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The map label for this gene is groL

Identifier: 92114282

GI number: 92114282

Start: 2428116

End: 2429759

Strand: Direct

Name: groL

Synonym: Csal_2160

Alternate gene names: 92114282

Gene position: 2428116-2429759 (Clockwise)

Preceding gene: 92114281

Following gene: 92114283

Centisome position: 65.68

GC content: 61.98

Gene sequence:

>1644_bases
ATGGCAGCTAAACAAATCAAATTCTCCGATGATGCCCGCAAGCGCATGGCGCGTGGTGTTAACGTTCTGGCTGATGCGGT
CAAGGTAACTCTCGGTCCGAAGGGACGTAACGTCGTACTGGAAAAGTCCTTCGGCTCTCCCACCGTGACCAAGGACGGTG
TATCCGTCGCCAAGGAAATCGAACTCAAGGACAAGTTCGAGAACATGGGCGCACAGATGGTCAAGGAAGTCGCTTCCAAG
ACCTCTGACGTGGCCGGCGACGGCACCACCACGGCAACCGTCCTCGCGCAGTCCATCGTCACCGAGGGCATGAAGGGCGT
CACCGCCGGCATGAACCCGATGGACCTCAAGCGTGGCATCGACCAGGCCGTCGACGCCGCCGTCAAGGAAATCCAGTCGC
TTTCCGTGCCCTGCACCGATGCCAAGGCCATCGCCCAGGTCGGCACCATTTCCGCCAATGGCGACAAGCGTATCGGCGAA
ATCATTGCCGATGCCATGCAGAAGGTCGGCAAGGAAGGCGTCATCACCGTCGATGAAGGTCGCGGCTTCGAAGACGAGCT
GGAAGTCGTCGAAGGCATGCAGTTCGATCGCGGTTACCTGTCGCCCTACTTCGTGACCAACCAGGACACCATGATGGTGG
AACTGGAAGATCCGTACCTGCTGATGGTCGACAAGAAGATCTCCAACATCCGCGAACTGCTGCCGGTGCTGGAAGCCGTC
GCCAAGTCCGGCAAGCCGTTGGGCATCATCGCCGAGGACATCGAAGGCGAAGCGCTGGCCACCCTGGTGGTCAACACCAT
GCGCGGCATCGTCAAGGCCGCGGCGACCAAGGCGCCCGGCTTCGGTGATCGTCGCAAGGCCATGCTGCAGGACATCGCCA
TCCTCACCGGTGGTACCGTGATTTCCGAGGAAGTCGGCTTGACCCTCGAGCAGGCCAACCTGGACCACCTGGGTAGCGCC
AAGCGCGTCACCATGTCCAAGGAAAACACCACCATCATCGACGGTGCCGGTGTCGAAGCCGATATCGAAGCGCGCGTCAG
CCAGATTCGCGCCCAGATCGAAGACACCAGCTCCGATTACGATCGCGAGAAGCTGCAGGAGCGTGTCGCCAAGCTGGCCG
GCGGTGTCGCGGTCATCCGCGTGGGCGCAGCCACCGAGTTCGAGATGAAAGAGAAGAAGGCTCGCGTCGAAGACGCGCTG
CACTCGACTCGTGCTGCCGTCGAGGAAGGCGTGGTGCCGGGGGGCGGTACCGCTCTGGTCCGCATCCTGAACAAGCTCGT
CGACCTCAAGGGCGACAACGAAGACCAGACCCACGGGATTGCCATCGCCCTGCGCGCCATGGAAGCCCCGCTGCGTCAGA
TCGTGACCAACGCGGGTCAGGAAGCGTCCGTCATCGTCAACCAGGTCAAGGCCGGCGAAGGTAACTACGGTTACAACGCA
CAAACCGGCGAGTATGGCGACCTGTTCGACATGGGCGTTCTCGACCCGGCCAAGGTCACGCGCAGCGCGCTGCAGTCCGC
TGGTTCCGTGGCGGGTCTGATGATCACCACCGAAGCCATGATCGCCGACGACCCGGACGAGAAAGAAGCCGGTGGCGGCG
CACCGGACATGGGCGGCATGGGAGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
CTCGCCGTCGCCGAGTGATCTTCACGCTCGCCGAGCACATTTTCGTTTCACGTTTGCGCGATGCATCGCGCCTACTACCT
ACTAATGGGAAGAGCTAGAC

Downstream 100 bases:

>100_bases
CGCTGCCAGCCGATTCCCGGGCCCTGTCCCGTGGCACGAACCCCTGCCGGGCGACCGGCAGGGGTTTTTCGTTGCCGGCC
GGTCACCGGTGCCGTAGCCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKQIKFSDDARKRMARGVNVLADAVKVTLGPKGRNVVLEKSFGSPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASK
TSDVAGDGTTTATVLAQSIVTEGMKGVTAGMNPMDLKRGIDQAVDAAVKEIQSLSVPCTDAKAIAQVGTISANGDKRIGE
IIADAMQKVGKEGVITVDEGRGFEDELEVVEGMQFDRGYLSPYFVTNQDTMMVELEDPYLLMVDKKISNIRELLPVLEAV
AKSGKPLGIIAEDIEGEALATLVVNTMRGIVKAAATKAPGFGDRRKAMLQDIAILTGGTVISEEVGLTLEQANLDHLGSA
KRVTMSKENTTIIDGAGVEADIEARVSQIRAQIEDTSSDYDREKLQERVAKLAGGVAVIRVGAATEFEMKEKKARVEDAL
HSTRAAVEEGVVPGGGTALVRILNKLVDLKGDNEDQTHGIAIALRAMEAPLRQIVTNAGQEASVIVNQVKAGEGNYGYNA
QTGEYGDLFDMGVLDPAKVTRSALQSAGSVAGLMITTEAMIADDPDEKEAGGGAPDMGGMGGMGGMM

Sequences:

>Translated_547_residues
MAAKQIKFSDDARKRMARGVNVLADAVKVTLGPKGRNVVLEKSFGSPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASK
TSDVAGDGTTTATVLAQSIVTEGMKGVTAGMNPMDLKRGIDQAVDAAVKEIQSLSVPCTDAKAIAQVGTISANGDKRIGE
IIADAMQKVGKEGVITVDEGRGFEDELEVVEGMQFDRGYLSPYFVTNQDTMMVELEDPYLLMVDKKISNIRELLPVLEAV
AKSGKPLGIIAEDIEGEALATLVVNTMRGIVKAAATKAPGFGDRRKAMLQDIAILTGGTVISEEVGLTLEQANLDHLGSA
KRVTMSKENTTIIDGAGVEADIEARVSQIRAQIEDTSSDYDREKLQERVAKLAGGVAVIRVGAATEFEMKEKKARVEDAL
HSTRAAVEEGVVPGGGTALVRILNKLVDLKGDNEDQTHGIAIALRAMEAPLRQIVTNAGQEASVIVNQVKAGEGNYGYNA
QTGEYGDLFDMGVLDPAKVTRSALQSAGSVAGLMITTEAMIADDPDEKEAGGGAPDMGGMGGMGGMM
>Mature_546_residues
AAKQIKFSDDARKRMARGVNVLADAVKVTLGPKGRNVVLEKSFGSPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASKT
SDVAGDGTTTATVLAQSIVTEGMKGVTAGMNPMDLKRGIDQAVDAAVKEIQSLSVPCTDAKAIAQVGTISANGDKRIGEI
IADAMQKVGKEGVITVDEGRGFEDELEVVEGMQFDRGYLSPYFVTNQDTMMVELEDPYLLMVDKKISNIRELLPVLEAVA
KSGKPLGIIAEDIEGEALATLVVNTMRGIVKAAATKAPGFGDRRKAMLQDIAILTGGTVISEEVGLTLEQANLDHLGSAK
RVTMSKENTTIIDGAGVEADIEARVSQIRAQIEDTSSDYDREKLQERVAKLAGGVAVIRVGAATEFEMKEKKARVEDALH
STRAAVEEGVVPGGGTALVRILNKLVDLKGDNEDQTHGIAIALRAMEAPLRQIVTNAGQEASVIVNQVKAGEGNYGYNAQ
TGEYGDLFDMGVLDPAKVTRSALQSAGSVAGLMITTEAMIADDPDEKEAGGGAPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=50.1893939393939, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=50.1893939393939, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1790586, Length=525, Percent_Identity=76.7619047619048, Blast_Score=820, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=49.3383742911153, Blast_Score=517, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=48.3412322274881, Blast_Score=201, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.2319391634981, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322524, Length=188, Percent_Identity=25.531914893617, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=51.1406844106464, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=51.1406844106464, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=49.3358633776091, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=49.3358633776091, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=49.3358633776091, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=553, Percent_Identity=41.0488245931284, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=36.6920152091255, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=36.6920152091255, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24645179, Length=527, Percent_Identity=20.4933586337761, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_CHRSD (Q1QVJ7)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_574210.1
- ProteinModelPortal:   Q1QVJ7
- SMR:   Q1QVJ7
- STRING:   Q1QVJ7
- GeneID:   4026654
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_2160
- NMPDR:   fig|290398.4.peg.2626
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NKPETAT
- BioCyc:   CSAL290398:CSAL_2160-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57662; Mature: 57530

