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The map label for this gene is rnr [H]

Identifier: 92113014

GI number: 92113014

Start: 998120

End: 1000525

Strand: Direct

Name: rnr [H]

Synonym: Csal_0886

Alternate gene names: 92113014

Gene position: 998120-1000525 (Clockwise)

Preceding gene: 92113013

Following gene: 92113015

Centisome position: 27.0

GC content: 64.88

Gene sequence:

>2406_bases
ATGAATCATTGGAAACTCAGTGACGATCCGCATGCGGAACGTGAAGCGAGTAAATACGATAATCCCGTCCCCAGCCGCGA
ATACCTGTTCGCGCGCCTGGAGGAGTACGGCAAGCCCATCACCCCCGAAAACCTCAGCCGCATGCTGGCGGTGGACGACG
AGGAACGGCTGGAAGGCGTACGCCGCCGGCTGGCCGCCATGGAGCGCGATGGCCAGATTCTGCGCAATCGGCGTGGTGCC
TACGCCCTGATCGACAAGCTCGACCTCATCCGCGGCCGGGTTCAGGGGCATCGCGACGGCATGGGCTTCTTGATCCGCGA
GGATGGCAAGAAGCCCGATCTGGTATTGCCGCCTCGCCAGATGCGGCGTGTCTTCGACGGCGACCAGGTGCTGGTGCGCA
TCAGCGGCCGCGACCGGCGCGGTCGCGACGAGGCGACCATCGCCGAGGTGCTGGCGCGCAACACCCAGTCGCTGGTGGGG
GTCTACCGCCAGAATACCGCCGAGTTCGGGGTATTGATTCCCGAGAACTCGCGGATCTCCCAGGAAGTGATCGTGCCGCA
TAGCGCCAGCGGTGGTGCCCGCGACGGCCAGATCGTCGCGGTGCGCATCACCCAGCAACCGGCGACGCGGGTACAGCCGG
TCGGGGAGGTCACCGAAGTGCTCGGCGAGCGCATGGATCCGGGGATGGAAATCGACATCGCCATCCGCAGCTACGAGATT
CCCGCGGAATTTCCGCCCGAGGTGCATGCCGAGATCGCCGACATGTCGGCGTCCGTGGCCGAGGCCGACAAGCAGAACCG
GATCGATCTGCGCGATGTGCCGCTGGTGACCATCGACGACGAGTCTGCCAAGGACTTCGACGATGCCGTCTGCGCCTGGA
AAACCAAGTCCGGGAGCTGGAAGCTGGTAGTGGCGATCGCCGACGTCTCGCACTATGTGCGTCCGGGCAGCGCCCTGGAC
CAGGAGGCGATCACGCGCGGCACCTCGGTCTATTTCCCCGGCCAGGTCGTACCGATGCTGCCCGAGCTGCTGTCCAACGG
GCTGTGCTCGCTGAATCCCGAGGTGGACCGCCTGGCCCTGGTCTGCGAGATGAATATTTCGCCGAACGGGGCGATCAGCC
GCTACCGCTTCTACGAGGCGGTATTCCAGTCGCATGCGCGCCTGACCTACAACAAGGTCGCCGCGATCCTCGACGACGAG
GGGCCGGAAGCCGACGCCCTGCGCGAACAGTACCGGAATCTCGTGCCCTCGCTGAAGAACCTGAAAAGTCTCTACACGAT
CCTGCGCGAGGCACGCGAGGCGCGTGGTGCCATCGATTTCGAGACCACCGAGACGGAAATCATCTTCAACGAGGCGCGCA
AGATCGAGAAGATCGTGCCGCGCTCGCGCAACGATGCGCACAAGATCATCGAGGAATGCATGCTGGCCGCCAACGTGGCG
ACCGCGCGCTTTCTCGACAAGCACGATCTGCCGGCGCTGTATCGTATCCACGAGAAGCCTTCGCCGGAGCGCCTGGACAA
GCTGCGCCTGTTCCTCAACGAGCTGGGGCTGTCGCTGGGCGGCGGCGACGATCCTACGCCGCAGGACTATCGCGACCTTG
CCGAGGCGATCAAGGGACGGCCGGATGCCGACGTCATCCAGACGGTAATGCTGCGCTCGATGAGCCGCGCGGTCTATTCG
CCGCAGAACGACGGCCACTTCGGTCTGGCCTATCCGGCTTATGCGCATTTCACTTCGCCGATTCGCCGCTATCCGGATCT
GCTCGTGCATCGCGCCATCCGCTCGGTGATTCGAGGTCCGCGCCAGACCAATACCGTACTGCGTGCCGAGGGTGCGCCGG
TGGAGCCGCCCAGCAAGTGGGCGCCGTACACCTTCGAGCAGATGCTCGAACTCGGCGAGCATTGCTCGATGACCGAGCGG
CGCGCCGACGACGCGACACGTGACGTCGAGGATTGGCTGAAGTGCGAGTTCATGTCCGACAAGCTCGGCGAGATCTTCGA
CGGCACCATTGCCTCGGTGACGCAGTTCGGCGTCTTCGTGCGCCTCGACGATGTCTATGTGGAAGGGCTGGTGCACGTCA
CGTCGCTGCCGTCCGACTACTACCACTACGAGGCGGAAAAGCATCGCCTCAAGGGGGAGCGCAGCGGCATGTCCTATCGC
CTCGGCGATGGCGTGACCGTGCAGGTGGCACGCGTCGACCTGGACGAGCGCAAGATCGACTTCGAACTGGCCGACGACAA
GCCACGCCCGCATCGCTCCAACCGCGGCCGCAAGAAGCCGGCGTCTGGCGGTGCGTCGACACAGGGCAAGCAGGGGGCCG
GGCAGGACGGCAATGCCACCAAGAAATCGCGCGACGGCAAGCCGCGCCGGCGTTCTCGGCGTGGCAAGGGAGACAAGCGC
GGATGA

Upstream 100 bases:

>100_bases
CTGGCTGTGCCCGCTATACTGGCGTCATGATTGAATTTCATAACAACGCCATCGGCGCACCCTATTCGCTTGCCGGCTCG
CTCGTAAGGAAGTCATTACC

Downstream 100 bases:

>100_bases
GCGCCGGACACCGGAAAGTGAGGCCTCATGAAAGGTAAGTCGTCCCGGACGCGCGTCGCGACGCCCGAAGGTCTGGATGC
CGTCTACGGCGTACATGCCG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 801; Mature: 801

Protein sequence:

>801_residues
MNHWKLSDDPHAEREASKYDNPVPSREYLFARLEEYGKPITPENLSRMLAVDDEERLEGVRRRLAAMERDGQILRNRRGA
YALIDKLDLIRGRVQGHRDGMGFLIREDGKKPDLVLPPRQMRRVFDGDQVLVRISGRDRRGRDEATIAEVLARNTQSLVG
VYRQNTAEFGVLIPENSRISQEVIVPHSASGGARDGQIVAVRITQQPATRVQPVGEVTEVLGERMDPGMEIDIAIRSYEI
PAEFPPEVHAEIADMSASVAEADKQNRIDLRDVPLVTIDDESAKDFDDAVCAWKTKSGSWKLVVAIADVSHYVRPGSALD
QEAITRGTSVYFPGQVVPMLPELLSNGLCSLNPEVDRLALVCEMNISPNGAISRYRFYEAVFQSHARLTYNKVAAILDDE
GPEADALREQYRNLVPSLKNLKSLYTILREAREARGAIDFETTETEIIFNEARKIEKIVPRSRNDAHKIIEECMLAANVA
TARFLDKHDLPALYRIHEKPSPERLDKLRLFLNELGLSLGGGDDPTPQDYRDLAEAIKGRPDADVIQTVMLRSMSRAVYS
PQNDGHFGLAYPAYAHFTSPIRRYPDLLVHRAIRSVIRGPRQTNTVLRAEGAPVEPPSKWAPYTFEQMLELGEHCSMTER
RADDATRDVEDWLKCEFMSDKLGEIFDGTIASVTQFGVFVRLDDVYVEGLVHVTSLPSDYYHYEAEKHRLKGERSGMSYR
LGDGVTVQVARVDLDERKIDFELADDKPRPHRSNRGRKKPASGGASTQGKQGAGQDGNATKKSRDGKPRRRSRRGKGDKR
G

Sequences:

