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The map label for this gene is hemA

Identifier: 92113652

GI number: 92113652

Start: 1740809

End: 1742083

Strand: Direct

Name: hemA

Synonym: Csal_1528

Alternate gene names: 92113652

Gene position: 1740809-1742083 (Clockwise)

Preceding gene: 92113644

Following gene: 92113653

Centisome position: 47.09

GC content: 65.96

Gene sequence:

>1275_bases
ATGACGCTTCTCGCCCTGGGGATCAACCACAAGACCGCGACCATCGAGGTTCGCGAGCAGGTCGCCTTTACGCCGGCCGA
GCTGGCGGGCGCGTTGGCCGAACTCAAGTCGCTGCCCGGCGTCAACGAAGCGGCAGTACTGTCGACGTGCAACCGCACCG
AGCTTTATTGCGTGACCGACTCGCAAGGTGAGCGCGAGGTGCTCGATTGGCTGGGGCGCTTCCACGCGCTGCCGCCGGAA
ACCTTGATGCAAAGCGCCTACCACTACCTCGATGGCGAGGCGGCGCGGCACCTGATGCGTGTCGCGGCGGGCCTCGACTC
CATGGTGCTGGGCGAGCCGCAGATCCTGGGGCAGCTCAAGGAAGCCTATCAGCTCGCGCGTGACAACGCGGGGCTGGGGG
GCGAGCTGGAGCGCCTGTTCCAGCACACCTTTTCCGTCGCCAAGCAGGTACGCAGCGAGACCGGCATCGGCGAAAACCCG
GTGTCGGTGGCCTATGCCGCCGTCAGCCTGGCCAGCCACATCTTCGATGACTTCGGCCGTGCCCGTGCGCTGTTGATCGG
CGCCGGCGAGACCATCGAGCTGGTGGCCCGGCACCTGCGCGAAGCGGGTATCCGGGGGCTGACCGTGGCCAATCGTACCC
GCGAGCGTGCCGAGCTCCTGGCCCACGAAGTCGATGCCGAGGCGATTTCCCTGGGCGAGATTCCCCAGGCCCTGGCGCAT
GCCGACATCATCATCTCCTCAACGGCGAGCCCGCTGCCGATCCTGGGCAAGGGCATGGTCGAAAGTGCCCTGAAGAAGCG
TCGTCATCGCCCCATGTTCATGGTCGACATCGCCGTCCCTCGCGATATCGAATCCCAGGTGGGCGAGCTGGACGATGTCT
TCCTGTACAGCGTCGACGACTTGCAGGAAGTGATCGAGGAAAACCGCAAGCAACGCGCCGTGGCCGCCGCCCAGGCCGAG
TCTCTGATCGAGCATGGCATTCAGCACTGGCAGCACGAGCGCCGCGTGCGGGGTGCCGGGGATCTGATCCGGCGCTACCG
CGAGCAGGGCGAGGCGCTGCGCGAGGAGGCCGAGCGTCAGGCGCTGGCGCAGCTCGCGCGCGGCGAGGATCCCGAAAAGG
TCTTGCAGCGTCTGTCACGTCAATTGACCAACAAGTTGCTGCATGGTCCCACCCTGCGCTTGCGTGAAGCGTCGGGCGAG
GCACGACACGATATTCTCAAGGCGGCCGATACCCTGTTGATCGACCCGGCCGCATCGACACAGGACTCTGCATGA

Upstream 100 bases:

>100_bases
GCGGGGCTGGTATTCCGGCTTCGTCGCCCCCACATTGTCCGCCGCGCCCGAACGCAAAGGCCGGACGCTGCCGATAGACC
GATGTGATGACCGTGATTTC

Downstream 100 bases:

>100_bases
AAGCGACTCTGCGCACACGTCTCGATGGCTTCCAGGAACGCTTCGAAGAACTCGCCGCCTTGCTGGCCGAGCCCGACGTG
ATCGCTGATCAGGCGCGCTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTLLALGINHKTATIEVREQVAFTPAELAGALAELKSLPGVNEAAVLSTCNRTELYCVTDSQGEREVLDWLGRFHALPPE
TLMQSAYHYLDGEAARHLMRVAAGLDSMVLGEPQILGQLKEAYQLARDNAGLGGELERLFQHTFSVAKQVRSETGIGENP
VSVAYAAVSLASHIFDDFGRARALLIGAGETIELVARHLREAGIRGLTVANRTRERAELLAHEVDAEAISLGEIPQALAH
ADIIISSTASPLPILGKGMVESALKKRRHRPMFMVDIAVPRDIESQVGELDDVFLYSVDDLQEVIEENRKQRAVAAAQAE
SLIEHGIQHWQHERRVRGAGDLIRRYREQGEALREEAERQALAQLARGEDPEKVLQRLSRQLTNKLLHGPTLRLREASGE
ARHDILKAADTLLIDPAASTQDSA

Sequences:

>Translated_424_residues
MTLLALGINHKTATIEVREQVAFTPAELAGALAELKSLPGVNEAAVLSTCNRTELYCVTDSQGEREVLDWLGRFHALPPE
TLMQSAYHYLDGEAARHLMRVAAGLDSMVLGEPQILGQLKEAYQLARDNAGLGGELERLFQHTFSVAKQVRSETGIGENP
VSVAYAAVSLASHIFDDFGRARALLIGAGETIELVARHLREAGIRGLTVANRTRERAELLAHEVDAEAISLGEIPQALAH
ADIIISSTASPLPILGKGMVESALKKRRHRPMFMVDIAVPRDIESQVGELDDVFLYSVDDLQEVIEENRKQRAVAAAQAE
SLIEHGIQHWQHERRVRGAGDLIRRYREQGEALREEAERQALAQLARGEDPEKVLQRLSRQLTNKLLHGPTLRLREASGE
ARHDILKAADTLLIDPAASTQDSA
>Mature_423_residues
TLLALGINHKTATIEVREQVAFTPAELAGALAELKSLPGVNEAAVLSTCNRTELYCVTDSQGEREVLDWLGRFHALPPET
LMQSAYHYLDGEAARHLMRVAAGLDSMVLGEPQILGQLKEAYQLARDNAGLGGELERLFQHTFSVAKQVRSETGIGENPV
SVAYAAVSLASHIFDDFGRARALLIGAGETIELVARHLREAGIRGLTVANRTRERAELLAHEVDAEAISLGEIPQALAHA
DIIISSTASPLPILGKGMVESALKKRRHRPMFMVDIAVPRDIESQVGELDDVFLYSVDDLQEVIEENRKQRAVAAAQAES
LIEHGIQHWQHERRVRGAGDLIRRYREQGEALREEAERQALAQLARGEDPEKVLQRLSRQLTNKLLHGPTLRLREASGEA
RHDILKAADTLLIDPAASTQDSA

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=400, Percent_Identity=53, Blast_Score=400, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_CHRSD (Q1QXC7)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_573580.1
- ProteinModelPortal:   Q1QXC7
- SMR:   Q1QXC7
- STRING:   Q1QXC7
- GeneID:   4029230
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_1528
- NMPDR:   fig|290398.4.peg.2478
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- BioCyc:   CSAL290398:CSAL_1528-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46560; Mature: 46429

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 107-107 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLALGINHKTATIEVREQVAFTPAELAGALAELKSLPGVNEAAVLSTCNRTELYCVTD
CEEEEEECCCCEEEEEEHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEC
SQGEREVLDWLGRFHALPPETLMQSAYHYLDGEAARHLMRVAAGLDSMVLGEPQILGQLK
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCCCHHHHHHHH
EAYQLARDNAGLGGELERLFQHTFSVAKQVRSETGIGENPVSVAYAAVSLASHIFDDFGR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ARALLIGAGETIELVARHLREAGIRGLTVANRTRERAELLAHEVDAEAISLGEIPQALAH
HEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
ADIIISSTASPLPILGKGMVESALKKRRHRPMFMVDIAVPRDIESQVGELDDVFLYSVDD
HHHHEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCHHHHEECHHH
LQEVIEENRKQRAVAAAQAESLIEHGIQHWQHERRVRGAGDLIRRYREQGEALREEAERQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ALAQLARGEDPEKVLQRLSRQLTNKLLHGPTLRLREASGEARHDILKAADTLLIDPAAST
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHEECCCCCC
QDSA
CCCC
>Mature Secondary Structure 
TLLALGINHKTATIEVREQVAFTPAELAGALAELKSLPGVNEAAVLSTCNRTELYCVTD
EEEEEECCCCEEEEEEHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEC
SQGEREVLDWLGRFHALPPETLMQSAYHYLDGEAARHLMRVAAGLDSMVLGEPQILGQLK
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCCCHHHHHHHH
EAYQLARDNAGLGGELERLFQHTFSVAKQVRSETGIGENPVSVAYAAVSLASHIFDDFGR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ARALLIGAGETIELVARHLREAGIRGLTVANRTRERAELLAHEVDAEAISLGEIPQALAH
HEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
ADIIISSTASPLPILGKGMVESALKKRRHRPMFMVDIAVPRDIESQVGELDDVFLYSVDD
HHHHEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCHHHHEECHHH
LQEVIEENRKQRAVAAAQAESLIEHGIQHWQHERRVRGAGDLIRRYREQGEALREEAERQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ALAQLARGEDPEKVLQRLSRQLTNKLLHGPTLRLREASGEARHDILKAADTLLIDPAAST
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHEECCCCCC
QDSA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA