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The map label for this gene is lexA

Identifier: 92114192

GI number: 92114192

Start: 2339522

End: 2340160

Strand: Direct

Name: lexA

Synonym: Csal_2070

Alternate gene names: 92114192

Gene position: 2339522-2340160 (Clockwise)

Preceding gene: 92114185

Following gene: 92114193

Centisome position: 63.29

GC content: 66.82

Gene sequence:

>639_bases
ATGTCTCGCTCGCTAACCTCGCGCCAACAACACGTCTTCGATTTCATCGTCAAGACCATGAACGAGCTCGGCTATCCGCC
GACCCGCGCCGAGATCGCCCGCGCACTGGGCTTTCGTTCGCCCAACGCCGCCGAGGAGCATCTCCGAGCGCTCGATCGCA
AGGGCGTGATCCGCATGATCCCCGGCACCTCGCGCGGCATCCGGCTGACCGGCGAGGAGGACGCCGCAGCGACGAGCACC
GACGGCCTGCCCGTGGTCGGCGAAGTGGCCGCGGGCAGTCCGATTCTCGCGGCGGCGCACATCGATCGCCACTGCCCGCT
CGCACCGGATTATTTCACGCCGCGTGCCGATTACCTGCTGCGGGTGCGCGGGCTGTCGATGAAGGATGCCGGCATTCTCG
ACGGCGATTTGCTGGCCGTGCATCGCACGCAGCAGATTCGCGACGGGCAGATCGTCGTGGCCCGCCTCGACGACGAGGTG
ACCGTCAAGCGCTTCAAGCGCCAGGGACATCACGTCTGGCTAGTGGCCGAGAACGCCGACTTTGCCCCCATCGAAGTCGA
CCTGCGTCACCAGGACCTGGAAATCGAAGGACTGGGCGTGGGGGTGATTCGCGGCGGCGGCGGCAACGGCCTGCACTGA

Upstream 100 bases:

>100_bases
TACAGCGCAGCGCATTGCGTCTGGACGGTTGCACCACGCCAAAGACTGGATACAATCACATACTGTATACTTGAACACGT
CAGTGCCCGCCGGAGGCCCC

Downstream 100 bases:

>100_bases
GGCCCCACTGGCCCACGCCATGCGCAAGATCCTCCACGCCGACTGCGACTGCTTCTACGCCGCCGTGGAAATGCGCGACG
ACCCGGCGCTGCGCGACGTC

Product: SOS-response transcriptional repressor, LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSRSLTSRQQHVFDFIVKTMNELGYPPTRAEIARALGFRSPNAAEEHLRALDRKGVIRMIPGTSRGIRLTGEEDAAATST
DGLPVVGEVAAGSPILAAAHIDRHCPLAPDYFTPRADYLLRVRGLSMKDAGILDGDLLAVHRTQQIRDGQIVVARLDDEV
TVKRFKRQGHHVWLVAENADFAPIEVDLRHQDLEIEGLGVGVIRGGGGNGLH

Sequences:

>Translated_212_residues
MSRSLTSRQQHVFDFIVKTMNELGYPPTRAEIARALGFRSPNAAEEHLRALDRKGVIRMIPGTSRGIRLTGEEDAAATST
DGLPVVGEVAAGSPILAAAHIDRHCPLAPDYFTPRADYLLRVRGLSMKDAGILDGDLLAVHRTQQIRDGQIVVARLDDEV
TVKRFKRQGHHVWLVAENADFAPIEVDLRHQDLEIEGLGVGVIRGGGGNGLH
>Mature_211_residues
SRSLTSRQQHVFDFIVKTMNELGYPPTRAEIARALGFRSPNAAEEHLRALDRKGVIRMIPGTSRGIRLTGEEDAAATSTD
GLPVVGEVAAGSPILAAAHIDRHCPLAPDYFTPRADYLLRVRGLSMKDAGILDGDLLAVHRTQQIRDGQIVVARLDDEVT
VKRFKRQGHHVWLVAENADFAPIEVDLRHQDLEIEGLGVGVIRGGGGNGLH

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=204, Percent_Identity=62.7450980392157, Blast_Score=258, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_CHRSD (Q1QVT7)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_574120.1
- ProteinModelPortal:   Q1QVT7
- SMR:   Q1QVT7
- STRING:   Q1QVT7
- MEROPS:   S24.001
- GeneID:   4026532
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_2070
- NMPDR:   fig|290398.4.peg.1665
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   VEERAFP
- BioCyc:   CSAL290398:CSAL_2070-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 23135; Mature: 23003

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: ACT_SITE 126-126 ACT_SITE 163-163

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSLTSRQQHVFDFIVKTMNELGYPPTRAEIARALGFRSPNAAEEHLRALDRKGVIRMI
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEC
PGTSRGIRLTGEEDAAATSTDGLPVVGEVAAGSPILAAAHIDRHCPLAPDYFTPRADYLL
CCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHEEE
RVRGLSMKDAGILDGDLLAVHRTQQIRDGQIVVARLDDEVTVKRFKRQGHHVWLVAENAD
EEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCEEEEEECCCC
FAPIEVDLRHQDLEIEGLGVGVIRGGGGNGLH
CCEEEEEEECCCEEEEEEEEEEEECCCCCCCC
>Mature Secondary Structure 
SRSLTSRQQHVFDFIVKTMNELGYPPTRAEIARALGFRSPNAAEEHLRALDRKGVIRMI
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEC
PGTSRGIRLTGEEDAAATSTDGLPVVGEVAAGSPILAAAHIDRHCPLAPDYFTPRADYLL
CCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHEEE
RVRGLSMKDAGILDGDLLAVHRTQQIRDGQIVVARLDDEVTVKRFKRQGHHVWLVAENAD
EEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCEEEEEECCCC
FAPIEVDLRHQDLEIEGLGVGVIRGGGGNGLH
CCEEEEEEECCCEEEEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA