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The map label for this gene is hflK [H]

Identifier: 92113405

GI number: 92113405

Start: 1459102

End: 1460460

Strand: Direct

Name: hflK [H]

Synonym: Csal_1279

Alternate gene names: 92113405

Gene position: 1459102-1460460 (Clockwise)

Preceding gene: 92113404

Following gene: 92113406

Centisome position: 39.47

GC content: 62.1

Gene sequence:

>1359_bases
ATGGCTTGGAACGAGCCTGGTGGTGGAAATCAGCAGGACCCGTGGAGCGGTGGCGGTGGTCGCCGTGGTAGCGGAGGGGG
CAATGGTGGTAATAACCAGGGTCCACCGGATCTCGACGAGGCGCTGAAGAAGTTTCAGGACAAACTGAGCCGCTTGATGG
GCAAGCGCGGCAAGCGCGGCGGCGATGGCAATGGCGGTGCTTCGGGCGGCAAGGGCAACCCCTTCATACTGCCGGCGGTA
CTGACGGTATTGGCTCTGGTGATCTGGGCCGGTTCCGGTTTTTACCGGGTCGATCAGTCCGAACGCGGGGTGGTGCTGCG
CTTCGGCGAGTATCATGAAACCGTGGGGCCTGGCCTGCACTGGAATCCGACGTTCGTCGATCAGGTGACGATGGTCAATG
TCACCGAGGTGCGTTCGTTCCGCCAGGACGCCTCGATGCTGACCAGCGATACCAACATCGTCACGGTACGCCTCTCGGCA
CAGTATCAGGTCTCCAATCCGCGTGATTACGTGCTCAATGTACGCAATCCGGAGCAGAGCCTGCGCAATGCCCTCGATTC
CACGCTGCGTCACGTGGTGGGCGCGAGCGGCATGCAGAACGTGCTGACCAGTACCACGGAGGTCGAGGAGGTCAAGGAGA
TCGACGAGGGCGGCGAGGTGCCGGACATGCCGGAAACCGTGACCGATCCCAGCGAGCTGCCGGTCATCACCATGACGCCG
CCGGTGCCGGACTCGTTGCTCAGCGGCCGTGAAGAGCTCGGGCCGATGGTGGCCAAGCGTCTTCAGGAATCGCTGGATGC
CTATGGGTTGGGCTTGCGCTTGCAGACCGTGAACCTCGAAAGCACCCAGGCGCCTGAAGAAGTGCAGGAAGCCGTGGATG
ACGTGATTCGCTCGCGCGAGGATCGTCAGCGCCTGATCAACGAGGCGCGTGCCTACGAGAATGCGCTGCAACCGCGTACC
GAAGGTAATGCGCAGCGTCTCATCGAGGAGGCCACCGGGTATCGCAATTCGGTCGTGGCCGATGCACAGGGTCAGACCAG
TCGCTTCCTGTCGGTGCTGGGCGAGTATCAGCAGGCGCCGGAGGTCACGCGTCAGCGTCTCTATCTGGATACGTTGAGCG
ACGTGCTGGGCAACAATCGCAAGGCATTGCTCGATGTGGGACCGCAAAACAATTCCATGATCTACCTGCCGCTCGATCAG
TTGCGTCAGCCGCGTTCGTCGAACGCCGACAACGGTGACAGCCAGGAGGCTCGGGAGTTGGAATCGATCTCCCAGCAGGT
GCAGAACGAGCCGCTTTCCGGTAGCGACAACACGAGCAGTCAGCGCCAGTCGGGCGGCATTTCGCGGGAGGGTCGTTAA

Upstream 100 bases:

>100_bases
GGGAGCCCTCGATCGCCCGGAATGGGAACGCCCCTGACAGCGCCCGTCATGGGTGTCCCCGGCGAGATGCATCGCAATCA
ATGCATAGTGGAGAAGACGT

Downstream 100 bases:

>100_bases
TCATGGTCAACAATCGTGCCTTAGGTATCGTCGCACTGCTGGCCGTGGGGGCCTGGCTCGCAAGTGCCAGCCTGTATGTG
GTGACGGAAACGCAGCGGGC

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAWNEPGGGNQQDPWSGGGGRRGSGGGNGGNNQGPPDLDEALKKFQDKLSRLMGKRGKRGGDGNGGASGGKGNPFILPAV
LTVLALVIWAGSGFYRVDQSERGVVLRFGEYHETVGPGLHWNPTFVDQVTMVNVTEVRSFRQDASMLTSDTNIVTVRLSA
QYQVSNPRDYVLNVRNPEQSLRNALDSTLRHVVGASGMQNVLTSTTEVEEVKEIDEGGEVPDMPETVTDPSELPVITMTP
PVPDSLLSGREELGPMVAKRLQESLDAYGLGLRLQTVNLESTQAPEEVQEAVDDVIRSREDRQRLINEARAYENALQPRT
EGNAQRLIEEATGYRNSVVADAQGQTSRFLSVLGEYQQAPEVTRQRLYLDTLSDVLGNNRKALLDVGPQNNSMIYLPLDQ
LRQPRSSNADNGDSQEARELESISQQVQNEPLSGSDNTSSQRQSGGISREGR

Sequences:

>Translated_452_residues
MAWNEPGGGNQQDPWSGGGGRRGSGGGNGGNNQGPPDLDEALKKFQDKLSRLMGKRGKRGGDGNGGASGGKGNPFILPAV
LTVLALVIWAGSGFYRVDQSERGVVLRFGEYHETVGPGLHWNPTFVDQVTMVNVTEVRSFRQDASMLTSDTNIVTVRLSA
QYQVSNPRDYVLNVRNPEQSLRNALDSTLRHVVGASGMQNVLTSTTEVEEVKEIDEGGEVPDMPETVTDPSELPVITMTP
PVPDSLLSGREELGPMVAKRLQESLDAYGLGLRLQTVNLESTQAPEEVQEAVDDVIRSREDRQRLINEARAYENALQPRT
EGNAQRLIEEATGYRNSVVADAQGQTSRFLSVLGEYQQAPEVTRQRLYLDTLSDVLGNNRKALLDVGPQNNSMIYLPLDQ
LRQPRSSNADNGDSQEARELESISQQVQNEPLSGSDNTSSQRQSGGISREGR
>Mature_451_residues
AWNEPGGGNQQDPWSGGGGRRGSGGGNGGNNQGPPDLDEALKKFQDKLSRLMGKRGKRGGDGNGGASGGKGNPFILPAVL
TVLALVIWAGSGFYRVDQSERGVVLRFGEYHETVGPGLHWNPTFVDQVTMVNVTEVRSFRQDASMLTSDTNIVTVRLSAQ
YQVSNPRDYVLNVRNPEQSLRNALDSTLRHVVGASGMQNVLTSTTEVEEVKEIDEGGEVPDMPETVTDPSELPVITMTPP
VPDSLLSGREELGPMVAKRLQESLDAYGLGLRLQTVNLESTQAPEEVQEAVDDVIRSREDRQRLINEARAYENALQPRTE
GNAQRLIEEATGYRNSVVADAQGQTSRFLSVLGEYQQAPEVTRQRLYLDTLSDVLGNNRKALLDVGPQNNSMIYLPLDQL
RQPRSSNADNGDSQEARELESISQQVQNEPLSGSDNTSSQRQSGGISREGR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=425, Percent_Identity=38.3529411764706, Blast_Score=255, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 49242; Mature: 49111

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNEPGGGNQQDPWSGGGGRRGSGGGNGGNNQGPPDLDEALKKFQDKLSRLMGKRGKRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GDGNGGASGGKGNPFILPAVLTVLALVIWAGSGFYRVDQSERGVVLRFGEYHETVGPGLH
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCHHHHCCCCCC
WNPTFVDQVTMVNVTEVRSFRQDASMLTSDTNIVTVRLSAQYQVSNPRDYVLNVRNPEQS
CCCCHHHHEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCEEEEECCCHHHH
LRNALDSTLRHVVGASGMQNVLTSTTEVEEVKEIDEGGEVPDMPETVTDPSELPVITMTP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECC
PVPDSLLSGREELGPMVAKRLQESLDAYGLGLRLQTVNLESTQAPEEVQEAVDDVIRSRE
CCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCHH
DRQRLINEARAYENALQPRTEGNAQRLIEEATGYRNSVVADAQGQTSRFLSVLGEYQQAP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHH
EVTRQRLYLDTLSDVLGNNRKALLDVGPQNNSMIYLPLDQLRQPRSSNADNGDSQEAREL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHH
ESISQQVQNEPLSGSDNTSSQRQSGGISREGR
HHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
AWNEPGGGNQQDPWSGGGGRRGSGGGNGGNNQGPPDLDEALKKFQDKLSRLMGKRGKRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GDGNGGASGGKGNPFILPAVLTVLALVIWAGSGFYRVDQSERGVVLRFGEYHETVGPGLH
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCHHHHCCCCCC
WNPTFVDQVTMVNVTEVRSFRQDASMLTSDTNIVTVRLSAQYQVSNPRDYVLNVRNPEQS
CCCCHHHHEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCEEEEECCCHHHH
LRNALDSTLRHVVGASGMQNVLTSTTEVEEVKEIDEGGEVPDMPETVTDPSELPVITMTP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECC
PVPDSLLSGREELGPMVAKRLQESLDAYGLGLRLQTVNLESTQAPEEVQEAVDDVIRSRE
CCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCHH
DRQRLINEARAYENALQPRTEGNAQRLIEEATGYRNSVVADAQGQTSRFLSVLGEYQQAP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHH
EVTRQRLYLDTLSDVLGNNRKALLDVGPQNNSMIYLPLDQLRQPRSSNADNGDSQEAREL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHH
ESISQQVQNEPLSGSDNTSSQRQSGGISREGR
HHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]