>Translated_801_residues
MNHWKLSDDPHAEREASKYDNPVPSREYLFARLEEYGKPITPENLSRMLAVDDEERLEGVRRRLAAMERDGQILRNRRGA
YALIDKLDLIRGRVQGHRDGMGFLIREDGKKPDLVLPPRQMRRVFDGDQVLVRISGRDRRGRDEATIAEVLARNTQSLVG
VYRQNTAEFGVLIPENSRISQEVIVPHSASGGARDGQIVAVRITQQPATRVQPVGEVTEVLGERMDPGMEIDIAIRSYEI
PAEFPPEVHAEIADMSASVAEADKQNRIDLRDVPLVTIDDESAKDFDDAVCAWKTKSGSWKLVVAIADVSHYVRPGSALD
QEAITRGTSVYFPGQVVPMLPELLSNGLCSLNPEVDRLALVCEMNISPNGAISRYRFYEAVFQSHARLTYNKVAAILDDE
GPEADALREQYRNLVPSLKNLKSLYTILREAREARGAIDFETTETEIIFNEARKIEKIVPRSRNDAHKIIEECMLAANVA
TARFLDKHDLPALYRIHEKPSPERLDKLRLFLNELGLSLGGGDDPTPQDYRDLAEAIKGRPDADVIQTVMLRSMSRAVYS
PQNDGHFGLAYPAYAHFTSPIRRYPDLLVHRAIRSVIRGPRQTNTVLRAEGAPVEPPSKWAPYTFEQMLELGEHCSMTER
RADDATRDVEDWLKCEFMSDKLGEIFDGTIASVTQFGVFVRLDDVYVEGLVHVTSLPSDYYHYEAEKHRLKGERSGMSYR
LGDGVTVQVARVDLDERKIDFELADDKPRPHRSNRGRKKPASGGASTQGKQGAGQDGNATKKSRDGKPRRRSRRGKGDKR
G
>Mature_801_residues
MNHWKLSDDPHAEREASKYDNPVPSREYLFARLEEYGKPITPENLSRMLAVDDEERLEGVRRRLAAMERDGQILRNRRGA
YALIDKLDLIRGRVQGHRDGMGFLIREDGKKPDLVLPPRQMRRVFDGDQVLVRISGRDRRGRDEATIAEVLARNTQSLVG
VYRQNTAEFGVLIPENSRISQEVIVPHSASGGARDGQIVAVRITQQPATRVQPVGEVTEVLGERMDPGMEIDIAIRSYEI
PAEFPPEVHAEIADMSASVAEADKQNRIDLRDVPLVTIDDESAKDFDDAVCAWKTKSGSWKLVVAIADVSHYVRPGSALD
QEAITRGTSVYFPGQVVPMLPELLSNGLCSLNPEVDRLALVCEMNISPNGAISRYRFYEAVFQSHARLTYNKVAAILDDE
GPEADALREQYRNLVPSLKNLKSLYTILREAREARGAIDFETTETEIIFNEARKIEKIVPRSRNDAHKIIEECMLAANVA
TARFLDKHDLPALYRIHEKPSPERLDKLRLFLNELGLSLGGGDDPTPQDYRDLAEAIKGRPDADVIQTVMLRSMSRAVYS
PQNDGHFGLAYPAYAHFTSPIRRYPDLLVHRAIRSVIRGPRQTNTVLRAEGAPVEPPSKWAPYTFEQMLELGEHCSMTER
RADDATRDVEDWLKCEFMSDKLGEIFDGTIASVTQFGVFVRLDDVYVEGLVHVTSLPSDYYHYEAEKHRLKGERSGMSYR
LGDGVTVQVARVDLDERKIDFELADDKPRPHRSNRGRKKPASGGASTQGKQGAGQDGNATKKSRDGKPRRRSRRGKGDKR
G

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=475, Percent_Identity=29.6842105263158, Blast_Score=196, Evalue=9e-50,
Organism=Homo sapiens, GI190014625, Length=475, Percent_Identity=29.6842105263158, Blast_Score=196, Evalue=1e-49,
Organism=Homo sapiens, GI19115966, Length=527, Percent_Identity=27.5142314990512, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI219521928, Length=527, Percent_Identity=27.5142314990512, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI134288890, Length=391, Percent_Identity=30.4347826086957, Blast_Score=154, Evalue=5e-37,
Organism=Homo sapiens, GI156105695, Length=302, Percent_Identity=27.4834437086093, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI156105693, Length=302, Percent_Identity=27.4834437086093, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI87082383, Length=747, Percent_Identity=53.2797858099063, Blast_Score=795, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=670, Percent_Identity=27.4626865671642, Blast_Score=190, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI212645896, Length=480, Percent_Identity=29.1666666666667, Blast_Score=182, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17553506, Length=433, Percent_Identity=28.6374133949192, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324552, Length=430, Percent_Identity=29.0697674418605, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320499, Length=566, Percent_Identity=23.321554770318, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24649634, Length=442, Percent_Identity=30.0904977375566, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI19922976, Length=374, Percent_Identity=29.4117647058824, Blast_Score=139, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24654597, Length=374, Percent_Identity=29.4117647058824, Blast_Score=139, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24654592, Length=374, Percent_Identity=29.4117647058824, Blast_Score=139, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 90051; Mature: 90051

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHWKLSDDPHAEREASKYDNPVPSREYLFARLEEYGKPITPENLSRMLAVDDEERLEGV
CCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHH
RRRLAAMERDGQILRNRRGAYALIDKLDLIRGRVQGHRDGMGFLIREDGKKPDLVLPPRQ
HHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEECCHHH
MRRVFDGDQVLVRISGRDRRGRDEATIAEVLARNTQSLVGVYRQNTAEFGVLIPENSRIS
HHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
QEVIVPHSASGGARDGQIVAVRITQQPATRVQPVGEVTEVLGERMDPGMEIDIAIRSYEI
CEEEECCCCCCCCCCCCEEEEEEECCCCHHCCCHHHHHHHHHHHCCCCCEEEEEEEEEEC
PAEFPPEVHAEIADMSASVAEADKQNRIDLRDVPLVTIDDESAKDFDDAVCAWKTKSGSW
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHEEEEECCCCE
KLVVAIADVSHYVRPGSALDQEAITRGTSVYFPGQVVPMLPELLSNGLCSLNPEVDRLAL
EEEEEEECHHHHCCCCCCCCHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCEEEE
VCEMNISPNGAISRYRFYEAVFQSHARLTYNKVAAILDDEGPEADALREQYRNLVPSLKN
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LKSLYTILREAREARGAIDFETTETEIIFNEARKIEKIVPRSRNDAHKIIEECMLAANVA
HHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TARFLDKHDLPALYRIHEKPSPERLDKLRLFLNELGLSLGGGDDPTPQDYRDLAEAIKGR
HHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
PDADVIQTVMLRSMSRAVYSPQNDGHFGLAYPAYAHFTSPIRRYPDLLVHRAIRSVIRGP
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RQTNTVLRAEGAPVEPPSKWAPYTFEQMLELGEHCSMTERRADDATRDVEDWLKCEFMSD
CCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHH
KLGEIFDGTIASVTQFGVFVRLDDVYVEGLVHVTSLPSDYYHYEAEKHRLKGERSGMSYR
HHHHHHCCHHHHHHHHCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHCCCCEE
LGDGVTVQVARVDLDERKIDFELADDKPRPHRSNRGRKKPASGGASTQGKQGAGQDGNAT
CCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KKSRDGKPRRRSRRGKGDKRG
CCCCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MNHWKLSDDPHAEREASKYDNPVPSREYLFARLEEYGKPITPENLSRMLAVDDEERLEGV
CCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHH
RRRLAAMERDGQILRNRRGAYALIDKLDLIRGRVQGHRDGMGFLIREDGKKPDLVLPPRQ
HHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEECCHHH
MRRVFDGDQVLVRISGRDRRGRDEATIAEVLARNTQSLVGVYRQNTAEFGVLIPENSRIS
HHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
QEVIVPHSASGGARDGQIVAVRITQQPATRVQPVGEVTEVLGERMDPGMEIDIAIRSYEI
CEEEECCCCCCCCCCCCEEEEEEECCCCHHCCCHHHHHHHHHHHCCCCCEEEEEEEEEEC
PAEFPPEVHAEIADMSASVAEADKQNRIDLRDVPLVTIDDESAKDFDDAVCAWKTKSGSW
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHEEEEECCCCE
KLVVAIADVSHYVRPGSALDQEAITRGTSVYFPGQVVPMLPELLSNGLCSLNPEVDRLAL
EEEEEEECHHHHCCCCCCCCHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCEEEE
VCEMNISPNGAISRYRFYEAVFQSHARLTYNKVAAILDDEGPEADALREQYRNLVPSLKN
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LKSLYTILREAREARGAIDFETTETEIIFNEARKIEKIVPRSRNDAHKIIEECMLAANVA
HHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TARFLDKHDLPALYRIHEKPSPERLDKLRLFLNELGLSLGGGDDPTPQDYRDLAEAIKGR
HHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
PDADVIQTVMLRSMSRAVYSPQNDGHFGLAYPAYAHFTSPIRRYPDLLVHRAIRSVIRGP
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RQTNTVLRAEGAPVEPPSKWAPYTFEQMLELGEHCSMTERRADDATRDVEDWLKCEFMSD
CCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHH
KLGEIFDGTIASVTQFGVFVRLDDVYVEGLVHVTSLPSDYYHYEAEKHRLKGERSGMSYR
HHHHHHCCHHHHHHHHCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHCCCCEE
LGDGVTVQVARVDLDERKIDFELADDKPRPHRSNRGRKKPASGGASTQGKQGAGQDGNAT
CCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KKSRDGKPRRRSRRGKGDKRG
CCCCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]