYGNEVIFMLHASAIASVVTIMDLTGAARFVYARFYAPFDAFLFVAAIYLCLTFAILYLFRYLEKKLLAHLKP
ING

Sequences:

>Translated_243_residues
MEQLNAWFTELLADNAIFTANTLGYYLDGLGNTVRLVFLSLVIGLLLAVPLAIARGSRRKWIKWPVFFYTYVFRGTPLLI
QLYMIYYGVVFIEGIQDTILWVVLKDAFFPALIAFTLNTAAYTTEIFHGAIKATSRGEIEAARAYGMSRGLMMRRIILPS
AFRRALPAYGNEVIFMLHASAIASVVTIMDLTGAARFVYARFYAPFDAFLFVAAIYLCLTFAILYLFRYLEKKLLAHLKP
ING
>Mature_243_residues
MEQLNAWFTELLADNAIFTANTLGYYLDGLGNTVRLVFLSLVIGLLLAVPLAIARGSRRKWIKWPVFFYTYVFRGTPLLI
QLYMIYYGVVFIEGIQDTILWVVLKDAFFPALIAFTLNTAAYTTEIFHGAIKATSRGEIEAARAYGMSRGLMMRRIILPS
AFRRALPAYGNEVIFMLHASAIASVVTIMDLTGAARFVYARFYAPFDAFLFVAAIYLCLTFAILYLFRYLEKKLLAHLKP
ING

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=220, Percent_Identity=49.0909090909091, Blast_Score=191, Evalue=3e-50,
Organism=Escherichia coli, GI1787086, Length=213, Percent_Identity=36.6197183098592, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1788226, Length=214, Percent_Identity=34.5794392523364, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1787087, Length=218, Percent_Identity=26.605504587156, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1786873, Length=214, Percent_Identity=29.9065420560748, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788646, Length=218, Percent_Identity=28.4403669724771, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=29.1866028708134, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786874, Length=235, Percent_Identity=24.2553191489362, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 27478; Mature: 27478

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLNAWFTELLADNAIFTANTLGYYLDGLGNTVRLVFLSLVIGLLLAVPLAIARGSRRK
CCHHHHHHHHHHHCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
WIKWPVFFYTYVFRGTPLLIQLYMIYYGVVFIEGIQDTILWVVLKDAFFPALIAFTLNTA
CEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYTTEIFHGAIKATSRGEIEAARAYGMSRGLMMRRIILPSAFRRALPAYGNEVIFMLHAS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHH
AIASVVTIMDLTGAARFVYARFYAPFDAFLFVAAIYLCLTFAILYLFRYLEKKLLAHLKP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ING
CCC
>Mature Secondary Structure
MEQLNAWFTELLADNAIFTANTLGYYLDGLGNTVRLVFLSLVIGLLLAVPLAIARGSRRK
CCHHHHHHHHHHHCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
WIKWPVFFYTYVFRGTPLLIQLYMIYYGVVFIEGIQDTILWVVLKDAFFPALIAFTLNTA
CEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYTTEIFHGAIKATSRGEIEAARAYGMSRGLMMRRIILPSAFRRALPAYGNEVIFMLHAS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHH
AIASVVTIMDLTGAARFVYARFYAPFDAFLFVAAIYLCLTFAILYLFRYLEKKLLAHLKP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ING
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]