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKQIKFSDDARKRMARGVNVLADAVKVTLGPKGRNVVLEKSFGSPTVTKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQSIVTEGMKGVTAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHH
DQAVDAAVKEIQSLSVPCTDAKAIAQVGTISANGDKRIGEIIADAMQKVGKEGVITVDEG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCC
RGFEDELEVVEGMQFDRGYLSPYFVTNQDTMMVELEDPYLLMVDKKISNIRELLPVLEAV
CCCHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCCEEEEECHHHHHHHHHHHHHHHH
AKSGKPLGIIAEDIEGEALATLVVNTMRGIVKAAATKAPGFGDRRKAMLQDIAILTGGTV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
ISEEVGLTLEQANLDHLGSAKRVTMSKENTTIIDGAGVEADIEARVSQIRAQIEDTSSDY
EHHHHCCEEECCCCHHCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
DREKLQERVAKLAGGVAVIRVGAATEFEMKEKKARVEDALHSTRAAVEEGVVPGGGTALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RILNKLVDLKGDNEDQTHGIAIALRAMEAPLRQIVTNAGQEASVIVNQVKAGEGNYGYNA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
QTGEYGDLFDMGVLDPAKVTRSALQSAGSVAGLMITTEAMIADDPDEKEAGGGAPDMGGM
CCCCCCCCHHCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCHHCCCCCCCCCCCC
GGMGGMM
CCCCCCC
>Mature Secondary Structure 
AAKQIKFSDDARKRMARGVNVLADAVKVTLGPKGRNVVLEKSFGSPTVTKDGVSVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQSIVTEGMKGVTAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHH
DQAVDAAVKEIQSLSVPCTDAKAIAQVGTISANGDKRIGEIIADAMQKVGKEGVITVDEG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCC
RGFEDELEVVEGMQFDRGYLSPYFVTNQDTMMVELEDPYLLMVDKKISNIRELLPVLEAV
CCCHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCCEEEEECHHHHHHHHHHHHHHHH
AKSGKPLGIIAEDIEGEALATLVVNTMRGIVKAAATKAPGFGDRRKAMLQDIAILTGGTV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
ISEEVGLTLEQANLDHLGSAKRVTMSKENTTIIDGAGVEADIEARVSQIRAQIEDTSSDY
EHHHHCCEEECCCCHHCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
DREKLQERVAKLAGGVAVIRVGAATEFEMKEKKARVEDALHSTRAAVEEGVVPGGGTALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RILNKLVDLKGDNEDQTHGIAIALRAMEAPLRQIVTNAGQEASVIVNQVKAGEGNYGYNA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
QTGEYGDLFDMGVLDPAKVTRSALQSAGSVAGLMITTEAMIADDPDEKEAGGGAPDMGGM
CCCCCCCCHHCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCHHCCCCCCCCCCCC
GGMGGMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA