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The map label for this gene is folD

Identifier: 92114170

GI number: 92114170

Start: 2312179

End: 2313042

Strand: Direct

Name: folD

Synonym: Csal_2048

Alternate gene names: 92114170

Gene position: 2312179-2313042 (Clockwise)

Preceding gene: 92114163

Following gene: 92114171

Centisome position: 62.55

GC content: 66.55

Gene sequence:

>864_bases
ATGACCGCTCAGTTGATCGACGGCAAGGCGATTGCCGCTAATGTCCGCGAACAGGTATCTCGCCAGGTCCAGGCACGCCG
CCAGGAAGGCAAGCGCGCACCGGGGCTCGCGGTCGTCCTCGTCGGTGAAGACCCCGCCTCCGAGGTGTACGTTCGCAACA
AGCATCGCGCCTGCGACAAGGCCGGGGTGCACTCGGTGCAGCACAAGCTGCCGGCCGACACCACGCAGGCCGACCTCGAG
GCGTTGATCGACTCGCTGAATGCCGACTGCAGCATCGACGGCATTCTGGTCCAGTTGCCACTGCCCGACCATCTCGACGC
CCGCCCGATTCTCGAGCGGATTCGCCCCGACAAGGACGTCGATGGCTTCCATCCTTACAACCTCGGCCGACTCGCTCAGC
GACTGCCGGTCCTGCGCCCTTGCACCCCCAAGGGCATCATGACGCTATTGCAGGAAAGCGGCATTCATGCGCGCGGCCTG
GACGCGGTCATCGTGGGCGCCTCCAATATCGTCGGCCGCCCCATGGCCCTGGAGCTGATGCTGGCCGGCAGCACGACCAC
GGTCTGCCACCGTTTCACCCGTGACCTCGAATCACACGTACGGCGCGCCGATCTTCTCGTCGTCGCCGTCGGGCGGCCGG
GACTGGTCAAGGGCGAATGGGTCAAGGAAGGCGCCGTGGTCATCGATGTGGGGATCAACCGTCAGGACGACGGCAAGCTC
GCCGGTGACGTGGAGTTCGCCCCCGCCGCGGCGCGCGCCAGCTACATCACGCCCGTACCGGGGGGCGTGGGACCCATGAC
GGTGGCTTCCCTGCTGGAAAACACGCTGTTCGCCGCCGAACTGCACGACGGCATGCACGCCTAG

Upstream 100 bases:

>100_bases
GCGCGGCAAGGATACATTGACTGCGCCTCCCAGCGTGCGAAAATTGCGCCTCTTTTAACGCCGCCCGACACCGGGCCTAG
CAAGCCAAAGGAACGAGTCG

Downstream 100 bases:

>100_bases
CGTACAGGCGTTACAATGAACGGCTACATCCAGTTCGAGAAAGGAGTGGAGAGATGAGCGACAAAGAAATGAACGTCGAG
AGCTTCAACCTCGACCATAC

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTAQLIDGKAIAANVREQVSRQVQARRQEGKRAPGLAVVLVGEDPASEVYVRNKHRACDKAGVHSVQHKLPADTTQADLE
ALIDSLNADCSIDGILVQLPLPDHLDARPILERIRPDKDVDGFHPYNLGRLAQRLPVLRPCTPKGIMTLLQESGIHARGL
DAVIVGASNIVGRPMALELMLAGSTTTVCHRFTRDLESHVRRADLLVVAVGRPGLVKGEWVKEGAVVIDVGINRQDDGKL
AGDVEFAPAAARASYITPVPGGVGPMTVASLLENTLFAAELHDGMHA

Sequences:

