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The map label for this gene is mutL

Identifier: 92113401

GI number: 92113401

Start: 1454422

End: 1456356

Strand: Direct

Name: mutL

Synonym: Csal_1275

Alternate gene names: 92113401

Gene position: 1454422-1456356 (Clockwise)

Preceding gene: 92113400

Following gene: 92113402

Centisome position: 39.34

GC content: 66.25

Gene sequence:

>1935_bases
ATGACGCATACTCGACGCATTCACATTCTCGACCCTCGACTCGCCAACCAGATCGCGGCCGGCGAGGTCGTCGAACGTCC
GGCCTCCGTGGTCAAGGAACTGGTCGAGAACGCCATCGATGCCGGCAGTCAGCGCATCGAGATCGATCTCGAATCCGGGG
GCGCGCGGTTGATCCGCGTGCGCGACGATGGCCGGGGCATCGATCAGGAGGATCTGCCGCTGGCACTGTCACGGCATGCC
ACCAGCAAGATCGCCTCGCTGGACGATCTGGAGGGAGTGGATAGTCTCGGCTTTCGCGGCGAGGCCCTGGCATCGATCAG
CTCGGTGTCGCGCCTGGAGTTGATTTCCAACACTCACGACGAGCCGAGCGATGGCTGGCGGGTCGTCGCCGAGGGGCGCC
AGATGGAGCCGCGGGTGACGCCTGCACCGCATCCGCGGGGCAGCTCGGTGGTCGTGCGCGATCTGTTCTTCAACACGCCG
GCGCGTCGCAAGTTTCTGCGTACCGAAAAGACCGAGTTCGGGCATGTCGAAGAAGCCTTTCGGCGCCTGGCGCTGTCGCG
CTACGACATCGGCTGGATTCTGCGGCACAACCAGAAGGTGGTGCATCAACTGCGCGCGGGCGATGCCTCGACATCCATGG
AACGCCGGGTCGGTGCGCTGCTGGGCCGCAAGTTTCTGGAAAATGCCCTGCACGTGGATATCGAGGCGACGGGCTTGCGT
CTGTGGGGATGGGTGGGATTGCCCACTCACTCCCGCGCCCAGGCGGACCAGCAGTACTTCTTCGTCAATGGGCGTGTCGT
GCGGGACCGGCTGGTGGCGCACGCCGTGCGTCAGGCGTATCGCGACGTCATGTTCCATGGCCGCCATCCGGTCTTCGTGC
TGTATCTCGAACTCGATCCGCATGTGGTCGATGTCAATGTGCACCCCACCAAGCACGAGGTGCGCTTCCGCGATGGCCGG
CTGGTGCACGACTTCCTGTTCTCCAGTCTGCATCGTGCCCTGGCCGATGTGCGGCCCAACGCCACATCGACGGAGGGAGG
AGACGAGGCCACGCCGTCGACGGATGCGACGACGGCGACAGCCGCCGAGGCATCGGCGGGCCAGGCCGAGCCGCGCTGGC
AGCAGCAGGGCATGGCGTTGGCCGCAGGCCAGGAGCGGGAGCGACCCGCGGCGCATCGCGTGCGTGAGTTCATGGCCGGT
TATCGTGCGCTGCACCCCGAGCACGAGGCGTCGTTGCTGACCCCGCAGCCACAGGAAGCGGCGGAAGAAGCGGCGGGGAC
ACCCGCTCCGCCGGCGTCATCGTCGCCCGCAATGGCCGAGACCGACGACACTCAGGCGCCGCCCCTGGGGTACGCCGTGG
CGCAACTGCATGGCGTGTACATTCTGTCCCAGACCGAGCGCGGCCTGGTGGTGGTCGACATGCACGCCGCCCACGAGCGC
ATCACCTACGAGCGCATGAAGCAGCAGGTACACGGCGACGGTCAGGCGCTGGGTCGACTGCAGACGCAGCCGCTGCTGGT
GCCGGTGTCGATCGCTGCCAGCGCCCGCGAGGTGGAAACCGCCGAGAACGAGCGCGCCACCTTCGAGCGGCTGGGCGTCG
AACTGGATGTCGCCGGACCGGAAACCCTGCTGGTGCGACAGGTGCCGGTACTGCTGGGCAATGCCGATGTCGAGGCCTTG
ATCCACGACATGCTCGGTGACCTGGAGCGTTTCGGGCGCTCCGATCGCCTGGAGGTCCATATCAACGAGCTGCTTTCCAG
CATGGCATGCCACGGCAGCGTGCGCGCCAATCGCCGGCTGACGGTGCCCGAAATGAATGCGCTGCTGCGCGACATGGAGC
GCACCGAGCGCAGCGGGCAATGCAACCACGGTCGTCCCACCTGGACCGAAATGTCGATGCATGAGCTGGACAAGTTGTTT
CTACGCGGTCAGTGA

Upstream 100 bases:

>100_bases
ATCTCAATGGCGACATTCTGCGCGTGGGCCAGGTCCTGAAGATTCCGCAGTCGTAAGCGCGCGCATGACGCGCGCCGCTT
GCGCGAGGCACAATGGTGTT

Downstream 100 bases:

>100_bases
CCCCGCTGACCGGCTACCGTTTCAGGACTTTCGATGAGTGATACACGGCCACTGGCCCTTTTGCTGATGGGCCCGACGGC
GGCCGGCAAGACCGATCTGG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MTHTRRIHILDPRLANQIAAGEVVERPASVVKELVENAIDAGSQRIEIDLESGGARLIRVRDDGRGIDQEDLPLALSRHA
TSKIASLDDLEGVDSLGFRGEALASISSVSRLELISNTHDEPSDGWRVVAEGRQMEPRVTPAPHPRGSSVVVRDLFFNTP
ARRKFLRTEKTEFGHVEEAFRRLALSRYDIGWILRHNQKVVHQLRAGDASTSMERRVGALLGRKFLENALHVDIEATGLR
LWGWVGLPTHSRAQADQQYFFVNGRVVRDRLVAHAVRQAYRDVMFHGRHPVFVLYLELDPHVVDVNVHPTKHEVRFRDGR
LVHDFLFSSLHRALADVRPNATSTEGGDEATPSTDATTATAAEASAGQAEPRWQQQGMALAAGQERERPAAHRVREFMAG
YRALHPEHEASLLTPQPQEAAEEAAGTPAPPASSSPAMAETDDTQAPPLGYAVAQLHGVYILSQTERGLVVVDMHAAHER
ITYERMKQQVHGDGQALGRLQTQPLLVPVSIAASAREVETAENERATFERLGVELDVAGPETLLVRQVPVLLGNADVEAL
IHDMLGDLERFGRSDRLEVHINELLSSMACHGSVRANRRLTVPEMNALLRDMERTERSGQCNHGRPTWTEMSMHELDKLF
LRGQ

Sequences:

>Translated_644_residues
MTHTRRIHILDPRLANQIAAGEVVERPASVVKELVENAIDAGSQRIEIDLESGGARLIRVRDDGRGIDQEDLPLALSRHA
TSKIASLDDLEGVDSLGFRGEALASISSVSRLELISNTHDEPSDGWRVVAEGRQMEPRVTPAPHPRGSSVVVRDLFFNTP
ARRKFLRTEKTEFGHVEEAFRRLALSRYDIGWILRHNQKVVHQLRAGDASTSMERRVGALLGRKFLENALHVDIEATGLR
LWGWVGLPTHSRAQADQQYFFVNGRVVRDRLVAHAVRQAYRDVMFHGRHPVFVLYLELDPHVVDVNVHPTKHEVRFRDGR
LVHDFLFSSLHRALADVRPNATSTEGGDEATPSTDATTATAAEASAGQAEPRWQQQGMALAAGQERERPAAHRVREFMAG
YRALHPEHEASLLTPQPQEAAEEAAGTPAPPASSSPAMAETDDTQAPPLGYAVAQLHGVYILSQTERGLVVVDMHAAHER
ITYERMKQQVHGDGQALGRLQTQPLLVPVSIAASAREVETAENERATFERLGVELDVAGPETLLVRQVPVLLGNADVEAL
IHDMLGDLERFGRSDRLEVHINELLSSMACHGSVRANRRLTVPEMNALLRDMERTERSGQCNHGRPTWTEMSMHELDKLF
LRGQ
>Mature_643_residues
THTRRIHILDPRLANQIAAGEVVERPASVVKELVENAIDAGSQRIEIDLESGGARLIRVRDDGRGIDQEDLPLALSRHAT
SKIASLDDLEGVDSLGFRGEALASISSVSRLELISNTHDEPSDGWRVVAEGRQMEPRVTPAPHPRGSSVVVRDLFFNTPA
RRKFLRTEKTEFGHVEEAFRRLALSRYDIGWILRHNQKVVHQLRAGDASTSMERRVGALLGRKFLENALHVDIEATGLRL
WGWVGLPTHSRAQADQQYFFVNGRVVRDRLVAHAVRQAYRDVMFHGRHPVFVLYLELDPHVVDVNVHPTKHEVRFRDGRL
VHDFLFSSLHRALADVRPNATSTEGGDEATPSTDATTATAAEASAGQAEPRWQQQGMALAAGQERERPAAHRVREFMAGY
RALHPEHEASLLTPQPQEAAEEAAGTPAPPASSSPAMAETDDTQAPPLGYAVAQLHGVYILSQTERGLVVVDMHAAHERI
TYERMKQQVHGDGQALGRLQTQPLLVPVSIAASAREVETAENERATFERLGVELDVAGPETLLVRQVPVLLGNADVEALI
HDMLGDLERFGRSDRLEVHINELLSSMACHGSVRANRRLTVPEMNALLRDMERTERSGQCNHGRPTWTEMSMHELDKLFL
RGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=310, Percent_Identity=33.8709677419355, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI4505913, Length=491, Percent_Identity=27.4949083503055, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI310128478, Length=491, Percent_Identity=27.4949083503055, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI4505911, Length=364, Percent_Identity=26.6483516483516, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI189458898, Length=364, Percent_Identity=26.6483516483516, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI310128480, Length=446, Percent_Identity=26.2331838565022, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI189458896, Length=355, Percent_Identity=25.6338028169014, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI263191589, Length=219, Percent_Identity=28.7671232876712, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI91992162, Length=270, Percent_Identity=27.4074074074074, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI91992160, Length=270, Percent_Identity=27.4074074074074, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI310128482, Length=381, Percent_Identity=23.8845144356955, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI310128484, Length=381, Percent_Identity=23.8845144356955, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI310128486, Length=356, Percent_Identity=24.1573033707865, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790612, Length=570, Percent_Identity=44.3859649122807, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=34.9056603773585, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=347, Percent_Identity=26.5129682997118, Blast_Score=122, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=377, Percent_Identity=31.5649867374005, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324247, Length=363, Percent_Identity=26.4462809917355, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323063, Length=450, Percent_Identity=24.6666666666667, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325093, Length=734, Percent_Identity=20.5722070844687, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136968, Length=314, Percent_Identity=36.624203821656, Blast_Score=192, Evalue=8e-49,
Organism=Drosophila melanogaster, GI17136970, Length=350, Percent_Identity=26, Blast_Score=112, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CHRSD (Q1QY28)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_573329.1
- ProteinModelPortal:   Q1QY28
- SMR:   Q1QY28
- STRING:   Q1QY28
- GeneID:   4027748
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_1275
- NMPDR:   fig|290398.4.peg.1265
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   CSAL290398:CSAL_1275-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 71510; Mature: 71378

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTRRIHILDPRLANQIAAGEVVERPASVVKELVENAIDAGSQRIEIDLESGGARLIRV
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEE
RDDGRGIDQEDLPLALSRHATSKIASLDDLEGVDSLGFRGEALASISSVSRLELISNTHD
ECCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCHHCCCCCHHHHHHHHHHHHHHHHCCCC
EPSDGWRVVAEGRQMEPRVTPAPHPRGSSVVVRDLFFNTPARRKFLRTEKTEFGHVEEAF
CCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHHHHHHCCCCCCCHHHHH
RRLALSRYDIGWILRHNQKVVHQLRAGDASTSMERRVGALLGRKFLENALHVDIEATGLR
HHHHHHHCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCEE
LWGWVGLPTHSRAQADQQYFFVNGRVVRDRLVAHAVRQAYRDVMFHGRHPVFVLYLELDP
EEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
HVVDVNVHPTKHEVRFRDGRLVHDFLFSSLHRALADVRPNATSTEGGDEATPSTDATTAT
EEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
AAEASAGQAEPRWQQQGMALAAGQERERPAAHRVREFMAGYRALHPEHEASLLTPQPQEA
HHHCCCCCCCCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
AEEAAGTPAPPASSSPAMAETDDTQAPPLGYAVAQLHGVYILSQTERGLVVVDMHAAHER
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEECCCCEEEEEEHHHHHH
ITYERMKQQVHGDGQALGRLQTQPLLVPVSIAASAREVETAENERATFERLGVELDVAGP
HHHHHHHHHHCCCHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHCCEEEECCCC
ETLLVRQVPVLLGNADVEALIHDMLGDLERFGRSDRLEVHINELLSSMACHGSVRANRRL
CEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCEE
TVPEMNALLRDMERTERSGQCNHGRPTWTEMSMHELDKLFLRGQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
THTRRIHILDPRLANQIAAGEVVERPASVVKELVENAIDAGSQRIEIDLESGGARLIRV
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEE
RDDGRGIDQEDLPLALSRHATSKIASLDDLEGVDSLGFRGEALASISSVSRLELISNTHD
ECCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCHHCCCCCHHHHHHHHHHHHHHHHCCCC
EPSDGWRVVAEGRQMEPRVTPAPHPRGSSVVVRDLFFNTPARRKFLRTEKTEFGHVEEAF
CCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHHHHHHCCCCCCCHHHHH
RRLALSRYDIGWILRHNQKVVHQLRAGDASTSMERRVGALLGRKFLENALHVDIEATGLR
HHHHHHHCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCEE
LWGWVGLPTHSRAQADQQYFFVNGRVVRDRLVAHAVRQAYRDVMFHGRHPVFVLYLELDP
EEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
HVVDVNVHPTKHEVRFRDGRLVHDFLFSSLHRALADVRPNATSTEGGDEATPSTDATTAT
EEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
AAEASAGQAEPRWQQQGMALAAGQERERPAAHRVREFMAGYRALHPEHEASLLTPQPQEA
HHHCCCCCCCCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
AEEAAGTPAPPASSSPAMAETDDTQAPPLGYAVAQLHGVYILSQTERGLVVVDMHAAHER
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEECCCCEEEEEEHHHHHH
ITYERMKQQVHGDGQALGRLQTQPLLVPVSIAASAREVETAENERATFERLGVELDVAGP
HHHHHHHHHHCCCHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHCCEEEECCCC
ETLLVRQVPVLLGNADVEALIHDMLGDLERFGRSDRLEVHINELLSSMACHGSVRANRRL
CEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCEE
TVPEMNALLRDMERTERSGQCNHGRPTWTEMSMHELDKLFLRGQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA