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The map label for this gene is bcr [H]

Identifier: 92113599

GI number: 92113599

Start: 1674398

End: 1675615

Strand: Direct

Name: bcr [H]

Synonym: Csal_1475

Alternate gene names: 92113599

Gene position: 1674398-1675615 (Clockwise)

Preceding gene: 92113597

Following gene: 92113600

Centisome position: 45.3

GC content: 63.96

Gene sequence:

>1218_bases
GTGACTCGACTCAATGCGCGACGTTTGGCGCTGCTGGTGGCGGCCAATACCGCCCTGGCGCCTTTCGCCATCGATGCCTA
TCTACCCGCCATGCCGACGCTCGCCGAGGCGGTGAACGCCAGCGTGCATCACACCGAGCTGTCGTTGAGCGTGTTCCTGT
TCGGCTTCGCCATCGGCCAGCTGCTGTGCGGCCCGCTGTCGGATCGCTTTGGCCGGCGTCCGGTGCTGTTGACCGGGCTG
GTGGTGTTTCTGGTCGCCAGTCTGGGCATCATGCAGGTGTCGTCGCTGGAAACGCTCTGGGGGCTGCGTTTCGTCCAGGC
CCTGGGGGGCGGGGCCTGCGTGGTCAATTCCGCGGCCATCGTGCGCGACTGTTTCAGCGGACGCGAGGCCGCCAAGGTGA
TGTCGACCATGGCGATGATCCTGATGCTCGCCCCGCTGGTGGCGCCCACGGTGGGAAGCGTGCTGCTGGGATTCTTCAAC
TGGCAGTCGATCTTTCTGTTCCTGGCGCTGTATGCCGCCTTCCTGCTGTTCTTTCTGGGCACGCGCCTGCCCGAGACCCA
TGGGCGCGATCCCGACGCACCGTCGATGCGCCAGGTGTTGCGCAACTATGCCAGCGTCATTCGTCATCGCGAGGCGATGG
GCTACATCTGCGCCGTGTCGATGTCGTTCGCGGGCATGTTTGCCTTCATCACCGGGTCGCCGTACCTGTACATGGAGCAC
TACGGCATTTCGGCGGCGGTCTATCCGTTCGTGTTCGGGGCCAACATCCTGGTCATGGCCTCTTCCAACCGTCTCAACAT
CTATCTGTTGAAGAGACGCACGCCGCAGCAGAATCTCGTGGTGGGGCTGGGCATTCAGTTATGTGCCGGGGTGGCCCTGG
TGGCGTTGATCCTGTCGGGCATGGACTCGATCTACAGCGTCGCGCCGCTGATGGTGGTGTTCGTGGGCATGCAGGGGTTG
ATCGCACCGAACGCGATGTCCTCGATGCTCGATCACTTCCCGAACATGAGCGCGACGGCCACGGCGCTGCAAGGGTGTCT
GCAATTTTCCAGCGGCGCCTTCGCCGGCATGCTGGTGGGGGCCTTCGAGATCGCCAGTGCCTGGCCGACGGTACTGACGA
TGCTGGGCGCTTCCTTGCTGGGCAATATCGGCGTGCGGGTACTGGCCGGTCGAGCCTTGGGGGCTCAGGAGGAAGAAGGG
GCAGTGACCGAACGGTAG

Upstream 100 bases:

>100_bases
TTATCGGCTATGATGAGCGCACTAGCCGTTAGCCTTCTTCATGTTGGCGTGCCGGCCCCGTCGGAGCCGGCACGACTCTG
TACGTTCTTCAGGAGATGTC

Downstream 100 bases:

>100_bases
ACGGGGCGCAACGCGTCGGCGTAACTCGGAGTGACATTCGTCATCTTTTGTCATGAAGCTGTCATCTTCATTGGGCATCT
TAGGTGTCGCGAAGGTTGAA

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTRLNARRLALLVAANTALAPFAIDAYLPAMPTLAEAVNASVHHTELSLSVFLFGFAIGQLLCGPLSDRFGRRPVLLTGL
VVFLVASLGIMQVSSLETLWGLRFVQALGGGACVVNSAAIVRDCFSGREAAKVMSTMAMILMLAPLVAPTVGSVLLGFFN
WQSIFLFLALYAAFLLFFLGTRLPETHGRDPDAPSMRQVLRNYASVIRHREAMGYICAVSMSFAGMFAFITGSPYLYMEH
YGISAAVYPFVFGANILVMASSNRLNIYLLKRRTPQQNLVVGLGIQLCAGVALVALILSGMDSIYSVAPLMVVFVGMQGL
IAPNAMSSMLDHFPNMSATATALQGCLQFSSGAFAGMLVGAFEIASAWPTVLTMLGASLLGNIGVRVLAGRALGAQEEEG
AVTER

Sequences:

>Translated_405_residues
MTRLNARRLALLVAANTALAPFAIDAYLPAMPTLAEAVNASVHHTELSLSVFLFGFAIGQLLCGPLSDRFGRRPVLLTGL
VVFLVASLGIMQVSSLETLWGLRFVQALGGGACVVNSAAIVRDCFSGREAAKVMSTMAMILMLAPLVAPTVGSVLLGFFN
WQSIFLFLALYAAFLLFFLGTRLPETHGRDPDAPSMRQVLRNYASVIRHREAMGYICAVSMSFAGMFAFITGSPYLYMEH
YGISAAVYPFVFGANILVMASSNRLNIYLLKRRTPQQNLVVGLGIQLCAGVALVALILSGMDSIYSVAPLMVVFVGMQGL
IAPNAMSSMLDHFPNMSATATALQGCLQFSSGAFAGMLVGAFEIASAWPTVLTMLGASLLGNIGVRVLAGRALGAQEEEG
AVTER
>Mature_404_residues
TRLNARRLALLVAANTALAPFAIDAYLPAMPTLAEAVNASVHHTELSLSVFLFGFAIGQLLCGPLSDRFGRRPVLLTGLV
VFLVASLGIMQVSSLETLWGLRFVQALGGGACVVNSAAIVRDCFSGREAAKVMSTMAMILMLAPLVAPTVGSVLLGFFNW
QSIFLFLALYAAFLLFFLGTRLPETHGRDPDAPSMRQVLRNYASVIRHREAMGYICAVSMSFAGMFAFITGSPYLYMEHY
GISAAVYPFVFGANILVMASSNRLNIYLLKRRTPQQNLVVGLGIQLCAGVALVALILSGMDSIYSVAPLMVVFVGMQGLI
APNAMSSMLDHFPNMSATATALQGCLQFSSGAFAGMLVGAFEIASAWPTVLTMLGASLLGNIGVRVLAGRALGAQEEEGA
VTER

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=359, Percent_Identity=32.033426183844, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI48994889, Length=401, Percent_Identity=29.925187032419, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790146, Length=230, Percent_Identity=32.1739130434783, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787065, Length=264, Percent_Identity=29.9242424242424, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082312, Length=335, Percent_Identity=28.0597014925373, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790794, Length=246, Percent_Identity=28.0487804878049, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324264, Length=163, Percent_Identity=28.8343558282209, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43112; Mature: 42980

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLNARRLALLVAANTALAPFAIDAYLPAMPTLAEAVNASVHHTELSLSVFLFGFAIGQ
CCCCCHHHEEEEEECCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLCGPLSDRFGRRPVLLTGLVVFLVASLGIMQVSSLETLWGLRFVQALGGGACVVNSAAI
HHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
VRDCFSGREAAKVMSTMAMILMLAPLVAPTVGSVLLGFFNWQSIFLFLALYAAFLLFFLG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRLPETHGRDPDAPSMRQVLRNYASVIRHREAMGYICAVSMSFAGMFAFITGSPYLYMEH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
YGISAAVYPFVFGANILVMASSNRLNIYLLKRRTPQQNLVVGLGIQLCAGVALVALILSG
CCCHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHC
MDSIYSVAPLMVVFVGMQGLIAPNAMSSMLDHFPNMSATATALQGCLQFSSGAFAGMLVG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHH
AFEIASAWPTVLTMLGASLLGNIGVRVLAGRALGAQEEEGAVTER
HHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRLNARRLALLVAANTALAPFAIDAYLPAMPTLAEAVNASVHHTELSLSVFLFGFAIGQ
CCCCHHHEEEEEECCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLCGPLSDRFGRRPVLLTGLVVFLVASLGIMQVSSLETLWGLRFVQALGGGACVVNSAAI
HHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
VRDCFSGREAAKVMSTMAMILMLAPLVAPTVGSVLLGFFNWQSIFLFLALYAAFLLFFLG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRLPETHGRDPDAPSMRQVLRNYASVIRHREAMGYICAVSMSFAGMFAFITGSPYLYMEH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
YGISAAVYPFVFGANILVMASSNRLNIYLLKRRTPQQNLVVGLGIQLCAGVALVALILSG
CCCHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHC
MDSIYSVAPLMVVFVGMQGLIAPNAMSSMLDHFPNMSATATALQGCLQFSSGAFAGMLVG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHH
AFEIASAWPTVLTMLGASLLGNIGVRVLAGRALGAQEEEGAVTER
HHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]