>Translated_287_residues
MTAQLIDGKAIAANVREQVSRQVQARRQEGKRAPGLAVVLVGEDPASEVYVRNKHRACDKAGVHSVQHKLPADTTQADLE
ALIDSLNADCSIDGILVQLPLPDHLDARPILERIRPDKDVDGFHPYNLGRLAQRLPVLRPCTPKGIMTLLQESGIHARGL
DAVIVGASNIVGRPMALELMLAGSTTTVCHRFTRDLESHVRRADLLVVAVGRPGLVKGEWVKEGAVVIDVGINRQDDGKL
AGDVEFAPAAARASYITPVPGGVGPMTVASLLENTLFAAELHDGMHA
>Mature_286_residues
TAQLIDGKAIAANVREQVSRQVQARRQEGKRAPGLAVVLVGEDPASEVYVRNKHRACDKAGVHSVQHKLPADTTQADLEA
LIDSLNADCSIDGILVQLPLPDHLDARPILERIRPDKDVDGFHPYNLGRLAQRLPVLRPCTPKGIMTLLQESGIHARGLD
AVIVGASNIVGRPMALELMLAGSTTTVCHRFTRDLESHVRRADLLVVAVGRPGLVKGEWVKEGAVVIDVGINRQDDGKLA
GDVEFAPAAARASYITPVPGGVGPMTVASLLENTLFAAELHDGMHA

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=293, Percent_Identity=44.3686006825939, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI94721354, Length=293, Percent_Identity=43.3447098976109, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI222136639, Length=289, Percent_Identity=42.560553633218, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI36796743, Length=221, Percent_Identity=28.0542986425339, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786741, Length=284, Percent_Identity=64.7887323943662, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17568735, Length=293, Percent_Identity=40.6143344709898, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319558, Length=286, Percent_Identity=45.1048951048951, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321643, Length=297, Percent_Identity=42.7609427609428, Blast_Score=226, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6322933, Length=315, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136816, Length=292, Percent_Identity=49.3150684931507, Blast_Score=255, Evalue=2e-68,
Organism=Drosophila melanogaster, GI17136818, Length=292, Percent_Identity=49.3150684931507, Blast_Score=254, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24645718, Length=287, Percent_Identity=44.5993031358885, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI17137370, Length=287, Percent_Identity=44.5993031358885, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI62472483, Length=287, Percent_Identity=44.5993031358885, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI45551871, Length=287, Percent_Identity=44.5993031358885, Blast_Score=221, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_CHRSD (Q1QVV9)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_574098.1
- ProteinModelPortal:   Q1QVV9
- SMR:   Q1QVV9
- STRING:   Q1QVV9
- GeneID:   4025948
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_2048
- NMPDR:   fig|290398.4.peg.1506
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   DVVYETA
- BioCyc:   CSAL290398:CSAL_2048-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30736; Mature: 30605

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQLIDGKAIAANVREQVSRQVQARRQEGKRAPGLAVVLVGEDPASEVYVRNKHRACDK
CCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHEECCCHHHHHH
AGVHSVQHKLPADTTQADLEALIDSLNADCSIDGILVQLPLPDHLDARPILERIRPDKDV
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCC
DGFHPYNLGRLAQRLPVLRPCTPKGIMTLLQESGIHARGLDAVIVGASNIVGRPMALELM
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECHHHCCCCEEEEEE
LAGSTTTVCHRFTRDLESHVRRADLLVVAVGRPGLVKGEWVKEGAVVIDVGINRQDDGKL
EECCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCEECCCCEEEEECCCCCCCCCE
AGDVEFAPAAARASYITPVPGGVGPMTVASLLENTLFAAELHDGMHA
ECCCEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAQLIDGKAIAANVREQVSRQVQARRQEGKRAPGLAVVLVGEDPASEVYVRNKHRACDK
CCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHEECCCHHHHHH
AGVHSVQHKLPADTTQADLEALIDSLNADCSIDGILVQLPLPDHLDARPILERIRPDKDV
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCC
DGFHPYNLGRLAQRLPVLRPCTPKGIMTLLQESGIHARGLDAVIVGASNIVGRPMALELM
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECHHHCCCCEEEEEE
LAGSTTTVCHRFTRDLESHVRRADLLVVAVGRPGLVKGEWVKEGAVVIDVGINRQDDGKL
EECCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCEECCCCEEEEECCCCCCCCCE
AGDVEFAPAAARASYITPVPGGVGPMTVASLLENTLFAAELHDGMHA
ECCCEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA